MXPA02005806A - Near infrared fluorescent contrast agent and fluorescence imaging. - Google Patents

Near infrared fluorescent contrast agent and fluorescence imaging.

Info

Publication number
MXPA02005806A
MXPA02005806A MXPA02005806A MXPA02005806A MXPA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A MX PA02005806 A MXPA02005806 A MX PA02005806A
Authority
MX
Mexico
Prior art keywords
contrast agent
near infrared
infrared fluorescent
fluorescent contrast
fluorescence
Prior art date
Application number
MXPA02005806A
Other languages
Spanish (es)
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Masafumi Okumura
Yoshio Inagaki
Toru Harada
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MXPA02005806A publication Critical patent/MXPA02005806A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)

Abstract

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
MXPA02005806A 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging. MXPA02005806A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/009959 WO2001043781A1 (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging

Publications (1)

Publication Number Publication Date
MXPA02005806A true MXPA02005806A (en) 2010-10-26

Family

ID=8167530

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005806A MXPA02005806A (en) 1999-12-15 1999-12-15 Near infrared fluorescent contrast agent and fluorescence imaging.

Country Status (19)

Country Link
EP (1) EP1237583A1 (en)
JP (1) JP2003517025A (en)
KR (1) KR20020082207A (en)
CN (1) CN1217701C (en)
AU (1) AU2097500A (en)
BG (1) BG106822A (en)
BR (1) BR9917587A (en)
CA (1) CA2394539C (en)
EA (1) EA200200635A1 (en)
EE (1) EE200200321A (en)
HU (1) HUP0204024A2 (en)
IL (1) IL149798A0 (en)
MX (1) MXPA02005806A (en)
NO (1) NO328630B1 (en)
PL (1) PL355891A1 (en)
SK (1) SK8142002A3 (en)
TR (1) TR200201567T2 (en)
WO (1) WO2001043781A1 (en)
YU (1) YU44402A (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (en) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc Fluorescent contrast agent
JP5074044B2 (en) * 2007-01-18 2012-11-14 オリンパス株式会社 Fluorescence observation apparatus and method of operating fluorescence observation apparatus
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
CA2809798C (en) 2009-08-28 2018-09-18 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046663A (en) 2009-08-28 2011-03-10 Fujifilm Corp Near infrared fluorescent imaging agent
CN102781307B (en) 2009-09-22 2016-01-20 文森医学公司 For the system and method for the virtual refractive index match of diffusive medium
US20130158394A1 (en) * 2010-01-14 2013-06-20 The Regents Of The University Of California Devices, Systems and Methods to Detect and Reduce or Prevent Entry of Inflammatory Mediators into Milk Ducts
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
EP2806781B1 (en) 2012-01-23 2018-03-21 Washington University Goggle imaging systems and methods
US10743768B2 (en) 2012-10-15 2020-08-18 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
MX358184B (en) 2013-03-15 2018-08-08 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors.
AU2014373656B2 (en) 2013-12-31 2019-12-05 Cornell University Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
ES2794778T3 (en) 2014-12-15 2020-11-19 Memorial Sloan Kettering Cancer Center Cyclic peptides with improved selectivity of nerve binding, nanoparticles bound with said cyclic peptides and use of the same for live imaging of nerve tissues in real time
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
DK3166606T3 (en) 2015-06-03 2018-08-13 Surgimab S A S FLUORESCING CONJUGATES
CN105222828B (en) * 2015-09-30 2017-05-24 东南大学 Synchronization measurement device for wall-adherent jet speed field and concentration field and method
EP3389726A1 (en) 2015-12-15 2018-10-24 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
CN110167601A (en) 2016-11-30 2019-08-23 纪念斯隆凯特琳癌症中心 Inhibitor-small nanoparticle of functionalization ultra micro and its method
CN111970960A (en) 2018-03-30 2020-11-20 珀金埃尔默健康科学有限公司 System and method for 3D reconstruction of anatomical organs and contents using Short Wave Infrared (SWIR) projection tomography
WO2021119423A1 (en) 2019-12-13 2021-06-17 Washington University Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
CN114459862A (en) * 2022-01-13 2022-05-10 华腾实业（深圳）股份有限公司 High-identification fungus fluorescent staining solution

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3224538B2 (en) * 1990-05-15 2001-10-29 ダイアトロン・コーポレイション Fluorescent porphyrin as fluorescent probe and fluorescent phthalocyanine-polyethylene glycol, polyol and saccharide derivative
CA2211470A1 (en) * 1995-01-30 1996-08-08 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
JP2000095758A (en) * 1998-09-18 2000-04-04 Schering Ag Near-infrared, fluorescent contrast medium, and its production

Also Published As

Publication number Publication date
HUP0204024A2 (en) 2003-04-28
PL355891A1 (en) 2004-05-31
BG106822A (en) 2003-01-31
CA2394539A1 (en) 2001-06-21
CN1384760A (en) 2002-12-11
WO2001043781A1 (en) 2001-06-21
NO20022837L (en) 2002-06-14
EP1237583A1 (en) 2002-09-11
SK8142002A3 (en) 2002-12-03
CA2394539C (en) 2009-10-27
YU44402A (en) 2005-03-15
BR9917587A (en) 2002-08-06
NO20022837D0 (en) 2002-06-14
KR20020082207A (en) 2002-10-30
EE200200321A (en) 2003-10-15
CN1217701C (en) 2005-09-07
JP2003517025A (en) 2003-05-20
TR200201567T2 (en) 2002-11-21
EA200200635A1 (en) 2002-12-26
IL149798A0 (en) 2002-11-10
NO328630B1 (en) 2010-04-12
AU2097500A (en) 2001-06-25

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