EP0933349B1 - Verfahren zur Herstellung von optisch aktiven Chrysanthemumsäure - Google Patents

Verfahren zur Herstellung von optisch aktiven Chrysanthemumsäure Download PDF

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EP0933349B1
EP0933349B1 EP99101475A EP99101475A EP0933349B1 EP 0933349 B1 EP0933349 B1 EP 0933349B1 EP 99101475 A EP99101475 A EP 99101475A EP 99101475 A EP99101475 A EP 99101475A EP 0933349 B1 EP0933349 B1 EP 0933349B1
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optically active
alkyl group
chrysanthemic acid
hydrogen atom
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EP0933349A1 (de
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Makoto Itagaki
Gohfu Suzukamo
Kazuaki Sasaki
Kunihiko Fujita
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Sumitomo Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Definitions

  • the present invention relates to a method for producing an optically active chrysanthemic acid (cyclopropanecarboxylic acid) derivative.
  • Optically active cyclopropanecarboxylic acid derivatives are important intermediates for drugs and pesticides.
  • (+)-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid known as chrysanthemum mono-carboxylic acid constitutes an acid component of synthetic pyrethroid insecticide.
  • the insecticidal activity of a trans-pyrethroid ester is usually higher than that of a cis-isomer.
  • pyrethroid esters of (+)-trans-chrysanthemum mono-carboxylic acid(hereinafter referred to as "chrysanthemic acid”) or chrysanthemic acid enriched with the (+)-trans-chrysanthemic acid have exhibited excellent insecticidal activity. Accordingly, an industrially advantageous method to produce (+)-trans-chrysanthemic acid or chrysanthemic acid enriched with the (+)-trans-chrysanthemic acid has been desired.
  • chrysanthemic acid optically enriched with one isomer e.g. (+)-trans-chrysanthemic acid can be purified by crystallization using an optical active amine in the production of an optically active chrysanthemic acid, whereby (+)-trans-chrysanthemic acid having excellent optical purity can be obtained with surprisingly good efficiency compared with the case of using racemic chrysanthemic acid, and trans isomer ratio of the chrysanthemic acid can also be improved efficiently when trans isomer having not less than 50% trans-isomer ratio are applied.
  • JP-B-52-034617 discloses a method for producing an optically active chrysanthemic acid ester, comprising reacting diazo acetic acid ester with a dimethyl hexadiene in the presence of assymetric copper complex.
  • the present invention provides:
  • Chrysanthemic acid having a trans isomer ratio of not less than 50% and an optical purity of not less than 10% e.e can be obtained by any method, for example, it can be produced in the following manner.
  • the "optical purity" or e.e.% of (+)-trans-chrysanthemic acid in the trans isomer is calculated based on the analysis using optically active column and is defined, for example, by the following equation: 100 X ⁇ [(+)-trans-chrysanthemic acid - (-)-trans-chrysanthemic acid] / [(+)-trans-chrysanthemic acid + (-)-trans-chrysanthemic acid] ⁇ .
  • the optically active chrysanthemic acid can be obtained by reacting 2,5-dimethyl-2,4-hexadiene with diazoacetate of the formula (I): N 2 CHCO 2 R 7 wherein R 7 represents an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group, in the presence of an asymmetric copper complex to produce optically active chrysanthemic acid esters (cyclopropanation step); and decomposing chrysanthemic acid esters with an alkali or acid (hydrolysis step).
  • diazoacetate of the formula (I): N 2 CHCO 2 R 7 wherein R 7 represents an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group
  • trans isomer ratio of not less than 50% and optical purity of not less than 20% e.e is preferably employed, more preferably, chrysanthemic acid having trans isomer ratio of from 60%e.e. to 95% e.e. and optical purity of from 30% e.e. to 90% e.e is employed.
