EP0894532B1 - Vorrichtung und Verfahren zur Extraktion bzw. Handhabung von biologischen Flüssigkeiten in dünnwändigen Behältern - Google Patents
Vorrichtung und Verfahren zur Extraktion bzw. Handhabung von biologischen Flüssigkeiten in dünnwändigen Behältern Download PDFInfo
- Publication number
- EP0894532B1 EP0894532B1 EP98500181A EP98500181A EP0894532B1 EP 0894532 B1 EP0894532 B1 EP 0894532B1 EP 98500181 A EP98500181 A EP 98500181A EP 98500181 A EP98500181 A EP 98500181A EP 0894532 B1 EP0894532 B1 EP 0894532B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptacle
- sections
- section
- thin
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
- B01L3/0296—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids from piercable tubing, e.g. in extracorporeal blood sampling
Definitions
- the present invention refers to a method and apparatus for handling and extracting biological samples held in receptacles with thin walls such as those obtained by sectioning a tubular element with a number of pockets for the purpose of holding the samples to be analyzed.
- the present invention offers important characteristics of novelty and inventive activity in relation to the state of the art, enabling biological liquids to be handled in a manner which offers considerable security against external contamination and avoids the possibility of leakage from the sample.
- the invention is especially applicable to the treatment of blood products, such as whole blood, red cells, serum etc. and facilitates the carrying out of analysis thereof.
- blood, red cells, serum, etc. from a sample taken from a donor which is intended, for example, for transfusion are usually stored in PVC pockets together with an anti-coagulant and are duly labelled.
- the contents of the pockets must be analyzed on numerous occasions, at least for each patient who may be given a transfusion, and in these processes it is highly important to prevent accidental contamination (both contamination of the exterior by the contents of the pocket and contamination of the contents from the exterior) and also to prevent confusion occurring in the identification of the samples.
- each pocket is provided with a long PVC tube which is filled with liquid from the pocket after extraction and is immediately sealed at several points and at its end by welding the walls of the tube by the high frequency method (or any other method).
- the tube and the pocket can be marked (for example with numbers or bar codes) a number of times so that each segment contains at least one distinguishing mark.
- the electrodes can leave a notch in the welded joint so that subsequently the segments can be separated from one another by traction leaving both ends completely closed and avoiding any leakage of liquid. This whole process is safe and free of contamination.
- a test tube is usually taken and placed on a tube rack, and the segment is cut by means of scissors and is emptied by way of the tube, then the empty segment is thrown away and the test is carried out on the tube, which has previously been marked with the same number as that which identifies the pocket.
- the present invention seeks to overcome the problems described above, by providing a method as defined in claim 1 and an apparatus as defined in claim 2 for extracting and handling blood samples held in container elements with thin walls, enabling the said operations to be carried out safely and aseptically, without any real possibility of actual contact with the analysis personnel and enabling the samples to be identified easily during the whole cycle of tests.
- the present invention provides apparatus comprising an intermediate receptacle to receive the tubular element holding the sample of biological liquid, the said receptacle being constructed in a manner which is generally similar to that of a test tube, in order to make it possible for the sample to be handled in a manner similar to that which would be used in the case of a test tube, the said intermediate receptacle internally comprising buffering and centring means for the purpose of receiving the tubular receptacle with thin walls for holding the sample of biological liquid, thus creating a lower small container for collecting the biological liquid which will be released from the tubular element which holds it by any suitable means.
- the size of the intermediate receptacle must be such that, in relation to the tubular element containing the biological sample it enables pipetting to be carried out, possibly by an automatic device of the said intermediate receptacle.
- the method for handling the biological liquid samples will therefore basically comprise the following successive stages:
- the device for carrying out this procedure should preferably be manufactured from a low cost plastic material, which is provided internally with means for centring and holding the tubular element holding the biological sample and a small container for collecting the biological liquid after the said tubular element has been ruptured and squeezed, means being provided for rupturing the tubular element and for squeezing out its contents.
- the intermediate receptacle will be produced from two parts or sections, one of which comprises the centring and holding means for the tubular element which holds the biological sample and likewise, means such as projections, blades or other suitable components for the purpose of making cuts in the tubular element containing the biological sample.
- one section will preferably be connected to the other, either by being moulded in one piece or by being constructed with external hinges which may be situated in the lower portion of a cover extending lengthwise or laterally.
- Figures 1 and 2 are both views in cross-section, shown diagrammatically, of one form of device according to the present invention.
- Figure 3 shows a view from above of a device according to the present invention, which makes it possible to appreciate the internal visibility of the tubular element, due to the fact that it is transparent.
