EP1102573A2 - Boite pour medicaments - Google Patents

Boite pour medicaments

Info

Publication number
EP1102573A2
EP1102573A2 EP99952305A EP99952305A EP1102573A2 EP 1102573 A2 EP1102573 A2 EP 1102573A2 EP 99952305 A EP99952305 A EP 99952305A EP 99952305 A EP99952305 A EP 99952305A EP 1102573 A2 EP1102573 A2 EP 1102573A2
Authority
EP
European Patent Office
Prior art keywords
drug
medicament container
container according
doses
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99952305A
Other languages
German (de)
English (en)
Inventor
Dieter Dr. Hafner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HAFNER, DIETER, DR.
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1102573A2 publication Critical patent/EP1102573A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0445—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system for preventing drug dispensing during a predetermined time period

Definitions

  • the invention relates to a medicament container for holding single or single and / or multiple rows of medicament doses arranged on carrier elements.
  • drug doses can be in solid, powdery, pastose or liquid form and tablets, coated tablets ,. Capsules, ampoules, pastes and the like.
  • the drug doses are mounted in the drug container in such a way that they can be removed individually or in groups, if appropriate together with their carrier element, through a removal area of the drug container.
  • a further state of the art is known from DE 35 18 531, a device for storing and promptly taking medication, which consists of a medicament container in the form of a dragee container, on which a signal transmitter which can be activated according to settable time intervals is arranged.
  • a reading device for reading out information relating to the medicament in the medicament container, coded on an enclosed part or to the medicament container itself.
  • receptacles for medicinal products into which medicinal products can be filled and which have a removal opening which is provided with a closure. Whenever the removal opening for removing a doctor is opened, a timer is reset. If the time of taking, ie the time at which the medicament container is opened, is exceeded, the medicament container emits a warning signal.
  • the invention is based on the object of designing a medicament container with the features of the preamble of patent claim 1 in such a way that it offers improved information and monitoring functionality for the patient and the removal of the medicament contained in it is particularly simple.
  • the essence of the invention is considered to be based on the drugs, i.e.
  • a coding to the drug doses and / or the carrier elements and to provide a code reading device on the drug container, by means of which, when the drug doses or carrier elements are removed from the drug container, a temporarily relative movement between the code reading device and the coding can be read, displayable and / or with the drug-specific information stored
  • the time of extraction can be used as a pair of values, in particular can be saved for compliance assessment and / or can be transferred to other data processing facilities.
  • the invention now makes it possible to read information relating to each individual drug dose in a targeted manner into a memory via the code reading device and to use it via a processor which can be provided either externally or internally in the drug container.
  • a processor which can be provided either externally or internally in the drug container. This can be done as follows, for example.
  • the user pulls on a carrier strip, for example in order to remove the first coated tablet from the medicament container.
  • the dragee itself is read via the code reading device and the coded information is displayed and used.
  • the invention has made it possible to read out coded information for each individual medicament dose and to make it available to the user to deliver.
  • an ad can be started with the text "take the next dose in three hours together with a preparation B" or, for example, an ad is started "you have taken preparation A, the next drug dose is preparation B" which is to be taken immediately ".
  • preparation B without a break, e.g. indicated that the next preparation is preparation C, which after e.g. is to take two hours.
  • contraindications and incompatibilities or warnings when the expiry date of the drug has expired can be shown on the display for each drug dose, possibly also combined with an acoustic warning signal.
  • the display may show "Do not take at " or "You have taken two doses of X, Y medication at too short intervals, beware of overdose” or "Expiry date exceeded”.
  • a patient code in the memory of the device, which is compared with a drug patient code that can be read in via the drug dose or the carrier. If the code read by the medicament or the carrier does not match the code stored in the device, this means that medication unsuitable and not intended for the patient has been inserted in the medicament container and this has an acoustic and / or visual warning, e.g. on the alphanumeric display.