  • the optically active organic amine for optically resolving the optically active chrysanthemic acid includes, for example, an optically active organic amine of the formula (A-1): wherein R 1 and R 2 respectively represent a hydrogen atom, an alkyl group, an aralkyl group or an aryl group; X and Y respectively represent a hydrogen atom, a halogen atom, a alkyl group or a alkoxyl group; and * represents an asymmetric carbon atom; or an optically active organic amine of the formula (A-2): wherein R 1 and R 2 respectively represent a hydrogen atom, an alkyl group, an aralkyl group or an aryl group; R 3 represents an alkyl group having 1 to 6 carbon atoms, and * represents an asymmetric carbon atom; or an optically active organic amine of the formula (A-3): wherein R 4 represents a naphthyl group, a cyclohexyl group, or a pheny
  • the optically active amine includes, for example, optically active compounds such as 1-phenyl-2-(p-tolyl)ethylamine, ⁇ -(1-naphthyl)-ethylamine, ⁇ -(2-naphthyl)-ethylamine, 1-phenylethylamine, erythro- ⁇ , ⁇ -diphenyl- ⁇ -hydroxyethylamine, N-methylephedrine, N-(2,2,2-trichloro-1-formamideethyl)piperidine, 2-benzylamino-1-butanol, ephedrine, cis-N-benzyl-2-(hydroxymethyl)cyclohexylamine, N-(p-hydroxybenzyl)-1-phenylethylamine, N-(p-hydroxybenzyl)-1-(p-tolyl)ethylamine, N-(p-hydroxybenzyl)-1-(p-isopropylphenyl)eth
  • Optical resolution is performed by reacting the optically active chrysanthemic acid with an optically active amine (optical resolution agent) of the formula (A-1), (A-2), (A-3) or (A-4).
  • optically active amine optical resolution agent
  • the optical resolution is usually performed in a solvent.
  • a solvent there can be used aromatic hydrocarbons such as benzene, toluene and xylene; aliphatic hydrocarbons such as hexane and heptane; alcohols such as water, methanol and ethanol; ketones such as acetone and methyl isobutyl ketone; and ethers such as dioxane and tetrahydrofuran.
  • aromatic hydrocarbons such as benzene, toluene and xylene
  • aliphatic hydrocarbons such as hexane and heptane
  • alcohols such as water, methanol and ethanol
  • ketones such as acetone and methyl isobutyl ketone
  • ethers such as dioxane and tetrahydrofuran.
  • the amount of the solvent varies depending on the solvent and conditions of the post treatments and is not specifically limited, and an optimum amount is optionally set according to the respective conditions.
  • the amount of the optical resolution agent is usually from 0.2 to 1.2 mol, and preferably from 0.3 to 1.1 mol, per mol of chrysanthemic acid.
  • optical resolution agent and chrysanthemic acid are usually dissolved in the solvent above under stirring or standing.
  • the mixture may be heated to dissolve, if necessary.
  • a diastereomer crystal comprising an optical resolution agent and optically active chrysanthemic acid is usually formed to deposit from the solution on standing at an ambient temperature or by cooling the solution.
  • the deposited crystal may be collected as it is, or alternatively, it may be totally or partially dissolved by heating and then cooled to deposit the crystal, if necessary.
  • the dissolution and deposition is usually conducted at a temperature ranging from -20 to 150°C, and preferably from -10 to 100°C.
  • the deposited diastereomer crystal is usually separated by filtration.
  • the diastereomer salt separated as a crystal is then decomposed with an acid or alkali and extracted to obtain the optically active chrysanthemic acid with higher trans ratio and optical purity.
  • the used optical resolution agent can be recovered.
  • an optically active chrysanthemic acid is obtained by decomposing the diastereomer salt, obtained by means of the above method, with hydrochloric acid or sulfuric acid and extracting the resultant with an organic solvent. Furthermore, the agent for optical resolution is recovered by making the aqueous layer weak alkali and extracting it.
  • the optical resolution agent can be recovered by decomposing the disatereomer salt, obtained by means of the above method, with a base such as sodium hydroxide, and extracting the resultant with an organic solvent in the weak alkali condition. Thereafter, the aqueous layer is acidified and extracted, thereby making it possible to obtain an optically active chrysanthemic acid.
  • a base such as sodium hydroxide
  • optical resolution agent recovered by these methods can be reused.
