EP0914318A1 - Pyrazine - Google Patents

Pyrazine

Info

Publication number
EP0914318A1
EP0914318A1 EP97920835A EP97920835A EP0914318A1 EP 0914318 A1 EP0914318 A1 EP 0914318A1 EP 97920835 A EP97920835 A EP 97920835A EP 97920835 A EP97920835 A EP 97920835A EP 0914318 A1 EP0914318 A1 EP 0914318A1
Authority
EP
European Patent Office
Prior art keywords
formula
group
pyrazine
compound
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97920835A
Other languages
English (en)
French (fr)
Inventor
Frank Hibbert
Keith Jones
Martine Max-Planck-Institut KEENAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kings College London
Original Assignee
Kings College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609972.6A external-priority patent/GB9609972D0/en
Priority claimed from GBGB9624653.3A external-priority patent/GB9624653D0/en
Application filed by Kings College London filed Critical Kings College London
Publication of EP0914318A1 publication Critical patent/EP0914318A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97920835A 1996-05-11 1997-05-06 Pyrazine Withdrawn EP0914318A1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9609972 1996-05-11
GBGB9609972.6A GB9609972D0 (en) 1996-05-11 1996-05-11 Pyrazines
GB9624653 1996-11-27
GBGB9624653.3A GB9624653D0 (en) 1996-11-27 1996-11-27 Synthesis of coelenterazine
PCT/GB1997/001227 WO1997043267A1 (en) 1996-05-11 1997-05-06 Pyrazines

Publications (1)

Publication Number Publication Date
EP0914318A1 true EP0914318A1 (de) 1999-05-12

Family

ID=26309321

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97920835A Withdrawn EP0914318A1 (de) 1996-05-11 1997-05-06 Pyrazine

Country Status (3)

Country Link
EP (1) EP0914318A1 (de)
CA (1) CA2253910A1 (de)
WO (1) WO1997043267A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2441792C (en) 2001-04-25 2010-08-03 Lilly Icos Llc Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction
EP1501514B1 (de) * 2002-05-03 2012-12-19 Exelixis, Inc. Proteinkinasemodulatoren und verfahren zur derer anwendung
US7704995B2 (en) 2002-05-03 2010-04-27 Exelixis, Inc. Protein kinase modulators and methods of use
US8263585B2 (en) 2007-05-04 2012-09-11 Novartis Ag Organic compounds
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
PT3354650T (pt) 2008-12-19 2022-06-20 Vertex Pharma Compostos úteis como inibidores da cinase atr
EP2569286B1 (de) * 2010-05-12 2014-08-20 Vertex Pharmaceuticals Inc. Verbindungen als hemmer der atr-kinase
MX2012013081A (es) 2010-05-12 2013-05-09 Vertex Pharma Compuestos utiles como inhibidores de cinasa atr.
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
WO2012178125A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP2014522818A (ja) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
MX2014003796A (es) 2011-09-30 2015-01-16 Vertex Pharma Compuestos utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
IN2014CN02501A (de) 2011-09-30 2015-06-26 Vertex Pharma
CA2850566C (en) 2011-09-30 2022-05-03 Vertex Pharmaceuticals Incorporated Process for making 4-[chloro-n-hydroxycarbonimidoyl]phenyl derivative
US8853217B2 (en) 2011-09-30 2014-10-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CN102432614A (zh) * 2011-11-16 2012-05-02 泰州凯美迪生物医药技术有限公司 腔肠素的合成方法
JP2015515478A (ja) 2012-04-05 2015-05-28 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物及びそれらの併用療法
EP2904406B1 (de) 2012-10-04 2018-03-21 Vertex Pharmaceuticals Incorporated Verfahren zur bestimmung der durch atr-inhibition auftretenden vermehrten dna-schädigung
EP2909202A1 (de) 2012-10-16 2015-08-26 Vertex Pharmaceuticals Incorporated Als atr-kinaseinhibitoren nützliche verbindungen
PL3808749T3 (pl) 2012-12-07 2023-07-10 Vertex Pharmaceuticals Incorporated Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych
WO2014143240A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
JP6543252B2 (ja) 2013-12-06 2019-07-10 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ＡＴＲキナーゼ阻害剤として有用な２−アミノ−６−フルオロ−Ｎ−［５−フルオロ−ピリジン−３−イル］ピラゾロ［１，５−ａ］ピリミジン−３−カルボキサミド化合物、その調製、その異なる固体形態および放射性標識された誘導体
MX2016015874A (es) 2014-06-05 2017-03-27 Vertex Pharma Derivados radiomarcadores de un compuesto de 2-amino-6-fluoro-n-[5 -fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida util como inhibidor de ataxia telangiectasia mutada y rad3 relacionado (atr) cinasa, preparacion de tal compuesto y diferentes formas solidas del mismo.
PT3157566T (pt) 2014-06-17 2019-07-11 Vertex Pharma Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr
CA3000684A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
CN105968114B (zh) * 2016-05-27 2018-11-09 山东大学 一种腔肠素类似物及其制备方法与应用
IL277071B1 (en) 2018-03-08 2024-03-01 Incyte Corp Aminopyrizine diol compounds as PI3K–y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
KR20230135541A (ko) * 2022-03-16 2023-09-25 (주)아름테라퓨틱스 신규한 화합물 및 이의 체크포인트 키나제 2 저해 용도

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9743267A1 *

Also Published As

Publication number Publication date
CA2253910A1 (en) 1997-11-20
WO1997043267A1 (en) 1997-11-20

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Legal Events

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