EP1110542A3 - Orale Metoprolol-Dosisform des Typs "einmal täglich" - Google Patents

Orale Metoprolol-Dosisform des Typs "einmal täglich" Download PDF

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Publication number
EP1110542A3
EP1110542A3 EP01107023A EP01107023A EP1110542A3 EP 1110542 A3 EP1110542 A3 EP 1110542A3 EP 01107023 A EP01107023 A EP 01107023A EP 01107023 A EP01107023 A EP 01107023A EP 1110542 A3 EP1110542 A3 EP 1110542A3
Authority
EP
European Patent Office
Prior art keywords
dosage form
once
oral dosage
metoprolol
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01107023A
Other languages
English (en)
French (fr)
Other versions
EP1110542B1 (de
EP1110542A2 (de
Inventor
Anand R. Baichwal
Troy W. Mccall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penwest Pharmaceuticals Co
Original Assignee
Mendell Edward Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mendell Edward Co Inc filed Critical Mendell Edward Co Inc
Priority to EP04013021A priority Critical patent/EP1470816A3/de
Publication of EP1110542A2 publication Critical patent/EP1110542A2/de
Publication of EP1110542A3 publication Critical patent/EP1110542A3/de
Application granted granted Critical
Publication of EP1110542B1 publication Critical patent/EP1110542B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
EP01107023A 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich" Expired - Lifetime EP1110542B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04013021A EP1470816A3 (de) 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich"

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/232,719 US5399362A (en) 1994-04-25 1994-04-25 Once-a-day metoprolol oral dosage form
US232719 1994-04-25
EP95917552A EP0723435B1 (de) 1994-04-25 1995-04-06 Orale metoprolol-dosisform des typs "einmal täglich"

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP95917552A Division EP0723435B1 (de) 1994-04-25 1995-04-06 Orale metoprolol-dosisform des typs "einmal täglich"

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP04013021A Division EP1470816A3 (de) 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich"

Publications (3)

Publication Number Publication Date
EP1110542A2 EP1110542A2 (de) 2001-06-27
EP1110542A3 true EP1110542A3 (de) 2001-09-19
EP1110542B1 EP1110542B1 (de) 2004-09-08

Family

ID=22874261

Family Applications (3)

Application Number Title Priority Date Filing Date
EP95917552A Expired - Lifetime EP0723435B1 (de) 1994-04-25 1995-04-06 Orale metoprolol-dosisform des typs "einmal täglich"
EP04013021A Withdrawn EP1470816A3 (de) 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich"
EP01107023A Expired - Lifetime EP1110542B1 (de) 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich"

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP95917552A Expired - Lifetime EP0723435B1 (de) 1994-04-25 1995-04-06 Orale metoprolol-dosisform des typs "einmal täglich"
EP04013021A Withdrawn EP1470816A3 (de) 1994-04-25 1995-04-06 Orale Metoprolol-Dosisform des Typs "einmal täglich"

Country Status (16)

Country Link
US (1) US5399362A (de)
EP (3) EP0723435B1 (de)
JP (1) JPH08512062A (de)
KR (1) KR0184339B1 (de)
CN (1) CN1131028C (de)
AT (2) ATE207345T1 (de)
AU (1) AU684944B2 (de)
CA (1) CA2164619C (de)
DE (2) DE69533492T2 (de)
DK (2) DK0723435T3 (de)
ES (2) ES2223669T3 (de)
FI (1) FI118001B (de)
HU (1) HU226375B1 (de)
IL (1) IL113325A (de)
PT (2) PT723435E (de)
WO (1) WO1995028917A1 (de)

