EP1089710A1 - Formulations pharmaceutiques injectables de derives de la partricine - Google Patents

Formulations pharmaceutiques injectables de derives de la partricine

Info

Publication number
EP1089710A1
EP1089710A1 EP99914507A EP99914507A EP1089710A1 EP 1089710 A1 EP1089710 A1 EP 1089710A1 EP 99914507 A EP99914507 A EP 99914507A EP 99914507 A EP99914507 A EP 99914507A EP 1089710 A1 EP1089710 A1 EP 1089710A1
Authority
EP
European Patent Office
Prior art keywords
formulation according
partricin
derivative
lipid
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99914507A
Other languages
German (de)
English (en)
Other versions
EP1089710B1 (fr
Inventor
Tiberio Bruzzese
Valerio Maria Ferrari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pro Aparts - Investimentos E Consultoria Lda
Original Assignee
Quatex NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quatex NV filed Critical Quatex NV
Priority to DK99914507T priority Critical patent/DK1089710T3/da
Publication of EP1089710A1 publication Critical patent/EP1089710A1/fr
Application granted granted Critical
Publication of EP1089710B1 publication Critical patent/EP1089710B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/797Lipid particle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/797Lipid particle
    • Y10S977/798Lipid particle having internalized material
    • Y10S977/799Containing biological material
    • Y10S977/801Drug
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/905Specially adapted for travel through blood circulatory system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/926Topical chemical, e.g. cosmetic or sunscreen

