EP1322647A1 - Nouvelles formes polymorphes de 5- 4- 2- n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate et procede de preparation associe - Google Patents
Nouvelles formes polymorphes de 5- 4- 2- n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate et procede de preparation associeInfo
- Publication number
- EP1322647A1 EP1322647A1 EP01971336A EP01971336A EP1322647A1 EP 1322647 A1 EP1322647 A1 EP 1322647A1 EP 01971336 A EP01971336 A EP 01971336A EP 01971336 A EP01971336 A EP 01971336A EP 1322647 A1 EP1322647 A1 EP 1322647A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyridyl
- thiazolidine
- ethoxy
- benzyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN805CH2000 | 2000-09-26 | ||
INMA080500 | 2000-09-26 | ||
PCT/US2001/029896 WO2002026737A1 (fr) | 2000-09-26 | 2001-09-25 | Nouvelles formes polymorphes de 5-[4-[2-[n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate et procede de preparation associe |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1322647A1 true EP1322647A1 (fr) | 2003-07-02 |
Family
ID=29266775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01971336A Withdrawn EP1322647A1 (fr) | 2000-09-26 | 2001-09-25 | Nouvelles formes polymorphes de 5- 4- 2- n-methyl-n-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate et procede de preparation associe |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1322647A1 (fr) |
JP (1) | JP2004509961A (fr) |
AU (1) | AU9123201A (fr) |
BR (1) | BR0114196A (fr) |
CA (1) | CA2426117A1 (fr) |
CZ (1) | CZ2003864A3 (fr) |
HU (1) | HUP0301161A3 (fr) |
IL (1) | IL155036A0 (fr) |
MX (1) | MXPA03002580A (fr) |
NO (1) | NO324968B1 (fr) |
NZ (1) | NZ525498A (fr) |
PL (1) | PL360661A1 (fr) |
SK (1) | SK3752003A3 (fr) |
WO (1) | WO2002026737A1 (fr) |
ZA (1) | ZA200303223B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
GB9726563D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
WO2000064892A2 (fr) | 1999-04-23 | 2000-11-02 | Smithkline Beecham P.L.C. | Nouvelle composition pharmaceutique |
US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
PL351684A1 (en) | 1999-04-23 | 2003-06-02 | Smithkline Beecham Plc | Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt |
WO2004062667A1 (fr) * | 2003-01-08 | 2004-07-29 | Dr. Reddy's Laboratories Limited | Forme amorphe du maleate de rosiglitazone et procede de preparation |
GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
EP1468997A3 (fr) * | 2003-04-18 | 2004-11-03 | CHEMI S.p.A. | Formes polymorphes de maléate de rosiglitatone |
GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
EP1753759A2 (fr) * | 2004-03-31 | 2007-02-21 | Sandoz AG | Nouveau co-precipite de rosiglitazone amorphe |
CN1956981A (zh) * | 2004-05-11 | 2007-05-02 | 参天制药株式会社 | 角膜结膜病变治疗剂 |
JP2005350451A (ja) * | 2004-05-11 | 2005-12-22 | Santen Pharmaceut Co Ltd | 角結膜障害治療剤 |
CZ296472B6 (cs) * | 2004-07-27 | 2006-03-15 | Zentiva, A. S | Sul kyseliny stavelové s 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidin-2,4-dionu azpusob její prípravy a její pouzití |
ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
EP2184055A1 (fr) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Procédé de préparation de formes galéniques solides de maléate de rosiglitazone |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3856378T2 (de) * | 1987-09-04 | 2000-05-11 | Beecham Group Plc | Substituierte Thiazolidindionderivate |
GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
EP0844997A1 (fr) * | 1996-06-19 | 1998-06-03 | Dr. Reddy's Research Foundation | Nouvelles formes polymorphes de la troglitazone ayant une activite anti-diabetique augmentee et procede pour leur preparation |
CN1221417A (zh) * | 1996-07-26 | 1999-06-30 | 雷迪博士研究基金会 | 具有抗糖尿病、降低血脂、抗高血压性能的噻唑烷二酮化合物,其制备方法及其药物组合物 |
GB9726566D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
PL351684A1 (en) * | 1999-04-23 | 2003-06-02 | Smithkline Beecham Plc | Polymorph of 5−[4−[2− (n−methyl−n−( 2−pyridyl)amino) ethoxy]benzyl] thiazolidine−2,4−dione, maleic acid salt |
WO2000064892A2 (fr) * | 1999-04-23 | 2000-11-02 | Smithkline Beecham P.L.C. | Nouvelle composition pharmaceutique |
-
2001
- 2001-09-25 BR BR0114196-1A patent/BR0114196A/pt not_active Application Discontinuation
- 2001-09-25 HU HU0301161A patent/HUP0301161A3/hu unknown
- 2001-09-25 MX MXPA03002580A patent/MXPA03002580A/es active IP Right Grant
- 2001-09-25 AU AU9123201A patent/AU9123201A/xx active Pending
- 2001-09-25 WO PCT/US2001/029896 patent/WO2002026737A1/fr active IP Right Grant
- 2001-09-25 IL IL15503601A patent/IL155036A0/xx unknown
- 2001-09-25 NZ NZ525498A patent/NZ525498A/en unknown
- 2001-09-25 CZ CZ2003864A patent/CZ2003864A3/cs unknown
- 2001-09-25 PL PL01360661A patent/PL360661A1/xx not_active Application Discontinuation
- 2001-09-25 EP EP01971336A patent/EP1322647A1/fr not_active Withdrawn
- 2001-09-25 CA CA002426117A patent/CA2426117A1/fr not_active Abandoned
- 2001-09-25 SK SK375-2003A patent/SK3752003A3/sk not_active Application Discontinuation
- 2001-09-25 JP JP2002531121A patent/JP2004509961A/ja active Pending
-
2003
- 2003-03-25 NO NO20031356A patent/NO324968B1/no unknown
- 2003-04-24 ZA ZA200303223A patent/ZA200303223B/xx unknown
Non-Patent Citations (1)
Title |
---|
See references of WO0226737A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002026737A8 (fr) | 2003-11-06 |
HUP0301161A2 (hu) | 2003-11-28 |
NO20031356L (no) | 2003-05-26 |
WO2002026737A1 (fr) | 2002-04-04 |
AU9123201A (en) | 2002-04-08 |
JP2004509961A (ja) | 2004-04-02 |
CZ2003864A3 (cs) | 2004-01-14 |
NZ525498A (en) | 2004-11-26 |
CA2426117A1 (fr) | 2002-04-04 |
BR0114196A (pt) | 2003-07-22 |
SK3752003A3 (sk) | 2005-03-04 |
NO324968B1 (no) | 2008-01-14 |
PL360661A1 (en) | 2004-09-20 |
IL155036A0 (en) | 2003-10-31 |
ZA200303223B (en) | 2004-07-26 |
MXPA03002580A (es) | 2003-10-15 |
NO20031356D0 (no) | 2003-03-25 |
HUP0301161A3 (en) | 2005-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030423 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: DR. REDDY'S LABORATORIES LTD. |
|
TPAC | Observations filed by third parties |
Free format text: ORIGINAL CODE: EPIDOSNTIPA |
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17Q | First examination report despatched |
Effective date: 20060406 |
|
RTI1 | Title (correction) |
Free format text: NOVEL POLYMORPHIC FORMS OF 5-??4-??2-??N-METHYL-N-(2-PYRIDYL)AMINO ETHOXY BENZYL THIAZOLIDINE-2,4-DIONE MALEIC ACID SALT AND PROCESS FOR THEIR PREPARATION |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20081223 |
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1057209 Country of ref document: HK |