EP0823941A4 - Human antibodies derived from immunized xenomice - Google Patents
Human antibodies derived from immunized xenomiceInfo
- Publication number
- EP0823941A4 EP0823941A4 EP95918935A EP95918935A EP0823941A4 EP 0823941 A4 EP0823941 A4 EP 0823941A4 EP 95918935 A EP95918935 A EP 95918935A EP 95918935 A EP95918935 A EP 95918935A EP 0823941 A4 EP0823941 A4 EP 0823941A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- human antibodies
- antibodies derived
- immunized xenomice
- xenomice
- immunized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1995/005500 WO1996034096A1 (en) | 1995-04-28 | 1995-04-28 | Human antibodies derived from immunized xenomice |
CA002219486A CA2219486A1 (en) | 1995-04-28 | 1995-04-28 | Human antibodies derived from immunized xenomice |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0823941A1 EP0823941A1 (en) | 1998-02-18 |
EP0823941A4 true EP0823941A4 (en) | 2001-09-19 |
Family
ID=25679770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95918935A Withdrawn EP0823941A4 (en) | 1995-04-28 | 1995-04-28 | Human antibodies derived from immunized xenomice |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0823941A4 (en) |
AU (1) | AU2466895A (en) |
CA (1) | CA2219486A1 (en) |
WO (1) | WO1996034096A1 (en) |
Families Citing this family (1456)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US7084260B1 (en) | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
US6300129B1 (en) * | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5795966A (en) † | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
EP0966971A1 (en) | 1996-04-23 | 1999-12-29 | Chugai Seiyaku Kabushiki Kaisha | Cerebral stroke/cerebral edema preventive or remedy containing il-8 binding inhibitor as active ingredient |
WO1998006431A2 (en) * | 1996-08-16 | 1998-02-19 | Osther Kurt B | Method for treating diabetes |
KR20080059467A (en) | 1996-12-03 | 2008-06-27 | 아브게닉스, 인크. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
AU2008200005B2 (en) * | 1996-12-03 | 2012-05-17 | Amgen Fremont Inc. | Transgenic Mammals Having Human Ig Loci Including Plural Vh and Vk Regions and Antibodies Produced Therefrom |
ATE407696T1 (en) | 1997-03-21 | 2008-09-15 | Chugai Pharmaceutical Co Ltd | PREVENTIVE OR CURE FOR THE TREATMENT OF MULTIPLE SCLERosis, CONTAINING ANTAGONISTIC ANTI-IL6 RECEPTOR ANTIBODIES AS THE ACTIVE INGREDIENTS |
US20020173629A1 (en) | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
KR20080027967A (en) | 1997-08-15 | 2008-03-28 | 츄가이 세이야꾸 가부시키가이샤 | Preventives and/or remedies for systemic lupus erythematosus containing anti-il-6 receptor antibody as the active ingredient |
EP1895002B1 (en) | 1998-11-04 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Novel trypsin family serine proteases |
ATE305506T1 (en) * | 1998-12-09 | 2005-10-15 | Protein Design Labs Inc | USE OF IL-12 ANTIBODIES TO TREAT PSORIASIS |
EE05627B1 (en) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | Human monoclonal antibodies to CTLA-4 |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
OA11917A (en) | 1998-12-23 | 2006-04-13 | Abgenix Inc | Human monoclonal antibodies to ctla-4. |
EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
EP1176198A4 (en) | 1999-04-09 | 2002-10-30 | Chugai Pharmaceutical Co Ltd | Novel fetal genes |
IL146005A0 (en) | 1999-05-07 | 2002-07-25 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
ES2529706T3 (en) | 1999-06-01 | 2015-02-24 | Biogen Idec Ma Inc. | A blocking monoclonal antibody against the alpha1-I domain of VLA-1, and its use for the treatment of inflammatory disorders |
EP2135953B1 (en) | 1999-06-02 | 2014-04-23 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, Nr. 10 |
US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
MXPA02000961A (en) * | 1999-07-29 | 2003-08-20 | Medarex Inc | Human monoclonal antibodies to prostate specific membrane antigen. |
TWI290832B (en) | 1999-08-23 | 2007-12-11 | Chugai Pharmaceutical Co Ltd | Expression enhancer for HM1.24 antigen |
CA2589418A1 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
WO2001018200A1 (en) | 1999-09-06 | 2001-03-15 | Chugai Seiyaku Kabushiki Kaisha | Tsg-like gene |
JP4838961B2 (en) | 1999-09-21 | 2011-12-14 | 中外製薬株式会社 | Transporter genes OATP-B, C, D, and E |
PL354961A1 (en) | 1999-10-01 | 2004-03-22 | Chugai Seiyaku Kabushiki Kaisha | Prevention and treatment of diseases associated with blood coagulation |
US7173111B2 (en) | 2000-01-24 | 2007-02-06 | Haruo Sugiyama | Wt1-interacting protein WTIP |
AU2002219944B2 (en) | 2000-11-28 | 2008-02-21 | Medimmune, Llc | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
WO2001058956A2 (en) | 2000-02-10 | 2001-08-16 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
US6653448B1 (en) | 2000-03-29 | 2003-11-25 | Curagen Corporation | Wnt-7B-like polypeptides and nucleic acids encoding same |
GB0006398D0 (en) * | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
CA2747325A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
AU2001259215A1 (en) * | 2000-04-28 | 2001-11-12 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
CA2409267C (en) | 2000-05-26 | 2017-02-28 | Immunex Corporation | Interleukin-4 antagonists and compositions thereof |
US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
CA2413160A1 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
KR20120053525A (en) | 2000-06-16 | 2012-05-25 | 캠브리지 안티바디 테크놀로지 리미티드 | Antibodies that immunospecifically bind to blys |
CN101525384A (en) | 2000-06-29 | 2009-09-09 | 艾博特公司 | A bispecific antibody and the making method and the application thereof |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
UA81743C2 (en) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS |
US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
AU2001296507A1 (en) * | 2000-10-02 | 2002-04-15 | Chiron Corporation | Human anti-cd40 antibodies |
WO2005019269A2 (en) | 2002-11-27 | 2005-03-03 | Minerva Biotechnologies Corporation | Techniques and compositions for the diagnosis and treatment of cancer (muc1) |
EP2341060B1 (en) | 2000-12-12 | 2019-02-20 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
ME00502B (en) | 2001-01-05 | 2011-10-10 | Amgen Fremont Inc | Antibodies to insulin-like growth factor i receptor |
WO2002059154A2 (en) * | 2001-01-26 | 2002-08-01 | Abgenix, Inc. | Neutralizing human monoclonal antibodies against hiv-1, their production and uses |
US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
CN1564826A (en) | 2001-02-09 | 2005-01-12 | 人类基因组科学公司 | Human G-protein chemokine receptor (CCR5) HDGNR10 |
US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
WO2002076196A1 (en) | 2001-03-22 | 2002-10-03 | Abbott Gmbh & Co. Kg | Transgenic animals expressing antibodies specific for genes of interest and uses thereof |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
WO2002081639A2 (en) | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc2 and diagnostic and therapeutic uses thereof |
AU2002305151A1 (en) | 2001-04-06 | 2002-10-21 | Georgetown University | Gene scc-112 and diagnostic and therapeutic uses thereof |
WO2002081642A2 (en) | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc-3 and diagnostic and therapeutic uses thereof |
DE60236646D1 (en) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 antibodies |
WO2002083854A2 (en) | 2001-04-13 | 2002-10-24 | Biogen, Inc. | Antibodies to vla-1 |
CA2658221C (en) | 2001-04-27 | 2012-11-27 | Kyowa Hakko Kirin Co., Ltd. | Anti-cd40 monoclonal antibody |
WO2002092017A2 (en) | 2001-05-16 | 2002-11-21 | Albert Einstein College Of Medicine Of Yeshiva University | Human antipneumococcal antibodies from non-human animals |
WO2002097033A2 (en) | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
US7329405B2 (en) | 2001-08-23 | 2008-02-12 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
US7153507B2 (en) * | 2001-08-23 | 2006-12-26 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
US7981863B2 (en) | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
WO2003029296A1 (en) * | 2001-10-02 | 2003-04-10 | Chiron Corporation | Human anti-cd40 antibodies |
AR039067A1 (en) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | ANTIBODIES FOR CD40 |
CA2847885C (en) | 2001-11-30 | 2022-03-22 | Amgen Fremont Inc. | Transgenic animals bearing human ig.lambda. light chain genes |
ES2425738T3 (en) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
ES2536709T3 (en) | 2002-02-14 | 2015-05-27 | Chugai Seiyaku Kabushiki Kaisha | Use of acetic acid to eliminate problems induced by the Fe ion in anti-HM1.24 or anti-IL6R antibody formulations |
JP2005530490A (en) | 2002-03-29 | 2005-10-13 | シェーリング コーポレイション | Human monoclonal antibody and method for interleukin-5 and composition comprising the same |
JPWO2003083116A1 (en) | 2002-03-29 | 2005-08-04 | 中外製薬株式会社 | Transporter inhibitor screening method |
US7244565B2 (en) | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
SI1503794T1 (en) | 2002-04-12 | 2012-09-28 | Medarex Inc | Methods of treatement using ctla-4 antibodies |
JP2005535572A (en) | 2002-04-12 | 2005-11-24 | メディミューン,インコーポレーテッド | Recombinant anti-interleukin-9 antibody |
CA2429483A1 (en) | 2002-05-17 | 2003-11-17 | Amrad Operations Pty Ltd. | Immunointeractive molecules |
DK1513934T3 (en) | 2002-06-06 | 2011-05-02 | Oncotherapy Science Inc | Genes and polypeptides related to human colon cancer diseases |
SI1513934T1 (en) | 2002-06-06 | 2011-06-30 | Oncotherapy Science Inc | Genes and polypeptides relating to human colon cancers |
JP4643255B2 (en) | 2002-06-10 | 2011-03-02 | バクシネックス インコーポレーティッド | Differentially expressed genes and encoded polypeptides in breast and bladder cancer |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
AU2003251900B2 (en) | 2002-07-15 | 2008-12-18 | President And Fellows Of Harvard College | Methods and compositions for modulating T helper (Th) cell development and function |
EP2371389A3 (en) | 2002-08-14 | 2012-04-18 | MacroGenics, Inc. | FcgammaRIIB-specific antibodies and methods of use thereof |
EP1541165A4 (en) | 2002-08-27 | 2009-06-24 | Chugai Pharmaceutical Co Ltd | Method of stabilizing protein solution preparation |
CA2496400A1 (en) | 2002-09-09 | 2004-03-18 | Dana-Farber Cancer Institute, Inc. | Bh3 peptides and method of use thereof |
JP5525118B2 (en) | 2002-09-11 | 2014-06-18 | 中外製薬株式会社 | Protein purification method |
TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
TW200413539A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Genes and polypeptides relating to prostate cancers |
US7622270B2 (en) | 2002-10-22 | 2009-11-24 | Eisai R&D Management Co., Ltd. | Methods of isolating dopaminergic neuron precursor cells |
WO2004039981A1 (en) | 2002-10-30 | 2004-05-13 | Chugai Seiyaku Kabushiki Kaisha | Membrane protein originating in mast cells |
NZ563471A (en) | 2002-11-08 | 2009-04-30 | Ablynx Nv | Camelidae antibodies against imminoglobulin E and use thereof for the treatment of allergic disorders |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
EP1572106B1 (en) | 2002-11-15 | 2010-05-05 | Novartis Vaccines and Diagnostics, Inc. | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
EP1578799B8 (en) | 2002-12-02 | 2011-03-23 | Amgen Fremont Inc. | Antibodies directed to tumor necrosis factor and uses thereof |
ATE490323T1 (en) | 2002-12-29 | 2010-12-15 | Toudai Tlo Ltd | ADIPONECTIN RECEPTOR AND GENE CODING IT |
EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
EP2241330A1 (en) | 2003-02-14 | 2010-10-20 | The Curators Of The University Of Missouri | Contraceptive methods and compositions related to proteasomal interference |