  • the display can also show “Attention! The medicine you have taken is not for you, do not take it ".
  • blocking means on the medicament container, which in such a case block the patient's access to the medicament doses or make impossible.
  • Such locking devices can be, for example, a slide valve at the removal area. It is also possible that the medicine is pulled back into the container by motor so that the user no longer has access.
  • the invention not to store the patient code permanently and permanently in the medicament container, but rather to provide a patient identification device on the medicament container or in connection therewith.
  • a keyboard that the patient can use before using the medication container, i.e. e.g. must enter a PIN number when switching on or before each removal. If this does not match a PIN number read in by the medicinal product, the locking device becomes active which blocks the removal area or otherwise withdraws the medicinal product doses from access by the unauthorized user.
  • a fingerprint sensor as the patient identification device, which recognizes the authorization of the patient via a fingerprint that has been read in and generates a device release code that must match a patient code that is stored on the drug dose or on the carrier and must be read out to start the electronics of the medication container, to activate a release device or to deactivate the blocking device.
  • Such a safety device prevents pharmaceutical containers e.g. are confused in old people's homes and a patient does not take medicines intended for him.
  • the display may show "This is the
  • the patient code it is also possible for security reasons to read the patient code anew each time it is removed and to compare it with the data stored on the device side or made available by the patient identification device. It is also possible to provide the patient with different drug-specific and / or dose-dependent intervals of time, which are stored in the code, and to adopt them in an automatic electronic alarm device which is activated after the subsequent interval of intake entered via the code has expired.
  • All information which can be output via a display device can also be stored, if appropriate as a withdrawal time / dose information value pair, the stored information can be read out of the medicament container or its built-in memory and evaluated by the doctor, a research company or the like.
  • the drug doses do not necessarily have to be arranged on conventional carriers, such as blisters. It is just as possible to provide a transport storage device in the manner of a magazine, through which the drug doses can be supplied to the removal area in an orderly manner. Medicines of different types can then again be arranged in a carrier element, in a container or in a magazine.
  • the code reading device according to the invention together with the special drug-specific codes, ensures that the user of the device takes the multiple medicines of different effects at the right time of taking and the intake is also stored accordingly, so that it can be evaluated for compliance purposes.
  • the carrier elements can also be individual elements which can be pushed out or pulled out of the medicament container one after the other.
  • this can Serve a small box that has a removal opening, such as a photo corner or an adhesive tape dispenser.
  • the carrier elements for the medicament doses which are designed as individual elements, can be connected to one another in one or more rows. It is only important that the coding attached to it or on the medicinal products itself is read out and electronically utilized when it is pulled out or out (by a motorized transport device for the carrier or the magazine, if applicable).
  • the carrier elements can be designed as conventional blisters. However, it is also possible to use a flat, flexible base element as the carrier element, on one surface of which one or more drug doses are fixed. A cover layer is provided for fixation, which has a reduced flexibility compared to the base element, in particular a lower ductility. If the elastic, flexible base element is now pulled over an edge, the top layer will jump off the base element due to its higher brittleness or tear so that the drug dose is released.
  • the removal area of the pharmaceutical device has an opening edge over which the carrier elements can be moved in order to be bent at an angle which causes the cover layer to burst open, releasing the drug dose.
  • a carrier element made of a flat, flexible base element is provided on one surface thereof, to fix the drug dose or more thereof by means of an intermediate element in such a way that the intermediate element permits detachment of the drug dose when the base element is pulled over an opening edge, which is arranged in the removal area.
  • the intermediate element can be an adhesive layer.
  • a blob of gelatin, frosting or the like as an intermediate element which, under normal storage conditions of the medicament or medicament container, ensures that the medicament doses are adequately held on the carrier strip, but releases the medicament when the strip is pulled over an edge.
