EP1011621A4 - Verfahren und zusammensetzungen zum bleichen von zähnen - Google Patents
Verfahren und zusammensetzungen zum bleichen von zähnenInfo
- Publication number
- EP1011621A4 EP1011621A4 EP98946860A EP98946860A EP1011621A4 EP 1011621 A4 EP1011621 A4 EP 1011621A4 EP 98946860 A EP98946860 A EP 98946860A EP 98946860 A EP98946860 A EP 98946860A EP 1011621 A4 EP1011621 A4 EP 1011621A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- bioactive
- teeth
- whitening
- biocompatible glass
- particulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C12/00—Powdered glass; Bead compositions
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
- C03C4/0021—Compositions for glass with special properties for biologically-compatible glass for dental use
Definitions
- the present invention relates to methods for whitening, lightening, bleaching or removing stains from teeth using certain bioactive glass compositions.
- a tooth is comprised of an inner dentin layer and an outer hard enamel layer that is the protective layer of the tooth.
- the enamel layer of the tooth is naturally an opaque white or slightly off-white color. It is this enamel layer that can become stained or discolored.
- the enamel layer of the tooth is composed of hydroxyapatite mineral crystals that create a somewhat porous surface. It is believed that this porous nature of the enamel layer is what allows staining agents and discoloring substances to permeate the enamel and discolor the tooth.
- the tooth naturally acquires a film called pellicle, made up of salivary glycoproteins. The pellicle may also acquire stain.
- teeth or “teeth” are used herein, they are intended to mean a material which is apatite and the acquired pellicle.
- WO 96/10985 discloses particulate bioactive silica containing glasses that can reduce pulpal irritation of a tooth and/or strengthen the structure of a tooth and therefore have use in the treatment of hypersensitive teeth. It is suggested that such glasses can consist solely of silicon oxide or silicon hydroxide or can contain one or more additional elements selected from Ca, P, Na, K, Al, B, N, Mg, Ti, or F. It is also suggested that it is advisable to use bioactive glass compositions comprising calcium and phosphate which can help induce remineralisation of dentin or alternatively to use separate sources of calcium and phosphate together with a bioactive glass not containing them.
- WO 97/27148 discloses particulate bioactive and biocompatible glasses which can remineralise teeth and are of particular use in the reduction of dentin hypersensitivity.
- the present invention provides a method of whitening teeth, which comprises contacting a tooth structure with a tooth- whitening amount of a particulate bioactive and biocompatible glass.
- whitening is used herein at all occurrences to include bleaching, lightening, or removing stain from the teeth.
- the present invention provides a method for whitening, lightening or bleaching teeth.
- the method is also useful for removing stains from teeth.
- the method includes contacting teeth with an effective tooth-whitening amount of bioactive glass as disclosed in WO 96/10985 and WO 97/27148.
- multiple applications are carried out. Each application may include between about 0.02 to 0.3 grams of bioactive glass.
- the instant method of whitening teeth comprises contacting the teeth with said effective tooth-whitening amount of bioactive glass twice daily for two weeks or more.
- tooth- whitening amount is used herein, it is intended to mean any amount that will result in a Vita shade guide lightening of one or more shades in a patient with a pre-treatment shade darker than A3.5 after 4 weeks of application twice daily for two minutes or more per application.
- the present invention provides a method for whitening teeth which comprises contacting teeth with an effective tooth-whitening amount of particulate bioactive and biocompatible glass comprising silicon oxide or hydroxide and optionally one or more elements selected from Na, K, Ca, Mg, B, Ti, Al, P, N or F.
- the bioactive glass comprises at least Na, Ca and P, although it is possible to use simple sodium silica glasses together with external sources of calcium and phosphate. It will be understood by the skilled artisan that an external source of calcium and phosphate may be from saliva itself, or may be formulated into the oral hygiene composition.
- a bioactive glass in accordance with the present invention is a glass composition that will form a layer of hydroxy carbonate apatite in vitro when placed in a simulated body fluid.
- Bioactive glasses in accordance with the present invention may be prepared by a variety of processes, e.g., melt-derived or sol gel and may have a variety of compositional elements and ranges. For example, the following composition by weight will provide an acceptable and preferred bioactive glass:
- Bioactive glasses with these properties provide a more efficacious material for interaction with the tooth structure.
