EP1237583A1 - Near infrared fluorescent contrast agent and fluorescence imaging - Google Patents
Near infrared fluorescent contrast agent and fluorescence imagingInfo
- Publication number
- EP1237583A1 EP1237583A1 EP99965468A EP99965468A EP1237583A1 EP 1237583 A1 EP1237583 A1 EP 1237583A1 EP 99965468 A EP99965468 A EP 99965468A EP 99965468 A EP99965468 A EP 99965468A EP 1237583 A1 EP1237583 A1 EP 1237583A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- contrast agent
- salt
- near infrared
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229960002078 sevoflurane Drugs 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 125000004436 sodium atom Chemical group 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Definitions
- the pharmaceutically acceptable salt may be any as long as it forms a nontoxic salt with the compound of the formula [I].
- examples thereof include alkali metal salts such as sodium salt, potassium salt; salt of alkaline earth metal such as magnesium salt, calcium salt and the like; organic ammonium salt such as ammonium salt, triethyl ammonium salt, tributyl ammonium salt, pyridinium salt and the like; salt of amino acid such as lysine salt, arginine salt and the like.
- alkali metal salts such as sodium salt, potassium salt
- salt of alkaline earth metal such as magnesium salt, calcium salt and the like
- organic ammonium salt such as ammonium salt, triethyl ammonium salt, tributyl ammonium salt, pyridinium salt and the like
- salt of amino acid such as lysine salt, arginine salt and the like.
- Particularly preferred is sodium salt causing less toxicity in the living body.
- L 2 , L 3 , L 4 , L 5 , L 6 and L 7 are as defined above and L 8 is an optionally substituted methine group, are reacted in the presence of a base and a solvent to give a compound of the formula [VI-3]
- heterocyclic quaternary salt compound Q3 (3.75 g) were added methanol (25 ml), triethylamine (3.5 ml), dianyl compound A6 (1.95 g) and acetic anhydride (2.4 ml), and the mixture was stirred at room temperature for 1 hour. The insoluble matter was filtered off, and a solution of sodium acetate (3.9 g) in a small amount of methanol was added to the filtrate. The mixture was stirred at room temperature for 1 hour. The resulting crystals were collected by filtration and washed with a small amount of methanol. To the crystals was added water (10 ml) for dissolution.
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1999/009959 WO2001043781A1 (en) | 1999-12-15 | 1999-12-15 | Near infrared fluorescent contrast agent and fluorescence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1237583A1 true EP1237583A1 (en) | 2002-09-11 |
Family
ID=8167530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99965468A Withdrawn EP1237583A1 (en) | 1999-12-15 | 1999-12-15 | Near infrared fluorescent contrast agent and fluorescence imaging |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1237583A1 (sh) |
| JP (1) | JP2003517025A (sh) |
| KR (1) | KR20020082207A (sh) |
| CN (1) | CN1217701C (sh) |
| AU (1) | AU2097500A (sh) |
| BG (1) | BG106822A (sh) |
| BR (1) | BR9917587A (sh) |
| CA (1) | CA2394539C (sh) |
| EA (1) | EA200200635A1 (sh) |
| EE (1) | EE200200321A (sh) |
| HU (1) | HUP0204024A2 (sh) |
| IL (1) | IL149798A0 (sh) |
| MX (1) | MXPA02005806A (sh) |
| NO (1) | NO328630B1 (sh) |
| PL (1) | PL355891A1 (sh) |
| SK (1) | SK8142002A3 (sh) |
| TR (1) | TR200201567T2 (sh) |
| WO (1) | WO2001043781A1 (sh) |
| YU (1) | YU44402A (sh) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011025950A2 (en) | 2009-08-28 | 2011-03-03 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| WO2011038006A1 (en) | 2009-09-22 | 2011-03-31 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| WO2014062716A1 (en) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| WO2015103420A1 (en) | 2013-12-31 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
| WO2016100340A1 (en) | 2014-12-15 | 2016-06-23 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| WO2017106525A1 (en) | 2015-12-15 | 2017-06-22 | Memorial Sloan Kettering Cancer Center | Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization |
| WO2018102372A1 (en) | 2016-11-30 | 2018-06-07 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
| US11989803B2 (en) | 2018-03-30 | 2024-05-21 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (ja) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | 蛍光造影剤 |
| JP5074044B2 (ja) * | 2007-01-18 | 2012-11-14 | オリンパス株式会社 | 蛍光観察装置および蛍光観察装置の作動方法 |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| JP2011046663A (ja) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| WO2011088392A2 (en) * | 2010-01-14 | 2011-07-21 | The Regents Of The University Of California | Devices, systems and methods to detect and reduce or prevent entry of inflammatory mediators into milk ducts |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| EP3338617B1 (en) | 2012-01-23 | 2020-08-19 | Washington University | Goggle imaging systems and devices |
