EP0129785B1 - Conteneur pour médicaments - Google Patents

Conteneur pour médicaments Download PDF

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Publication number
EP0129785B1
EP0129785B1 EP19840106800 EP84106800A EP0129785B1 EP 0129785 B1 EP0129785 B1 EP 0129785B1 EP 19840106800 EP19840106800 EP 19840106800 EP 84106800 A EP84106800 A EP 84106800A EP 0129785 B1 EP0129785 B1 EP 0129785B1
Authority
EP
European Patent Office
Prior art keywords
pulse
foregoing
foil
tablet
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP19840106800
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German (de)
English (en)
Other versions
EP0129785A2 (fr
EP0129785A3 (en
Inventor
Udo Simon
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AT84106800T priority Critical patent/ATE40790T1/de
Publication of EP0129785A2 publication Critical patent/EP0129785A2/fr
Publication of EP0129785A3 publication Critical patent/EP0129785A3/de
Application granted granted Critical
Publication of EP0129785B1 publication Critical patent/EP0129785B1/fr
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container

Definitions

  • the invention relates to a device for storing and for reminding a patient of the need to take medication with the features of the preamble of claim 1.
  • Pharmaceuticals often have to be taken at regular intervals. For example, the regular intake of insulin preparations, for example, is often vital for the recipient. Heart preparations also require regular application. Last but not least, contraceptive pills are also considered, which - to ensure effective protection for the recipient - must be taken in a regular daily cycle.
  • Certain groups of people such as adolescents or the elderly, either lack the conscientiousness required for an exact intake or there is a memory deficiency that makes the patient or recipient forget to take them regularly.
  • a container for pills, tablets or the like which essentially has the shape of a can, the lower part of which is rotatably arranged relative to a cover part provided with a removal opening.
  • a timer designed as a microprocessor, with a signaling device is built into the container, which is designed to be programmable and is activated as a function of the rotary movements that are necessary to remove pills. With such a device, it is possible to remind the patient or pill recipient to take the medication.
  • a monitoring device which essentially consists of an alarm clock which can be operated in a stationary manner, for example a radio alarm clock, which is intended to control the removal of pills from a foil pack by means of an additional device.
  • the "scanning" of the foil pack takes place electro-optically in that the pill receiving chambers of the foil pack are illuminated by means of a light source and a photosensitive element, so that a registration of the number of pills taken out or an activation of an alarm transmitter connected to the alarm clock is possible.
  • This known device can essentially only be operated in a stationary manner, is complex and expensive and fails particularly when non-transparent film packs are to be scanned.
  • the invention has for its object to provide a portable, compact device for storing and taking medication for a period of time in such a way that regular intake is vigorously promoted and the signal transmitter contained in the device, activated after settable time intervals, is activated immediately upon removal of the drug dose the drug container is linked.
  • This object is achieved by the combination of the characterizing features of patent claim 1.
  • the invention makes it possible for the first time to detect the removal of dragees from a film pack with simple means, the signal transmitter being activated only when the dragee is pressed through the film of the film pack. It is therefore not possible to activate or reset the signal transmitter, for example by opening the medicament container and then closing it again.
  • the signal transmitter in the case of particularly high-quality pharmaceuticals, it can make sense to design the signal transmitter as an integral part of the pharmaceutical container, the film being able to serve directly as a carrier for the electronic components, for example an integrated circuit. If the device according to the invention is to be used in conjunction with cheap medicinal products, it is advisable to attach the electronic signal transmitter to the medicament pack by means of a detachable connection, care then being taken to ensure that electrical contact is made between the conductor track sections and applied to the film the signal generator in the connection area is taken care of.
  • the device is secured against adjustment by third parties. It is advantageous for the invention that only the doctor or pharmacist can set the memory to the time of use and the memory content is thus protected against misuse. It is advantageous in the invention to electrically switch off the inputs after the programming process, which can be done manually or automatically (for example 5 minutes after actuation of the first set input).
  • Claim 8 ensures that that the impulse line is really severed when a dragee is pushed through. If the claim speaks of wavy or zigzag, then all embodiments are meant, for example also a U-shaped, meandering, spiral-shaped or the like. Laying of the impulse line over the receiving pocket of the dragee container. Experience has shown that the cover films usually break open in the form of a sickle along the edge of the receiving pockets when pressing through dragees. If the "zigzag arrangement" of the impulse line covers these edge areas, the desired severing effect will certainly be achieved.
  • the idea of activating any inputs by cutting an impulse line is also transferred to the set inputs.
  • the setting inputs are provided with setting pulse lines that can be cut through manually or by machine and activated, the pharmacist or doctor can, for example, use a pointed pen or the like to carry out the desired initial activation and determine the first taking time and the taking cycles in which the device applies to the patient the next intake reminds.
  • there are two different types of set inputs namely the first for entering a first intake time and the second for entering the cycle time.
  • the programming of the set inputs can also be carried out without errors by laypersons.
  • Either a template is placed over the defined or standardized arrangement of the set inputs, which, for example, bears an imprint in accordance with the time intervals to be programmed (intake cycle, for example, 3 hours) and which has a hole arrangement that comes to lie above the set inputs and only allows the set inputs to be separated, which are to be severed for the corresponding period.
  • the severing itself then has to be carried out by a pointed object which is pushed through the holes.
  • Claim 12 is concerned with the sensing electronics circuit, which recognizes the change in state by tearing the pulse line.
  • the sensing electronics circuit should have two flip-flops connected in series on the input side, the outputs of which are each connected to an exclusive-OR gate.