- the addition of fluoride in the glass composition will enhance and strengthen the tooth structure.
- Other examples include sol gel glasses having, for example, about 40 to about 86% by weight Si ⁇ 2, substantially no amount of sodium, about 6-36% by weight Ca and about 2-12% by weight P2O5.
- a biocompatible glass in accordance with the present invention is one that does not trigger an overwhelmingly adverse immune response.
- extremely small particles are used.
- particles that are in the range of 2 mm to submicron are beneficial.
- Particle size in accordance with the present invention is determined by scanning electron microscopy or laser light scattering techniques (e.g., Coulter LS100).
- the relatively small bioactive particulate glass does not generate a significant immune response.
- macrophages and rendered inactive in this application may be formulated as oral hygiene compositions such as dentifrices, toothpaste, gels, powders, mouthwashes, irrigating solutions, and presentations for sucking or chewing such as gums, pastilles, tablets, and lozenges.
- Such oral hygiene compositions suitably comprise between 0.1 to 50% by weight, preferably 1 to 25% by weight, more preferably 5 to 10% by weight of the bioactive glass.
- the oral hygiene compositions suitable for this invention will contain the usual carriers, binders, surfactants, humectants, coloring agents, pigments, antiplaque agents, anti-bacterial agents, bioadhesive-type agents, abrasives, anticaries agents, flavorings, sweeteners, bulking agents, and the like.
- an abrasive typically includes amorphous, gelled, precipitated, or fumed silica, plastics particles, alumina, calcium carbonate, and zinc orthophosphate, insoluble metaphosphates and calcium pyrophosphate.
- Silica is an especially preferred abrasive for use herein.
- U.S. Patent 4,822,599 listing a series of dentifrice abrasives also references commercial sources and methods for their preparation.
- the bioactive glass particles may replace all, some, or none of the abrasive currently used in toothpastes.
- Inorganic thickeners may be included in the dentifrices of the present invention and include fumed silicas such as Cabosil available from Cabot Corporation, and thickening silicas including those available from J. M. Huber designated Zeodent 165.
- Organic thickeners such as natural and synthetic gums and colloids may also be incorporated in the dentifrice composition of the present invention.
- thickeners examples include carrageenan (Irish moss), xanthan gum and sodium carboxymethyl cellulose, starch, polyvinlpyrrolidone, hydroxy ethyl propyl cellulose, hydroxbutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose (co-dried blends of microcrystalline cellulose/cellulose gum).
- the inorganic or organic thickener may be incorporated in the compositions of the present invention at a concentration of about 0.05 to about 2% by weight and preferably about 0.1 to about 1.5% by weight.
- Fluoride-providing salts having anti-caries efficacy may also be incorporated in the oral compositions of the present invention and are characterized by their ability to release fluoride ions in water. It is preferable to employ a water-soluble salt fluoride providing about 10 to 5,000 ppm of fluoride ion and preferably about 1000 to 1500 ppm of fluoride ion. Among these materials are water-soluble alkali metal salts, for example, sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Sodium monofluorophosphate is the preferred fluoride-providing salt.
- Pigments used in the practice of the present invention include non-toxic, water insoluble inorganic pigments such as titanium dioxide and chromium oxide greens, ultramarine blues and pinks and ferric oxides as well as water insoluble dye lakes prepared by extending calcium or aluminum salts of FD&C dyes on alumina such as FD&C Green #1 lake, FD&C Blue #2 lake, FD&C R&D #30 lake and FD&C Yellow #15 lake.
- the pigments have a particle size in the range of 5-1000 microns, preferably 250-500 microns, and are present at a concentration of 0.5 to 3 % by weight.
- Dyes are generally sensitive to the presence of the peroxide ingredient and are not included in the dentifrice although FD&C Green #3 has been found to be resistant to fading when Ca ⁇ 2 is present in the dentifrice.
- flavoring or sweetening material may be employed.
- suitable flavoring ingredients are flavoring oils, e.g., oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, and orange, and methyl salicylate.
- suitable sweetening agents include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillartine, and sodium saccharin.
- flavor and sweetening agents may together comprise from 0.01 % to 5% or more of the preparations.
- Non-limiting examples thereof include preservatives, silicones and chlorophyll compounds, vitamins such as vitamins B6, B12, C, E and K, antibacterial agents such as chlorhexidine, halogenated diphenyl ethers such as triclosan, desensitizing agents such as potassium nitrate and potassium citrate and mixtures thereof.