Definitions

  • This invention relates to new injectable pharmaceutical formulations containing partricin derivatives as the active ingredient.
  • the new pharmaceutical formulations enclose at least one derivative of partricin in the form of a free base, or a pharmaceutically acceptable water-soluble salt of it, in a solubilizing/dispersing medium made up of a lipid and/or phospholipid emulsion in water.
  • the afore-said documents also describe the preparation of their salts with acids, acceptable from a pharmacological and pharmaceutical point of view, and report that such salts are unusually water-soluble. It has already been ascertained that the partricin derivatives, described in the afore-said European patent applications, can also be used in clinical practice, for human and veterinary application as drugs for treatment of several pathologies sensitive to the partricin derivatives; in particular, injectable formulations may be prepared enclosing such derivatives, evidencing the advantages deriving from the water-solubility of the said partricin derivatives.
  • formulations may permit, for instance, using a derivative of partricin' s as the active ingredient (e.g., N-dimethylaminoacetyl-partricin A 2-dimethylamino- ethylamide diascorbate - code name SPA-S-843) for instance with the addition of ascorbic acid, as antioxidant, and of lactose as excipient.
  • a derivative of partricin' s as the active ingredient
  • the freeze-dried product is normally dissolved in 5% glucose solution at the time of use and administered by slow intravenous infusion.
  • One of the subjects of the present invention is in fact an injectable pharmaceutical formulation enclosing at least one partricin derivative in the form of free base - or of water-soluble pharmaceutically acceptable salt thereof, with acids that are acceptable from a pharmaceutical and pharmacological point of view - in a solubilizing/dispersing medium made up of a lipid and/or phospholipid emulsion in water such that the resulting emulsion be iso-osmotic.
  • the expression "partricin derivative” indicates the derivatives of partricin described in patent applications EP-A-0434943, EP-A-0489308, GB-A- 1359473 (equivalent to US 3780173) and GB-A-1046774 (equivalent to US 3961047).
  • preferred formulations are those wherein the partricin derivative is a derivative of partricin A and/or B presenting the carboxyl in position C18 of the macrolidic ring in the form of ester or of neutral amide or of amide containing a basic nitrogen group in the side chain, and those wherein the derivative is further substituted, on the primary amino group of mycosamine in the form of amide with an acid containinga basic nitrogen group in the side chain.
  • a partricin derivative specially preferred for the formulations of the invention is N- dimethylaminoacetyl-partricin A 2-dimethylamino-ethylamide.
  • the formulations of the invention enclose a partricin derivative in the form of a free base
  • a surfactant and/or a co-solvent is preferred in order to avoid any eventual problem of active ingredient solubilization before its inclusion in the lipid emulsion; alternatively, this trouble can be avoided by sonication of the particles, elevation of the system temperature e.g., from room temperature to 40-50°C, and etc..
  • these salts are preferably formed with at least one, preferably two, acid equivalents, preferably ascorbic or aspar.tic acid; the salt preferred for the formulations of the invention is N-dimethylaminoacetyl-partricin A 2- dimethylamino-ethylamide diascorbate, as such or as its free base.
  • the formulations of the invention comprise a pharmaceutically effective quantity of the partricin derivative; the dose of partricin derivative per unit to be administered remains substantially equal to that of the traditional formulations. In particular, the quantity ranges from 1 to 100 mg, preferably 10 to 50 mg.
  • the partricin derivative enclosed in the formulations of the invention is, preferably, in the form of solution, of micellar pseudosolution, of encapsulated inclusion compound, or of suspension of sub-micronized particles, their size being smaller than 5 ⁇ m, preferably smaller or equal to 3 ⁇ m, to avert the risk of pulmonary embolism; following sterilization (by sterilizing filtration or other suitable method) , the partricin derivative can directly be added to the lipid emulsion or, preferably, stored in the dry state, following suitable processing (e.g., through freeze-drying) , to improve long-term stability and be added to the lipid emulsion just prior to its therapeutic use by parenteral injection, particularly intravasal and, preferably, intravenous route .
  • suitable processing e.g., through freeze-drying
  • the solubilizing/dispersing medium is a lipid emulsion, preferably oil-in-water, containing lipids and/or phospholipids, in the form of droplets, vesicles, nanospheres , etc .
  • the lipids and/or phospholipids used in the formulations of the present invention can be from different origin, that is, animal and/or vegetable and/or synthetic and/or semisynthetic origin (hydrogenated fats and the like).
  • the lipids are preferably taken from the group of the mono-, di- or triglycerides; specially triglycerides; when of vegetable origin preferably from olives, for instance triolein, or from soybeans, when of animal origin preferably fish oils.
  • the phospholipids, in particular the phosphatidylcholines, when of vegetable origin are typically soybean lecithins, when of animal origin are selected preferably from egg yolk lecithins .
  • phospholipids preferred for the formulations of the invention, are those selected from the group of the distearoilphosphatidyl-choline, dimyristoilphosphatidylcholine, dimyristoilphosphatidylglycerol, phosphatidyl-ethanolamine, phosphatidylserine , phosphatidyl-inositol . Hydrogenate lipids and/or phospholipids too can be used in the formulations of the invention.
  • phospholipids When phospholipids are used alone, they can be in the form of multilamellar or unilamellar, large or small vesicles, optionally containing sterols. In other cases, lipids and/or phospholipids can be present in the form of lipid nanospheres able to encapsulate the partricin derivative.
  • the concentration of the lipids eventually present in the formulations of the invention varies from 1 to 25%, being it usually 10-20% while the concentration of the phospholipids eventually present can vary from 0.05% to 5%.
  • the formulations of the invention can also enclose an excipient and/or a pharmaceutically acceptable adjuvant, such as those commonly used in the formulations intended for injectable use and according to the evidence of the experts in the field, for instance selected from the sugar group, preferably lactose, glucose, saccharose, maltose; antioxidants , preferably ascorbic acid, sodium ascorbate, vitamin E; preservatives, preferably alkyl paraben, benzyl alcohol; ionic or non-ionic surfactants, preferably sodium laurylsulfate, sodium deoxycholate, Tween ® , particularly Tween 80, polysorbates, Cremophor (LE or other); acid or neutral or basic buffers, preferably mono- or bi-basic phosphates; co-solvents;
  • the formulations of the invention can moreover be realized in both a pharmaceutical form wherein the partricin derivative is already inserted in the lipid and/or phospholipid emulsion together with any eventual excipient and/or adjuvant, and in a pharmaceutical form wherein the partricin derivative is preserved in an anhydrous state (in the form, for instance, of a lyophile), together with any eventual excipient and/or adjuvant, separated from the lipid and/or phospholipid emulsion, together with any eventual excipient and/or adjuvant, in which it is extempore inserted before therapeutic administration.
  • the formulations of the invention are useful to prepare a medicament intended for the clinical treatment of pathologies sensitive to the action of the partricin derivative, such as, f.i., those described in EP-A-0434943, EP-A-0489308, GB- A-1359473 and GB-A-1046774 and several other pathologies.