  • the old output information stored in the upstream flip-flop (input connected to ground through the intact pulse line) is pushed through to the input of the downstream flip-flop, which in turn represents the old state.
  • the new input information (input "high”, as pulled up with a "pull-up” current source) is read into the upstream flip-flop.
  • the two flip-flops are in different states, to which the downstream exclusive-OR gate reacts, switches through logically and emits a start pulse. If several two-bit shift registers are provided which are to be queried next to one another, the output information of the exclusive-OR gates which are present next to one another must be linked by a simple OR gate.
  • the life of the batteries to be used is reduced to the order of magnitude of the drug lifetimes, so that the device can be used for almost all types of drugs and can be stored together with the batteries used by the pharmaceutical manufacturer, pharmacist and / or doctor without the device suffering damage.
  • Claim 15 makes it possible to check a very large number of receiving pockets with a far smaller number of inputs.
  • the basic principle here is to connect in parallel each impulse line section, which is guided over a tablet, to a resistor applied to the film in a thick-film process.
  • a digital ohm meter in the form of an analog-digital converter must then be present on the input side, which responds to the change in resistance occurring when a pulse line section is cut and emits a start pulse.
  • the resistors in such a resistor chain have different values and is the digital ohm Meter is able to select resistance jumps of different heights and - depending on the height of the change in resistance - to control different stored times as intake interval times, it is possible with such a device to illustrate difficult intake cycles with a plurality of different intake times almost without confusion.
  • Claim 18 provides a further signal source which not only tells the patient that he has to take another pill, but also tells him which of the different types of pills in a packet it is his turn. It could be thought, for example, to design the further signal source as a red light-emitting diode, which clearly indicates to the patient that the red-colored dragees in the package are to be taken. If the additional signal source does not light up, the "other" coated tablets can be taken. Such a device can be particularly useful, for example, if, for example, day and night times require different intake cycles of different tablets. In order not to overwhelm the battery of the device, it can be advantageous to be able to activate the light-emitting diodes - as in a wristwatch - by pressing a button.
  • the device shown in Fig. 1 consists of a drage container 1, on one side edge 2 of which the signal generator 3 is arranged, which is provided as an electrical clock with a signal generator 4 in the form of a "beep loudspeaker" and / or an optical signal generator 21.
  • the detachable connection between the drip container 1 formed from two films (12, 12 ') glued to one another and the signal transmitter 3 is designed as a snap-lock connection 5, in which two retaining lips 7, 8 are provided which are integral with the housing 6 of the signal transmitter 3 are, which form a receiving slot 9 for the edge 2 between them and act on the two surfaces 10, 11 of the foils 12, 12 'under pressure, thereby ensuring a sufficiently firm fit.
  • an impulse line 14 is provided which extends over the receiving pockets 15 of the dragees 13 and cuts through the severable film 12 'when the dragees are pushed through is, so that there is a voltage change at the start input 16 connected to the pulse line 14, which activates the electronic timer and reminds the patient of the next dragee after the time preset by the setting device 17.
  • a plurality of further pulse lines 18 are provided with a common pulse line, each of which are each guided only via a receiving pocket 15 and are connected to separate further start inputs 19.
  • the electrical connection between the pulse lines 14, 18 and the start inputs 16, 19 can be made via spring contacts which are arranged in the receiving slot 9. Such spring contacts have long been known for contacting printed circuit boards.
  • the signal generator 3 is provided with a digital time display device 20, on which the time remaining until the medication is taken is displayed.
  • FIG. 2 shows an integrated circuit as a signal generator, which is connected on the input side to eight start pulse lines 42 via start inputs 41. These are - FIG. 2 shows different embodiments - guided in a zigzag, wave-like or the like manner over the receiving pockets 43 and then connected together to a ground line 44.
  • the first setting inputs 45 being provided for entering a first intake time (the patient should take the first pill, for example, in 24 hours), the second setting inputs 46 are for Enter at least one cycle time (the patient should take another pill every 12 hours after taking the first pill).
  • set input groups 45, 46 separable areas 47, 48 are also provided in the setting pulse lines 49, 50, which can be easily cut with a pin due to thinned film areas 51.
  • the set pulse lines are also connected to the ground line 44 as long as they are intact. If the connection is missing due to severed areas 47, 48, the corresponding input is activated.
  • An R-C link is also provided as the time base in FIG. 2, but can also be replaced by a watch quartz.
  • a piezo loudspeaker is designated as the signal source at 52, and a battery as the voltage source at 53.
  • the basic circuit diagram shown in FIG. 3 deals with the part of the electronics which is connected downstream of the inputs 41 and is provided for recognizing the change in state of the pulse lines.
  • the impulse lines are designated by dashed lines at 42.
  • Each input is provided with a pull-up current source 55 which energizes the D input of a downstream first flip-flop 56 when the input from the ground line 44 is switched off and reads into the flip-flop 56 when a clock occurs on the clock line 57 , so that its output line 58 reflects the new state "pulse line cut through" and passes it on to the first input 59 of an exclusive-OR gate 60.
  • each pulse line section 70 placed over a receiving pocket 43 has a resistor 71 connected in parallel.
  • An analog / digital converter 72 is connected downstream of the start input 41 and, when a change in resistance occurs in the upstream start pulse line, emits a start pulse to the downstream time base.
  • a device can be created on the basis of the network shown in FIG indicates different intake cycles of different pharmaceuticals.
  • FIG. 6 shows a perforated template 80 which is laid over the film 12 in the area of the setting inputs 45, 46 and only releases the setting inputs which have to be severed in order to set the printed times.
  • the perforated template and programming stamp can have certain color samples that can be specified by the doctor on the prescription. The pharmacist is then able to program the medication container correctly based solely on the color of the perforated template or the stamp.