- Figure 4 shows a diagrammatic cross-section of the device itself.
- Figures 5 and 6 are views in perspective of a device according to the present invention, showing the components in an open position and in a closed position, respectively.
- Figure 7 shows a cross-section of a device according to the present invention showing the positioning of a pipetting needle.
- a cut will be made in one of the said receptacles indicated with the numeral 1 in Figure 1, this being the usual tubular unit containing various individual containers of the same sample; in order to carry out various tests, the said unit is placed centrally inside a special device which basically comprises a section 2 for the purpose of holding the tubular element, a section 3 which can be connected to section 2 and which is designed to compress and rupture at various points of receptacle 1, and a section 4 in the lower portion of which a small container is arranged, this said lower portion being preferably common to sections 2 and 3 and preferably designed to catch the sample of liquid to be analyzed. At least one of the said sections or components 2 and 3 will be constructed from a transparent material, in order to make it possible to read from outside the identification marks of the sample which refer to the receptacle containing the sample.
- this receptacle being preferably constructed from a thin plastic material
- the said receptacle will be held in position by means of an abutment 5 which may have various forms, and will be subjected to the action of section 3 of the device, which will in the first place produce transverse compression of the receptacle 1 and will also rupture the walls of the receptacle by contact at several points, one point being preferably situated close to the lower end and another point or points being situated close to the upper portion, in order to permit an intake of air to permit complete emptying of the tube; this will contribute to the compression effect of section 3 upon section 2, thereby squeezing the tube, the contents of which will be conveyed into the lower small container 4 in the form of a liquid mass 6, which will then be available to receive reagents, the said small container being capable of being partially removed it necessary, and also capable of being further handled, all of these operations being carried out by means of a pipetting system as shown
- sections 2 and 3 of the device will be hinged to each other at the lower section 4.
- the main characteristic of the device is that the two sections 2 and 3 can be moved in relation to one another, in order to clamp and compress the inner tubular receptacle or container 1, whereby the arrangement of both sections can be variable; for example, they can be movable rectilinearly, in form of laterally hinged container and cover parts, or arranged in any other manner which achieves the required aims, i.e., that the receptacle with thin walls carrying the sample for analysis is well centred, that the liquid contained in the said tubular receptacle is collected, and also that once the integral components of the device have been adapted so as to ensure that the receptacle is ruptured and squeezed, the unit which is constructed in this manner offers fluid-tight conditions which are similar to those of a test tube, and which makes it possible for the device to be used in the later analytical stages.
- the device which is the subject of the present invention will comprise an internal passage 8 which will be substantially concentric with the liquid mass 6 in the lower small container 4, so as to enable the pipetting needle 7 to be inserted, and similarly the device will be provided with means for cutting the tubular element, the said means being constructed in the form of sharp points or projecting points of another type, knife components, etc. which are shown diagrammatically in the drawings and indicated by the numerals 9, 10 and 11.
- One of these components will cut into the tubular component near the lower end, which is designed as an outlet for the contents of the receptacle, while the other means, if they are provided, will be situated in the higher portion of the receptacle for the purpose of enabling air to be taken inside the said receptacle, in order to assist the process of emptying the same.
- the component 2 is provided with projecting points 9, 10 and 11 and the element or section 3 has corresponding recesses 12, 13 and 14 in order to permit the cutting components to be partially inserted into the tubular component 1 for the purpose of rupturing its walls.
- the described method will comprise a first stage of centring and axially holding the tubular element inside the rupturing and squeezing device, subsequently simultaneously rupturing transversely at a point close to the lower end of the tubular element and optionally at points which are situated in the extreme upper portion of the same and finally compressing the receptacle in order to squeeze out the liquid held inside the same, the empty tubular receptacle becoming lodged inside the device, the said device being manufactured from transparent materials in order to enable the used receptacle to act as a holder for the marks identifying the sample, thus enabling the sample to be identified both visually and automatically in an automated analytical apparatus.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Devices For Opening Bottles Or Cans (AREA)
Claims (10)
- Verfahren zum Extrahieren und Handhaben biologischer Flüssigkeiten aus dünnwandigen röhrenförmigen Behältern, in welchen diese enthalten sind, und zum Handhaben derselben, bei dem ein dünnwandiges röhrenförmiges Element zum Halten einer Flüssigkeitsprobe verwendet wird, wobei das röhrenförmige Element äußerlich mit identifizierenden Markierungen versehen und in ein Gerät mit transparenten Wänden eingeführt ist, so dass es lateral und axial zentriert ist, und wobei das Gerät zum Ausführen eines kontrollierten Auseinanderbrechens des Behälters an einem Punkt ausgelegt ist, welcher nahe seinem unteren Ende liegt, um den Behälter zu leeren, und wahlweise an Punkten, welche nahe an seinem oberen Ende liegen, um einen Lufteinlass bereitzustellen, ferner das röhrenförmige Element transversal komprimiert wird, um dieses zusammenzudrücken, und wobei das röhrenförmige Element fest in dem zerbrechenden und zusammendrückenden Gerät untergebracht ist, so dass sichergestellt wird, dass die identifizierenden Daten der in den dünnwandigen Behälter enthaltenen Probe weiterhin gelesen werden können.