JP5356648B2 (en) | 2003-02-20 | 2013-12-04 | シアトル ジェネティックス, インコーポレイテッド | Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
HUE025347T2 (en) | 2003-03-19 | 2016-02-29 | Biogen Ma Inc | NOGO receptor binding protein |
CA2519528C (en) | 2003-03-19 | 2016-01-26 | Abgenix, Inc. | Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof |
US7354584B2 (en) | 2003-04-11 | 2008-04-08 | Medimmune, Inc. | Recombinant IL-9 antibodies |
US20040241808A1 (en) * | 2003-04-14 | 2004-12-02 | Renata Pasqualini | Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
EP2228445A1 (en) | 2003-06-18 | 2010-09-15 | Chugai Seiyaku Kabushiki Kaisha | Fucose Transporter |
EP3037105B1 (en) | 2003-06-27 | 2021-03-17 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
JP2008500005A (en) | 2003-07-15 | 2008-01-10 | バロス リサーチ インスティテュート | Compositions and methods for immunotherapy of cancer and infectious diseases |
HN2004000285A (en) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTIBODIES DIRECTED TO c-MET |
BR0318454A (en) | 2003-08-08 | 2006-09-12 | Abgenix Inc | parathyroid hormone (pth) targeting antibodies and their uses |
EP1652923B1 (en) | 2003-08-08 | 2011-10-12 | Perseus Proteomics Inc. | Gene overexpressed in cancer |
WO2005014795A2 (en) | 2003-08-08 | 2005-02-17 | Genenews Inc. | Osteoarthritis biomarkers and uses thereof |
WO2005014854A1 (en) | 2003-08-08 | 2005-02-17 | Licentia, Ltd. | Materials and methods for colorectal cancer screening, diagnosis, and therapy |
AR045563A1 (en) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | ANTIBODIES DIRECTED TO M-CSF |
AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
AU2003271186A1 (en) | 2003-10-14 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
US7638606B2 (en) | 2003-11-07 | 2009-12-29 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
US8454963B2 (en) * | 2003-11-13 | 2013-06-04 | Musc Foundation For Research Development | Tissue targeted complement modulators |
CN1914226B (en) | 2003-11-25 | 2012-02-01 | 达纳-法伯癌症研究院有限公司 | Antibodies against SARS-COV and methods of use thereof |
ES2324538T3 (en) | 2003-12-05 | 2009-08-10 | Multimmune Gmbh | ANTI-HSP THERAPEUTIC AND DIAGNOSTIC ANTIBODIES. |
US7312320B2 (en) | 2003-12-10 | 2007-12-25 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
LT2805728T (en) | 2003-12-23 | 2020-05-25 | Genentech, Inc. | Novel anti-IL 13 antibodies and uses thereof |
PT2311873T (en) | 2004-01-07 | 2018-11-20 | Novartis Vaccines & Diagnostics Inc | M-csf-specific monoclonal antibody and uses thereof |
AP2006003689A0 (en) | 2004-01-09 | 2006-08-31 | Pfizer | Antibodies to MAdCAM |
MXPA06009072A (en) | 2004-02-09 | 2007-03-29 | Human Genome Sciences Inc | Albumin fusion proteins. |
AU2005227313A1 (en) | 2004-03-19 | 2005-10-06 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through V gene manipulation |
US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
JP4938451B2 (en) | 2004-03-23 | 2012-05-23 | オンコセラピー・サイエンス株式会社 | Methods for diagnosis of non-small cell lung cancer |
EP1786463A4 (en) | 2004-03-26 | 2009-05-20 | Human Genome Sciences Inc | Antibodies against nogo receptor |
EP1755673B1 (en) | 2004-04-12 | 2014-07-23 | MedImmune, LLC | Anti-il-9 antibody formulations and uses thereof |
EP1761784B1 (en) | 2004-05-24 | 2016-10-26 | Universität Zu Köln | Identification of ergothioneine transporter and therapeutic uses thereof |
US9228008B2 (en) | 2004-05-28 | 2016-01-05 | Idexx Laboratories, Inc. | Canine anti-CD20 antibodies |
AU2005250216B2 (en) | 2004-06-01 | 2009-12-10 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
CN102727880A (en) | 2004-06-01 | 2012-10-17 | 西奈山医学院 | Genetically engineered swine influenza virus and uses thereof |
EP1602926A1 (en) | 2004-06-04 | 2005-12-07 | University of Geneva | Novel means and methods for the treatment of hearing loss and phantom hearing |
AU2005258335B2 (en) | 2004-06-24 | 2011-03-17 | Biogen Ma Inc. | Treatment of conditions involving demyelination |
CA2601417C (en) | 2004-07-01 | 2018-10-30 | Novo Nordisk A/S | Human anti-kir antibodies |
KR20070036130A (en) | 2004-07-16 | 2007-04-02 | 화이자 프로덕츠 인코포레이티드 | Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody |
CA2574177C (en) | 2004-07-22 | 2019-01-08 | Eisai Co., Ltd. | Lrp4/corin dopaminergic neuron progenitor cell markers |
CN101014245A (en) | 2004-08-03 | 2007-08-08 | 比奥根艾迪克Ma公司 | Taj in neuronal function |
AP2007003921A0 (en) | 2004-08-16 | 2007-02-28 | Atugen Ag | Therapeutic uses of inhibitors of rtp801 |
CA2478458A1 (en) | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
AU2004224925C1 (en) | 2004-08-30 | 2011-07-21 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
CA2580921C (en) | 2004-09-21 | 2016-04-12 | Medimmune, Inc. | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
EP1805222B1 (en) | 2004-10-01 | 2011-02-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Antibodies directed to the mammalian eag1 ion channel protein |
US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
CA2585098C (en) | 2004-10-22 | 2018-12-18 | Revivicor, Inc. | Porcine genomic kappa and lambda light chain sequences |
AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
DE602005025525D1 (en) | 2004-11-17 | 2011-02-03 | Amgen Inc | COMPLETE HUMAN MONOCLONAL ANTIBODIES AGAINST IL-13 |
EP2808033A1 (en) | 2004-11-19 | 2014-12-03 | Biogen Idec MA Inc. | Treatment for multiple sclerosis |
GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
EP2769990A3 (en) | 2004-12-02 | 2015-02-25 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY |
US8124091B2 (en) | 2004-12-06 | 2012-02-28 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
EP1838737B1 (en) | 2004-12-20 | 2011-04-06 | Amgen Fremont Inc. | Binding proteins specific for human matriptase |
AU2005319382B2 (en) | 2004-12-21 | 2011-04-07 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
JPWO2006067847A1 (en) | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | Antibody production method using cells in which fucose transporter function is inhibited |
CN102580084B (en) | 2005-01-21 | 2016-11-23 | 健泰科生物技术公司 | The fixed dosage of HER antibody is administered |
EP1851245B1 (en) | 2005-01-26 | 2012-10-10 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
CA2599589A1 (en) | 2005-02-07 | 2006-08-17 | Genenews,Inc. | Mild osteoarthritis biomarkers and uses thereof |
US7998695B2 (en) | 2005-02-10 | 2011-08-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
WO2006088925A2 (en) | 2005-02-14 | 2006-08-24 | Wyeth | Use of il17-f in diagnosis and therapy of airway inflammation |
RU2007129263A (en) | 2005-02-14 | 2009-03-20 | Вайет (Us) | ANTIBODIES TO INTERLEUKIN-17F AND OTHER IL-17F MEDIA-BASED ANTAGONISTS SIGNAL TRANSMISSION AND THEIR APPLICATION |
US20060263357A1 (en) | 2005-05-05 | 2006-11-23 | Tedder Thomas F | Anti-CD19 antibody therapy for autoimmune disease |
KR101289537B1 (en) | 2005-02-15 | 2013-07-31 | 듀크 유니버시티 | Anti-cd19 antibodies and uses in oncology |
DK2332408T3 (en) | 2005-02-17 | 2013-12-02 | Biogen Idec Inc | Treatment of neurological diseases |
WO2006089141A2 (en) | 2005-02-18 | 2006-08-24 | Dana-Farber Cancer Institute | Antibodies against cxcr4 and methods of use thereof |
TWI406870B (en) | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
CN103251946A (en) | 2005-02-23 | 2013-08-21 | 健泰科生物技术公司 | Extending time to disease progression or survival in cancer patients using a her dimerization inhibitor |
AU2006218489B2 (en) | 2005-03-02 | 2011-02-24 | Biogen Ma Inc. | KIM-1 antibodies for treatment of Th2-mediated conditions |
JP2008531730A (en) | 2005-03-04 | 2008-08-14 | キュアーディーエム、インク. | Methods and pharmaceutical compositions for treating type I diabetes mellitus and other conditions |
BRPI0608855A2 (en) | 2005-03-08 | 2010-02-02 | Pharmacia & Upjohn Co Llc | anti - madcam antibody compositions process for their preparation and use of anti - madcam antibody |
WO2007059082A1 (en) | 2005-11-10 | 2007-05-24 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
US8859495B2 (en) | 2005-03-30 | 2014-10-14 | Minerva Biotechnologies Corporation | Methods for stimulating or enhancing proliferation of non-tumorous cells expressing MUC1 receptors |
DK1875244T3 (en) | 2005-03-30 | 2019-04-29 | Minerva Biotechnologies Corp | Proliferation of MUC1-Expressing Cells |
KR20140068234A (en) | 2005-03-31 | 2014-06-05 | 더 제너럴 하스피탈 코포레이션 | Monitoring and modulating hgf/hgfr activity |
ES2592271T3 (en) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide production methods by regulating the association of polypeptides |
PL2645106T3 (en) | 2005-04-04 | 2017-11-30 | Biogen Ma Inc. | Methods for evaluating an immune response to a therapeutic agent |
EP1876236B9 (en) | 2005-04-08 | 2015-02-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
GT200600148A (en) | 2005-04-14 | 2006-11-22 | METHODS FOR THE TREATMENT AND PREVENTION OF FIBROSIS | |
US9296816B2 (en) | 2005-04-15 | 2016-03-29 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
EP1874820A4 (en) | 2005-04-20 | 2010-09-22 | Amgen Fremont Inc | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies |
DOP2006000093A (en) | 2005-04-25 | 2007-01-31 | Pfizer | ANTIBODIES AGAINST MYOSTATIN |
NZ562234A (en) | 2005-04-26 | 2009-09-25 | Pfizer | P-cadherin antibodies |
PA8672101A1 (en) | 2005-04-29 | 2006-12-07 | Centocor Inc | ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES |
WO2006124269A2 (en) * | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
EP3805245A1 (en) | 2005-05-17 | 2021-04-14 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
EA013821B1 (en) | 2005-05-25 | 2010-08-30 | Кьюрдм, Инк. | Human proislet peptide, derivatives and analogs thereof, and methods of using same |
SG162728A1 (en) | 2005-05-27 | 2010-07-29 | Biogen Idec Inc | Tweak binding antibodies |
KR101367544B1 (en) | 2005-06-10 | 2014-02-26 | 추가이 세이야쿠 가부시키가이샤 | Stabilizer for protein preparation comprising meglumine and use thereof |
BRPI0613306A2 (en) * | 2005-06-22 | 2010-12-28 | Genentech Inc | isolated antibodies, immunoglobulin polypeptides, ifnar2 antibody, nucleic acid molecule, host cell, cell line, antibody production method, composition, method for diagnosing the presence of ifnar2, method of treating a disease and methods |
US20070110757A1 (en) | 2005-06-23 | 2007-05-17 | Ziping Wei | Antibody formulations having optimized aggregation and fragmentation profiles |
CN101252951B (en) | 2005-06-30 | 2011-12-21 | 森托科尔公司 | Anti-IL-23 antibodies, compositions, methods and uses |
AU2006269458B2 (en) | 2005-07-08 | 2012-11-08 | Biogen Ma Inc. | Sp35 antibodies and uses thereof |
EP2336780A1 (en) | 2005-07-27 | 2011-06-22 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
JP5457671B2 (en) | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | M-CSF specific monoclonal antibody and use thereof |
DK1919503T3 (en) | 2005-08-10 | 2014-12-15 | Macrogenics Inc | Identification and preparation of antibodies with variant fc regions and methods of use thereof |
WO2007019865A2 (en) | 2005-08-18 | 2007-02-22 | Genmab A/S | Therapy with cd4 binding peptides and radiation |
CN101370525B (en) | 2005-08-19 | 2013-09-18 | Abbvie公司 | Dual variable domain immunoglobin and uses thereof |
PT1915397E (en) | 2005-08-19 | 2015-04-30 | Univ Pennsylvania | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders |
EP2500359A3 (en) | 2005-08-19 | 2012-10-17 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
HUE025608T2 (en) | 2005-09-07 | 2016-03-29 | Amgen Fremont Inc | Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1) |