  • a receptacle for the detached medicament doses can be provided in the region of the removal opening.
  • the code reading device provides him with the information "Please move on and replace further doses of medication”. He will continue to do this until the display device indicates that all medication to be taken is now in the receptacle and can be taken at once or at a short distance.
  • the code and the code reading device can have different embodiments. For example, it is possible to provide a magnetic strip and a magnetic read head in order to read out the coding.
  • the coding is also possible to design the coding as a barcode, which is also printed on the carrier when the drug doses are packaged. Further coding options can be a hole code or an edge code that can be scanned optically or mechanically. It is also possible in exactly the same way to design the coding in the form of conductor track sections which can then be read out via contact elements.
  • FIG. 1 is a schematic representation of a first embodiment of a medicament container with medicament doses in the form of dragées, which are attached to a wound carrier element,
  • Fig. 2 shows a drug container, in which the drug doses in one
  • Magazine are arranged in the manner of a drum magazine
  • FIG. 3 shows a schematic illustration of a medicament container with medicament doses applied to strip-like carrier elements, - o -
  • 3a is an enlarged view of two strip-like carriers connected to one another via a tension element for use in the medicament container according to FIG. 3,
  • Fig. 4 is a schematic sectional view of a special embodiment of the
  • FIG. 5 shows a schematic sectional illustration of a further special embodiment of a carrier
  • Fig. 6 shows a drug dose in the form of a coated tablet with the coding attached to it.
  • a medicament container 1 is shown there, in which 2 medicament doses 3 are accommodated in a receiving chamber and are fastened on a carrier element 4.
  • the carrier element 4 is designed as an elongated strip and rolled up spirally in the receiving chamber 2.
  • the carrier element 4 can be pulled out of the receiving chamber 2 through an opening 5 of a removal area 6, so that the medicament doses 3 can be detached from the carrier element 4 and taken.
  • each drug dose 3 is also provided with separate information, for example it may be sufficient to apply only one item of information in the drug container 1, for example on the carrier element 4, which is then before, at or is read out after the first removal movement.
  • the subsequent (for example 26) medicament doses 3 are not provided with a coding 7, only the penultimate and the last one can for example be coded again and emit a signal with the message "Medicines in the pack are running out, please refill”.
  • the code reading device 8 is connected via a line 9 to a processor 10, which comprises a memory device 11 and a time base 12.
  • the information supplied to it via line 9 is stored in the memory device 11 via the processor 10.
  • the time base 12 serves to record the time of removal in real time and also to store it in the storage device 11.
  • an alarm device which emits an alarm signal via an acoustic signal generator 13 if a withdrawal period read in via the coding 7 and the code reading device 8 is undershot or exceeded, which according to the invention can be easily and separately defined for each individual drug dose 3.
  • a display device 14 in the form of an alphanumeric display is also connected to the processor 10, on which read-in or evaluated information can be made available to the user, such as e.g. Warning when the intake interval is too short or too long, contraindications, device diagnosis, expiry date exceeded and the like.
  • An interface 15 and / or a transmitting device 16 are also connected to the processor 10. Data read into the memory device 11 can be transmitted to a computer via the interface 15. If the transmitting device 16 is provided, it is also possible to transmit the storage information to the receiver wirelessly, for example via a communication network. To clarify that the information does not necessarily have to be attached to the carrier element 4, but also to the drug dose 3, is the drawing. 6 provided. There is a barcode pattern on the surface of the drug dose 3.
  • a patient identification device 70 is also connected to the processor 10, via which the patient can enter a PIN number sequence, for example via a keypad 71, in order to authorize the use of the medicament container 1. If no match is found between the code entered and a patient code stored or read from the drug dose 3 or the carrier element 4, a locking device in the form of a slide 72 is activated, which makes access to the drug doses 3 or the carrier element 4 impossible.
  • the medicament container 1 shown there has a receiving chamber 2 of circular cross-section, in which a drum magazine 20 is rotatably mounted, which can be rotated within its round receiving chamber 2 by means of a handle or a motor drive (not shown).
