EP0951291A1 - Medicament destine au traitement du cancer - Google Patents
Medicament destine au traitement du cancerInfo
- Publication number
- EP0951291A1 EP0951291A1 EP97948892A EP97948892A EP0951291A1 EP 0951291 A1 EP0951291 A1 EP 0951291A1 EP 97948892 A EP97948892 A EP 97948892A EP 97948892 A EP97948892 A EP 97948892A EP 0951291 A1 EP0951291 A1 EP 0951291A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cancer
- medicament
- drakocephalum
- kotshyi
- boss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the invention relates to a medicament for cancer therapy, which is based on biology.
- Cancer is a disease in which body cells grow uncontrollably.
- Various therapies are known to prevent or at least limit such cell growth.
- One of the most frequently used therapies at the moment is the so-called chemotherapy, which triggers considerable side effects, but without leading to lasting success.
- the object of the invention is a pharmaceutical or pharmaceutical
- the anti-cancer agent according to the invention is a medicament which contains two plant substances with a cytotoxic effect and which can be administered orally and / or rectally and / or parenterally.
- This combination anti-cancer preparation preferably contains extracts from two plants, namely Peganum harmala L. and Drakocephalum Kotshyi Boss, which contain anti-cancer substances. Such plants are native to Iran.
- the ingredients or contents of the plant extracts to be used according to the invention were first prepared as alcoholic and aqueous extracts or solutions. Granules are produced from the resulting mixture. The extracts and granules obtained in this way were processed into tablets and other pharmaceutical forms of administration so that they could be administered to patients.
- the drug according to the invention shows u. a. cytotoxic, anti-phlogistic, anti-inflammatory, analgesic, antibacterial and anti-viral effects.
- the biological anti-cancer agent according to the invention acts as a mitotic inhibitor and interferes with the itosis phase in the cell division of cancerous cells.
- the biological anti-cancer agent according to the invention binds to the deoxiribonucleic acid (DNA) chain after administration and thereby prevents the formation of ribonucleic acid (RNA). On this basis, it affects the amino acids of cancer-affected cells and thus prevents cancer cell growth.
- DNA deoxiribonucleic acid
- RNA ribonucleic acid
- the molecular structure of the biological anti-cancer agent or preparation according to the invention is designed so that the agent functions as a physiological and body-compatible agent in the body. It has been shown that the medicament or preparation according to the invention produces positive therapeutic effects in various cancer tumors, for example mom carcinoma, carcino e of the gastrointestinal tract, brain tumors and others.
- a particular advantage of the invention is that the positive therapeutic effect against the cancer cells is achieved without any notable side effects.
- the medicament or preparation according to the invention has no negative side effects on the blood picture and the natural blood components when administered.
- the medicament or preparation according to the invention can be administered as a mono- and / or combination therapy preparation with other biological substances and anti-tumor agents which have been produced on a biological and / or conventional basis.
- the medicament or preparation according to the invention has a synergistic effect in combination with oral oxygen therapy, whereby the anti-cancer effect is enhanced.
- the agent or preparation according to the invention has a relaxation and relaxation effect, especially with smooth muscles.
- the medicament or preparation according to the invention has immunostimulating and immunomodulating effects. These properties have been studied and confirmed in animals whose immune system has been paralyzed by diethylbenzan traces (DMBA) as a carcinogenic and immunosuppressive agent. After treatment with the biological anti-cancer agent according to the invention, an immune stimulation and immune modulation was determined and documented in these animals. These positive effects on the human immune system have also been demonstrated. A decrease in tumor markers could also be detected in cancer patients treated with the medicament or preparation according to the invention.
- DMBA diethylbenzan traces
- LD 50 lethal dose
- the cancer-inhibiting effect of the medicament or preparation according to the invention has been confirmed and documented by various cell examinations and effects on cancer cells of humans and monkeys.
- the extract obtained and produced according to the invention from two special plants and its fractions have been allowed to act on cancer cells and control cells.
- the course of this action was checked by an electronic microscope. Ultrastructural damage to the cancer cells was shown in comparison with healthy control cells.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un médicament destiné au traitement du cancer et contenant deux principes actifs végétaux biologiques, notamment des extraits des plantes Peganum Harmala L. et Drakocephalum Kotshyi Boss, ayant une action cytotoxique et des propriétés carcinolytiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1997/006155 WO1999024048A1 (fr) | 1997-11-06 | 1997-11-06 | Medicament destine au traitement du cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0951291A1 true EP0951291A1 (fr) | 1999-10-27 |
Family
ID=8166782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97948892A Withdrawn EP0951291A1 (fr) | 1997-11-06 | 1997-11-06 | Medicament destine au traitement du cancer |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0951291A1 (fr) |
JP (1) | JP2001514671A (fr) |
CA (1) | CA2276276A1 (fr) |
WO (1) | WO1999024048A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
WO2012027481A1 (fr) * | 2010-08-24 | 2012-03-01 | Gtx, Inc. | Composés utilisés dans le traitement du cancer |
CN102286085B (zh) * | 2011-07-25 | 2014-06-11 | 新疆大学 | 一种骆驼蓬脂转移蛋白及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1034135A (zh) * | 1987-10-27 | 1989-07-26 | 新疆医学院第二附属医院 | 骆驼蓬种子浸膏的制备方法 |
CN1047528C (zh) * | 1993-11-18 | 1999-12-22 | 王世渝 | 一种骆驼蓬制剂 |
-
1997
- 1997-11-06 CA CA002276276A patent/CA2276276A1/fr not_active Abandoned
- 1997-11-06 WO PCT/EP1997/006155 patent/WO1999024048A1/fr not_active Application Discontinuation
- 1997-11-06 EP EP97948892A patent/EP0951291A1/fr not_active Withdrawn
- 1997-11-06 JP JP52524399A patent/JP2001514671A/ja active Pending
Non-Patent Citations (1)
Title |
---|
See references of WO9924048A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999024048A1 (fr) | 1999-05-20 |
JP2001514671A (ja) | 2001-09-11 |
CA2276276A1 (fr) | 1999-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17P | Request for examination filed |
Effective date: 19991111 |
|
17Q | First examination report despatched |
Effective date: 20010314 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010601 |