  • an optically active chrysanthemic acid which comprises reacting 2,5-dimethyl-2,4-hexadiene with diazoacetates of the formula (I) as defined above, in the presence of an asymmetric copper complex to produce optically active chrysanthemic acid esters (cyclopropanation step); and contacting the chrysanthemic acid ester with an alkali or acid (hydrolysis step).
  • the alkyl group of diazoacetate used in the above cyclopropanation step includes, for example, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, t-butyl, pentyl, hexyl and cyclohexyl groups.
  • the asymmetric copper complex used in the above cyclopropanation step is prepared from a copper compound and an optically active organic compound (hereinafter referred to as "an optically active ligand") (Pure & Appl. Chem., Vol. 57, No. 12, 1839, 1985, Tetrahedron Lett., 32, 7373 (1991), Tetrahedron Lett., 35, 7985 (1994)).
  • an optically active ligand an optically active organic compound
  • the copper compound includes, for example, mono- or divalent copper compounds such as copper naphthenate, copper trifluoromethanesulfonate, copper acetate, copper bromide and copper chloride. These compounds may be used alone or in combination thereof.
  • the optically active ligand includes, for example, optically active bisoxazoline compound, optically active salicylideneamino alcohol compound, optically active diamine compound, optically active semicorrin compound and optically active camphor compound.
  • Preferred examples thereof include optically active salicylideneamino alcohol compound, optically active bisoxazoline compound and optically active ethylenediamine compound.
  • optically active bisoxazoline compound is of the formula (L-1): wherein R 8 and R 9 are different and represent an optionally substituted phenyl group or a hydrogen atom,
  • the optically active bisoxazoline compound (L-1) includes, for example, 2,2' -methylenebis[(4R)-phenyl-5,5-dimethyloxazoline], 2,2'-methylenebis[(4R)-phenyl-5,5-diethyloxazoline], 2,2'-methylenebis[(4R)-phenyl-5,5-di-n-propyloxazoline], 2,2' -methylenebis[(4R)-phenyl-5,5-di-i-propyloxazoline], 2,2'-methylenebis[(4R)-phenyl-5,5-dicyclohexyloxazoline], 2,2' -methylenebis[(4R)-phenyl-5,5-diphenyloxazoline], 2,2' -methylenebis[(4R)-phenyl-5,5-di-(2-methylphenyl) oxazoline], 2,2'-methylenebis[(4R)-phenyl-5,5-d
  • the optically active salicylideneamino alcohol compound includes a compound of the formula (L-2): wherein R 13 and R 14 respectively represent an alkyl group, an aralkyl group or an aryl group, Z represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aralkyl group or an aryl group, and * represents an asymmetric carbon atom.
  • R 13 of the optically active salicylideneamino alcohol compound (L-2) includes, for example, methyl, ethyl, iso-propyl, iso-butyl, t-butyl, benzyl and phenyl groups.
  • R 14 includes, for example, methyl, ethyl, iso-propyl, iso-butyl, t-butyl and benzyl groups, and phenyl group which may be substituted with an alkyl group, a halogen atom or an alkoxy group.
  • the optically active ethylenediamine alcohol compound includes a compound of the formula (L-3): wherein R represents a hydrogen atom or a alkyl group, m represents an integer of 1 to 3, and * represents an asymmetric carbon atom.
  • Specific compound of the optically active ethylenediamine compound (L-3) includes, for example, compounds wherein R is a hydrogen atom or a methyl group and m is an integer of 1 to 3.
  • Specific examples thereof includes bis[N-(2,4,6-trimethylphenyl)methyl-(1R),(2R)-diphenylethylenediamine and an antipode thereof having (1S), (2S) configuration.
  • the asymmetric copper complex can be prepared by mixing the above copper compound with the optically active ligand in a solvent.
  • the solvent used herein includes, for example, aromatic hydrocarbons such as toluene and xylene and aliphatic halogenated hydrocarbons such as dichloromethane and dichloroethane. Furthermore, 2,5-dimethyl-2,4-hexadiene may also be used as the solvent.
  • the solvent is usually used in a 10- to 500-fold amount based on the weight of the copper compound.