JP2009508494A (en) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Compositions comprising receptor-binding protein (RAP) variants specific for proteins comprising CR and uses thereof |
EP1934261B1 (en) | 2005-09-26 | 2014-10-29 | Medarex, L.L.C. | Human monoclonal antibodies to cd70 |
ES2542501T3 (en) | 2005-09-30 | 2015-08-06 | Abbvie Deutschland Gmbh & Co Kg | Protein binding domains of the protein family of repulsive targeting molecules (RGM) and functional fragments thereof, as well as their use |
CA2625773C (en) | 2005-10-14 | 2015-05-12 | Fukuoka University | Inhibition of interleukin-6 (il-6) receptor promotes pancreatic islet transplantation |
AR058135A1 (en) | 2005-10-21 | 2008-01-23 | Chugai Pharmaceutical Co Ltd | AGENTS FOR THE TREATMENT OF CARDIOPATIAS |
US8249814B2 (en) | 2005-10-21 | 2012-08-21 | Genenews Inc. | Method, computer readable medium, and system for determining a probability of colorectal cancer in a test subject |
AU2006311828B2 (en) | 2005-11-04 | 2013-07-11 | Biogen Ma Inc. | Methods for promoting neurite outgrowth and survival of dopaminergic neurons |
WO2007056227A2 (en) | 2005-11-04 | 2007-05-18 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
BRPI0618338A2 (en) | 2005-11-07 | 2011-08-23 | Scripps Resarch Inst | use of tissue factor signaling inhibitor, method for identifying an agent that inhibits tf / viia signaling, pharmaceutical compositions and kit |
EP2338517A1 (en) | 2005-11-14 | 2011-06-29 | Ribomic Inc | Method for treatment or prevention of disease associated with functional disorder of regulatory T cell |
AR057582A1 (en) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | AGENTS TO DELETE INDUCTION OF CYTOTOXIC T LYMPHOCYTES |
US20090269335A1 (en) | 2005-11-25 | 2009-10-29 | Keio University | Therapeutic agent for prostate cancer |
TWI461436B (en) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
EP2567973B1 (en) | 2005-11-28 | 2014-05-14 | Zymogenetics, Inc. | IL-21 antagonists |
CN102898519B (en) | 2005-11-30 | 2015-10-28 | Abbvie公司 | Monoclonal antibody of anti-amyloid beta protein and uses thereof |
EP2289909B1 (en) | 2005-11-30 | 2014-10-29 | AbbVie Inc. | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
EP2543384A3 (en) | 2005-12-02 | 2013-04-10 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
PL2529747T3 (en) | 2005-12-02 | 2018-08-31 | Icahn School Of Medicine At Mount Sinai | Chimeric Newcastle Disease viruses presenting non-native surface proteins and uses thereof |
CN105859886A (en) | 2005-12-02 | 2016-08-17 | 健泰科生物技术公司 | Compositions and methods associated with antibodies that bind to IL-22 and IL-22R |
EP1979379B1 (en) | 2005-12-02 | 2013-09-18 | Dana-Farber Cancer Institute | Carbonic anhydrase ix (g250) antibodies and methods of use thereof |
EP1954311A4 (en) | 2005-12-07 | 2009-12-23 | Medarex Inc | Ctla-4 antibody dosage escalation regimens |
RS52357B (en) | 2005-12-13 | 2012-12-31 | Medimmune Limited | Binding proteins specific for insulin-like growth factors and uses thereof |
ES2535856T3 (en) | 2005-12-15 | 2015-05-18 | Genentech, Inc. | Methods and compositions for targeting polyubiquitin |
EP1977763A4 (en) | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | Antibody-containing stabilizing preparation |
AU2006332713B2 (en) | 2005-12-30 | 2013-01-17 | Takeda Pharmaceutical Company Limited | Metalloproteinase binding proteins |
AR056857A1 (en) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES |
DK2463305T3 (en) | 2006-01-12 | 2016-08-29 | Alexion Pharma Inc | Antibodies to OX-2 / CD200 and uses thereof |
ES2350269T3 (en) | 2006-01-18 | 2011-01-20 | The General Hospital Corporation | METHODS TO INCREASE LYMPHATIC FUNCTION. |
NL2000439C2 (en) | 2006-01-20 | 2009-03-16 | Quark Biotech | Therapeutic applications of inhibitors of RTP801. |
AU2007219159B8 (en) | 2006-01-25 | 2012-06-28 | Roger Kingdon Craig | Generation of heavy-chain only antibodies in transgenic animals |
CN103215293B (en) | 2006-01-27 | 2015-10-28 | 比奥根Ma公司 | NOGO receptor antagonist |
US8771686B2 (en) | 2006-01-27 | 2014-07-08 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody |
CA2642419A1 (en) | 2006-02-06 | 2007-08-16 | Rhode Island Hospital | Gpr30 estrogen receptor in breast cancers |
TWI417301B (en) | 2006-02-21 | 2013-12-01 | Wyeth Corp | Antibodies against human il-22 and uses therefor |
TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
EP2014297B1 (en) | 2006-03-20 | 2013-03-13 | Japan Science and Technology Agency | Control of intracellular target molecule by ip3 receptor-binding protein |
US8278421B2 (en) | 2006-03-20 | 2012-10-02 | Xoma Techolology Ltd. | Human antibodies specific for gastrin materials and methods |
WO2007114325A1 (en) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
EP2003960B1 (en) | 2006-03-31 | 2015-06-10 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
EP2008106A2 (en) | 2006-03-31 | 2008-12-31 | Dana-Farber Cancer Institute | Methods of determining cellular chemosensitivity |
WO2007126455A2 (en) | 2006-04-05 | 2007-11-08 | Genentech, Inc. | Method for using boc/cdo to modulate hedgehog signaling |
US9260516B2 (en) | 2006-04-07 | 2016-02-16 | Osaka University | Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor |
CA2648846A1 (en) | 2006-04-07 | 2007-10-18 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Antibody compositions and methods for treatment of neoplastic disease |
TW200813091A (en) | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
WO2007119796A1 (en) | 2006-04-14 | 2007-10-25 | Medical And Biological Laboratories Co., Ltd. | Mutant polypeptide having effector function |
DK2034830T3 (en) | 2006-05-25 | 2014-10-27 | Biogen Idec Inc | ANTI-VLA-1 ANTIBODY FOR TREATMENT OF CASES |
RS53168B (en) | 2006-05-30 | 2014-06-30 | Genentech Inc. | Antibodies and immunoconjugates and uses therefor |
CL2007001623A1 (en) | 2006-06-06 | 2008-01-18 | Genentech Inc | Anti-dll4 antibody; polynucleotide that encodes it; vector and host cell comprising said polynucleotide; method for making the antibody and immunojugate; method of detection of dll4 and diagnostic method of a disorder associated with dll4; composition comprising the antibody. |
CL2007001665A1 (en) | 2006-06-08 | 2008-01-18 | Chugai Pharmaceutical Co Ltd | Antibody or fragment thereof with neutralizing activity of protein nr 10; agent who understands it; and its use to prevent or treat an inflammatory disease. |
SG177907A1 (en) | 2006-06-14 | 2012-02-28 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
EP2505209A1 (en) | 2006-06-26 | 2012-10-03 | MacroGenics, Inc. | Fcgamma-RIIB-specific antibodies and methods of the use thereof |
US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
EP2471815B1 (en) | 2006-07-11 | 2016-03-30 | University Of Medicine And Dentistry Of New Jersey | Proteins, nucleic acids encoding the same and associated methods of use |
PE20081004A1 (en) | 2006-07-13 | 2008-09-18 | Chugai Pharmaceutical Co Ltd | INDUCING AGENTS OF CELLULAR DEATH |
JP5622390B2 (en) | 2006-07-18 | 2014-11-12 | サノフイ | Anti-EPHA2 antagonist antibody for cancer treatment |
WO2008010556A1 (en) | 2006-07-21 | 2008-01-24 | Chugai Seiyaku Kabushiki Kaisha | Remedy for renal disease |
CL2007002225A1 (en) | 2006-08-03 | 2008-04-18 | Astrazeneca Ab | SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A |
CN103524619B (en) | 2006-08-03 | 2016-10-05 | 阿斯利康(瑞典)有限公司 | Antibody and application thereof for α V β 6 |
ES2613957T3 (en) | 2006-08-04 | 2017-05-29 | Medimmune Limited | Antibodies against ERBB2 |
CN101626783A (en) | 2006-08-04 | 2010-01-13 | 诺华有限公司 | EPHB3-specific antibody and its application |
EP3111955B1 (en) | 2006-08-14 | 2019-01-23 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis and treatment of cancer using anti-desmoglein-3 antibody |
EP3415532A1 (en) | 2006-08-18 | 2018-12-19 | XOMA Technology Ltd. | Prlr-specific antibody and uses thereof |
BRPI0716088B8 (en) | 2006-08-28 | 2021-05-25 | Kyowa Hakko Kirin Co Ltd | isolated antibody, composition, isolated nucleic acid molecule, vector, method for producing an antibody, hybridoma, and kit |
US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
ES2378407T3 (en) | 2006-09-01 | 2012-04-12 | Therapeutic Human Polyclonals, Inc. | Increased expression of human or humanized immunoglobulin in non-human transgenic animals |
HUE052220T2 (en) | 2006-09-08 | 2021-04-28 | Abbvie Bahamas Ltd | Interleukin -13 binding proteins |
EP2061906B1 (en) | 2006-09-12 | 2011-08-31 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of lung cancer using pdgfra, kit or kdr gene as genetic marker |
EP2083017A4 (en) | 2006-09-14 | 2011-01-12 | Med & Biological Lab Co Ltd | Antibody having enhanced adcc activity and method for production thereof |
EP2099467B1 (en) | 2006-10-03 | 2017-05-10 | University Of Medicine And Dentistry Of New Jersey | Atap peptides, nucleic acids encoding the same and associated methods of use |
MX2009003738A (en) | 2006-10-12 | 2009-07-17 | Forerunner Pharma Res Co Ltd | Diagnosis and treatment of cancer using anti-ereg antibody. |
MX2009003542A (en) | 2006-10-12 | 2009-04-15 | Wyeth Corp | Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates. |
EP2064335A4 (en) | 2006-10-16 | 2011-03-30 | Medimmune Llc | Molecules with reduced half-lives, compositions and uses thereof |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
CA2666559A1 (en) | 2006-10-20 | 2008-04-24 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
US9023993B2 (en) | 2006-10-20 | 2015-05-05 | Chugai Seiyaku Kabushiki Kaisha | Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient |
US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
RS53942B1 (en) | 2006-10-27 | 2015-08-31 | Genentech Inc. | Antibodies and immunoconjugates and uses therefor |
WO2008052796A1 (en) | 2006-11-03 | 2008-05-08 | U3 Pharma Gmbh | Fgfr4 antibodies |
WO2008055260A2 (en) | 2006-11-03 | 2008-05-08 | Wyeth | Glycolysis-inhibiting substances in cell culture |
WO2008064306A2 (en) | 2006-11-22 | 2008-05-29 | Curedm, Inc. | Methods and compositions relating to islet cell neogenesis |
AU2007355108B2 (en) | 2006-11-27 | 2013-07-11 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
CN101678100A (en) | 2006-12-06 | 2010-03-24 | 米迪缪尼有限公司 | methods of treating systemic lupus erythematosus |
WO2008070780A1 (en) | 2006-12-07 | 2008-06-12 | Novartis Ag | Antagonist antibodies against ephb3 |
WO2008072723A1 (en) | 2006-12-14 | 2008-06-19 | Forerunner Pharma Research Co., Ltd. | ANTI-Claudin-3 MONOCLONAL ANTIBODY, AND TREATMENT AND DIAGNOSIS OF CANCER USING THE SAME |
WO2008076960A2 (en) | 2006-12-18 | 2008-06-26 | Genentech, Inc. | Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases |
JP5645409B2 (en) | 2006-12-20 | 2014-12-24 | ゾーマ (ユーエス) リミテッド ライアビリティ カンパニー | Method for treating IL-1β related diseases |
CA2674140C (en) | 2007-01-05 | 2018-05-15 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
US20100111851A1 (en) | 2007-01-05 | 2010-05-06 | The University Of Tokyo | Diagnosis and treatment of cancer by using anti-prg-3 antibody |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
ES2464815T3 (en) | 2007-01-09 | 2014-06-04 | Biogen Idec Ma Inc. | SP35 antibodies and their uses |
US7776331B1 (en) | 2007-01-16 | 2010-08-17 | Abbott Laboratories | Methods of treating plaque psoriasis |
TWI438208B (en) | 2007-01-23 | 2014-05-21 | Chugai Pharmaceutical Co Ltd | Agents for suppressing chronic rejection reaction |
BRPI0806403A2 (en) | 2007-02-09 | 2011-09-06 | Genentech Inc | anti-robo4 antibody, use an antibody and imaging method |
JP5507851B2 (en) | 2007-02-09 | 2014-05-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | GABA neuron progenitor cell marker 65B13 |