- vitamins such as vitamins B6, B12, C, E and K
- antibacterial agents such as chlorhexidine
- halogenated diphenyl ethers such as triclosan
- desensitizing agents such as potassium nitrate and potassium citrate and mixtures thereof.
- bioactive glasses are well known to those of ordinary skill in the art and need no further description here. Similarly, the making of gels, toothpastes, rinses, mouthwashes, gums, chewing gums are also well known in the art. Bioactive glasses can be introduced into these products by a variety of methods including simple mixing. Those of ordinary skill in the art will appreciate that in some circumstances it will be necessary to keep the bioactive glass from coming into contact with the aqueous or other components of the delivery vehicle to prevent the bioactive glass from pre-reacting. This can be accomplished by a variety of ways known to those of ordinary skill in the art including, for example, two piece syringes with a mixing chamber.
- bioactive glass composition of the present invention can also be applied in a saline or distilled water based medium.
- the present invention also provides the use of a bioactive and biocompatible glass as herein before defined optionally together with a source of calcium and/or phosphate in the manufacture of a composition for whitening teeth.
- the 7.5% dentifrice as described in the Example included 7.5% by weight of a bioactive glass having the following composition:
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Geochemistry & Mineralogy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Ceramic Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Glass Compositions (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5922297P | 1997-09-18 | 1997-09-18 | |
US59222P | 1997-09-18 | ||
PCT/US1998/018500 WO1999013852A1 (en) | 1997-09-18 | 1998-09-18 | Methods and compositions for whitening teeth |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1011621A1 EP1011621A1 (de) | 2000-06-28 |
EP1011621A4 true EP1011621A4 (de) | 2000-12-27 |
EP1011621B1 EP1011621B1 (de) | 2005-06-08 |
Family
ID=22021584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98946860A Expired - Lifetime EP1011621B1 (de) | 1997-09-18 | 1998-09-18 | Verfahren und zusammensetzungen zum bleichen von zähnen |
Country Status (28)
Country | Link |
---|---|
US (1) | US6365132B1 (de) |
EP (1) | EP1011621B1 (de) |
JP (1) | JP2001516709A (de) |
KR (1) | KR100548110B1 (de) |
CN (1) | CN1149066C (de) |
AR (1) | AR015451A1 (de) |
AT (1) | ATE297185T1 (de) |
AU (1) | AU741771B2 (de) |
BG (1) | BG65005B1 (de) |
BR (1) | BR9812339A (de) |
CA (1) | CA2304010C (de) |
CO (1) | CO4970703A1 (de) |
DE (1) | DE69830500T2 (de) |
DK (1) | DK1011621T3 (de) |
ES (1) | ES2242297T3 (de) |
HK (1) | HK1028959A1 (de) |
HU (1) | HUP0100323A2 (de) |
ID (1) | ID24592A (de) |
IL (1) | IL135043A0 (de) |
IN (1) | IN191261B (de) |
PE (1) | PE116899A1 (de) |
PL (1) | PL194695B1 (de) |
PT (1) | PT1011621E (de) |
SK (1) | SK3822000A3 (de) |
TR (1) | TR200000740T2 (de) |
TW (1) | TWI228995B (de) |
WO (1) | WO1999013852A1 (de) |
ZA (1) | ZA988573B (de) |
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KR100491275B1 (ko) * | 1996-01-29 | 2005-08-04 | 유니버시티 오브 매릴랜드 앳 발티모어 | 생활성유리조성물및생활성유리를사용한치료방법 |
US5735942A (en) | 1996-02-07 | 1998-04-07 | Usbiomaterials Corporation | Compositions containing bioactive glass and their use in treating tooth hypersensitivity |
US6756060B1 (en) | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
IN191261B (de) * | 1997-09-18 | 2003-10-18 | Univ Maryland | |
WO2000015167A1 (en) | 1998-09-10 | 2000-03-23 | Usbiomaterials Corporation | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