  • the amount of the optically active ligand is usually from 0.8 to 5 mol, and preferably from 1 to 2 mol, per mol of the copper compound.
  • water is preferably excludes in the above reaction.
  • the above reaction temperature is not specifically limited.
  • the reaction is usually carried out at the temperature within a range from 0 to 50°C.
  • the complex when the complex is prepared by using a divalent copper compound, an object can be sufficiently attained even if the divalent copper compound is not reduced to form a monovalent copper compound by using a reducing agent such as phenylhydrazine.
  • the reaction between the copper compound and the optically active ligand is usually carried out in the atmosphere of an inert gas such as argon and nitrogen.
  • the asymmetric copper complex can be obtained in such a manner, but the copper complex may be isolated or can be used as it is in the reaction between 2,5-dimethyl-2,4-hexadiene and the diazoacetate (I) without being isolated.
  • the amount of the asymmetric copper complex used in the reaction between 2,5-dimethyl-2,4-hexadiene and the diazoacetates (I) is usually from 0.0001 to 0.01 mol, and preferably from 0.0005 to 0.01 mol, per mol of the diazoacetate (I).
  • Specific method of reacting 2,5-dimethyl-2,4-hexadiene with the diazoacetate (I) in the presence of the asymmetric copper complex includes, for example, a method adding the diazoacetate (I) dissolved in a solvent to a mixture of the asymmetric copper complex obtained as described above and 2,5-dimethyl-2,4-hexadiene.
  • the solvent includes, for example, halogenated hydrocarbons such as dichloromethane, 1,2-dichloroethane, chloroform and carbon tetrachloride; aliphatic hydrocarbons such as hexane, heptane and cyclohexane; aromatic hydrocarbons such as benzene, toluene and xylene; and esters such as methyl acetate and ethyl acetate. It is also possible to use 2,5-dimethyl-2,4-hexadiene as the solvent. These solvents can also be used in combination.
  • halogenated hydrocarbons such as dichloromethane, 1,2-dichloroethane, chloroform and carbon tetrachloride
  • aliphatic hydrocarbons such as hexane, heptane and cyclohexane
  • aromatic hydrocarbons such as benzene, toluene and xylene
  • esters such as methyl acetate
  • the solvent is usually used in a 1- to 30-fold amount, and preferably 5- to 20-fold amount, based on the weight of the diazoacetate (I).
  • reaction between 2,5-dimethyl-2,4-hexadiene and the diazoacetate (I) is usually carried out in an atmosphere of an inert gas such as argon and nitrogen.
  • 2,5-dimethyl-2,4-hexadine is usually used in the amount of 1 to 50 mol, and preferably 5 to 30 mol, per mol of the diazoacetate (I).
  • the above reaction temperature is not specifically limited.
  • the reaction can be carried out at the temperature of not more than a boiling point of the solvent when using the solvent, but is usually carried out at the temperature within a range from 0 to 120°C, and preferably from 5 to 100°C.
  • optically active chrysanthemic acid esters with considerably good purity can be obtained in the above reaction by distilling off the solvent, but can be optionally isolated by a conventional method such as distillation and column chromatography, if necessary.
  • the ester residue of the optically active chrysanthemic acid esters obtained by the above reaction includes, for example, methyl, ethyl, n-propyl, i-propyl, i-butyl, t-butyl, pentyl, hexyl and cyclohexyl groups.
  • the resulting optically active chrysanthemic acid esters can be converted into the corresponding chrysanthemic acid by contacting with an acid or an aqueous alkali solution (hydrolysis step).
  • the amount of an alkali compound of the aqueous alkali solution used is usually from 1 to 20 mol, and preferably from 1 to 10 mol, per mol of the chrysanthemic acid esters.
  • the chrysanthemic acid particularly having a trans isomer ratio of not less than 50% and an optical purity of not less than 10% e.e. thus obtained may be used in the optical resolution step as it is, or optionally used in combination with chrysanthemic acid enriched with the trans isomer.