US8685666B2 (en) | 2007-02-16 | 2014-04-01 | The Board Of Trustees Of Southern Illinois University | ARL-1 specific antibodies and uses thereof |
WO2008101184A2 (en) | 2007-02-16 | 2008-08-21 | The Board Of Trustees Of Southern Illinois University | Arl-1 specific antibodies |
KR101508397B1 (en) | 2007-02-22 | 2015-04-08 | 제넨테크, 인크. | Methods for detecting inflammatory bowel disease |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8192740B2 (en) | 2007-02-27 | 2012-06-05 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient |
WO2008109440A2 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
CL2008000719A1 (en) | 2007-03-12 | 2008-09-05 | Univ Tokushima Chugai Seiyaku | THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO |
RU2488593C2 (en) | 2007-03-13 | 2013-07-27 | Юниверсити Оф Цюрих | Human tumour-associated monoclonal antibody |
MX2009010120A (en) | 2007-03-22 | 2009-10-19 | Ucb Pharma Sa | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof. |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
WO2008118324A2 (en) | 2007-03-26 | 2008-10-02 | Macrogenics, Inc. | Composition and method of treating cancer with an anti-uroplakin ib antibody |
CA2682170A1 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Llc | Antibodies with decreased deamidation profiles |
UY30994A1 (en) | 2007-04-02 | 2008-11-28 | Amgen Fremont Inc | ANTI-IGE ANTIBODIES |
WO2008143878A1 (en) | 2007-05-14 | 2008-11-27 | Medimmune, Llc | Methods of reducing eosinophil levels |
RU2009147281A (en) | 2007-05-21 | 2011-06-27 | Дженентек, Инк. (Us) | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF LUPUS |
JP5117765B2 (en) | 2007-05-28 | 2013-01-16 | 国立大学法人 東京大学 | Tumor diagnostic agent for PET containing anti-ROBO1 antibody |
ES2583377T3 (en) | 2007-06-08 | 2016-09-20 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
PT2170390T (en) | 2007-06-14 | 2019-02-12 | Biogen Ma Inc | Natalizumab antibody formulations |
CA2691434C (en) | 2007-06-21 | 2020-07-21 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
ES2751022T3 (en) | 2007-07-09 | 2020-03-30 | Genentech Inc | Prevention of reduction of disulfide bonds during recombinant production of polypeptides |
EP3246045A1 (en) | 2007-07-26 | 2017-11-22 | Osaka University | Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient |
CN101802211B (en) | 2007-08-02 | 2014-10-01 | 诺维莫尼公司 | Anti-RANTES antibodies and methods of use thereof |
PT2186889E (en) | 2007-08-20 | 2015-06-17 | Oncotherapy Science Inc | Cdca1 peptide and pharmaceutical agent comprising the same |
CN101835792B (en) | 2007-08-20 | 2015-04-15 | 肿瘤疗法科学股份有限公司 | FOXM1 peptide and medicinal agent comprising the same |
MX2010002018A (en) | 2007-08-20 | 2010-05-27 | Oncotherapy Science Inc | Cdh3 peptide and medicinal agent comprising the same. |
JOP20080381B1 (en) | 2007-08-23 | 2023-03-28 | Amgen Inc | Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9) |
EP2615114B1 (en) | 2007-08-23 | 2022-04-06 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
ES2672769T3 (en) | 2007-08-29 | 2018-06-18 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their uses |
SG185940A1 (en) | 2007-08-30 | 2012-12-28 | Curedm Group Holdings Llc | Compositions and methods of using proislet peptides and analogs thereof |
WO2009033743A1 (en) | 2007-09-13 | 2009-03-19 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
US8828382B2 (en) | 2007-09-26 | 2014-09-09 | U3 Pharma Gmbh | Heparin-binding epidermal growth factor-like growth factor binding proteins |
CN101874042B9 (en) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | Method for changing isoelectric point of antibody by using amino acid substitution of CDR |
AU2008304111B2 (en) | 2007-09-27 | 2014-04-24 | Amgen Inc. | Pharmaceutical formulations |
WO2009041062A1 (en) | 2007-09-28 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican-3 antibody having improved kinetics in plasma |
AU2008308163B2 (en) | 2007-10-02 | 2013-03-21 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient |
CN106244651A (en) | 2007-10-15 | 2016-12-21 | 中外制药株式会社 | The preparation method of antibody |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
SG185316A1 (en) | 2007-10-19 | 2012-11-29 | Immunas Pharma Inc | ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO Aβ OLIGOMER, AND USE THEREOF |
JP5620106B2 (en) | 2007-10-24 | 2014-11-05 | 株式会社糖鎖工学研究所 | Polypeptide having enhanced effector function |
PE20091163A1 (en) | 2007-11-01 | 2009-08-09 | Wyeth Corp | ANTIBODIES FOR GDF8 |
JP5767475B2 (en) | 2007-11-05 | 2015-08-19 | メディミューン,エルエルシー | How to treat scleroderma |
CN104888193A (en) | 2007-11-07 | 2015-09-09 | 健泰科生物技术公司 | Compositions and methods for treatment of microbial disorders |
AU2008323701B2 (en) | 2007-11-07 | 2015-03-26 | Genentech, Inc | Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
SG10201405835TA (en) | 2007-11-12 | 2014-10-30 | U3 Pharma Gmbh | Axl antibodies |
CN104109208A (en) | 2007-11-14 | 2014-10-22 | 中外制药株式会社 | Diagnosis And Treatment Of Cancer Using Anti-gpr49 Antibody |
ES2962777T3 (en) | 2007-11-15 | 2024-03-21 | Amgen Inc | Antioxidant-stabilized aqueous antibody formulation for parenteral administration |
AR069333A1 (en) | 2007-11-15 | 2010-01-13 | Chugai Pharmaceutical Co Ltd | MONOCLONAL ANTIBODIES THAT JOIN THE TIROSIN QUINASA ANEXELEKTO (AXL) RECEIVER, HYBRIDOMES THAT PRODUCE THEM AND THEIR USES |
US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
TWI468417B (en) | 2007-11-30 | 2015-01-11 | Genentech Inc | Anti-vegf antibodies |
US20110129459A1 (en) | 2007-12-05 | 2011-06-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-nr10 antibody and use thereof |
CN104162155A (en) | 2007-12-05 | 2014-11-26 | 中外制药株式会社 | Therapeutic agent for pruritus |
EP2222701B1 (en) | 2007-12-06 | 2017-11-01 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
US20110262425A1 (en) | 2007-12-12 | 2011-10-27 | National Cancer Center | Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof |
PL2391650T3 (en) | 2007-12-20 | 2015-03-31 | Xoma Us Llc | Methods for the treatment of gout |
RU2547939C2 (en) | 2007-12-26 | 2015-04-10 | Биотест Аг | Anti-cd138 immunoconjugates and using them |
WO2009080831A1 (en) | 2007-12-26 | 2009-07-02 | Biotest Ag | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
MX341344B (en) | 2007-12-26 | 2016-08-16 | Biotest Ag | Agents targeting cd138 and uses thereof. |
JP2011508738A (en) | 2007-12-26 | 2011-03-17 | バイオテスト・アクチエンゲゼルシヤフト | Method and agent for improving targeting of CD138 expressing tumor cells |
PE20091174A1 (en) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT |
US8962806B2 (en) | 2007-12-28 | 2015-02-24 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
BRPI0907046A2 (en) | 2008-01-18 | 2015-07-28 | Medimmune Llc | Engineered cysteine antibody, isolated nucleic acid, vector, host cell, antibody conjugate, pharmaceutical composition, methods of detecting cancer, autoimmune, inflammatory or infectious disorders in an individual and inhibiting proliferation of a target cell |
JP5701064B2 (en) | 2008-01-25 | 2015-04-15 | アムジエン・インコーポレーテツド | Ferroportin antibody and method of use thereof |
CN102124105A (en) | 2008-02-08 | 2011-07-13 | 伊缪纳斯制药株式会社 | Antibody capable of binding specifically to Abeta-oligomer, and use thereof |
AU2009212273B2 (en) | 2008-02-08 | 2014-07-31 | Astrazeneca Ab | Anti-IFNAR1 antibodies with reduced Fc ligand affinity |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
KR20100126515A (en) | 2008-03-18 | 2010-12-01 | 아보트 러보러터리즈 | Methods for treating psoriasis |
WO2009118300A1 (en) | 2008-03-25 | 2009-10-01 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
SG2014014138A (en) | 2008-03-31 | 2014-07-30 | Genentech Inc | Compositions and methods for treating and diagnosing asthma |
CL2009000647A1 (en) | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition for treating or preventing liver cancer comprising a combination of a chemotherapeutic agent and an anti-glypican 3 antibody; agent for attenuating a side effect comprising said antibody; method of treating or preventing liver cancer of a subject. |
WO2009124109A1 (en) | 2008-04-04 | 2009-10-08 | The Government Of The U.S. A. As Represented By The Secretary Of The Dept. Of Health &Human Services | Human monoclonal antibodies specific for cd22 |
NZ602884A (en) | 2008-04-11 | 2014-08-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
KR101634719B1 (en) | 2008-04-25 | 2016-06-29 | 다이액스 코포레이션 | Antibodies against fcrn and use thereof |
SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
US9315577B2 (en) | 2008-05-01 | 2016-04-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
JP5624535B2 (en) | 2008-05-02 | 2014-11-12 | シアトル ジェネティクス,インコーポレーテッド | Methods and compositions for preparing antibodies and antibody derivatives having low core fucosylation |
JP5890174B2 (en) | 2008-05-09 | 2016-03-22 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | Antibody against terminal glycation end product receptor (RAGE) and use thereof |
WO2009148896A2 (en) | 2008-05-29 | 2009-12-10 | Nuclea Biotechnologies, LLC | Anti-phospho-akt antibodies |
US9226934B2 (en) | 2008-06-02 | 2016-01-05 | The University Of Tokyo | Anti-cancer drug |
US9109026B2 (en) | 2008-06-03 | 2015-08-18 | Abbvie, Inc. | Dual variable domain immunoglobulins and uses thereof |
RU2010153580A (en) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND THEIR APPLICATION |
CA2728243C (en) | 2008-06-05 | 2020-03-10 | National Cancer Center | Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer |
AU2009269704B2 (en) | 2008-06-16 | 2014-06-12 | Patrys Limited | LM-antibodies, functional fragments, LM-1 target antigen, and methods for making and using same |
US8575314B2 (en) | 2008-06-20 | 2013-11-05 | National University Corporation Okayama University | Antibody against oxidized LDL/β2GPI complex and use of the same |
WO2010002862A2 (en) | 2008-07-01 | 2010-01-07 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (fgfr3) binding proteins |
BRPI0915825A2 (en) | 2008-07-08 | 2015-11-03 | Abbott Lab | prostaglandin binding proteins and uses thereof |
MX2010014574A (en) | 2008-07-08 | 2011-04-27 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof. |
CA2729961C (en) | 2008-07-09 | 2018-05-01 | Biogen Idec Ma Inc. | Li113, li62 variant co2, anti-lingo antibodies |
DK2318832T3 (en) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated slides and related methods |
MX2011001409A (en) | 2008-08-14 | 2011-03-29 | Cephalon Australia Pty Ltd | Anti-il-12/il-23 antibodies. |
RU2547595C2 (en) | 2008-08-18 | 2015-04-10 | Пфайзер Инк | Anti-ccr2 antibodies |
CA2736799A1 (en) | 2008-08-25 | 2010-03-11 | Burnham Institute For Medical Research | Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use |
PE20110593A1 (en) | 2008-09-03 | 2011-09-10 | Genentech Inc | MULTI-SPECIFIC ANTIBODIES |
CN102282172B (en) | 2008-09-07 | 2014-02-19 | 台湾醣联生技医药股份有限公司 | Anti-extended type i glycosphingolipid antibody, derivatives thereof and use |
WO2010032060A1 (en) | 2008-09-19 | 2010-03-25 | Medimmune Llc | Antibodies directed to dll4 and uses thereof |
EP2344180A2 (en) | 2008-09-23 | 2011-07-20 | Wyeth LLC | Methods for predicting production of activating signals by cross-linked binding proteins |
KR101826224B1 (en) | 2008-09-30 | 2018-02-06 | 아블렉시스, 엘엘씨 | Non-human mammals for the production of chimeric antibodies |
KR20110069144A (en) | 2008-10-09 | 2011-06-22 | 미네르바 바이오테크놀로지 코포레이션 | Method for inducing pluripotency in cells |