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CA2164513C (en) * 1994-04-25 1999-09-21 Anand R. Baichwal Sustained release excipient
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
DE60038536T2 (de) * 1999-09-30 2009-06-10 Penwest Pharmaceuticals Co. Matrixsystem mit verzögerter freisetzung für hochlösliche wirkstoffe
US20030190360A1 (en) * 2001-03-13 2003-10-09 Baichwal Anand R. Chronotherapeutic dosage forms containing glucocorticosteroid and methods of treatment
US8329216B2 (en) * 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
CN1610551A (zh) * 2001-07-06 2005-04-27 恩德制药公司 用作止痛剂的6－羟基羟吗啡酮的肠胃外给药
JP2005022975A (ja) * 2001-08-09 2005-01-27 Wakunaga Pharmaceut Co Ltd 徐放性医薬組成物
WO2003026743A2 (en) * 2001-09-26 2003-04-03 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
US6635675B2 (en) 2001-11-05 2003-10-21 Cypress Bioscience, Inc. Method of treating chronic fatigue syndrome
AU2003230805A1 (en) * 2002-04-05 2003-10-27 Penwest Pharmaceuticals Co. Sustained release metoprolol formulations
US6936574B2 (en) * 2002-08-30 2005-08-30 Halliburton Energy Services, Inc. Process for controlling gas migration during well cementing
LT1562567T (lt) 2002-11-22 2017-08-25 Grünenthal GmbH Pasirinktų analgetikų ir cox-ii slopiklių derinys
US7314640B2 (en) * 2003-07-11 2008-01-01 Mongkol Sriwongjanya Formulation and process for drug loaded cores
US20050118267A1 (en) * 2003-09-19 2005-06-02 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
NZ545921A (en) * 2003-09-19 2009-09-25 Penwest Pharmaceuticals Co Delayed released dosage forms
EP1722758A1 (de) * 2004-02-11 2006-11-22 Athpharma Limited Chronotherapeutische zusammensetzungen und anwendungsverfahren dafür
CA2548864C (en) * 2005-06-06 2012-12-11 Nitto Denko Corporation Percutaneous absorption-type pharmaceutical preparation
EP1743638A1 (de) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmazeutische Formulierungen von substituierten Pyrazolinderivaten
US20070053983A1 (en) * 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
US8440695B2 (en) * 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
US8691272B2 (en) * 2005-12-30 2014-04-08 Intelgenx Corp. Multilayer tablet
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
US8124598B2 (en) * 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US20090124650A1 (en) * 2007-06-21 2009-05-14 Endo Pharmaceuticals, Inc. Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
WO2010015029A1 (en) 2008-08-06 2010-02-11 Gosforth Centre (Holdings) Pty Ltd Compositions and methods for treating psychiatric disorders
PT2331210E (pt) 2008-09-05 2014-08-25 Gruenenthal Gmbh Combinação farmacêutica de 3-(3-dimetilamino-1-etil-2- metilpropil)fenol e um antiepiléptico
US20100190752A1 (en) * 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
CN101716157B (zh) * 2008-10-09 2013-02-27 北京德众万全药物技术开发有限公司 一种美托洛尔口服药物组合物及其制备方法
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
WO2011023392A1 (en) 2009-08-28 2011-03-03 Grünenthal GmbH Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
PT2582366E (pt) 2010-06-15 2016-01-26 Gruenenthal Gmbh Combinação terapêutica para o tratamento da dor
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
CN102552196B (zh) * 2011-12-20 2013-08-14 中国药科大学 利用喷雾干燥法制备琥珀酸美托洛尔缓释微囊的方法
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US8912226B2 (en) 2012-05-18 2014-12-16 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r) -6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a NSAR
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US9345689B2 (en) 2012-05-18 2016-05-24 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant
US9320725B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US9308196B2 (en) 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US20150133516A1 (en) 2013-11-13 2015-05-14 Brian K. Adams Methods and Compositions for Treating ADHD
WO2017004526A1 (en) 2015-07-02 2017-01-05 University Of Louisville Research Foundation, Inc. EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DELIVERY OF miRNA AND METHODS FOR TREATMENT OF CANCER

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309405A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
EP0311582A1 (de) * 1987-10-08 1989-04-12 Aktiebolaget Hässle Pharmazeutisches Präparat mit verzögerter Abgabe eines Dihydropyridins und eines beta-Adrenorezeptor-Antagonisten und Herstellungsverfahren dessen
EP0360562A2 (de) * 1988-09-19 1990-03-28 Edward Mendell Co., Inc. Direkt verpressbare Füllstoffe zur verzögerten Freisetzung
GB2264866A (en) * 1992-03-13 1993-09-15 Synepos Ag Beta-blocker solutions for oral administration
WO1995013055A1 (en) * 1993-11-12 1995-05-18 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metoprolol

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US4309405A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
EP0311582A1 (de) * 1987-10-08 1989-04-12 Aktiebolaget Hässle Pharmazeutisches Präparat mit verzögerter Abgabe eines Dihydropyridins und eines beta-Adrenorezeptor-Antagonisten und Herstellungsverfahren dessen
EP0360562A2 (de) * 1988-09-19 1990-03-28 Edward Mendell Co., Inc. Direkt verpressbare Füllstoffe zur verzögerten Freisetzung
GB2264866A (en) * 1992-03-13 1993-09-15 Synepos Ag Beta-blocker solutions for oral administration
WO1995013055A1 (en) * 1993-11-12 1995-05-18 Edward Mendell Co., Inc. Sustained release formulations for 24 hour release of metoprolol

Also Published As

Publication number Publication date
ES2161882T3 (es) 2001-12-16
HU226375B1 (en) 2008-10-28
DK1110542T3 (da) 2005-01-10
FI956210A (fi) 1995-12-22
MX9600024A (es) 1998-11-30
CA2164619C (en) 2000-06-20
EP0723435A1 (de) 1996-07-31
DE69523438T2 (de) 2002-05-16
PT1110542E (pt) 2005-01-31
EP1110542B1 (de) 2004-09-08
CN1127470A (zh) 1996-07-24
EP1470816A3 (de) 2005-03-02
AU2355695A (en) 1995-11-16
CN1131028C (zh) 2003-12-17
AU684944B2 (en) 1998-01-08
ES2223669T3 (es) 2005-03-01
HU9503457D0 (en) 1996-02-28
IL113325A0 (en) 1995-07-31
KR0184339B1 (ko) 1999-05-01
ATE275395T1 (de) 2004-09-15
CA2164619A1 (en) 1995-11-02
DE69533492D1 (de) 2004-10-14
FI956210A0 (fi) 1995-12-22
DE69523438D1 (de) 2001-11-29
DK0723435T3 (da) 2002-02-11
PT723435E (pt) 2002-02-28
FI118001B (fi) 2007-05-31
EP0723435B1 (de) 2001-10-24
HUT75103A (en) 1997-04-28
JPH08512062A (ja) 1996-12-17
US5399362A (en) 1995-03-21
DE69533492T2 (de) 2005-01-27
EP1470816A2 (de) 2004-10-27
EP1110542A2 (de) 2001-06-27
EP0723435A4 (de) 1996-11-06
WO1995028917A1 (en) 1995-11-02
IL113325A (en) 1999-03-12
ATE207345T1 (de) 2001-11-15

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