TR200201567T2 - Active fluorescent contrast agent and fluorescence imaging in the near infrared light region. - Google Patents
Active fluorescent contrast agent and fluorescence imaging in the near infrared light region.Info
- Publication number
- TR200201567T2 TR200201567T2 TR2002/01567T TR200201567T TR200201567T2 TR 200201567 T2 TR200201567 T2 TR 200201567T2 TR 2002/01567 T TR2002/01567 T TR 2002/01567T TR 200201567 T TR200201567 T TR 200201567T TR 200201567 T2 TR200201567 T2 TR 200201567T2
- Authority
- TR
- Turkey
- Prior art keywords
- contrast agent
- infrared
- fluorescence
- light region
- region
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 5
- 238000000799 fluorescence microscopy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Abstract
Bir molekül içinde üç ya da daha çok sülfonik asit grubuna sahip olan bir bilesigi içeren bir kizilötesine yakin isik bölgesinde aktif fluoresan kontrast maddesi ve bir fluoresans görüntü alma yöntemi anlatilmistir, bu yöntem, bu bulusun kizilötesine yakin isik bölgesinde aktif fluoresan kontrast maddesinin bir canli vücut içine verilmesi, vücudun bir uyarim isigina maruz birakilmasi ve kontrast maddesinden gelen kizilötesi bölgeye yakin fluoresansin bulgulanmasini içermektedir. Bu bulusun kizilötesine yakin isik bölgesinde akif fluoresan kontrast maddesi bir uyarim isigi ile uyarilmakta ve kizil ötesi bölgesine yakin bölgede fluoresans nesretmektedir. Bu kizilötesi fluoresansi biyolojik dokular içinden geçiste üstündür. Bu yüzden, canli bir vücudun derin bir kismindaki lezyonlarin bulgulanmasi mümkün kilinmistir.A fluorescence contrast agent and a fluorescence imaging method are described in a near-infrared light region containing a compound having three or more sulfonic acid groups in a molecule, which method involves the active fluorescent contrast agent in the light region near the infrared of this invention. administration includes exposing the body to an excitation light and detection of fluorescence near the infrared region from the contrast agent. In the light region close to the infrared of this invention, the active fluorescent contrast agent is stimulated by a stimulus light and generates fluorescence in the region near the infrared region. This infrared fluorescence is superior in transition through biological tissues. Therefore, it was possible to detect lesions in a deep part of a living body.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1999/009959 WO2001043781A1 (en) | 1999-12-15 | 1999-12-15 | Near infrared fluorescent contrast agent and fluorescence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200201567T2 true TR200201567T2 (en) | 2002-11-21 |
Family
ID=8167530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/01567T TR200201567T2 (en) | 1999-12-15 | 1999-12-15 | Active fluorescent contrast agent and fluorescence imaging in the near infrared light region. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1237583A1 (en) |
| JP (1) | JP2003517025A (en) |
| KR (1) | KR20020082207A (en) |
| CN (1) | CN1217701C (en) |
| AU (1) | AU2097500A (en) |
| BG (1) | BG106822A (en) |
| BR (1) | BR9917587A (en) |
| CA (1) | CA2394539C (en) |
| EA (1) | EA200200635A1 (en) |
| EE (1) | EE200200321A (en) |
| HU (1) | HUP0204024A2 (en) |
| IL (1) | IL149798A0 (en) |
| MX (1) | MXPA02005806A (en) |
| NO (1) | NO328630B1 (en) |
| PL (1) | PL355891A1 (en) |
| SK (1) | SK8142002A3 (en) |
| TR (1) | TR200201567T2 (en) |
| WO (1) | WO2001043781A1 (en) |
| YU (1) | YU44402A (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (en) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | Fluorescent contrast agent |
| JP5074044B2 (en) * | 2007-01-18 | 2012-11-14 | オリンパス株式会社 | Fluorescence observation apparatus and method of operating fluorescence observation apparatus |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| AU2010286592B2 (en) | 2009-08-28 | 2015-08-13 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| JP2011046663A (en) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | Near infrared fluorescent imaging agent |
| AU2010298388B2 (en) | 2009-09-22 | 2015-05-28 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| CN102711595A (en) * | 2010-01-14 | 2012-10-03 | 加利福尼亚大学董事会 | Devices, systems and methods to detect and reduce or prevent entry of inflammatory mediators into milk ducts |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| EP2806781B1 (en) | 2012-01-23 | 2018-03-21 | Washington University | Goggle imaging systems and methods |
