EA200200635A1 - FLUORESCENT CONTRAST AGENT FOR NEAR INFRARED SPECTRUM AND METHOD OF FLUORESCENT VISUALIZATION - Google Patents
FLUORESCENT CONTRAST AGENT FOR NEAR INFRARED SPECTRUM AND METHOD OF FLUORESCENT VISUALIZATIONInfo
- Publication number
- EA200200635A1 EA200200635A1 EA200200635A EA200200635A EA200200635A1 EA 200200635 A1 EA200200635 A1 EA 200200635A1 EA 200200635 A EA200200635 A EA 200200635A EA 200200635 A EA200200635 A EA 200200635A EA 200200635 A1 EA200200635 A1 EA 200200635A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- contrast agent
- near infrared
- spectrum
- fluorescent
- infrared region
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 6
- 238000002329 infrared spectrum Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000012800 visualization Methods 0.000 title 1
- 238000001228 spectrum Methods 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 238000001917 fluorescence detection Methods 0.000 abstract 1
- 238000000799 fluorescence microscopy Methods 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Abstract
В заявке описан флуоресцентный контрастный агент для ближней инфракрасной области спектра, содержащий соединение, имеющее в молекуле три или более групп сульфоновой кислоты, и способ флуоресцентной визуализации, предусматривающий введение флуоресцентного контрастного агента для ближней инфракрасной области спектра по настоящему изобретению в живой организм, облучение организма возбуждающим светом и обнаружение флуоресценции в ближней инфракрасной области спектра, испускаемой контрастным агентом. Флуоресцентный контрастный агент для ближней инфракрасной области спектра по настоящему изобретению облучают возбуждающим светом и он испускает флуоресценцию в ближней инфракрасной области спектра. Эта инфракрасная флуоресценция хорошо проходит через биологические ткани. Вследствие этого оказывается возможным обнаруживать повреждения в глубоко расположенных областях живого организма. Кроме того, контрастный агент по изобретению обладает хорошей растворимостью в воде и является малотоксичным и следовательно безопасным для применения.Международная заявка была опубликована вместе с отчетом о международном поиске.The application describes a fluorescent contrast agent for the near infrared region of the spectrum, containing a compound that has three or more sulfonic acid groups in a molecule, and a fluorescence imaging method that involves introducing the fluorescent contrast agent for the near infrared spectrum of the present invention into a living organism, irradiating the body with an exciting light and fluorescence detection in the near infrared region of the spectrum emitted by a contrast agent. The fluorescent contrast agent for the near infrared region of the spectrum of the present invention is irradiated with excitation light and it emits fluorescence in the near infrared region of the spectrum. This infrared fluorescence passes well through biological tissue. As a result, it is possible to detect lesions in deep areas of a living organism. In addition, the contrast agent of the invention has good solubility in water and is of low toxicity and therefore safe to use. The international application was published together with an international search report.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1999/009959 WO2001043781A1 (en) | 1999-12-15 | 1999-12-15 | Near infrared fluorescent contrast agent and fluorescence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200200635A1 true EA200200635A1 (en) | 2002-12-26 |
Family
ID=8167530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200635A EA200200635A1 (en) | 1999-12-15 | 1999-12-15 | FLUORESCENT CONTRAST AGENT FOR NEAR INFRARED SPECTRUM AND METHOD OF FLUORESCENT VISUALIZATION |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1237583A1 (en) |
| JP (1) | JP2003517025A (en) |
| KR (1) | KR20020082207A (en) |
| CN (1) | CN1217701C (en) |
| AU (1) | AU2097500A (en) |
| BG (1) | BG106822A (en) |
| BR (1) | BR9917587A (en) |
| CA (1) | CA2394539C (en) |
| EA (1) | EA200200635A1 (en) |
| EE (1) | EE200200321A (en) |
| HU (1) | HUP0204024A2 (en) |
| IL (1) | IL149798A0 (en) |
| MX (1) | MXPA02005806A (en) |
| NO (1) | NO328630B1 (en) |
| PL (1) | PL355891A1 (en) |
| SK (1) | SK8142002A3 (en) |
| TR (1) | TR200201567T2 (en) |
| WO (1) | WO2001043781A1 (en) |
| YU (1) | YU44402A (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (en) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | Fluorescent contrast agent |
| JP5074044B2 (en) * | 2007-01-18 | 2012-11-14 | オリンパス株式会社 | Fluorescence observation apparatus and method of operating fluorescence observation apparatus |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| CA2809798C (en) | 2009-08-28 | 2018-09-18 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| JP2011046663A (en) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | Near infrared fluorescent imaging agent |