AU2009303453B2 (en) | 2008-10-14 | 2015-02-26 | Dyax Corp. | Use of IGF-II/IGF-IIE binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis |
CN110317272A (en) | 2008-10-14 | 2019-10-11 | 霍夫曼-拉罗奇有限公司 | Immunoglobulin variants and application thereof |
US20120251502A1 (en) | 2008-10-24 | 2012-10-04 | The Government of the US as Represented by the Secretary of the Dept. of health | Human Ebola Virus Species and Compositions and Methods Thereof |
EP2348827B1 (en) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunocompromised ungulates |
CN102271707B (en) | 2008-10-29 | 2015-04-08 | 阿布林克斯公司 | Formulations of single domain antigen binding molecules |
JP6113404B2 (en) | 2008-10-29 | 2017-04-12 | アブリンクス エン.ヴェー. | Purification method of single domain antigen binding molecule |
US8642280B2 (en) | 2008-11-07 | 2014-02-04 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Teneurin and cancer |
HRP20230167T1 (en) | 2008-11-10 | 2023-03-31 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
EP2191843A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
EP2191842A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
SG10201708690SA (en) | 2008-12-09 | 2017-12-28 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
DK2370466T3 (en) | 2008-12-19 | 2015-08-03 | Univ Zuerich | Humane anti-alpha-synuclein-autoantistoffer |
CN106220734A (en) | 2008-12-19 | 2016-12-14 | 宏观基因有限公司 | Covalent diabodies and application thereof |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
WO2010073972A1 (en) | 2008-12-22 | 2010-07-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Method for obtaining pancreatic progenitor cell using neph3 |
JP2012513194A (en) | 2008-12-23 | 2012-06-14 | アストラゼネカ アクチボラグ | Targeted binding agents directed to α5β1 and uses thereof |
KR20170143025A (en) | 2008-12-23 | 2017-12-28 | 제넨테크, 인크. | Immunoglobulin variants with altered binding to protein a |
SG172427A1 (en) | 2008-12-26 | 2011-07-28 | Univ Tokyo | Diagnosis and treatment of cancer using anti-lgr7 antibody |
WO2010078526A1 (en) | 2008-12-31 | 2010-07-08 | Biogen Idec Ma Inc. | Anti-lymphotoxin antibodies |
EP2387584A1 (en) | 2009-01-14 | 2011-11-23 | IQ Therapeutics BV | Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins |
WO2010085510A1 (en) | 2009-01-20 | 2010-07-29 | Zadeh Homayoun H | Antibody mediated osseous regeneration |
WO2010087927A2 (en) | 2009-02-02 | 2010-08-05 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
US9085795B2 (en) | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
US8309530B2 (en) | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
EP2396035A4 (en) | 2009-02-12 | 2012-09-12 | Human Genome Sciences Inc | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
TWI541021B (en) | 2009-03-05 | 2016-07-11 | 艾伯維有限公司 | Il-17 binding proteins |
EP2405920A1 (en) | 2009-03-06 | 2012-01-18 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Novel therapy for anxiety |
JP2010210772A (en) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | Method of manufacturing liquid crystal display device |
MA33198B1 (en) | 2009-03-20 | 2012-04-02 | Genentech Inc | ANTI-HER DI-SPECIFIC ANTIBODIES |
EP2411412B1 (en) | 2009-03-24 | 2015-05-27 | Teva Biopharmaceuticals USA, Inc. | Humanized antibodies against light and uses thereof |
AU2010234849B2 (en) | 2009-03-30 | 2017-06-22 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
CA2752908A1 (en) | 2009-04-01 | 2010-10-07 | Genentech, Inc. | Treatment of insulin-resistant disorders |
US20100297127A1 (en) | 2009-04-08 | 2010-11-25 | Ghilardi Nico P | Use of il-27 antagonists to treat lupus |
US8647623B2 (en) | 2009-04-10 | 2014-02-11 | Kyowa Hakko Kirin Co., Ltd | Method for treatment of blood tumor using anti-TIM-3 antibody |
EP2241323A1 (en) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W and brain cancers |
RU2595379C2 (en) | 2009-04-16 | 2016-08-27 | АббВай Биотерапеутикс Инк. | ANTIBODIES AGAINST TNF-α AND USE THEREOF |
CN102459335B (en) | 2009-04-17 | 2015-11-25 | 伊缪纳斯制药株式会社 | Antibody of specific binding A beta oligomers and uses thereof |
BRPI1011394A8 (en) | 2009-04-18 | 2018-06-26 | Genentech Inc | method for assessing B cell linforma responsiveness to anti-cd40 antibody treatment |
CN102459342B (en) | 2009-04-27 | 2015-01-07 | 协和发酵麒麟株式会社 | Anti-il-3ra antibody for use in treatment of blood tumor |
CA2757638C (en) | 2009-04-29 | 2017-06-27 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Erg monoclonal antibodies |
CN102753579A (en) | 2009-05-01 | 2012-10-24 | 国立大学法人东京大学 | Anti-cadherin antibody |
AU2010244142B2 (en) | 2009-05-05 | 2016-07-21 | Novimmune Sa | Anti-IL-17F antibodies and methods of use thereof |
AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
JP5808052B2 (en) | 2009-05-29 | 2015-11-10 | 中外製薬株式会社 | Pharmaceutical composition comprising antagonist of EGF family ligand as ingredient |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
SG177265A1 (en) | 2009-06-17 | 2012-02-28 | Abbott Biotherapeutics Corp | Anti-vegf antibodies and their uses |
JP5918129B2 (en) | 2009-06-22 | 2016-05-18 | メディミューン,エルエルシー | Engineered Fc region for site-specific conjugation |
WO2011006001A1 (en) | 2009-07-09 | 2011-01-13 | Genentech, Inc. | Animal model for the evaluation of adjuvant therapies of cancer |
EP2451487A1 (en) | 2009-07-09 | 2012-05-16 | F. Hoffmann-La Roche AG | In vivi tumor vasculature imaging |
AU2010273585B2 (en) | 2009-07-13 | 2015-04-23 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2011014504A1 (en) | 2009-07-27 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza virus vectors and uses thereof |
TW201106972A (en) | 2009-07-27 | 2011-03-01 | Genentech Inc | Combination treatments |
CA2805505C (en) | 2009-07-30 | 2021-08-03 | Mount Sinai School Of Medecine | Chimeric influenza viruses having reduced ability to reassort with other influenza viruses and uses thereof |
NZ598127A (en) | 2009-07-31 | 2014-03-28 | Shin Maeda | Cancer metastasis inhibitor |
SG178177A1 (en) | 2009-07-31 | 2012-03-29 | Genentech Inc | Inhibition of tumor metastasis using bv8- or g-csf-antagonists |
AU2010280981B2 (en) | 2009-08-05 | 2016-01-28 | Nexigen Gmbh | Human HCV-interacting proteins and methods of use |
US8613924B2 (en) | 2009-08-06 | 2013-12-24 | Immunas Pharma, Inc. | Antibodies that specifically bind to A beta oligomers and use thereof |
EP2462161B1 (en) | 2009-08-06 | 2017-03-08 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
US20110039300A1 (en) | 2009-08-10 | 2011-02-17 | Robert Bayer | Antibodies with enhanced adcc functions |
LT2464725T (en) | 2009-08-11 | 2020-06-10 | F. Hoffmann-La Roche Ag | Production of proteins in glutamine-free cell culture media |
KR101778317B1 (en) | 2009-08-13 | 2017-09-13 | 얀센 백신스 앤드 프리벤션 비.브이. | Antibodies against human respiratory syncytial virus(rsv) and methods of use |
MX2012001716A (en) | 2009-08-14 | 2012-04-02 | Genentech Inc | Biological markers for monitoring patient response to vegf antagonists. |
WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
WO2011021381A1 (en) | 2009-08-17 | 2011-02-24 | 株式会社未来創薬研究所 | Pharmaceutical composition containing anti-hb-egf antibody as active ingredient |
WO2011024114A1 (en) | 2009-08-25 | 2011-03-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Targeting extracellular matrix molecules for the treatment of cancer |
EP2292266A1 (en) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Treating cancer by modulating copine III |
CN105131112A (en) | 2009-08-29 | 2015-12-09 | Abbvie公司 | Therapeutic dll4 binding proteins |
WO2011028811A2 (en) | 2009-09-01 | 2011-03-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
DK2473522T3 (en) | 2009-09-02 | 2016-11-28 | Genentech Inc | Smoothened MUTANT AND METHODS OF USING THE SAME |
MX353186B (en) | 2009-09-03 | 2018-01-05 | Genentech Inc | Methods for treating, diagnosing, and monitoring rheumatoid arthritis. |
CA2773662A1 (en) | 2009-09-11 | 2011-03-17 | Genentech, Inc. | Method to identify a patient with an increased likelihood of responding to an anti-cancer agent |
TW201127400A (en) | 2009-09-14 | 2011-08-16 | Abbott Lab | Methods for treating psoriasis |
ES2530732T3 (en) | 2009-09-17 | 2015-03-05 | Hoffmann La Roche | Diagnostic procedures for lung cancer |
EP2480573A1 (en) | 2009-09-22 | 2012-08-01 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
TW201118166A (en) | 2009-09-24 | 2011-06-01 | Chugai Pharmaceutical Co Ltd | HLA class I-recognizing antibodies |
US8926976B2 (en) | 2009-09-25 | 2015-01-06 | Xoma Technology Ltd. | Modulators |
EP2480888B1 (en) | 2009-09-25 | 2016-11-30 | XOMA Technology Ltd. | Screening methods |
EP2305285A1 (en) | 2009-09-29 | 2011-04-06 | Julius-Maximilians-Universität Würzburg | Means and methods for treating ischemic conditions |
ES2580229T3 (en) | 2009-09-30 | 2016-08-22 | F. Hoffmann-La Roche Ag | Anti-Notch3 antagonist antibodies for the treatment of a T-lymphocyte leukemia positive for a gamma-secretase inhibitor that does not respond to an anti-Notch1 antagonist antibody |
AR078470A1 (en) | 2009-10-02 | 2011-11-09 | Sanofi Aventis | ANTIBODIES THAT SPECIFICALLY JOIN THE EPHA2 RECEIVER |
EP2486152B1 (en) | 2009-10-07 | 2017-12-06 | F. Hoffmann-La Roche AG | Methods for diagnosing lupus |
EP2486141B1 (en) | 2009-10-07 | 2018-01-10 | MacroGenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
CA2776756A1 (en) | 2009-10-11 | 2011-04-14 | Biogen Idec Ma Inc. | Anti-vla-4 related assays |
CN102666875A (en) | 2009-10-15 | 2012-09-12 | 雅培制药有限公司 | Dual variable domain immunoglobulins and uses thereof |
WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
DK2494356T3 (en) | 2009-10-26 | 2017-05-15 | Genentech Inc | ASSAYS FOR THE DETECTION OF ANTIBODIES SPECIFIC TO THERAPEUTIC ANTI-IGE ANTIBODIES AND THEIR USE OF ANAPHYLAXY |
WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
TW201122101A (en) | 2009-10-28 | 2011-07-01 | Facet Biotech Corp | Anti-EGFR antibodies and their uses |
UY32979A (en) | 2009-10-28 | 2011-02-28 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
US20120213801A1 (en) | 2009-10-30 | 2012-08-23 | Ekaterina Gresko | Phosphorylated Twist1 and cancer |
US8420083B2 (en) | 2009-10-31 | 2013-04-16 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
WO2011060015A1 (en) | 2009-11-11 | 2011-05-19 | Genentech, Inc. | Methods and compositions for detecting target proteins |
CN105999263B (en) | 2009-11-13 | 2021-06-29 | 第一三共欧洲有限公司 | Materials and methods for treating or preventing human epidermal growth factor receptor-3 (HER-3) related diseases |
EP3037435B1 (en) | 2009-11-17 | 2019-08-07 | MUSC Foundation for Research Development | Human monoclonal antibodies to human nucleolin |
NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
AU2010329955A1 (en) | 2009-12-08 | 2012-05-24 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the RGM A protein for use in the treatment of retinal nerve fiber layer degeneration |
TWI505836B (en) | 2009-12-11 | 2015-11-01 | Genentech Inc | Anti-vegf-c antibodies and methods using same |
ES2594893T3 (en) | 2009-12-16 | 2016-12-23 | Abbvie Biotherapeutics Inc. | Anti HER2 antibodies and their uses |
SG181834A1 (en) | 2009-12-21 | 2012-07-30 | Genentech Inc | Antibody formulation |
PL2516465T3 (en) | 2009-12-23 | 2016-11-30 | Anti-bv8 antibodies and uses thereof | |
EP2521568B1 (en) | 2010-01-06 | 2018-07-25 | Dyax Corp. | Plasma kallikrein binding proteins |
CN102906115A (en) | 2010-01-11 | 2013-01-30 | 阿雷克森制药公司 | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
TWI505838B (en) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody |
US8685524B2 (en) | 2010-01-29 | 2014-04-01 | Toray Industries, Inc. | Polylactic acid-based resin sheet |