  • Drug doses 3 in the form of coated tablets are accommodated in recesses 21 of the drum magazine 20 which are open radially to the outside.
  • Codings 7 in the form of bar codes are indicated on the radially outward-facing surface of the drum magazine 20 and are read out via a code reading device 8. This does not necessarily have to lie in the area of the opening 5 of the removal area 6, but can also be attached at another location in such a way that it reads the coded information from the surface of the drum magazine.
  • the recesses 21 with the medicament doses 3 enclosed therein can initially be closed by a cover film.
  • the cover film can be removed, which is formed by the between the surface of the drum magazine 20 and the inwardly facing wall of the receiving chamber 2 Gap is easily possible.
  • the storage and utilization of the information within the pharmaceutical container 1 takes place at the in the drawing. 2 shown embodiment as well as in the figure. 1 shown.
  • the processor 10 is in the Fig. 2 illustrated embodiment as a patient identification device 70 connected to a fingerprint sensor 81, which today is commercially available. A drug is released only when the processor 10 recognizes the correct fingerprint and thus the authorization of the user. This can also be done again via a slide 72. However, it is also possible to block the rotary movement of the drum magazine 20, so that further medicinal products cannot be removed which would first have to be rotated in front of the opening 5 in order to be removed.
  • the drug doses 3 are attached to carrier elements 4, which are designed in the manner of elongated strips.
  • the strips can be connected to one another by connecting elements 30, so that when the preceding section is completely pulled out of the opening 5 of the medicament container 1, the subsequent section can also be pulled out in order to remove the medicament doses 3 arranged thereon.
  • Direction of arrow 32 presses up to opening 5 of removal area 6.
  • support elements 4 are now shown, which consist of a flat, flexible base element 40, on one surface of which the medicament doses 3 are fixed and covered by a cover layer 41, which compared to the base element 40 have a reduced flexibility, in particular a lower ductility and thus higher brittleness has such that when the carrier element 4 is bent, the cover layer 41 jumps off or bursts from the base element 40 and releases the drug dose 3.
  • the removal area 6 of the medicament container 1 expediently has an opening edge 42, over which the carrier element 4 is drawn, in order to ensure a defined bending angle, which ensures that the cover layer 41 peels off from the base element 40.
  • FIG. 5 shows a further embodiment of a carrier element 4, which likewise comprises a flat, flexible base element 50, on which the medicament doses 3 are fixed, for example in the form of dragées, by intermediate elements 51.
  • the intermediate elements 51 are designed such that they lose their connection function when the base element 50 is bent off and the drug dose 3 is released.
  • the intermediate element 51 can be an adhesive layer. However, it is also possible to provide a brittle, crumbly structure which crumbles when the base element 50 is strongly bent and loosens the connection to the drug dose 3.
  • FIG. 1 also shows a wiping element 60 which is combined with a receiving container 61.
  • the opening edge 42 can also be designed in the manner of a separating knife in order to be able to cut off the carrier strip again and again.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Boîte (1) pour médicaments, destinée à recevoir des doses (3) de médicament uniques ou placées sur des éléments de support (4) séparément ou sur une et/ou plusieurs rangées sous forme solide, de poudre, de pâte ou liquide, en particulier des comprimés, des pilules, des capsules, des ampoules, des pâtes et analogue. Lesdites doses (3) peuvent être prélevées à l'unité ou plusieurs à la fois, éventuellement avec leur élément de support (4), sur une zone de prélèvement située sur la boîte. Un code (7) est apposé sur les doses (3) de médicament et/ou sur les éléments de support (4) et la boîte (1) pour médicaments comporte un dispositif de lecture de code. Le prélèvement des doses (3) de médicament ou des éléments de support (4) de la boîte (1) pour médicaments entraîne un mouvement relatif temporaire entre le dispositif de lecture (8) de code et le code (7), grâce auquel les informations mises en mémoire et spécifiques au médicament peuvent être lues, affichées et/ou évaluées en tant que paire de valeurs avec le moment du prélèvement, et peuvent être mises en mémoire pour une évaluation de l'observation du traitement thérapeutique et/ou transférées à d'autres dispositifs de traitement de données.
EP99952305A 1998-08-08 1999-08-09 Boite pour medicaments Withdrawn EP1102573A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998135941 DE19835941A1 (de) 1998-08-08 1998-08-08 Arzneimittelbehälter
DE19835941 1998-08-08
PCT/DE1999/002448 WO2000007538A2 (fr) 1998-08-08 1999-08-09 Boite pour medicaments

