CA2394539A1 - Near infrared fluorescent contrast agent and fluorescence imaging - Google Patents

Near infrared fluorescent contrast agent and fluorescence imaging Download PDF

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Publication number
CA2394539A1
CA2394539A1 CA002394539A CA2394539A CA2394539A1 CA 2394539 A1 CA2394539 A1 CA 2394539A1 CA 002394539 A CA002394539 A CA 002394539A CA 2394539 A CA2394539 A CA 2394539A CA 2394539 A1 CA2394539 A1 CA 2394539A1
Authority
CA
Canada
Prior art keywords
contrast agent
near infrared
infrared fluorescent
fluorescent contrast
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002394539A
Other languages
French (fr)
Other versions
CA2394539C (en
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Masafumi Okumura
Yoshio Inagaki
Toru Harada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Fujifilm Holdings Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2394539A1 publication Critical patent/CA2394539A1/en
Application granted granted Critical
Publication of CA2394539C publication Critical patent/CA2394539C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)

Abstract

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
CA002394539A 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging Expired - Fee Related CA2394539C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/009959 WO2001043781A1 (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging

Publications (2)

Publication Number Publication Date
CA2394539A1 true CA2394539A1 (en) 2001-06-21
CA2394539C CA2394539C (en) 2009-10-27

Family

ID=8167530

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002394539A Expired - Fee Related CA2394539C (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging

Country Status (19)

Country Link
EP (1) EP1237583A1 (en)
JP (1) JP2003517025A (en)
KR (1) KR20020082207A (en)
CN (1) CN1217701C (en)
AU (1) AU2097500A (en)
BG (1) BG106822A (en)
BR (1) BR9917587A (en)
CA (1) CA2394539C (en)
EA (1) EA200200635A1 (en)
EE (1) EE200200321A (en)
HU (1) HUP0204024A2 (en)
IL (1) IL149798A0 (en)
MX (1) MXPA02005806A (en)
NO (1) NO328630B1 (en)
PL (1) PL355891A1 (en)
SK (1) SK8142002A3 (en)
TR (1) TR200201567T2 (en)
WO (1) WO2001043781A1 (en)
YU (1) YU44402A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114459862A (en) * 2022-01-13 2022-05-10 华腾实业（深圳）股份有限公司 High-identification fungus fluorescent staining solution

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (en) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc Fluorescent contrast agent
JP5074044B2 (en) 2007-01-18 2012-11-14 オリンパス株式会社 Fluorescence observation apparatus and method of operating fluorescence observation apparatus
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
JP2011046663A (en) 2009-08-28 2011-03-10 Fujifilm Corp Near infrared fluorescent imaging agent
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
CA2810822C (en) 2009-09-22 2018-03-06 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
CA2787129A1 (en) * 2010-01-14 2011-07-21 The Regents Of The University Of California Devices, systems and methods to detect and reduce or prevent entry of inflammatory mediators into milk ducts
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
EP3338617B1 (en) 2012-01-23 2020-08-19 Washington University Goggle imaging systems and devices
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
EP2968335B1 (en) 2013-03-15 2019-03-27 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
CN106455979A (en) 2013-12-31 2017-02-22 纪念斯隆-凯特琳癌症中心 Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
AU2015362663B2 (en) 2014-12-15 2020-07-09 Cornell University Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
KR20180014027A (en) * 2015-06-03 2018-02-07 서지마브 에스.에이.에스. Fluorescent conjugate
CN105222828B (en) * 2015-09-30 2017-05-24 东南大学 Synchronization measurement device for wall-adherent jet speed field and concentration field and method
WO2017106525A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
CN110167601A (en) 2016-11-30 2019-08-23 纪念斯隆凯特琳癌症中心 Inhibitor-small nanoparticle of functionalization ultra micro and its method
EP4072598A4 (en) 2019-12-13 2024-02-21 Washington University St Louis Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE206395T1 (en) * 1990-05-15 2001-10-15 Hyperion Inc FLUORESCENT PORPHYRIN AND FLUORESCENT PHTHALOCYANINE-POLYETHYLENE GLYCOL, POLYOL AND SACCHARIDE DERIVATIVES AS FLUORESCENT PROBE
CN1093768C (en) * 1995-01-30 2002-11-06 第一化学药品株式会社 Diagnostic marker
JP2000095758A (en) * 1998-09-18 2000-04-04 Schering Ag Near-infrared, fluorescent contrast medium, and its production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114459862A (en) * 2022-01-13 2022-05-10 华腾实业（深圳）股份有限公司 High-identification fungus fluorescent staining solution

Also Published As

Publication number Publication date
NO20022837L (en) 2002-06-14
KR20020082207A (en) 2002-10-30
HUP0204024A2 (en) 2003-04-28
AU2097500A (en) 2001-06-25
EP1237583A1 (en) 2002-09-11
IL149798A0 (en) 2002-11-10
NO328630B1 (en) 2010-04-12
CA2394539C (en) 2009-10-27
SK8142002A3 (en) 2002-12-03
EA200200635A1 (en) 2002-12-26
TR200201567T2 (en) 2002-11-21
EE200200321A (en) 2003-10-15
WO2001043781A1 (en) 2001-06-21
NO20022837D0 (en) 2002-06-14
BR9917587A (en) 2002-08-06
MXPA02005806A (en) 2010-10-26
JP2003517025A (en) 2003-05-20
CN1384760A (en) 2002-12-11
YU44402A (en) 2005-03-15
PL355891A1 (en) 2004-05-31
BG106822A (en) 2003-01-31
CN1217701C (en) 2005-09-07

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