  • Such chrysanthemic acid enriched with the trans isomer can be obtained, for example, by reacting (-)-cis chrysanthemic acid or chrysanthemic acid enriched with a (-)-trans isomer with t-butyl hydroperoxide and aluminum bromide in the presence of a toluene solvent (see JP5-37137B/1993).
  • the trans isomer ratio of the chrysanthemic acid enriched with the trans isomer used is not less than 80%, and preferably not less than 85%.
  • chrysanthemic acid having more improved trans/cis ratio and more improved optical purity in an industrially advantageous manner.
  • the aqueous layer was acidified with aqueous 5% sulfuric acid and extracted with toluene. Then, the toluene was distilled off to obtain 15.1 g of chrysanthemic acid having a trans/cis ratio of 85/15 and an optical purity of 96% e.e with respect to (+)-trans isomer and 95 % e.e. with respect to (+)-cis isomer. (yield: 50.3%).
  • chrysanthemic acid obtained by hydrolyzing the ethyl chrysanthemate with 1N sodium hydroxide was mixed with racemic chrysanthemic acid enriched with trans isomer (trans/cis ratio: 95/5) in a weight ratio of 6:4. 104.5 g of toluene was then added to 10.0 g of the mixed chrysanthemic acid, and the mixture was dissolved with stirring. Then, 7.48 g of (S)-1-phenyl-2-(p-tolyl)ethylamine (optical resolution agent) was added to the solution and dissolved with heating.
  • the deposited crystal was collected by filtration, washed with toluene and then dissolved in an aqueous 5% sodium hydroxide. After the agent for optical resolution was extracted with toluene, the aqueous layer was acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain 4.19 g of chrysanthemic acid having a trans/cis ratio of 87/13 and an optical purity of 95% e.e. with respect to (+)-trans isomer and 97% e.e. with respect to (+)-cis isomer (yield: t 41.9%).
  • chrysanthemic acid obtained by hydrolyzing the ethyl chrysantherrate with 1N sodium hydroxide was mixed with racemic chrysanthemic acid enriched with trans isomer (trans/cis ratio: 95/5) in a weight ratio of 4:6. 106.2 g of toluene was then added to 10.0 g of chrysanthemic acid, and the mixture was dissolved with stirring. Then, 7.40 g of (S)-1-phenyl-2-(p-tolyl)ethylamine ( optical resolution agent) was added to the solution and dissolved with heating.
  • the deposited crystal was collected by filtration, washed with toluene and then dissolved in an aqueous 5% sodium hydroxide.
  • the aqueous layer was acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain chrysanthemic acid having a trans/cis ratio of 81/19 and an optical purity of 99% e.e. with respect to (+)-trans isomer and 96% e.e. with respect to (+)-cis isomer(yield: 40.2%).
  • chrysanthemic acid obtained by alkali hydrolysis is mixed with racemic chrysanthemic acid enriched with trans isomer (trans/cis ratio: 95/5) in a weight ratio of 46:54.
  • Toluene is then added in an about 10-fold amount based on chrysanthemic acid, and the mixture is dissolved with stirring.
  • (S)-1-phenyl-2-(p-tolyl)ethylamine (optical resolution agent) was added in the amount of about 0.69 mol per mol of chrysanthemic acid and dissolved with heating.
  • the deposited crystal is collected by filtration, washed with toluene and then dissolved in an aqueous 5% sodium hydroxide.
  • the agent for optical resolution is extracted with toluene
  • the aqueous layer is acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain chrysanthemic acid having a trans/cis ratio of about 78/22 and an optical purity of about 95% e.e. with respect to (+)-trans isomer and 99%e.e. with respect to that (+)-cis isomer (yield: about 46%).
  • chrysanthemic acid obtained by alkali hydrolysis is mixed with racemic chrysanthemic acid enriched with trans isomer (trans/cis ratio: 95/5) in a weight ratio of 51:49.
  • Toluene is then added in an 10-fold amount based on chrysanthemic acid, and the mixture is dissolved with stirring.
  • (S)-1-phenyl-2-(p-tolyl)ethylamine (optical resolution agent ) is added in the amount of about 0.68 mol per mol of chrysanthemic acid and dissolved with heating.