- Verfahren zum Extrahieren und Handhaben biologischer Flüssigkeiten aus dünnwandigen röhrenförmigen Behältern (1), in welchen diese enthalten sind, und zum Handhaben derselben durch das Verfahren nach Anspruch 1, bei dem die Vorrichtung wenigstens zwei Abschnitte (2, 3) umfasst, welche miteinander verbunden werden können, wobei ein Abschnitt im Verhältnis zu dem anderen bewegbar ist, und Mittel zum radialen und axialen Halten des dünnwandigen röhrenförmigen Behälters umfasst, der eine Flüssigkeitsprobe enthält, und mit Mitteln versehen ist, mit denen die zwei Abschnitte der Vorrichtung zusammenwirken, um den dünnwandigen Behälter an gewünschten Punkten zerbrechen zu lassen, wobei die Abschnitte so ausgelegt sind, dass der dünnwandige Behälter zusammengedrückt werden kann, nachdem der Behälter zerbrochen wurde, und der Abschnitt (2), welcher den dünnwandigen Behälter direkt aufnimmt transparente Eigenschaften aufweist, um das äußerliche Lesen identifizierender Markierungen zu erleichtern, welche den Behälter identifizieren, der die zu analysierende Probe enthält.
- Vorrichtung gemäß Anspruch 2, dadurch gekennzeichnet, dass beide Abschnitte desselben mit einem Behälterabschnitt (4) mit flüssigkeitsdichten Eigenschaften verbunden sind, so dass er die zu analysierende Flüssigkeit aufnehmen kann, welche in dem dünnwandigen Behälter enthalten ist.
- Vorrichtung gemäß Anspruch 2 und 3, dadurch gekennzeichnet, dass die zwei verbindenden Abschnitte des Geräts und des Behälterabschnitts zum Aufnehmen desselben eine Einheit bilden, die aus Plastikmaterial hergestellt ist, wobei die zwei Hauptabschnitte des Geräts gelenkig miteinander und dem Behälterabschnitt verbunden sind.
- Vorrichtung gemäß Anspruch 2 und 3, dadurch gekennzeichnet, dass die zwei Abschnitte gelenkig miteinander verbunden und einer von ihnen einstückig mit dem Behälterabschnitt zum Aufnehmen der zu analysierenden Flüssigkeit ausgebildet ist.
- Vorrichtung gemäß Ansprüchen 2 bis 5, dadurch gekennzeichnet, dass einer der zwei Abschnitte einen axialen Kanal (8) zum Bereitstellen eines Zugangs für eine Pipettennadel enthält, welche so eingeführt werden kann, dass sie sich in den Behälterabschnitt hineinerstreckt.
- Vorrichtung gemäß Ansprüchen 2 bis 5, dadurch gekennzeichnet, dass einer der Abschnitte mit Schneidelementen (9, 10, 11) ausgestattet ist, welche zum Schneiden oder Perforieren des Behälters, der die zu analysierende Probe enthält, an den geforderten Punkten in der Lage ist.
- Vorrichtung gemäß Anspruch 7, dadurch gekennzeichnet, dass ein Abschnitt des Geräts mit Aussparungen (13, 14) ausgestattet ist, welche mit den Schneidelementen des anderen Abschnitts zum Zweck des Komprimierens und Schneidens des Behälters zusammenwirken, der die zu analysierende Flüssigkeit enthält.
- Vorrichtung gemäß Ansprüchen 2 bis 8, dadurch gekennzeichnet, dass Haltemittel (15, 16) zwischen zwei einstückigen Abschnitten des Geräts vorgesehen sind, um diesen zu ermöglichen, in einer Position festgestellt zu werden, nachdem sie miteinander in Eingriff gebracht wurden.