  • the texts of the four a/m documents are incorporated, for reference, in the present description, in particular as regards the partricin derivatives, their preparations and their described uses . All the above mentioned products (lipids, phospholipids, excipients etc.) are commercially available and must be specially purified, fractioned and declared suitable for the injectable use (non pyrogenic etc.)
  • the final composition should be such as to conduct to an iso- osmotic emulsion.
  • Industrial preparation of the emulsions requires the use of special equipment such as, in example, colloidal mills, two- stage pressure homogenizers , ultrasound generators, as is evident to an expert in the sector. Special attention will have to be paid to size control of the particles in suspension (sub-micron dimensions or, at any rate, not greater than 3-5 ⁇ m) , to their distribution interval and their homogeneity, as well as stability of the emulsion itself, as is evident to an expert of the sector.
  • An additional item of the present invention consists in a procedure for preparation of the formulations of the invention, comprising sterilization - preferably by sterilizing filtration of the solution, micellar pseudo- solution, encapsulated compound or suspension of sub- micronized particles of the partricin derivative -and subsequent inclusion in the lipid and/or phospholipid emulsion.
  • drying of the derivative is preferred - subsequent to sterilization and, at any rate, before inclusion in the lipid and/or phospholipid emulsion, of the solution, pseudo- solution or suspension of the partricin derivative preferably through freeze-drying.
  • the procedure according to the invention can also comprise the addition of a surface active agent and/or a co- solvent to the partricin derivative or sonication of the particles or rising of the system temperature, passing, i.e., from room temperature to 40°-50°C, before inclusion of the derivative into the lipid and/or phospholipid emulsion.
  • Incorporation of the drug in the lipid emulsion can occur in both the presence of the partricin derivative in the form of a solution, and in the solid state: in the latter case, the solid, for example a freeze-dried substance, can first be dissolved or dispersed in sterile water and the solution added to the emulsion or, better still, it can be directly solubilized with a portion of it. The final preparation will be sterile.
  • the final volume of the injectable formulation of the invention varies, in general from 5-10 ml when intended for bolus administration, to 100, 250, 500 ml when intended for slow, drip infusion over 1-5 hours, as evident to an expert of the sector.
  • the formulations of the invention can unexpectedly reduce and even eliminate, the local irritating effects when used by intravascular route, contrary to what commonly occurs when using more traditional formulations as those obtained in glucose solution (5% glucose solution) or in physiological solution (0.9% sodium chloride solution).
  • the formulations of the invention allow, for instance, incorporation of the more lipophylic (hydrophobic) derivatives of partricin, in particular if in the form of free bases, in the inner oily phase of the oil-in-water emulsion, enabling the derivatives to be released over longer times and with particular tropism for the cells of the reticuloendothelial system and for the organs rich thereof, with relative decrease of the blood levels and wide changes of their toxicity.
  • ampoule A The solution in ampoule A is freeze-dried and before use the solid residue re-dissolved with the diluent from ampoule B; the resulting mixture is slowly injected as a bolus dose, by intravenous route .
  • the mixture of sterile powders in ampoule A is dissolved with a portion (5-10 ml) of diluent from vial B; the mixture is then transferred, under sterile conditions, to vial B, corrected to about pH 7.5 with sterile phosphate buffer if necessary, and injected by slow intravenous infusion over 1 hour.
  • Example 4 Ampoule A - Active ingredient (see Example 2)
  • Example 5 Ampoule A - Active ingredient (see Example 2)
  • the content of ampoule A is treated with the diluent from vial B and administered by slow intravenous infusion, as indicated in Example 3.
  • Soybean lipids 10 g Soybean phospholipids
  • the active ingredient in ampoule A is treated with the diluent from vial B and administered as described in example
  • the mixture pH 5.5, is slowly injected by intravenous route as a bolus dose.
  • An injectable preparation of active ingredient (ampoule A - 50 mg of SPA-S-843) in 100 ml of a lipid emulsion (vial B) having the composition reported in Example 3 and obtained with the procedure as in the same Example 3, was compared for local tolerance with a formulation obtained by dissolving the content of another ampoule A, same as before, in 100 ml of 5% glucose standard solution. Both formulations (lipid and glucose) contained 0.5 mg of SPA-S-843/ml .
  • the tests were carried out in five adult male New Zealand albino rabbits weighing 2.8+0.2 kg, by daily injecting intravenously, over a time of 120 seconds, 2 ml in total (1 mg of £)PA ⁇ -S ⁇ 843) of both lipid and glucose solutions intp the marginal veins of the left and right ear respectively. This treatment was repeated for 3 or more days.
  • Example 12 The same lipid formulation as described in Example 12 was tested in the same experimental model by protracting the number of administrations into the rabbit ear marginal vein.
  • the SPA-S-843 lipid formulation substantially confirmed the substantial absence of local reactions and the superiority in comparison with standard injectable formulations.
  • SPA-S-843 free base was dissolved under nitrogen in a mixture of methylene chloride :methanol in the ratio 9:1 (1 mg/ml) and mixed with an equal volume of a methylene chloride solution of phospholipids (hydrogenated phosphatidylcholine and distearoyl phosphatidyl-choline) and with a methanol: ethylene chloride solution of cholesterol, so as to give a molar ratio of drug to lipids of 1:5:2:2.5, and the solvents were removed under reduced pressure.
  • the phospholipids were represented, for instance, by egg lecithin alone.
  • the dried drug-phospholipid film was suspended in a standard phosphate-saline buffer (PSB) and hand-shaken allowing the film to form lipidic vescicles.
  • PSB standard phosphate-saline buffer
  • the suspension was centrifuged for 1 hour and the pellet was additioned with maltose in the ratio 1:1 (w/w) and lyophilized.
  • the resulting mixture is injected by slow intravenous infusion over 1 hour .
  • the i.v. 50% lethal dose (LD so ) of the SPA-S-843 formulation, obtained according to Example 15, is increased from 70 mg/kg to >200 mg/kg
  • Example 16 A mixture of 25 mg of SPA-S-843, f.i. in the form of free base, 2.5 g of soybean oil and 2.5 g of egg-lecithin is treated with water under stirring to give an emulsion, the mixture is added with 5 g of maltose while stirring and preserved as a lyophilized formulation. After reconstitution with sterile distilled water, just before the use, the active ingredient is present as lipid nanosphere - encapsulated particles, having an average size of 25 to 50 nm.
  • the mixture is then diluted with 5% dextrose to the desired concentration, usually to 100 ml, to be injected by slow infusion within 1 hour by i.v. route.
  • the formulation shows a good distribution to sites of infection and low uptake by reticuloendothelial system.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
EP99914507A 1998-06-25 1999-03-11 Formulations pharmaceutiques injectables de derives de la partricine Expired - Lifetime EP1089710B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK99914507T DK1089710T3 (da) 1998-06-25 1999-03-11 Injicerbare farmaceutiske formuleringer af partricinderivater