  • the deposited crystal is collected by filtration, washed with toluene and then dissolved in an aqueous 5% sodium hydroxide.
  • the agent for optical resolution is extracted with toluene
  • the aqueous layer is acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain chrysanthemic acid having a trans/cis ratio of 72/28 and an optical purity of the (+)-trans isomer is 95% e.e. and that of (+)-cis isomer is 99% e.e. (yield: 51%).
  • the aqueous layer was acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain 20.8 g of chrysanthemic acid having a trans/cis ratio of 80/20 and an optical purity of the (+)-trans isomer was 96% e.e. and that of (+)-cis isomer was 98% e.e.(yield: 20.8%).
  • the amount of chrysanthemic acid t-butyl ester formed was determined by gas chromatography. As a result, it was 1.86 g and the yield was 83.1% based on t-butyl diazoacetate and, furthermore, the trans/cis ratio was 85/15.
  • 2,5-dimethyl-2,4-hexadiene (boiling point: 51°C/3990 Pa (30 mmHg)) was distilled off from the reaction mixture, the concentrated solution was subjected to luquid chromatography to measure the otpical activity, which revealed the optical purity of (+)-trans isomer was 86%e.e. and that of (+)-cis isomer was 67%e.e.
  • trans-rich racemic chrysanthemic obtained by decomposing the t-butyl chrysanthemate with trifluoroacetic acid is mixed with racemic chrysanthemic acid of which trans/cis ratio is 95/5 in a weight ratio of 60:40, and 10-fold amount of toluene to the chrysanthemic acid is added to the mixture, stirred and dissolved.
  • 1.0 mole of (S)- ⁇ -(1-naphthyl)-ethylamine, as a resolution agent, and 8% by weight of water per chrysanthemic acid are added thereto and the resulting mixture is heated to dissolved.
  • the amount of chrysanthemic acidethyl ester formed was determined by gas chromatography. As a result, it was 1.52 g and the yield was 77.7% based on t-butyl diazoacetate and, furthermore, the trans/cis ratio was 61/39. After 2,5-dimethyl-2,4-hexadiene (boiling point: 51°C/3990 Pa (30 mmHg)) was distilled off from the reaction mixture, Then, 10 ml of an aqueous 1N sodium hydroxide solution and 5 ml of ethanol were added to 1 g of the concentrate and alkali hydrolysis was performed by stirring at 100°C for 1 hour.
  • the chrysanthemic acid obtained by the alkali hydrolysis is mixed with trans-rich racemic chrysanthemic acid of which trans/cis ratio is 95/5 is mixed with the (+)-trans isomer in a weight ratio of 43:57, and 7-fold amount of toluene to the chrysanthemic acid is added to the mixture, stirred and dissolved.
  • 1.0 mole of (S)- ⁇ -(1-naphthyl)-ethylamine, as a resolution agent, and 8% by weight of water to chrysanthemic acid are added thereto and the resulting mixture is heated to dissolved.
  • the aqueous layer was acidified with aqueous 5% sulfuric acid and extracted with toluene to obtain 4.13 g of chrysanthemic acid having a trans/cis ratio of 98/2 and an optical purity of 97% e.e. with respect to (+)-trans isomer and 73%e.e. with respect to (+)-cis isomer (yield: 25.3%).

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Claims (8)

  1. Verfahren zur Herstellung einer optisch aktiven Chrysanthemsäure mit einem verbesserten Transisomeranteil und einer besseren optischen Reinheit, wobei das Verfahren die Stufe des Umsetzens von Chrysanthemsäure mit einem Transisomeranteil von nicht weniger als 50 % und einer optischen Reinheit von nicht weniger als 10 % e.e. mit einem optisch aktiven Amin zur optischen Trennung der Chrysanthemsäure umfasst.
  2. Verfahren nach Anspruch 1, wobei eine Chrysanthemsäure mit einem Transisomeranteil von 60-95 % und einer optischen Reinheit von 30-90 % e.e. mit einem optisch aktiven Amin umgesetzt wird.