| WO2014062716A1 (en) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
| CA2903994C (en) | 2013-03-15 | 2017-08-22 | Philip S. Low | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| EP3089653A1 (en) | 2013-12-31 | 2016-11-09 | Memorial Sloan Kettering Cancer Center | Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time |
| CN107249647A (en) | 2014-12-15 | 2017-10-13 | 纪念斯隆-凯特琳癌症中心 | The nano particle combined with enhanced nerve with reference to the cyclic peptide of selectivity, with the cyclic peptide and the purposes both this for nerve fiber imaging in real-time volume |
| WO2016179350A1 (en) | 2015-05-06 | 2016-11-10 | Washington University | Compounds having rd targeting motifs and methods of use thereof |
| KR20180014027A (en) | 2015-06-03 | 2018-02-07 | 서지마브 에스.에이.에스. | Fluorescent conjugate |
| CN105222828B (en) * | 2015-09-30 | 2017-05-24 | 东南大学 | Synchronization measurement device for wall-adherent jet speed field and concentration field and method |
| JP2019509252A (en) | 2015-12-15 | 2019-04-04 | メモリアル スローン ケタリング キャンサー センター | Imaging systems and methods for tissue differentiation, eg, visualization during surgery |
| BR112019010947A2 (en) | 2016-11-30 | 2019-10-01 | Univ Cornell | ultra-small inhibitor functionalized nanoparticles and methods thereof |
| EP4072598A4 (en) | 2019-12-13 | 2024-02-21 | Washington University St Louis | Near infrared fluorescent dyes, formulations and related methods |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
| CN114459862A (en) * | 2022-01-13 | 2022-05-10 | 华腾实业（深圳）股份有限公司 | High-identification fungus fluorescent staining solution |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69132750T2 (en) * | 1990-05-15 | 2002-06-20 | Hyperion Inc | FLUORESCENT PORPHYRIN AND FLUORESCENT PHTHALOCYANIN-POLYETHYLENE GLYCOL, POLYOL AND SACCHARID DERIVATIVES AS FLUORESCENT PROBE |
| CA2211470A1 (en) * | 1995-01-30 | 1996-08-08 | Daiichi Pure Chemicals Co., Ltd. | Diagnostic marker |
| JP2000095758A (en) * | 1998-09-18 | 2000-04-04 | Schering Ag | Near-infrared, fluorescent contrast medium, and its production |
-
1999
- 1999-12-15 BR BR9917587-8A patent/BR9917587A/en not_active Application Discontinuation
- 1999-12-15 JP JP2001544917A patent/JP2003517025A/en active Pending
- 1999-12-15 EA EA200200635A patent/EA200200635A1/en unknown
- 1999-12-15 CA CA002394539A patent/CA2394539C/en not_active Expired - Fee Related
- 1999-12-15 KR KR1020027007635A patent/KR20020082207A/en not_active Application Discontinuation
- 1999-12-15 CN CN998170437A patent/CN1217701C/en not_active Expired - Fee Related
- 1999-12-15 EE EEP200200321A patent/EE200200321A/en unknown
- 1999-12-15 SK SK814-2002A patent/SK8142002A3/en unknown
- 1999-12-15 IL IL14979899A patent/IL149798A0/en not_active IP Right Cessation
- 1999-12-15 PL PL99355891A patent/PL355891A1/en not_active Application Discontinuation
- 1999-12-15 WO PCT/EP1999/009959 patent/WO2001043781A1/en not_active Application Discontinuation
- 1999-12-15 YU YU44402A patent/YU44402A/en unknown
- 1999-12-15 MX MXPA02005806A patent/MXPA02005806A/en unknown
- 1999-12-15 EP EP99965468A patent/EP1237583A1/en not_active Withdrawn
- 1999-12-15 TR TR2002/01567T patent/TR200201567T2/en unknown
- 1999-12-15 HU HU0204024A patent/HUP0204024A2/en unknown
- 1999-12-15 AU AU20975/00A patent/AU2097500A/en not_active Abandoned
-
2002
- 2002-06-13 BG BG106822A patent/BG106822A/en unknown
- 2002-06-14 NO NO20022837A patent/NO328630B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2394539A1 (en) | 2001-06-21 |
| EE200200321A (en) | 2003-10-15 |
| WO2001043781A1 (en) | 2001-06-21 |
| JP2003517025A (en) | 2003-05-20 |
| BR9917587A (en) | 2002-08-06 |
| AU2097500A (en) | 2001-06-25 |
| BG106822A (en) | 2003-01-31 |
| IL149798A0 (en) | 2002-11-10 |
| SK8142002A3 (en) | 2002-12-03 |
| CN1217701C (en) | 2005-09-07 |
| MXPA02005806A (en) | 2010-10-26 |
| KR20020082207A (en) | 2002-10-30 |
| HUP0204024A2 (en) | 2003-04-28 |
| EP1237583A1 (en) | 2002-09-11 |
| YU44402A (en) | 2005-03-15 |
| CN1384760A (en) | 2002-12-11 |
| EA200200635A1 (en) | 2002-12-26 |
| NO20022837L (en) | 2002-06-14 |
| NO328630B1 (en) | 2010-04-12 |
| NO20022837D0 (en) | 2002-06-14 |
| PL355891A1 (en) | 2004-05-31 |
| CA2394539C (en) | 2009-10-27 |
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