Claims (19)

1. Dispositif pour prendre en compte et pour rappeler à un patient une prise requise de médicaments, qui comporte un réceptacle à médicaments auquel est associé un émetteur (3) de signaux, actionné après des intervalles de temps réglables à l'avance, qui est agencé en horloge électrique comportant un émetteur de signaux sonores (4) et/ou un indicateur de signaux optiques (21) et qui est muni d'une entrée de déclenchement (16) excitable électriquement, laquelle entrée, lors du premier prélèvement d'une dose de médicament, reçoit d'une canalisation (14) d'impulsions une impulsion électrique de déclenchement, caractérisé en ce que le réceptacle à médicaments est un réceptacle (1) à pilules, dans lequel les pilules (13) sont versées par coulage, ou maintenues par soudure ou par collage, entre une première feuille (12) munie de logements et une deuxième feuille (12') agencée de manière à pouvoir être rompue, et en ce que la canalisation (14) d'impulsions s'étend dans la région, de la deuxième feuille, que l'on doit rompre pour prélever les pilules (13), la canalisation (14) d'impulsions étant coupée lors de l'extraction des pilules (13) par rupture, ce qui provoque l'émission de l'impulsion de déclenchement.
2. Dispositif selon la revendication 1, caractérisé en ce que l'émetteur de signaux (3) fait partie intégrante du réceptacle (1, 30) à médicaments et la feuille (12) sert directement de support aux composants électroniques, par exemple un circuit intégré (40), ou en ce que l'émetteur de signaux (3) est maintenu sur le réceptacle (1) à pilules par une liaison amovible, de préférence une liaison à encliquetage à mouvement brusque.
3. Dispositif selon l'une des revendications précédentes, caractérisé en ce que la canalisation (14) d'impulsions est obtenue par métallisation sous vide ou par impression sur la feuille (12'), ou par injection sur/dans la feuille (12').
4. Dispositif selon l'une des revendications precédentes, caractérisé en ce qu'une canalisaton (14) d'impulsions commune est placée au-dessus de plusieurs ou de la totalité des poches réceptrices (15) du réceptacle (1) à pilules.
5. Dispositif selon l'une des revendications précédéntes, caractérisé en ce que le réceptacle (1) à pilules contient des médicaments de pouvoir et de persistance différents et l'émetteur de signaux (3) est muni d'un nombre correspondant de mémoires réglables ainsi que d'entrées de déclenchement (19), chaque poche réceptrice (15) comprenant elle-même une canalisation (18) d'impulsions qui est reliée à l'entrée de déclenchement correspondante.
6. Dispositif selon l'une des revendications précédentes, caractérisé en ce que l'émetteur de signaux (3) comporte un dispositif indicateur de temps (20) pour indiquer chaque fois le contenu de la mémoire qui est excitée et interrogée.
7. Dispositif selon l'une des revendications précédentes, caractérisé en ce que, pour entrer les contenus des mémoires, il est prévu un dispositif de réglage (17) qui est muni d'une fermeture verrouillable ou en ce qu'il est prévu des entrées de réglage (45,46) qui sont agencées de manière à pouvoir être mises électriquement hors-circuit en fonction du cycle programme.
8. Dispositif selon l'une des revendications précédentes, caractérisé en ce que les canalisation) (14) d'impulsions s'étendent au-dessus de chaque poche réceptrice (15) du réceptacle (1) à médicaments, sous forme d'ondes, de zigzag ou analogue.
9. Dispositif selon la revendication 7, caractérisé en ce que la ou les entrées de réglage (45, 46) sont excitables par des canalisations d'impulsions de réglage (49, 50) qui sont agencées de manière à pouvoir être coupées et qui sont, comme les canalisations (14) d'impulsions, placées sur la feuille (12) du réceptacle (1) à pilules.
10. Dispositif selon l'une des revendications 7 à 9, caractérisé en ce qu'il est prévu un premier groupe d'entrées de réglage (45) pour l'entrée d'un premier temps de prise ainsi qu'un deuxième groupe d'entrées de réglage (46) pour l'entrée de la durée du cycle.