- Vorrichtung gemäß Ansprüchen 2 bis 9, dadurch gekennzeichnet, dass die zwei einstückigen Abschnitte und der Behälterabschnitt zum Bilden einer Einheit miteinander in Eingriff gebracht werden können, deren Gesamtform ähnlich der eines Probenröhrchens ist.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES98500181T ES2227791T3 (es) | 1997-08-01 | 1998-07-30 | Procedimiento y dispositivo para la extraccion y manipulacion de liquidos biologicos contenidos en recipientes de paredes delgadas. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701710 | 1997-08-01 | ||
ES009701710A ES2140311B1 (es) | 1997-08-01 | 1997-08-01 | "procedimiento y dispositivo para la extraccion y manipulacion de liquidos biologicos contenidos en recipientes de paredes delgadas". |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0894532A2 EP0894532A2 (de) | 1999-02-03 |
EP0894532A3 EP0894532A3 (de) | 2000-07-26 |
EP0894532B1 true EP0894532B1 (de) | 2004-09-22 |
Family
ID=8300276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98500181A Expired - Lifetime EP0894532B1 (de) | 1997-08-01 | 1998-07-30 | Vorrichtung und Verfahren zur Extraktion bzw. Handhabung von biologischen Flüssigkeiten in dünnwändigen Behältern |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0894532B1 (de) |
JP (1) | JP2927784B2 (de) |
AR (1) | AR015411A1 (de) |
AT (1) | ATE276828T1 (de) |
BR (1) | BR9802827B1 (de) |
CZ (1) | CZ290694B6 (de) |
DE (1) | DE69826385T2 (de) |
ES (2) | ES2140311B1 (de) |
SK (1) | SK282943B6 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016011492A1 (en) * | 2014-07-24 | 2016-01-28 | Noble House Group Pty. Ltd. | Segment sampler |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094995A1 (de) * | 2004-03-31 | 2005-10-13 | Epr Labautomation Ag | Verfahren und vorrichtung zum speichern und dispensieren von kleinen flüssigkeitsmengen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3107009A (en) * | 1960-03-21 | 1963-10-15 | Eitel Mccullough Inc | Container with cooperating support frame |
US4399103A (en) * | 1981-01-28 | 1983-08-16 | Ferrara Louis T | Blood dispenser device |
US4790842A (en) * | 1986-09-15 | 1988-12-13 | Coburn Timothy J | Blood sample segment detaching and tearing device |
US4846005A (en) * | 1986-12-12 | 1989-07-11 | Baxter International Inc. | Set with attachable sample cell |
JPH0755498Y2 (ja) * | 1988-07-13 | 1995-12-20 | 川澄化学工業株式会社 | 輸血及び血液検査用の被検血液採取器具 |
-
1997
- 1997-08-01 ES ES009701710A patent/ES2140311B1/es not_active Expired - Fee Related
-
1998
- 1998-07-22 CZ CZ19982298A patent/CZ290694B6/cs not_active IP Right Cessation
- 1998-07-24 SK SK1010-98A patent/SK282943B6/sk not_active IP Right Cessation
- 1998-07-27 AR ARP980103677A patent/AR015411A1/es not_active Application Discontinuation
- 1998-07-30 ES ES98500181T patent/ES2227791T3/es not_active Expired - Lifetime
- 1998-07-30 AT AT98500181T patent/ATE276828T1/de not_active IP Right Cessation
- 1998-07-30 DE DE69826385T patent/DE69826385T2/de not_active Expired - Lifetime
- 1998-07-30 EP EP98500181A patent/EP0894532B1/de not_active Expired - Lifetime
- 1998-07-31 JP JP10216853A patent/JP2927784B2/ja not_active Expired - Fee Related
- 1998-07-31 BR BRPI9802827-8A patent/BR9802827B1/pt not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016011492A1 (en) * | 2014-07-24 | 2016-01-28 | Noble House Group Pty. Ltd. | Segment sampler |
Also Published As
Publication number | Publication date |
---|---|
EP0894532A2 (de) | 1999-02-03 |
ES2140311B1 (es) | 2000-10-16 |
JP2927784B2 (ja) | 1999-07-28 |
SK282943B6 (sk) | 2003-01-09 |
CZ229898A3 (cs) | 1999-02-17 |
DE69826385T2 (de) | 2005-09-29 |
DE69826385D1 (de) | 2004-10-28 |
AR015411A1 (es) | 2001-05-02 |
ATE276828T1 (de) | 2004-10-15 |
JPH11105985A (ja) | 1999-04-20 |
ES2140311A1 (es) | 2000-02-16 |
BR9802827A (pt) | 1999-11-03 |
SK101098A3 (en) | 1999-02-11 |
EP0894532A3 (de) | 2000-07-26 |
ES2227791T3 (es) | 2005-04-01 |
BR9802827B1 (pt) | 2010-11-03 |
CZ290694B6 (cs) | 2002-09-11 |
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