| CN102781307B (en) | 2009-09-22 | 2016-01-20 | 文森医学公司 | For the system and method for the virtual refractive index match of diffusive medium |
| US20130158394A1 (en) * | 2010-01-14 | 2013-06-20 | The Regents Of The University Of California | Devices, Systems and Methods to Detect and Reduce or Prevent Entry of Inflammatory Mediators into Milk Ducts |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| EP2806781B1 (en) | 2012-01-23 | 2018-03-21 | Washington University | Goggle imaging systems and methods |
| US10743768B2 (en) | 2012-10-15 | 2020-08-18 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| MX358184B (en) | 2013-03-15 | 2018-08-08 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors. |
| AU2014373656B2 (en) | 2013-12-31 | 2019-12-05 | Cornell University | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
| ES2794778T3 (en) | 2014-12-15 | 2020-11-19 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with improved selectivity of nerve binding, nanoparticles bound with said cyclic peptides and use of the same for live imaging of nerve tissues in real time |
| US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| DK3166606T3 (en) | 2015-06-03 | 2018-08-13 | Surgimab S A S | FLUORESCING CONJUGATES |
| CN105222828B (en) * | 2015-09-30 | 2017-05-24 | 东南大学 | Synchronization measurement device for wall-adherent jet speed field and concentration field and method |
| EP3389726A1 (en) | 2015-12-15 | 2018-10-24 | Memorial Sloan Kettering Cancer Center | Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization |
| CN110167601A (en) | 2016-11-30 | 2019-08-23 | 纪念斯隆凯特琳癌症中心 | Inhibitor-small nanoparticle of functionalization ultra micro and its method |
| CN111970960A (en) | 2018-03-30 | 2020-11-20 | 珀金埃尔默健康科学有限公司 | System and method for 3D reconstruction of anatomical organs and contents using Short Wave Infrared (SWIR) projection tomography |
| WO2021119423A1 (en) | 2019-12-13 | 2021-06-17 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
| CN114459862A (en) * | 2022-01-13 | 2022-05-10 | 华腾实业（深圳）股份有限公司 | High-identification fungus fluorescent staining solution |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3224538B2 (en) * | 1990-05-15 | 2001-10-29 | ダイアトロン・コーポレイション | Fluorescent porphyrin as fluorescent probe and fluorescent phthalocyanine-polyethylene glycol, polyol and saccharide derivative |
| CA2211470A1 (en) * | 1995-01-30 | 1996-08-08 | Daiichi Pure Chemicals Co., Ltd. | Diagnostic marker |
| JP2000095758A (en) * | 1998-09-18 | 2000-04-04 | Schering Ag | Near-infrared, fluorescent contrast medium, and its production |
-
1999
- 1999-12-15 AU AU20975/00A patent/AU2097500A/en not_active Abandoned
- 1999-12-15 EP EP99965468A patent/EP1237583A1/en not_active Withdrawn
- 1999-12-15 WO PCT/EP1999/009959 patent/WO2001043781A1/en not_active Application Discontinuation
- 1999-12-15 JP JP2001544917A patent/JP2003517025A/en active Pending
- 1999-12-15 SK SK814-2002A patent/SK8142002A3/en unknown
- 1999-12-15 IL IL14979899A patent/IL149798A0/en not_active IP Right Cessation
- 1999-12-15 KR KR1020027007635A patent/KR20020082207A/en not_active Application Discontinuation
- 1999-12-15 CN CN998170437A patent/CN1217701C/en not_active Expired - Fee Related
- 1999-12-15 EE EEP200200321A patent/EE200200321A/en unknown
- 1999-12-15 PL PL99355891A patent/PL355891A1/en not_active Application Discontinuation
- 1999-12-15 CA CA002394539A patent/CA2394539C/en not_active Expired - Fee Related
- 1999-12-15 BR BR9917587-8A patent/BR9917587A/en not_active Application Discontinuation
- 1999-12-15 YU YU44402A patent/YU44402A/en unknown
- 1999-12-15 HU HU0204024A patent/HUP0204024A2/en unknown
- 1999-12-15 TR TR2002/01567T patent/TR200201567T2/en unknown
- 1999-12-15 MX MXPA02005806A patent/MXPA02005806A/en unknown
- 1999-12-15 EA EA200200635A patent/EA200200635A1/en unknown
-
2002
- 2002-06-13 BG BG106822A patent/BG106822A/en unknown
- 2002-06-14 NO NO20022837A patent/NO328630B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204024A2 (en) | 2003-04-28 |
| PL355891A1 (en) | 2004-05-31 |
| BG106822A (en) | 2003-01-31 |
| CA2394539A1 (en) | 2001-06-21 |
| CN1384760A (en) | 2002-12-11 |
| WO2001043781A1 (en) | 2001-06-21 |
| NO20022837L (en) | 2002-06-14 |
| EP1237583A1 (en) | 2002-09-11 |
| SK8142002A3 (en) | 2002-12-03 |
| CA2394539C (en) | 2009-10-27 |
| YU44402A (en) | 2005-03-15 |
| BR9917587A (en) | 2002-08-06 |
| NO20022837D0 (en) | 2002-06-14 |
| KR20020082207A (en) | 2002-10-30 |
| EE200200321A (en) | 2003-10-15 |
| MXPA02005806A (en) | 2010-10-26 |
| CN1217701C (en) | 2005-09-07 |
| JP2003517025A (en) | 2003-05-20 |
| TR200201567T2 (en) | 2002-11-21 |
| IL149798A0 (en) | 2002-11-10 |
| NO328630B1 (en) | 2010-04-12 |
| AU2097500A (en) | 2001-06-25 |
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