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI981457 1998-06-25
IT1998MI001457A IT1301807B1 (it) 1998-06-25 1998-06-25 Formulazioni farmaceutiche iniettabili di derivati della partricina.
PCT/EP1999/001571 WO1999066902A1 (fr) 1998-06-25 1999-03-11 Formulations pharmaceutiques injectables de derives de la partricine

Publications (2)

Publication Number Publication Date
EP1089710A1 true EP1089710A1 (fr) 2001-04-11
EP1089710B1 EP1089710B1 (fr) 2005-08-10

Family

ID=11380320

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99914507A Expired - Lifetime EP1089710B1 (fr) 1998-06-25 1999-03-11 Formulations pharmaceutiques injectables de derives de la partricine

Country Status (11)

Country Link
US (1) US6586407B1 (fr)
EP (1) EP1089710B1 (fr)
JP (1) JP4719355B2 (fr)
KR (1) KR100622290B1 (fr)
AT (1) ATE301453T1 (fr)
DE (1) DE69926633T2 (fr)
DK (1) DK1089710T3 (fr)
ES (1) ES2245096T3 (fr)
IT (1) IT1301807B1 (fr)
PT (1) PT1089710E (fr)
WO (1) WO1999066902A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2627173E (pt) 2010-10-12 2015-07-24 Medicines Co Formulações de clevidipina em emulsão contendo agentes antimicrobianos
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
CN111867562B (zh) * 2018-03-07 2023-07-07 陈献 不溶性药物的水性制剂
WO2023285323A2 (fr) * 2021-07-12 2023-01-19 Bioseutica B.V. Procédé de production d'amcipatricine diascorbate et son utilisation pour le traitement d'infections fongiques invasives résistantes aux agents antifongiques classiques