US8815211B2 (en) | 2010-02-10 | 2014-08-26 | Fujifilm Ri Pharma Co., Ltd. | Radioactive metal-labeled anti-cadherin antibody |
RU2573994C2 (en) | 2010-02-10 | 2016-01-27 | Иммьюноджен, Инк | Anti-cd20 antibodies and thereof application |
US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
CN102985441B (en) | 2010-02-19 | 2015-04-22 | 俄克拉何马大学董事会 | Monoclonal antibodies that inhibit the Wnt signaling pathway and methods of production and use thereof |
KR20180044441A (en) | 2010-03-02 | 2018-05-02 | 애브비 인코포레이티드 | Therapeutic dll4 binding proteins |
WO2011108714A1 (en) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | Antibody constant region variant |
EP2542578A1 (en) | 2010-03-05 | 2013-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Smoc1, tenascin-c and brain cancers |
WO2011123495A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
TWI667346B (en) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | Antibodies with modified affinity to fcrn that promote antigen clearance |
EP3248462B1 (en) | 2010-03-31 | 2024-03-13 | Ablexis, LLC | Genetic engineering of mice for the production of chimeric antibodies |
WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
JP6002659B2 (en) | 2010-04-13 | 2016-10-05 | セルデックス・セラピューティクス・インコーポレイテッド | Antibodies that bind to human CD27 and uses thereof |
WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
DK3466977T3 (en) | 2010-04-16 | 2022-04-11 | Biogen Ma Inc | Anti-vla-4-antistoffer |
EP2561076A1 (en) | 2010-04-19 | 2013-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulating xrn1 |
WO2011133931A1 (en) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Use of il-27 antagonists for treating inflammatory bowel disease |
PL2563813T3 (en) | 2010-04-30 | 2016-01-29 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
IL208820A0 (en) | 2010-10-19 | 2011-01-31 | Rachel Teitelbaum | Biologic female contraceptives |
EP2568976B1 (en) | 2010-05-10 | 2015-09-30 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
WO2011141823A2 (en) | 2010-05-14 | 2011-11-17 | Orega Biotech | Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists |
LT2571532T (en) | 2010-05-14 | 2017-08-10 | Abbvie Inc. | Il-1 binding proteins |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
ES2932398T3 (en) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Antitumor T cell response enhancer |
JP5904552B2 (en) | 2010-05-28 | 2016-04-13 | 国立研究開発法人国立がん研究センター | Pancreatic cancer treatment |
EP2575882B1 (en) | 2010-06-02 | 2017-11-01 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
AU2011261362B2 (en) | 2010-06-03 | 2016-06-09 | Genentech, Inc. | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
US20130089538A1 (en) | 2010-06-10 | 2013-04-11 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute forBiomedical Researh | Treating cancer by modulating mammalian sterile 20-like kinase 3 |
DK3323830T3 (en) | 2010-06-19 | 2023-09-25 | Memorial Sloan Kettering Cancer Center | ANTI-GD2 ANTIBODIES |
MX2012014975A (en) | 2010-06-22 | 2013-03-12 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3. |
CN103068400A (en) | 2010-06-25 | 2013-04-24 | 阿斯顿大学 | Glycoproteins having lipid mobilizing properties and therapeutic uses thereof |
US20120009196A1 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
UY33492A (en) | 2010-07-09 | 2012-01-31 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
TWI627964B (en) | 2010-07-09 | 2018-07-01 | 傑森疫苗防護公司 | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
CN108314733A (en) | 2010-07-16 | 2018-07-24 | 埃博灵克斯股份有限公司 | The single domain antigen binding molecules of modification and its application |
SG187119A1 (en) | 2010-07-19 | 2013-02-28 | Hoffmann La Roche | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
KR20130126576A (en) | 2010-07-19 | 2013-11-20 | 에프. 호프만-라 로슈 아게 | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
DK2598526T3 (en) | 2010-07-29 | 2018-11-19 | Eleven Biotherapeutics Inc | CHEMICAL IL-1 RECEPTOR TYPE-I AGONISTS AND ANTAGONISTS |
EP2601216B1 (en) | 2010-08-02 | 2018-01-03 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
PE20131412A1 (en) | 2010-08-03 | 2014-01-19 | Abbvie Inc | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
AU2011286407A1 (en) | 2010-08-06 | 2013-02-21 | Amgen | Use of HER3 binding agents in prostate treatment |
EP2420250A1 (en) | 2010-08-13 | 2012-02-22 | Universitätsklinikum Münster | Anti-Syndecan-4 antibodies |
CA2808187A1 (en) | 2010-08-14 | 2012-02-23 | Abbvie Inc. | Amyloid-beta binding proteins |
PT3333188T (en) | 2010-08-19 | 2022-03-28 | Zoetis Belgium S A | Anti-ngf antibodies and their use |
TW201211252A (en) | 2010-08-26 | 2012-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
US9034333B2 (en) | 2010-08-27 | 2015-05-19 | University Of Zurich | Method for target and drug validation in inflammatory and/or cardiovascular diseases |
WO2012028697A1 (en) | 2010-09-01 | 2012-03-08 | Eth Zürich, Institute Of Molecular Biology And Biophysics | Affinity purification system based on donor strand complementation |
WO2012032143A1 (en) | 2010-09-10 | 2012-03-15 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Phosphorylated twist1 and metastasis |
PT2616090T (en) | 2010-09-17 | 2023-10-16 | Takeda Pharmaceuticals Co | Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph |
AU2011312205B2 (en) | 2010-10-05 | 2015-08-13 | Curis, Inc. | Mutant smoothened and methods of using the same |
EA031698B1 (en) | 2010-10-11 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Human anti-tau antibodies |
CN103561759B (en) | 2010-10-22 | 2016-10-12 | 西雅图遗传学公司 | Based on the synergism between antibody drug conjugate and the PI3K-AKT mTOR pathway inhibitor of statin in Austria (AURISTATIN) |
AU2011323784A1 (en) | 2010-10-25 | 2013-05-30 | Regents Of The University Of Minnesota | Therapeutic composition for treatment of glioblastoma |
US9328160B2 (en) | 2010-10-29 | 2016-05-03 | Perseus Proteomics Inc. | Anti-CDH3 antibody having high internalization capacity |
US20140093506A1 (en) | 2010-11-15 | 2014-04-03 | Marc Buehler | Anti-fungal-agents |
PT2644698T (en) | 2010-11-17 | 2018-01-31 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
CN103429737B (en) | 2010-11-30 | 2020-07-14 | 中外制药株式会社 | Cytotoxic induction therapeutic agent |
KR102385507B1 (en) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
UA112170C2 (en) | 2010-12-10 | 2016-08-10 | Санофі | ANTI-TUMOR COMBINATION CONTAINING AN ANTIBODY SPECIFICALLY RECOGNIZING CD38 AND BORTESOMB |
CN103380145B (en) | 2010-12-17 | 2016-10-12 | 生物控股有限公司 | The mankind's anti-SOD1 antibody |
PE20141060A1 (en) | 2010-12-21 | 2014-09-26 | Abbvie Inc | IL-1 ALPHA AND BETA DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND THEIR USE |
EP3222635A1 (en) | 2010-12-21 | 2017-09-27 | Selexys Pharmaceuticals Corporation | Anti-p-selectin antibodies and methods of their use and identification |
US20120275996A1 (en) | 2010-12-21 | 2012-11-01 | Abbott Laboratories | IL-1 Binding Proteins |
ES2720136T3 (en) | 2010-12-22 | 2019-07-18 | Teva Pharmaceuticals Australia Pty Ltd | Modified antibody with improved half-life |
CA2822969C (en) | 2010-12-31 | 2018-03-13 | Jay M. Short | Comprehensive monoclonal antibody generation |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
US20120171195A1 (en) | 2011-01-03 | 2012-07-05 | Ravindranath Mepur H | Anti-hla-e antibodies, therapeutic immunomodulatory antibodies to human hla-e heavy chain, useful as ivig mimetics and methods of their use |
JP2014506448A (en) | 2011-01-19 | 2014-03-17 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Binding proteins for inhibitors of clotting factors |
SG10201600531TA (en) | 2011-01-24 | 2016-02-26 | Univ Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
WO2012103240A2 (en) | 2011-01-25 | 2012-08-02 | Eleven Biotherapeutics, Inc. | Receptor binding agents |
US9540443B2 (en) | 2011-01-26 | 2017-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
WO2012104824A1 (en) | 2011-02-04 | 2012-08-09 | Ecole polytechnique fédérale de Lausanne (EPFL) | Therapeutic antibodies targeting app-c99 |
WO2012113775A1 (en) | 2011-02-21 | 2012-08-30 | University Of Zurich | Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders |
US20140093496A1 (en) | 2011-02-25 | 2014-04-03 | Chugai Seiyaku Kabushiki Kaisha | Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY |
RU2013140975A (en) | 2011-02-28 | 2015-04-10 | Дженентек, Инк. | BIOLOGICAL MARKERS AND METHODS FOR PREDICTING SUSCEPTIBILITY TO B-CELL ANTAGONISTS |
AR085911A1 (en) | 2011-03-16 | 2013-11-06 | Sanofi Sa | SAFE THERAPEUTIC DOSE OF A SIMILAR PROTEIN TO AN ANTIBODY WITH VUAL REGION |
EP2500073A1 (en) | 2011-03-17 | 2012-09-19 | ChromaCon AG | Method for identification and purification of multi-specific polypeptides |
CA2830628A1 (en) | 2011-03-18 | 2012-09-27 | Kagoshima University | Composition for treatment and diagnosis of pancreatic cancer |
WO2012129520A1 (en) | 2011-03-24 | 2012-09-27 | Texas Tech University System | Tcr mimic antibodies as vascular targeting tools |
JP6130350B2 (en) | 2011-03-30 | 2017-05-17 | アブリンクス エン.ヴェー. | Methods of treating immune disorders with single domain antibodies against TNFα |
EP3825325A3 (en) | 2011-03-30 | 2021-10-13 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
CA2834734A1 (en) | 2011-04-04 | 2012-10-11 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
AU2012239997A1 (en) | 2011-04-07 | 2013-10-17 | Amgen Inc. | Novel EGFR binding proteins |
US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
HUE037651T2 (en) | 2011-04-20 | 2018-09-28 | Medimmune Llc | Antibodies and other molecules that bind b7-h1 and pd-1 |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
JOP20200043A1 (en) | 2011-05-10 | 2017-06-16 | Amgen Inc | Methods of treating or preventing cholesterol related disorders |
CN107903325B (en) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | Multispecific FAB fusion proteins and methods of use thereof |
AU2012259162C1 (en) | 2011-05-21 | 2020-05-21 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
CA2837169C (en) | 2011-05-24 | 2021-11-09 | Zyngenia, Inc. | Multispecific complexes comprising angiopoietin-2-binding peptide and their uses |
AR086543A1 (en) | 2011-05-25 | 2014-01-08 | Bg Medicine Inc | GALECTIN-3 INHIBITORS AND METHODS OF USE OF THE SAME, PHARMACEUTICAL COMPOSITION |
EP2530088A1 (en) | 2011-05-30 | 2012-12-05 | Klinikum rechts der Isar der Technischen Universität München | Means and methods for diagnosing and treating multiple sclerosis |
CN103619353B (en) | 2011-06-02 | 2016-01-06 | 戴埃克斯有限公司 | Fc receptor binding protein |
SG10201902706VA (en) | 2011-06-03 | 2019-04-29 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
WO2012170071A1 (en) | 2011-06-06 | 2012-12-13 | Elan Pharmaceuticas, Inc | Mcam antagonists and methods of treatment |
WO2012168259A1 (en) | 2011-06-06 | 2012-12-13 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
US9561274B2 (en) | 2011-06-07 | 2017-02-07 | University Of Hawaii | Treatment and prevention of cancer with HMGB1 antagonists |
WO2012170740A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
KR102111171B1 (en) | 2011-06-10 | 2020-05-14 | 메디뮨 엘엘씨 | Anti-pseudomonas psl binding molecules and uses thereof |
US20140120555A1 (en) | 2011-06-20 | 2014-05-01 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer |
BR112013033258B1 (en) | 2011-06-23 | 2022-09-20 | University Of Zurich | ISOLATED ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF WHICH BINDS ALPHASINUCLEIN, COMPOSITION AND ITS USES |