Publications (1)

Publication Number Publication Date
EP1102573A2 true EP1102573A2 (fr) 2001-05-30

Family

ID=7876904

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99952305A Withdrawn EP1102573A2 (fr) 1998-08-08 1999-08-09 Boite pour medicaments

Country Status (3)

Country Link
EP (1) EP1102573A2 (fr)
DE (1) DE19835941A1 (fr)
WO (1) WO2000007538A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10101580B4 (de) * 2001-01-15 2005-11-03 Siemens Ag Verfahren und medizinisches System zur Versorgung eines Patienten mit einem Medikament
DE10146815B4 (de) * 2001-09-18 2005-05-04 Ing. Erich Pfeiffer Gmbh Spender für Medien
US7828147B2 (en) 2004-04-24 2010-11-09 Inrange Systems, Inc. Multi-layer medication carrier
EP3023088A1 (fr) * 2007-05-04 2016-05-25 Unit Dose Pack B.V. Procédé pour fixer une fiche d'information sur un article sous plaquette alvéolée, fiche d'information, et système utilisant cette fiche d'information
EP2026298A1 (fr) * 2007-07-26 2009-02-18 Vitaphone Nederland B.V. Verfahren, System und Vorrichtung zur Unterstützung eines Patienten bei der Einhaltung eines medizinischen Plans
EP2329463A1 (fr) * 2008-07-15 2011-06-08 Medicasafe, Inc. Procédé, système et appareil pour contrôler l'accès d'un patient à des médicaments
EP2680177A1 (fr) * 2012-06-29 2014-01-01 Evondos Oy Élément de distribution de gaz comportant une couche de support
DK2692327T3 (en) 2012-07-31 2015-03-02 Evondos Oy Method and system for controlling drug delivery from a drug dispenser
EP2704112A1 (fr) 2012-08-31 2014-03-05 Evondos Oy Procédé de fonctionnement d'un distributeur de médicament et distributeur de médicament
EP2740459A1 (fr) 2012-12-10 2014-06-11 Evondos Oy Procédé permettant de distribuer des médicaments et distributeur de médicament

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US3985264A (en) * 1972-08-11 1976-10-12 Joseph Denman Shaw Security system for controlled drugs
JPS5243354B2 (fr) * 1972-11-08 1977-10-29
DE3518531A1 (de) 1985-05-23 1986-11-27 Dieter Dipl.-Phys. Dr. 8500 Nürnberg Hafner Vorrichtung zur aufbewahrung und zeitlich veranlassten einnahme von arzneimitteln
US5102008A (en) * 1989-09-29 1992-04-07 Healthtech Services Corporation Interactive medication delivery system for pills and caplets prepackaged on strips
SE468540B (sv) * 1989-10-06 1993-02-08 Lars Valdemarsson Foerfarande anordning foer utportionering av medicin
DE4001645C2 (de) * 1990-01-20 1994-04-14 Hafner Dieter Dipl Phys Dr Rer Aufnahmevorrichtung für ein Arzneimittelbehältnis
NL9402206A (nl) * 1994-06-09 1996-01-02 Cons Health Entrepreneurs Bv Apotheeksysteem en afgifte-automaat voor een dergelijk systeem.
US5700998A (en) * 1995-10-31 1997-12-23 Palti; Yoram Drug coding and delivery system

Non-Patent Citations (1)

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Title
See references of WO0007538A2 *

Also Published As

Publication number Publication date
WO2000007538A2 (fr) 2000-02-17
WO2000007538A3 (fr) 2000-05-11
DE19835941A1 (de) 2000-02-17

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