  3. Verfahren nach Anspruch 1, wobei das optisch aktive Amin ein optisch aktives Amin der Formel (A-1) ist:
    Figure 00340001
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder eine Arylgruppe stehen,
    X und Y jeweils für ein Wasserstoffatom, ein Halogenatom, eine Alkylgruppe oder eine Alkoxygruppe stehen und
    * für ein asymmetrisches Kohlenstoffatom steht; oder ein optisch aktives Amin der Formel (A-2) ist:
    Figure 00340002
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder ein Arylgruppe stehen,
    R3 für eine Alkylgruppe mit 1-6 Kohlenstoffatomen steht und
    * für ein asymmetrisches Kohlenstoffatom steht; oder ein optisch aktives organisches Amin der Formel (A-3) ist:
    Figure 00350001
    worin R4 für eine Naphthylgruppe, eine Cyclohexylgruppe oder eine Phenylgruppe, die mit Halogen, Nitro, Alkyl oder Alkoxy substituiert sein kann, steht,
    R5 eine Alkylgruppe oder eine Benzylgruppe, die mit einer Alkylgruppe substituiert sein kann, bedeutet,
    R6 eine p-Hydroxyphenylgruppe oder eine 2-Hydroxy-3-alkoxyphenylgruppe, wenn R5 eine Alkylgruppe ist, bedeutet, und
    R6 eine p-Hydroxyphenylgruppe ist, wenn R5 eine Benzylgruppe ist, die mit einer Alkylgruppe substituiert sein kann, und
    * für ein asymmetrisches Kohlenstoffatom steht; oder ein optisch aktives organisches Amin der Formel (A-4) ist:
    Figure 00350002
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder eine Arylgruppe stehen und
    * für ein asymmetrisches Kohlenstoffatom steht.
  4. Verfahren nach Anspruch 1, wobei die Chrysanthemsäure mit einem Transisomeranteil von nicht weniger als 50 % und einer optischen Reinheit von nicht weniger als 10 % e.e. eine Chrysanthemsäure ist, die nach einem Verfahren erhältlich ist, das die Stufen eines Umsetzens von 2,5-Dimethyl-2,4-hexadien mit Diazoacetaten der Formel (I): N2CHCO2R7 worin R7 für eine Alkylgruppe mit 1-6 Kohlenstoffatomen oder eine Cycloalkylgruppe steht, in Gegenwart eines asymmetrischen Kupferkomplexes in einer Cyclopropanierungsstufe unter Bildung optisch aktiver Chrysanthemsäureester,
    eines Inberührungbringens der Chrysanthemsäureester mit einer Säure oder Base in einer Hydrolysestufe unter Bildung von Chrysanthemsäure und
    eines optischen Trennens der Chrysanthemsäure in einer optischen Trennungsstufe unter Verwendung mindestens eines optisch aktiven organischen Amins der Formel (A-1)
    Figure 00360001
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder eine Arylgruppe stehen,
    X und Y jeweils für ein Wasserstoffatom, ein Halogenatom, eine Alkylgruppe oder eine Alkoxygruppe stehen und
    * für ein asymmetrisches Kohlenstoffatom steht; oder eines optisch aktiven Amins der Formel (A-2):
    Figure 00360002
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder ein Arylgruppe stehen,
    R3 für eine Alkylgruppe mit 1-6 Kohlenstoffatomen steht und
    * für ein asymmetrisches Kohlenstoffatom steht; oder eines optisch aktiven organischen Amins der Formel (A-3):
    Figure 00370001
    worin R4 für eine Naphthylgruppe, eine Cyclohexylgruppe oder eine Phenylgruppe, die mit Halogen, Nitro, Alkyl oder Alkoxy substituiert sein kann, steht,
    R5 eine Alkylgruppe oder eine Benzylgruppe, die mit einer Alkylgruppe substituiert sein kann, bedeutet,
    R6 eine p-Hydroxyphenylgruppe oder eine 2-Hydroxy-3-alkoxyphenylgruppe, wenn R5 eine Alkylgruppe ist, bedeutet, und
    R6 eine p-Hydroxyphenylgruppe ist, wenn R5 eine Benzylgruppe ist, die mit einer Alkylgruppe substituiert sein kann, und
    * für ein asymmetrisches Kohlenstoffatom steht; oder eines optisch aktiven Amins der Formel (A-4):
    Figure 00370002
    worin R1 und R2 jeweils für ein Wasserstoffatom, eine Alkylgruppe, eine Aralkylgruppe oder eine Arylgruppe stehen und
    * für ein asymmetrisches Kohlenstoffatom steht, umfasst.