RU2641256C2 (en) | 2011-06-30 | 2018-01-16 | Чугаи Сейяку Кабусики Кайся | Heterodimerizated polypeptide |
JP2013040160A (en) | 2011-07-01 | 2013-02-28 | Genentech Inc | Use of anti-cd83 agonist antibody for treating autoimmune disease |
DE202011103324U1 (en) | 2011-07-12 | 2012-01-02 | Nekonal S.A.R.L. | Therapeutic anti-TIRC7 antibodies for use in immune and other diseases |
AU2012283039A1 (en) | 2011-07-13 | 2014-01-30 | Abbvie Inc. | Methods and compositions for treating asthma using anti-IL-13 antibodies |
US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
PE20190262A1 (en) | 2011-08-01 | 2019-02-25 | Genentech Inc | METHODS FOR TREATING CANCER BY USE OF PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS |
WO2013017656A1 (en) | 2011-08-02 | 2013-02-07 | Medizinische Universität Wien | Antagonists of ribonucleases for treating obesity |
EP2739652B1 (en) | 2011-08-04 | 2017-04-05 | Medizinische Universität Innsbruck | Cahgt1p inhibitors for use in the treatment of candidiasis |
JP6120848B2 (en) | 2011-08-15 | 2017-04-26 | メディミューン,エルエルシー | Anti-B7-H4 antibody and use thereof |
RU2014109985A (en) | 2011-08-17 | 2015-09-27 | Дженентек, Инк. | INHIBITION OF ANGIOGENESIS IN REFRACTOR TUMORS |
WO2013027802A1 (en) | 2011-08-23 | 2013-02-28 | 中外製薬株式会社 | Novel anti-ddr1 antibody having anti-tumor activity |
US9447192B2 (en) | 2011-09-09 | 2016-09-20 | Medimmune Limited | Anti-Siglec-15 antibodies and uses thereof |
EP4241785A3 (en) | 2011-09-20 | 2023-09-27 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
KR101720394B1 (en) | 2011-09-21 | 2017-03-27 | 후지레비오 가부시키가이샤 | Antibody against affinity complex |
WO2013041687A1 (en) | 2011-09-23 | 2013-03-28 | Amgen Research (Munich) Gmbh | Bispecific binding molecules for 5t4 and cd3 |
CA2850322C (en) | 2011-09-30 | 2023-10-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule inducing immune response to target antigen |
CA3186007A1 (en) | 2011-09-30 | 2013-04-04 | Chugai Seiyaku Kabushiki Kaisha | Ion concentration-dependent binding molecule library |
WO2013047748A1 (en) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
TW201817745A (en) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance |
US20140335089A1 (en) | 2011-09-30 | 2014-11-13 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting elimination of antigens |
US20140248294A1 (en) | 2011-10-05 | 2014-09-04 | University Of Bremen | Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases |
US9663573B2 (en) | 2011-10-05 | 2017-05-30 | Genentech, Inc. | Methods of treating liver conditions using Notch2 antagonists |
US20150299313A1 (en) | 2011-10-05 | 2015-10-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain |
US10132806B2 (en) | 2011-10-21 | 2018-11-20 | Augurex Life Sciences Corp. | Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis |
AR088512A1 (en) | 2011-10-24 | 2014-06-18 | Abbvie Inc | ANTIBODIES DIRECTED AGAINST TNF |
TW201323440A (en) | 2011-10-24 | 2013-06-16 | Abbvie Inc | Immunobinders directed against sclerostin |
US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
CN109078182B (en) | 2011-10-31 | 2022-08-12 | 弗·哈夫曼-拉罗切有限公司 | Antibody formulations |
CN104011207B (en) | 2011-10-31 | 2018-09-18 | 中外制药株式会社 | Control the antigen binding molecules of the association of heavy chain and light chain |
EP2773664A1 (en) | 2011-11-01 | 2014-09-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
EP2773667A1 (en) | 2011-11-01 | 2014-09-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
AU2012332587B2 (en) | 2011-11-01 | 2017-02-23 | Bionomics, Inc. | Antibodies and methods of treating cancer |
AU2012332588B2 (en) | 2011-11-01 | 2017-09-07 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
US9422351B2 (en) | 2011-11-03 | 2016-08-23 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
CN104271599A (en) | 2011-11-08 | 2015-01-07 | 辉瑞公司 | Methods of treating inflammatory disorders using anti-M-CSF antibodies |
US20140294732A1 (en) | 2011-11-08 | 2014-10-02 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute | Early diagnostic of neurodegenerative diseases |
US20140323549A1 (en) | 2011-11-08 | 2014-10-30 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
TWI679212B (en) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | Binding molecules for e3 of bcma and cd3 |
PE20141937A1 (en) | 2011-11-16 | 2014-12-18 | Amgen Inc | METHODS TO TREAT DISORDERS RELATED TO MUTANT VIII OF ELIMINATION OF EPIDERMAL GROWTH FACTOR |
SG11201402603WA (en) | 2011-11-28 | 2014-06-27 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
KR20140100532A (en) | 2011-11-30 | 2014-08-14 | 추가이 세이야쿠 가부시키가이샤 | Drug containing carrier into cell for forming immune complex |
ES2684950T3 (en) | 2011-12-08 | 2018-10-05 | Biotest Ag | Uses of immunoconjugates directed to CD138 |
EP2602621A1 (en) | 2011-12-08 | 2013-06-12 | Julius-Maximilians-Universität Würzburg | LASP-1, a novel urinary marker for transitional cell carcinoma detection |
EP2791173B1 (en) | 2011-12-14 | 2020-07-29 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
EP2791175A2 (en) | 2011-12-14 | 2014-10-22 | Abbvie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
CN104144946A (en) | 2011-12-19 | 2014-11-12 | 爱克索马美国有限责任公司 | Methods for treating acne |
EP3539982A3 (en) | 2011-12-23 | 2020-01-15 | Pfizer Inc | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
US20150030602A1 (en) | 2011-12-23 | 2015-01-29 | Phenoquest Ag | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
DK2797951T3 (en) | 2011-12-28 | 2018-03-12 | Immunoqure Ag | PROCEDURE FOR ISOLATING HUMAN ANTIBODIES. |
TWI593705B (en) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
TW201333035A (en) | 2011-12-30 | 2013-08-16 | Abbvie Inc | Dual specific binding proteins directed against IL-13 and/or IL-17 |
EP2800583A1 (en) | 2012-01-02 | 2014-11-12 | Novartis AG | Cdcp1 and breast cancer |
CN104411717A (en) | 2012-01-09 | 2015-03-11 | 斯克利普斯研究所 | Humanized antibodies with ultralong CDR3S |
AU2013208003B2 (en) | 2012-01-09 | 2017-12-14 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
US20130177574A1 (en) | 2012-01-11 | 2013-07-11 | Paul I. Terasaki Foundation Laboratory | ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE |
US10800847B2 (en) | 2012-01-11 | 2020-10-13 | Dr. Mepur Ravindranath | Anti-HLA class-IB antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (IVIG) useful as therapeutic IVIG mimetics and methods of their use |
AU2013207778B2 (en) | 2012-01-13 | 2017-10-12 | Genentech, Inc. | Biological markers for identifying patients for treatment with VEGF antagonists |
CN104471064B (en) | 2012-01-20 | 2018-11-02 | 中华人民共和国香港特别行政区政府 | Paramyxovirus and application thereof |
KR102129234B1 (en) | 2012-01-27 | 2020-07-02 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | Composition and method for the diagnosis and treatment of disease associated with neurite degeneration |
TW201334789A (en) | 2012-01-31 | 2013-09-01 | Genentech Inc | Anti-IgE antibodies and methods using same |
CN111533804A (en) | 2012-02-06 | 2020-08-14 | 印希彼有限公司 | CD47 antibodies and methods of use thereof |
JP6226752B2 (en) | 2012-02-09 | 2017-11-08 | 中外製薬株式会社 | Modified Fc region of antibody |
EP2812702B1 (en) | 2012-02-10 | 2019-04-17 | Seattle Genetics, Inc. | Diagnosis and management of CD30-expressing cancers |
DK2814844T3 (en) | 2012-02-15 | 2017-11-13 | Novo Nordisk As | ANTIBODIES THAT BIND AND BLOCK TRACTOR RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1) |
RS57827B1 (en) | 2012-02-15 | 2018-12-31 | Novo Nordisk As | Antibodies that bind peptidoglycan recognition protein 1 |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
CN104271122A (en) | 2012-02-16 | 2015-01-07 | 桑塔鲁斯股份有限公司 | Anti-vla1 (cd49a) antibody pharmaceutical compositions |
SG10201805584YA (en) | 2012-02-24 | 2018-08-30 | Chugai Pharmaceutical Co Ltd | ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB |
JP6407726B2 (en) | 2012-03-01 | 2018-10-24 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH | Long-life polypeptide binding molecule |
RU2014141536A (en) | 2012-03-16 | 2016-05-10 | Регенерон Фармасьютикалз, Инк. | MICE WHICH PRODUCE ANTIGEN-BINDING PROTEINS WITH PH-DEPENDENT BINDING CHARACTERISTICS |
RS57118B1 (en) | 2012-03-16 | 2018-06-29 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
LT2825037T (en) | 2012-03-16 | 2019-08-12 | Regeneron Pharmaceuticals, Inc. | Rodents expressing ph-sensitive immunoglobulin sequences |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
WO2013148232A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
AU2013240261A1 (en) | 2012-03-27 | 2014-09-18 | Genentech, Inc. | Diagnosis and treatments relating to HER3 inhibitors |
WO2013144240A1 (en) | 2012-03-29 | 2013-10-03 | Friedrich Miescher Institute For Biomedical Research | Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer |
DK2831117T3 (en) | 2012-03-29 | 2017-12-18 | Novimmune Sa | ANTI-TLR4 ANTIBODIES AND APPLICATIONS THEREOF |
JP6280031B2 (en) | 2012-03-29 | 2018-02-14 | 中外製薬株式会社 | Anti-LAMP5 antibody and use thereof |
CA2867588A1 (en) | 2012-03-30 | 2013-10-03 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2013151649A1 (en) | 2012-04-04 | 2013-10-10 | Sialix Inc | Glycan-interacting compounds |
CA2869704A1 (en) | 2012-04-04 | 2013-10-10 | Perseus Proteomics Inc. | Drug conjugate comprising anti-cdh3 (pcadherin) antibody |
EP2836514A4 (en) | 2012-04-13 | 2015-12-30 | Childrens Medical Center | Tiki inhibitors |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
US9480449B2 (en) | 2012-05-03 | 2016-11-01 | Fibrogen, Inc. | Methods for treating idiopathic pulmonary fibrosis |
EA039663B1 (en) | 2012-05-03 | 2022-02-24 | Амген Инк. | Use of an anti-pcsk9 antibody for lowering serum cholesterol ldl and treating cholesterol related disorders |
WO2013166290A1 (en) | 2012-05-04 | 2013-11-07 | Abbvie Biotherapeutics Inc. | P21 biomarker assay |
CA2871751C (en) | 2012-05-04 | 2021-08-24 | Dana-Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
EA030716B1 (en) | 2012-05-14 | 2018-09-28 | Байоджен Ма Инк. | Lingo-2 antagonists for treatment of conditions involving motor neurons |
CN104302177B (en) | 2012-05-17 | 2019-05-28 | 延伸生物科学股份有限公司 | Carrier for improved drug delivery |
WO2013177386A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US20150353630A1 (en) | 2012-05-30 | 2015-12-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for eliminating aggregated antigens |
DK2857420T3 (en) | 2012-05-30 | 2020-11-23 | Chugai Pharmaceutical Co Ltd | TARGET TISSUE SPECIFIC ANTIGIN BINDING MOLECULE |
SG11201407859YA (en) | 2012-05-31 | 2014-12-30 | Genentech Inc | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
JP6628966B2 (en) | 2012-06-14 | 2020-01-15 | 中外製薬株式会社 | Antigen binding molecule containing an altered Fc region |
JP6433889B2 (en) | 2012-06-15 | 2018-12-05 | ファイザー・インク | Improved antagonistic antibodies against GDF-8 and uses thereof |
SG11201408554QA (en) | 2012-06-22 | 2015-02-27 | Cytomx Therapeutics Inc | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
EP2866831A1 (en) | 2012-06-29 | 2015-05-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating diseases by modulating a specific isoform of mkl1 |
EP2870242A1 (en) | 2012-07-05 | 2015-05-13 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
US10656156B2 (en) | 2012-07-05 | 2020-05-19 | Mepur Ravindranath | Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E |
US20150224190A1 (en) | 2012-07-06 | 2015-08-13 | Mohamed Bentires-Alj | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction |
WO2014011955A2 (en) | 2012-07-12 | 2014-01-16 | Abbvie, Inc. | Il-1 binding proteins |