| WO2014149069A1 (en) | 2013-03-15 | 2014-09-25 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| WO2016193396A1 (en) | 2015-06-03 | 2016-12-08 | Surgimab S.A.S. | Fluorescent conjugates |
| CN105222828B (zh) * | 2015-09-30 | 2017-05-24 | 东南大学 | 一种贴壁射流速度场和浓度场的同步测量装置与方法 |
| US11712482B2 (en) | 2019-12-13 | 2023-08-01 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| CN114459862A (zh) * | 2022-01-13 | 2022-05-10 | 华腾实业（深圳）股份有限公司 | 一种高识别的真菌荧光染色液 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0529002B1 (en) * | 1990-05-15 | 2001-10-04 | Hyperion, Inc. | Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes |
| ATE264694T1 (de) * | 1995-01-30 | 2004-05-15 | Daiichi Pure Chemicals Co Ltd | Diagnostisches markierungsmittel |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
-
1999
- 1999-12-15 BR BR9917587-8A patent/BR9917587A/pt not_active Application Discontinuation
- 1999-12-15 TR TR2002/01567T patent/TR200201567T2/xx unknown
- 1999-12-15 EE EEP200200321A patent/EE200200321A/xx unknown
- 1999-12-15 JP JP2001544917A patent/JP2003517025A/ja active Pending
- 1999-12-15 KR KR1020027007635A patent/KR20020082207A/ko not_active Application Discontinuation
- 1999-12-15 HU HU0204024A patent/HUP0204024A2/hu unknown
- 1999-12-15 EA EA200200635A patent/EA200200635A1/ru unknown
- 1999-12-15 AU AU20975/00A patent/AU2097500A/en not_active Abandoned
- 1999-12-15 EP EP99965468A patent/EP1237583A1/en not_active Withdrawn
- 1999-12-15 MX MXPA02005806A patent/MXPA02005806A/es unknown
- 1999-12-15 WO PCT/EP1999/009959 patent/WO2001043781A1/en not_active Application Discontinuation
- 1999-12-15 CN CN998170437A patent/CN1217701C/zh not_active Expired - Fee Related
- 1999-12-15 CA CA002394539A patent/CA2394539C/en not_active Expired - Fee Related
- 1999-12-15 SK SK814-2002A patent/SK8142002A3/sk unknown
- 1999-12-15 IL IL14979899A patent/IL149798A0/xx not_active IP Right Cessation
- 1999-12-15 PL PL99355891A patent/PL355891A1/xx not_active Application Discontinuation
- 1999-12-15 YU YU44402A patent/YU44402A/sh unknown
-
2002
- 2002-06-13 BG BG106822A patent/BG106822A/bg unknown
- 2002-06-14 NO NO20022837A patent/NO328630B1/no unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO0143781A1 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011025950A2 (en) | 2009-08-28 | 2011-03-03 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| WO2011038006A1 (en) | 2009-09-22 | 2011-03-31 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| US11903675B2 (en) | 2012-10-15 | 2024-02-20 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| WO2014062716A1 (en) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| WO2015103420A1 (en) | 2013-12-31 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
| WO2016100340A1 (en) | 2014-12-15 | 2016-06-23 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| US10335501B2 (en) | 2014-12-15 | 2019-07-02 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with enhanced nerve-binding selectively, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| US10940216B2 (en) | 2014-12-15 | 2021-03-09 | Cornell University | Cyclic peptides with enhanced nerve-binding selectively, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| WO2017106525A1 (en) | 2015-12-15 | 2017-06-22 | Memorial Sloan Kettering Cancer Center | Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization |
| WO2018102372A1 (en) | 2016-11-30 | 2018-06-07 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| US11989803B2 (en) | 2018-03-30 | 2024-05-21 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography |
| WO2022129627A1 (en) | 2020-12-18 | 2022-06-23 | Phi Pharma Sa | Oligomeric compounds binding specifically to proteoglycans |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1384760A (zh) | 2002-12-11 |
| NO328630B1 (no) | 2010-04-12 |
| CN1217701C (zh) | 2005-09-07 |
| CA2394539C (en) | 2009-10-27 |
| IL149798A0 (en) | 2002-11-10 |
| YU44402A (sh) | 2005-03-15 |
| NO20022837L (no) | 2002-06-14 |
| EA200200635A1 (ru) | 2002-12-26 |
| JP2003517025A (ja) | 2003-05-20 |
| BR9917587A (pt) | 2002-08-06 |
| SK8142002A3 (en) | 2002-12-03 |
| TR200201567T2 (tr) | 2002-11-21 |
| AU2097500A (en) | 2001-06-25 |
| CA2394539A1 (en) | 2001-06-21 |
| KR20020082207A (ko) | 2002-10-30 |
| PL355891A1 (en) | 2004-05-31 |
| HUP0204024A2 (en) | 2003-04-28 |
| BG106822A (bg) | 2003-01-31 |
| EE200200321A (et) | 2003-10-15 |
| NO20022837D0 (no) | 2002-06-14 |
| WO2001043781A1 (en) | 2001-06-21 |
| MXPA02005806A (es) | 2010-10-26 |
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