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1359473A (en) * 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
GB1406774A (en) * 1973-02-15 1975-09-17 Prodotti Antibiotici Spa Esters of patricin and of partricin derivatives
GB1413256A (en) * 1973-05-14 1975-11-12 Prodotti Antibiotici Spa Water-solubilised antibiotics
GB1463348A (en) * 1974-09-03 1977-02-02 Prodotti Antibiotici Spa Water-solubilised compositions
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
JP2653245B2 (ja) * 1989-11-27 1997-09-17 日本新薬株式会社 脂肪乳剤
JP2830243B2 (ja) * 1989-12-21 1998-12-02 味の素株式会社 ポリエン含有組成物
IT1243404B (it) * 1990-12-03 1994-06-10 Prodotti Antibiotici Spa Derivati della partricina
IT1283149B1 (it) * 1996-07-12 1998-04-07 Prodotti Antibiotici Spa Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9966902A1 *

Also Published As

Publication number Publication date
ES2245096T3 (es) 2005-12-16
JP4719355B2 (ja) 2011-07-06
DE69926633T2 (de) 2006-05-18
KR20010071581A (fr) 2001-07-28
ITMI981457A1 (it) 1999-12-25
PT1089710E (pt) 2005-11-30
ATE301453T1 (de) 2005-08-15
US6586407B1 (en) 2003-07-01
WO1999066902A8 (fr) 2001-02-15
DE69926633D1 (de) 2005-09-15
EP1089710B1 (fr) 2005-08-10
WO1999066902A1 (fr) 1999-12-29
IT1301807B1 (it) 2000-07-07
DK1089710T3 (da) 2005-10-17
JP2002518431A (ja) 2002-06-25
KR100622290B1 (ko) 2006-09-11

Similar Documents

Publication Publication Date Title
JP2960867B2 (ja) 眼科用ビヒクルとして有用な水中油型ナノエマルジョンおよびその調製法
CA2578574C (fr) Compositions pour l'apport de medicaments hautement solubles dans l'eau
KR19990044445A (ko) Pge1 함유 동결건조 제제 및 그 제법
JP2006508104A (ja) 難溶性風邪薬の経口投与用マイクロエマルション濃縮液及びその製造方法
US20050049209A1 (en) Pharmaceutical compositions for delivering macrolides
EP1089710B1 (fr) Formulations pharmaceutiques injectables de derives de la partricine
JP2937135B2 (ja) Pge1含有凍結乾燥製剤及び製法
US7053061B2 (en) Amphotercin B structured emulsion
PT689441E (pt) Composicao farmaceutica na forma de um estojo ("kit")
CA3123002A1 (fr) Formulations stables d'anesthesiques et formes galeniques associees
AU2001280084A1 (en) Amphotericin B structured emulsion
JP3074731B2 (ja) 脂肪乳剤
JPH09124503A (ja) アミチアマイシン類の注射用の抗菌性組成物
JPH0672890A (ja) オーレオバシジン類の乳化製剤
JPH06256212A (ja) オーレオバシジン類のリポソーム製剤
JPH0489430A (ja) 低血圧維持剤
KR20000073825A (ko) 클라리스로마이신-함유 건조리포좀 조성물

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20001221

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PRO APARTS - INVESTIMENTOS E CONSULTORIA LDA

17Q First examination report despatched

Effective date: 20040923

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 69926633

Country of ref document: DE

Date of ref document: 20050915

Kind code of ref document: P

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: FIAMMENGHI-FIAMMENGHI

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20050403029

Country of ref document: GR

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2245096

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20060511

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20130325

Year of fee payment: 15

Ref country code: FI

Payment date: 20130327

Year of fee payment: 15

Ref country code: SE

Payment date: 20130327

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20130327

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20130225

Year of fee payment: 15

Ref country code: AT

Payment date: 20130220

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20130327

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20140327

Year of fee payment: 16

Ref country code: NL

Payment date: 20140326

Year of fee payment: 16

Ref country code: CH

Payment date: 20140327

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20140326

Year of fee payment: 16

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20140911

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20140331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140311

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 301453

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140311

REG Reference to a national code

Ref country code: GR

Ref legal event code: ML

Ref document number: 20050403029

Country of ref document: GR

Effective date: 20141002

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140911

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20141002

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140311

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140331

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20150401

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150331

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150331

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150311

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20160426

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20160224

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20160328

Year of fee payment: 18

Ref country code: GB

Payment date: 20160329

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150312

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20160331

Year of fee payment: 18

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140331

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69926633

Country of ref document: DE

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20170311

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20171130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20171003

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170311

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170311