US6190643B1 (en) | 1999-03-02 | 2001-02-20 | Patricia Stoor | Method for reducing the viability of detrimental oral microorganisms in an individual, and for prevention and/or treatment of diseases caused by such microorganisms; and whitening and/or cleaning of an individual's teeth |
WO2001072262A2 (en) | 2000-03-27 | 2001-10-04 | Schott Glas | New cosmetic, personal care, cleaning agent, and nutritional supplement compositions comprising bioactive glass and methods of making and using the same |
US7597900B2 (en) * | 2001-03-27 | 2009-10-06 | Schott Ag | Tissue abrasives |
EP1372574B1 (de) | 2001-03-30 | 2005-05-18 | King's College London | Verwendung von bioglas |
US7204874B2 (en) | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Root canal filling material |
US7211136B2 (en) * | 2001-10-24 | 2007-05-01 | Pentron Clinical Technologies, Llc | Dental filling material |
US7750063B2 (en) | 2001-10-24 | 2010-07-06 | Pentron Clinical Technologies, Llc | Dental filling material |
US7204875B2 (en) * | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Dental filling material |
US7303817B2 (en) * | 2001-10-24 | 2007-12-04 | Weitao Jia | Dental filling material |
DE102004050954A1 (de) * | 2004-10-18 | 2006-04-20 | Henkel Kgaa | Zahnglättende und mundgeruchsreduzierende Mund- und Zahnpflege- und reinigungsmittel |
US20070258916A1 (en) * | 2006-04-14 | 2007-11-08 | Oregon Health & Science University | Oral compositions for treating tooth hypersensitivity |
GB0609784D0 (en) * | 2006-05-17 | 2006-06-28 | Smile Studio Uk Ltd | Teeth whitening |
WO2008005509A2 (en) * | 2006-07-06 | 2008-01-10 | Massachusetts Institute Of Technology | Methods and compositions for altering biological surfaces |
US20090035227A1 (en) * | 2007-07-31 | 2009-02-05 | Stephan Hausmanns | Confectionery products comprising a tooth-friendly sweetener |
US20090324516A1 (en) * | 2008-06-27 | 2009-12-31 | Muscle Dave P | Composition and Method for Enhancing Flouride Uptake Using Bioactive Glass |
GB0813494D0 (en) * | 2008-07-23 | 2008-08-27 | Osspray Ltd | Method |
US20100086497A1 (en) * | 2008-10-08 | 2010-04-08 | Biofilm Limited | Tooth remineralisation |
CN102223922B (zh) * | 2008-11-25 | 2015-07-22 | 宝洁公司 | 包含凝胶网络和熔融二氧化硅的口腔护理组合物 |
US8551457B2 (en) | 2008-11-25 | 2013-10-08 | The Procter & Gamble Company | Oral care compositions comprising spherical fused silica |
AR076178A1 (es) | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | Composiciones dentifricas de accion doble para prevenir la hipersensibilidad y promover la remineralizacion |
AR076179A1 (es) | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | Composicion dentifrica no acuosa con vidrio bioaceptable y bioactivo y metodos de uso y fabricacion de la misma |
US9060947B2 (en) | 2009-08-03 | 2015-06-23 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
US8632754B2 (en) | 2009-08-03 | 2014-01-21 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
US8603442B2 (en) | 2009-08-03 | 2013-12-10 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
US8715625B1 (en) | 2010-05-10 | 2014-05-06 | The Clorox Company | Natural oral care compositions |
US9642687B2 (en) | 2010-06-15 | 2017-05-09 | The Procter & Gamble Company | Methods for whitening teeth |
CN107582413A (zh) | 2010-09-10 | 2018-01-16 | 荷兰联合利华有限公司 | 有益于牙齿的口腔护理组合物 |
EP2613850B1 (de) | 2010-09-10 | 2016-11-23 | Unilever PLC | Zusammengesetzter partikelwirkstoff und herstellungsverfahren dafür |
GB201113754D0 (en) | 2011-08-09 | 2011-09-21 | Glaxo Group Ltd | Composition |
BR112014004760B8 (pt) | 2011-09-08 | 2019-01-02 | Unilever Nv | composição de dentifrício, método de remineralização e/ou branqueamento de dentes |