  5. Verfahren nach Anspruch 4, wobei ein Ligand eines asymmetrischen Kupferkomplexes eine optisch aktive Bisoxazolinverbindung der Formel (L-1) ist:
    Figure 00380001
    worin R8 und R9 unterschiedlich sind und für eine optional substituierte Phenylgruppe oder ein Wasserstoffatom stehen,
    R10 und R11 für ein Wasserstoffatom, eine Alkylgruppe, eine Cycloalkylgruppe, eine optional substituierte Phenylgruppe oder eine Aralkylgruppe stehen oder
    R10 und R11 unter Bildung einer cyclischen Alkylengruppe kombiniert sein können und
    R12 für ein Wasserstoffatom oder eine Alkylgruppe steht.
  6. Verfahren nach Anspruch 4, wobei ein Ligand des asymmetrischen Kupferkomplexes eine optisch aktive Salicylidenaminoalkoholverbindung der Formel (L-2) ist:
    Figure 00380002
    worin R13 und R14 jeweils für eine Alkylgruppe, eine Aralkylgruppe oder eine Arylgruppe stehen,
    Z für ein Wasserstoffatom, ein Halogenatom, eine Alkylgruppe, eine Alkoxygruppe, eine Aralkylgruppe oder eine Arylgruppe steht und
    * ein asymmetrisches Kohlenstoffatom bedeutet.
  7. Verfahren nach Anspruch 4, wobei ein Ligand eines asymmetrischen Kupferkomplexes eine optisch aktive Ethylendiaminverbindung der Formel (L-3) ist:
    Figure 00390001
    worin R für ein Wasserstoffatom oder eine niedrige Alkylgruppe steht, m für eine ganze Zahl von 1 bis 3 steht und * ein asymmetrisches Kohlenstoffatom bedeutet.
  8. Verfahren nach Anspruch 1, wobei eine Chrysanthemsäure mit einer optischen Reinheit von nicht weniger als 20 % e.e. mit einem optisch aktiven Amin umgesetzt wird.
EP99101475A 1998-01-29 1999-01-27 Verfahren zur Herstellung von optisch aktiven Chrysanthemumsäure Expired - Lifetime EP0933349B1 (de)

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JP4320870B2 (ja) * 1999-10-18 2009-08-26 住友化学株式会社 （＋）−トランス第一菊酸の製造方法
KR20010074549A (ko) * 2000-01-25 2001-08-04 고사이 아끼오 키랄 구리 착물, 이의 제조 방법 및 이를 이용한 비대칭합성
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WO2004087317A1 (ja) * 2003-03-31 2004-10-14 Sumitomo Chemical Company, Limited 光学活性な銅触媒組成物
ITMI20041211A1 (it) * 2004-06-16 2004-09-16 Endura Spa Catalizzatori a base di complessi metallici per la sintesi di acido crisantemico otticamente attivo
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法
CN108486170A (zh) * 2018-03-12 2018-09-04 江苏扬农化工股份有限公司 一种右旋反式二氯菊酸的制备方法
CN108486171A (zh) * 2018-03-12 2018-09-04 江苏扬农化工股份有限公司 一种右旋反式第一菊酸的制备方法
CN110343040B (zh) * 2018-04-02 2021-12-21 中国科学院大连化学物理研究所 一种制备手性反式第一菊酸的方法
CN112125794A (zh) * 2019-06-24 2020-12-25 阜新达得利化工股份有限公司 三氟氯菊酸的改进的制备方法
CN114478230B (zh) * 2020-10-28 2024-04-16 中国科学院大连化学物理研究所 一种3-乙酰基-2,2-二甲基环丙烷羧酸的拆分方法

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