11. Dispositif selon l'une des revendications 7, 9, 10, caractérisé en ce qu'une disposition standard des entrées de réglage (45, 46) est agencée de manière à pouvoir être couverte par une matrice (80) à trous, qui est applicable sur la feuille (12) et qui est caractérisée par son emplacement imposé, ou par un poinçon de programmation (81) qui comporte des pointes de perforation (82), de telle façon que, dans le cas où une matrice (80) à trous est appliquée, seules les entrées de réglage (45) à couper soient accessibles sous les trous (83) de la feuille et puissent être coupées individuellement ou, dans le cas du poinçon de programmation (81), la disposition correspondante des pointes de perforation coupe simultanément les entrées de réglage (45, 46).
12. Dispositif selon l'une des revendications précédentes, caractérisé en ce que l'émetteur de signaux (3), qui est agencé en circuit intégré (40), comporte un circuit électronique de détection qui agit en particulier en organe différentiateur, qui est relié en amont aux canalisations (14) d'impulsions, et qui comporte, par exemple pour chaque canalisation, deux bascules (56, 61) montées en série pour former un registre à tiroirs à deux bits, lesquelles sont reliées en aval à une porte à ou-exclusif (60) dont la sortie (63) est reliée à une entrée de déclenchement (41) du circuit (40).
13. Dispositif selon l'une des revendications précédentes, caractérisé en ce que, pour économiser le courant, le ou les états des canalisations (14) d'impulsions ne sont contrôlés que pendant des impulsions d'interrogation de courte durée et espacées dans le temps.
14. Dispositif selon l'une des revendications 10 à 13, caractérisé en ce que l'interrogation des canalisations (14) d'impulsions n'intervient qu'après l'actionnement d'au moins l'une des entrées de réglage du premier groupe.
15. Dispositif selon l'une des revendications précédentes, caractérisé en ce que, en parallèle avec chaque segment (70) de canalisation d'impulsions placé au-dessus d'une poche réceptrice (43), il est monté une résistance (71) qui est placée sur la feuille de la même manière que les canalisations d'impulsions, de préférence par un pcocédé à couche épaisse, et en ce que le circuit comprend un montage (convertisseur analogique-numérique 72) qui est capable de constater la variation de la résistance totale et à l'entrée (73) duquel est raccordée la canalisation commune (42) d'impulsions de déclenchement.
16. Dispositif selon la revendication 15, caractérise en ce que les résistances (71) possèdent des valeurs différentes et la durée des intervalles entre les prises dépend de la valeur de l'augmentation de résistance qui apparaît à la suite du déchirement complet d'un segment (70) de canalisation d'impulsions qui lui est associé.
17. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il est prévu plusieurs entrées de déclenchement (41) qui sont agencées de manière à pouvoir être interrogées par un ou plusieurs convertisseurs analogique-numérique, en multiplex le cas échéant, et qui sont reliées chacune à une chaîne de résistances et de segments (70) de canalisation d'impulsions.
18. Dispositif selon l'une des revendications précédentes 2 à 17, caractérisé en ce que, pour distinguer la nature de la prochaine pilule à prendre, il est prévu au moins une autre source de signaux, par exemple optique, qui est reliée à une autre sortie du circuit (40) ou en ce qu un son modulé différemment ou une autre fréquence de son est adressé au haut-parleur (52) piézo- électrique.
19. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il est prévu un dispositif indicateur optique supplémentaire qui est agencé de manière à pouvoir être mis en circuit automatiquement, après un intervalle de temps que l'on peut choisir à l'avance, dans le cas où aucune pilule n'a été prélevée à l'actionnement de l'émetteur de signaux, et/ou dans le cas où, lorsque le dispositif indicateur supplémentaire est placé à la suite, l'émetteur de signaux est actionné après des intervalles de temps qui reviennent périodiquement.
EP19840106800 1983-06-25 1984-06-14 Conteneur pour médicaments Expired EP0129785B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84106800T ATE40790T1 (de) 1983-06-25 1984-06-14 Arzneimittelbehaelter.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3322920 1983-06-25
DE3322920 1983-06-25