CN104334150B (zh) | 2012-04-05 | 2017-09-12 | 荷兰联合利华有限公司 | 非水口腔护理组合物 |
BR112015006955B1 (pt) | 2012-10-12 | 2019-06-25 | Unilever N.V. | Composição para a higiene bucal, método para aprimorar a higiene bucal e processos para a fabricação da composição para a higiene bucal |
CN104768520B (zh) | 2012-11-05 | 2017-06-13 | 宝洁公司 | 热处理的沉淀二氧化硅 |
JP5653553B1 (ja) * | 2014-05-30 | 2015-01-14 | 株式会社松風 | イオン徐放性ガム組成物 |
JP5653551B1 (ja) * | 2014-05-30 | 2015-01-14 | 株式会社松風 | イオン徐放性口腔ケア組成物 |
EP2949311B1 (de) | 2014-05-30 | 2019-10-16 | Shofu Inc. | Dentalzusammensetzung enthaltend Glas mit verzögerter Freisetzung von Ionen |
CN104586636A (zh) * | 2015-02-03 | 2015-05-06 | 徐阳波 | 一种用于牙齿漂白和损伤修复的洁牙组合物 |
EP3473235A1 (de) | 2016-06-20 | 2019-04-24 | Helicon Medical, S.L. | Zusammensetzung von materialien zur zahnremineralisierung |
GB201621685D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Consumer Healthcare (Uk) Ip Ltd | Novel composition |
CN111093604B (zh) | 2017-08-18 | 2023-12-08 | 联合利华知识产权控股有限公司 | 口腔护理组合物 |
WO2019034348A1 (en) | 2017-08-18 | 2019-02-21 | Unilever N.V. | COMPOSITION OF ORAL CARE |
GB201721001D0 (en) * | 2017-12-15 | 2018-01-31 | Glaxosmithkline Consumer Healthcare (Uk) Ip Ltd | Novel Composition |
US10543067B2 (en) * | 2018-02-22 | 2020-01-28 | Tanaka Dental Products | Method, system, and kit for coloring dental ceramics |
CN108813084A (zh) * | 2018-05-29 | 2018-11-16 | 中国科学院化学研究所 | 一种含有磷硅酸盐玻璃的可咀嚼组合物及其制备方法 |
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GB202214700D0 (en) | 2022-10-06 | 2022-11-23 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Dentifrice composition |
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- 1998-09-17 PE PE1998000893A patent/PE116899A1/es not_active Application Discontinuation
- 1998-09-17 TW TW087115481A patent/TWI228995B/zh not_active IP Right Cessation
- 1998-09-18 EP EP98946860A patent/EP1011621B1/de not_active Expired - Lifetime
- 1998-09-18 ID IDW20000732A patent/ID24592A/id unknown
- 1998-09-18 CO CO98053988A patent/CO4970703A1/es unknown
- 1998-09-18 KR KR1020007002843A patent/KR100548110B1/ko not_active IP Right Cessation
- 1998-09-18 ZA ZA988573A patent/ZA988573B/xx unknown
- 1998-09-18 PL PL98342475A patent/PL194695B1/pl unknown
- 1998-09-18 AU AU93785/98A patent/AU741771B2/en not_active Ceased
- 1998-09-18 HU HU0100323A patent/HUP0100323A2/hu unknown
- 1998-09-18 DK DK98946860T patent/DK1011621T3/da active
- 1998-09-18 ES ES98946860T patent/ES2242297T3/es not_active Expired - Lifetime
- 1998-09-18 AT AT98946860T patent/ATE297185T1/de not_active IP Right Cessation
- 1998-09-18 TR TR2000/00740T patent/TR200000740T2/xx unknown
- 1998-09-18 CN CNB988111780A patent/CN1149066C/zh not_active Expired - Lifetime
- 1998-09-18 SK SK382-2000A patent/SK3822000A3/sk unknown
- 1998-09-18 BR BR9812339-4A patent/BR9812339A/pt not_active Application Discontinuation
- 1998-09-18 JP JP2000511478A patent/JP2001516709A/ja active Pending
- 1998-09-18 IL IL13504398A patent/IL135043A0/xx unknown
- 1998-09-18 PT PT98946860T patent/PT1011621E/pt unknown
- 1998-09-18 CA CA002304010A patent/CA2304010C/en not_active Expired - Lifetime
- 1998-09-18 WO PCT/US1998/018500 patent/WO1999013852A1/en active IP Right Grant
- 1998-09-18 DE DE69830500T patent/DE69830500T2/de not_active Expired - Lifetime
- 1998-09-18 AR ARP980104657A patent/AR015451A1/es not_active Application Discontinuation
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2000
- 2000-03-17 US US09/527,721 patent/US6365132B1/en not_active Expired - Lifetime
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