MXPA02005806A - Near infrared fluorescent contrast agent and fluorescence imaging. - Google Patents

Near infrared fluorescent contrast agent and fluorescence imaging.

Info

Publication number
MXPA02005806A
MXPA02005806A MXPA02005806A MXPA02005806A MXPA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A
Authority
MX
Mexico
Prior art keywords
contrast agent
near infrared
infrared fluorescent
fluorescent contrast
fluorescence
Prior art date
Application number
MXPA02005806A
Other languages
Spanish (es)
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Masafumi Okumura
Yoshio Inagaki
Toru Harada
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MXPA02005806A publication Critical patent/MXPA02005806A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Abstract

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
MXPA02005806A 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging. MXPA02005806A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/009959 WO2001043781A1 (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging

Publications (1)

Publication Number Publication Date
MXPA02005806A true MXPA02005806A (en) 2010-10-26

Family

ID=8167530

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005806A MXPA02005806A (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging.

Country Status (19)

Country Link
EP (1) EP1237583A1 (en)
JP (1) JP2003517025A (en)
KR (1) KR20020082207A (en)
CN (1) CN1217701C (en)
AU (1) AU2097500A (en)
BG (1) BG106822A (en)
BR (1) BR9917587A (en)
CA (1) CA2394539C (en)
EA (1) EA200200635A1 (en)
EE (1) EE200200321A (en)
HU (1) HUP0204024A2 (en)
IL (1) IL149798A0 (en)
MX (1) MXPA02005806A (en)
NO (1) NO328630B1 (en)
PL (1) PL355891A1 (en)
SK (1) SK8142002A3 (en)
TR (1) TR200201567T2 (en)
WO (1) WO2001043781A1 (en)
YU (1) YU44402A (en)

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* Cited by examiner, † Cited by third party
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US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (en) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc Fluorescent contrast agent
JP5074044B2 (en) * 2007-01-18 2012-11-14 オリンパス株式会社 Fluorescence observation apparatus and method of operating fluorescence observation apparatus
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046663A (en) 2009-08-28 2011-03-10 Fujifilm Corp Near infrared fluorescent imaging agent
AU2010298388B2 (en) 2009-09-22 2015-05-28 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
CN102711595A (en) * 2010-01-14 2012-10-03 加利福尼亚大学董事会 Devices, systems and methods to detect and reduce or prevent entry of inflammatory mediators into milk ducts
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
EP2806781B1 (en) 2012-01-23 2018-03-21 Washington University Goggle imaging systems and methods
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
CA2903994C (en) 2013-03-15 2017-08-22 Philip S. Low Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
EP3089653A1 (en) 2013-12-31 2016-11-09 Memorial Sloan Kettering Cancer Center Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
CN107249647A (en) 2014-12-15 2017-10-13 纪念斯隆-凯特琳癌症中心 The nano particle combined with enhanced nerve with reference to the cyclic peptide of selectivity, with the cyclic peptide and the purposes both this for nerve fiber imaging in real-time volume
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
KR20180014027A (en) 2015-06-03 2018-02-07 서지마브 에스.에이.에스. Fluorescent conjugate
CN105222828B (en) * 2015-09-30 2017-05-24 东南大学 Synchronization measurement device for wall-adherent jet speed field and concentration field and method
JP2019509252A (en) 2015-12-15 2019-04-04 メモリアル スローン ケタリング キャンサー センター Imaging systems and methods for tissue differentiation, eg, visualization during surgery
BR112019010947A2 (en) 2016-11-30 2019-10-01 Univ Cornell ultra-small inhibitor functionalized nanoparticles and methods thereof
EP4072598A4 (en) 2019-12-13 2024-02-21 Washington University St Louis Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
CN114459862A (en) * 2022-01-13 2022-05-10 华腾实业（深圳）股份有限公司 High-identification fungus fluorescent staining solution

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69132750T2 (en) * 1990-05-15 2002-06-20 Hyperion Inc FLUORESCENT PORPHYRIN AND FLUORESCENT PHTHALOCYANIN-POLYETHYLENE GLYCOL, POLYOL AND SACCHARID DERIVATIVES AS FLUORESCENT PROBE
CA2211470A1 (en) * 1995-01-30 1996-08-08 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
JP2000095758A (en) * 1998-09-18 2000-04-04 Schering Ag Near-infrared, fluorescent contrast medium, and its production

Also Published As

Publication number Publication date
CA2394539A1 (en) 2001-06-21
EE200200321A (en) 2003-10-15
WO2001043781A1 (en) 2001-06-21
JP2003517025A (en) 2003-05-20
BR9917587A (en) 2002-08-06
AU2097500A (en) 2001-06-25
BG106822A (en) 2003-01-31
IL149798A0 (en) 2002-11-10
SK8142002A3 (en) 2002-12-03
CN1217701C (en) 2005-09-07
KR20020082207A (en) 2002-10-30
HUP0204024A2 (en) 2003-04-28
EP1237583A1 (en) 2002-09-11
YU44402A (en) 2005-03-15
CN1384760A (en) 2002-12-11
EA200200635A1 (en) 2002-12-26
TR200201567T2 (en) 2002-11-21
NO20022837L (en) 2002-06-14
NO328630B1 (en) 2010-04-12
NO20022837D0 (en) 2002-06-14
PL355891A1 (en) 2004-05-31
CA2394539C (en) 2009-10-27

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