Publications (3)

Publication Number Publication Date
EP0129785A2 EP0129785A2 (fr) 1985-01-02
EP0129785A3 EP0129785A3 (en) 1986-03-05
EP0129785B1 true EP0129785B1 (fr) 1989-02-15

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EP19840106800 Expired EP0129785B1 (fr) 1983-06-25 1984-06-14 Conteneur pour médicaments

Country Status (4)

Country Link
EP (1) EP0129785B1 (fr)
AT (1) ATE40790T1 (fr)
DE (1) DE3476732D1 (fr)
HK (1) HK10890A (fr)

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US7828147B2 (en) 2004-04-24 2010-11-09 Inrange Systems, Inc. Multi-layer medication carrier
US8019471B2 (en) 2004-04-24 2011-09-13 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system

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FR2745922B1 (fr) * 1996-03-05 1998-05-22 Jager Ivan Dispositif pour rememorer une operation relative a un objet determine et application de ce dispositif
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EP0796605A1 (fr) * 1996-03-21 1997-09-24 Alusuisse Technology & Management AG Feuille de fermeture avec pistes conductrices
CA2272017A1 (fr) 1998-05-29 1999-11-29 Alusuisse Technology & Management Ltd. Opercule avec bandes conductrices
FR3007835B1 (fr) * 2013-06-28 2015-06-19 Commissariat Energie Atomique Membrane et systeme de controle d'une ouverture de la membrane

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7828147B2 (en) 2004-04-24 2010-11-09 Inrange Systems, Inc. Multi-layer medication carrier
US8019471B2 (en) 2004-04-24 2011-09-13 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system

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Publication number Publication date
DE3476732D1 (en) 1989-03-23
ATE40790T1 (de) 1989-03-15
EP0129785A2 (fr) 1985-01-02
EP0129785A3 (en) 1986-03-05
HK10890A (en) 1990-02-16

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