AU2013289971A1 (en) | 2012-07-13 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
EP2888238A4 (en) | 2012-08-21 | 2016-01-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
RU2729831C2 (en) | 2012-08-24 | 2020-08-12 | Чугаи Сейяку Кабусики Кайся | Versions of fcγriib-specific fc-region |
JP6774164B2 (en) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | Mouse FcγRII specific Fc antibody |
EP3718556A3 (en) | 2012-08-31 | 2020-12-30 | University Of Virginia Patent Foundation | Target peptides for immunotherapy and diagnostics |
KR20150046316A (en) | 2012-08-31 | 2015-04-29 | 이뮤노젠 아이엔씨 | Diagnostic assays and kits for detection of folate receptor 1 |
AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
EP2892544A4 (en) | 2012-09-05 | 2016-11-02 | Univ Virginia Patent Found | Target peptides for colorectal cancer therapy and diagnostics |
TWI660972B (en) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | Anti-mcam antibodies and associated methods of use |
EP2898327A1 (en) | 2012-09-19 | 2015-07-29 | Dana-Farber Cancer Institute, Inc. | Dynamic bh3 profiling |
EP2711016A1 (en) | 2012-09-21 | 2014-03-26 | Covagen AG | Novel IL-17A binding molecules and medical uses thereof |
US10689705B2 (en) | 2012-09-27 | 2020-06-23 | Chugai Seiyaku Kabushiki Kaisha | FGFR3 fusion gene and pharmaceutical drug targeting same |
WO2014050926A1 (en) | 2012-09-28 | 2014-04-03 | 中外製薬株式会社 | Method for evaluating blood coagulation reaction |
NO2760138T3 (en) | 2012-10-01 | 2018-08-04 | ||
WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
CA3139031A1 (en) | 2012-10-04 | 2014-04-10 | Dana-Farber Cancer Institute, Inc. | Human monoclonal anti-pd-l1 antibodies and methods of use |
US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
WO2014063205A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
KR20190107184A (en) | 2012-11-01 | 2019-09-18 | 애브비 인코포레이티드 | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
PT2918603T (en) | 2012-11-08 | 2018-10-30 | Univ Miyazaki | Antibody capable of specifically recognizing transferrin receptor |
US20140154255A1 (en) | 2012-11-30 | 2014-06-05 | Abbvie Biotherapeutics Inc. | Anti-vegf antibodies and their uses |
ES2784631T3 (en) | 2012-12-03 | 2020-09-29 | Novimmune Sa | Anti-CD47 antibodies and methods of using them |
US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
UA118255C2 (en) | 2012-12-07 | 2018-12-26 | Санофі | Compositions comprising anti-cd38 antibodies and lenalidomide |
EP3686218A1 (en) | 2012-12-10 | 2020-07-29 | Biogen MA Inc. | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
AU2013359001A1 (en) | 2012-12-13 | 2015-07-23 | The Board Of Regents Of The University Of Oklahoma | Target peptides for ovarian cancer therapy and diagnostics |
ES2929942T3 (en) | 2012-12-18 | 2022-12-05 | Icahn School Med Mount Sinai | Influenza virus vaccines and their uses |
BR112015014063A2 (en) | 2012-12-19 | 2018-10-30 | Amplimmune Inc | human anti-b7-h4 antibodies and their uses. |
EP2935326B1 (en) | 2012-12-21 | 2020-06-10 | Biogen MA Inc. | Human anti-tau antibodies |
EP2935332B1 (en) | 2012-12-21 | 2021-11-10 | MedImmune, LLC | Anti-h7cr antibodies |
US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
EP3517545A1 (en) | 2012-12-31 | 2019-07-31 | Neurimmune Holding AG | Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases |
US10717965B2 (en) | 2013-01-10 | 2020-07-21 | Gloriana Therapeutics, Inc. | Mammalian cell culture-produced neublastin antibodies |
JO3519B1 (en) | 2013-01-25 | 2020-07-05 | Amgen Inc | Antibody constructs for CDH19 and CD3 |
WO2014114801A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Inc. | Antibodies targeting cdh19 for melanoma |
US9834610B2 (en) | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
MX2015010115A (en) | 2013-02-06 | 2016-05-31 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof. |
AR094873A1 (en) | 2013-02-25 | 2015-09-02 | Genentech Inc | METHODS AND COMPOSITIONS TO DETECT AND TREAT MUTANTS OF AKT RESISTANT TO DRUGS |
WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
SI2968467T1 (en) | 2013-03-13 | 2020-11-30 | F. Hoffmann-La Roche Ag | Formulations with reduced oxidation |
CA2906057A1 (en) | 2013-03-13 | 2014-10-02 | Genentech, Inc. | Antibody formulations |
CN107693781B (en) | 2013-03-13 | 2021-11-09 | 巴扎德制药公司 | Chimeric cytokine formulations for ocular delivery |
CA2904630A1 (en) | 2013-03-13 | 2014-10-02 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
AR095399A1 (en) | 2013-03-13 | 2015-10-14 | Genentech Inc | FORMULATIONS WITH REDUCED OXIDATION, METHOD |
US20140314778A1 (en) | 2013-03-13 | 2014-10-23 | Genentech, Inc. | Formulations with reduced oxidation |
PT2968466T (en) | 2013-03-13 | 2018-10-22 | Hoffmann La Roche | Formulations with reduced oxidation |
CN105228649B (en) | 2013-03-14 | 2019-01-18 | 雅培制药有限公司 | HCV Ag-Ab combination measurement is with method and used in composition therein |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9790478B2 (en) | 2013-03-14 | 2017-10-17 | Abbott Laboratories | HCV NS3 recombinant antigens and mutants thereof for improved antibody detection |
EP2970443A4 (en) | 2013-03-14 | 2017-01-11 | Parkash S. Gill | Cancer treatment using antibodies that bind cell surface grp78 |
WO2014159242A1 (en) | 2013-03-14 | 2014-10-02 | Novartis Ag | Notch 3 mutants and uses thereof |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
WO2014159764A1 (en) | 2013-03-14 | 2014-10-02 | Amgen Inc. | Chrdl-1 antigen binding proteins and methods of treatment |
JP6591395B2 (en) | 2013-03-15 | 2019-10-16 | ジェネンテック, インコーポレイテッド | Cell culture compositions containing antioxidants and methods for polypeptide production |
AR095374A1 (en) | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | UNION MOLECULES FOR BCMA AND CD3 |
US9469686B2 (en) | 2013-03-15 | 2016-10-18 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
EP2968508B1 (en) | 2013-03-15 | 2022-04-27 | Sanofi Pasteur Biologics, LLC | Antibodies against clostridium difficile toxins and methods of using the same |
US9822166B2 (en) | 2013-03-15 | 2017-11-21 | Dana-Farber Cancer Institute, Inc. | Flavivirus neutralizing antibodies and methods of use thereof |
AU2014233503A1 (en) | 2013-03-15 | 2015-09-24 | Abbvie Biotechnology Ltd. | Anti-CD25 antibodies and their uses |
WO2014151680A1 (en) | 2013-03-15 | 2014-09-25 | Biogen Idec Ma Inc. | Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies |
BR112015023797A2 (en) | 2013-03-15 | 2017-10-24 | Abbvie Inc | dual specificity binding proteins directed against il-1b and / or il-17 |
US20140377253A1 (en) | 2013-03-15 | 2014-12-25 | Abbvie Biotherapeutics Inc. | Fc variants |
HUE045859T2 (en) | 2013-03-15 | 2020-01-28 | Amgen Res Munich Gmbh | Single chain binding molecules comprising n-terminal abp |
CN105705165B (en) | 2013-03-15 | 2020-04-24 | 纪念斯隆-凯特琳癌症中心 | High affinity anti-GD 2 antibodies |
BR112015023752B1 (en) | 2013-03-15 | 2023-11-14 | Zyngenia, Inc. | MODULAR RECOGNITION DOMAIN (MRD), COMPLEX COMPRISING MRD AND CETUXIMAB, USES OF THE COMPLEX TO INHIBIT ANGIOGENESIS AND TREAT CANCER AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPLEX |
US9505849B2 (en) | 2013-03-15 | 2016-11-29 | Amgen Research (Munich) Gmbh | Antibody constructs for influenza M2 and CD3 |
CA2903589A1 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Cell culture media and methods of antibody production |
BR112015023084A2 (en) | 2013-03-15 | 2017-11-21 | Abbvie Biotechnology Ltd | monoclonal anti-cd25 antibody or anti-cd25 binding fragment of a monoclonal antibody, antibody-drug conjugate, pharmaceutical composition, nucleic acid, vector, prokaryotic and eukaryotic host cell, method for producing an anti-cd25 antibody or binding fragment anti-cd25, and use of a monoclonal anti-cd25 antibody from an antibody-drug conjugate or pharmaceutical composition |
EP3783017A1 (en) | 2013-04-02 | 2021-02-24 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
WO2014165818A2 (en) | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions and methods for preventing and treating prostate cancer |
US20160053023A1 (en) | 2013-04-09 | 2016-02-25 | Annexon, Inc. | Methods of treatment for neuromyelitis optica |
TWI679019B (en) | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | Anti-il-4/anti-il-13 bispecific antibody formulations |
LT2981822T (en) | 2013-05-06 | 2020-12-28 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
WO2014182972A2 (en) | 2013-05-10 | 2014-11-13 | The Regents Of The University Of California | Diagnostic and monitoring system for huntington's disease |
JP6537143B2 (en) | 2013-05-16 | 2019-07-03 | 国立大学法人京都大学 | Method of diagnosing prognosis of cancer |
CN106414489A (en) | 2013-05-24 | 2017-02-15 | 米迪缪尼有限公司 | Anti-b7-h5 antibodies and their uses |
CA2914369C (en) | 2013-06-06 | 2023-02-14 | Igenica Biotherapeutics, Inc. | Anti-c10orf54 antibodies and uses thereof |
US10781259B2 (en) | 2013-06-06 | 2020-09-22 | Magenta Therapeutics, Inc. | Modified antibodies and related compounds, compositions, and methods of use |
ES2753419T3 (en) | 2013-06-07 | 2020-04-08 | Univ Duke | Complement factor H inhibitors |
JP6442404B2 (en) | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | Method for predicting treatment prognosis in patients with relapsing-remitting multiple sclerosis (RRMS), and method for determining new treatment indication |
US9499628B2 (en) | 2013-06-14 | 2016-11-22 | Children's Hospital Medical Center | Method of boosting the immune response in neonates |
EP3015115A4 (en) | 2013-06-24 | 2017-02-22 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma |
EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
JP6267792B2 (en) | 2013-06-28 | 2018-01-24 | アムジエン・インコーポレーテツド | Methods for treating homozygous familial hypercholesterolemia |
AU2014286131C1 (en) | 2013-07-03 | 2020-02-13 | Immunoqure Ag | Human anti-IFN-alpha antibodies |
MX2015017341A (en) | 2013-07-09 | 2016-07-06 | Anexxon Inc | Anti-complement factor c1q antibodies and uses thereof. |
KR20230118704A (en) | 2013-07-16 | 2023-08-11 | 제넨테크, 인크. | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
EP3022224A2 (en) | 2013-07-18 | 2016-05-25 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
AU2014290361B2 (en) | 2013-07-18 | 2019-04-18 | Taurus Biosciences, Llc | Humanized antibodies with ultralong complementarity determining regions |
WO2015021308A1 (en) | 2013-08-07 | 2015-02-12 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
WO2015019286A1 (en) | 2013-08-07 | 2015-02-12 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment friedreich's ataxia |
EP3033356B1 (en) | 2013-08-14 | 2020-01-15 | Sachdev Sidhu | Antibodies against frizzled proteins and methods of use thereof |
PL3036320T3 (en) | 2013-08-19 | 2021-11-02 | Biogen Ma Inc. | Control of protein glycosylation by culture medium supplementation and cell culture process parameters |
US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
US10456470B2 (en) | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
WO2015035044A2 (en) | 2013-09-04 | 2015-03-12 | Abbvie Biotherapeutics Inc. | Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
CN105682666B (en) | 2013-09-06 | 2021-06-01 | 中央研究院 | Activation of human iNKT cells using glycolipids |
JP6663852B2 (en) | 2013-09-19 | 2020-03-13 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | BH3 profiling method |
US20160229922A1 (en) | 2013-09-20 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hemorrhagic diseases by anti-protein-c antibody |
UA122478C2 (en) | 2013-09-27 | 2020-11-25 | Дженентек, Інк. | Anti-pdl1 antibody formulations |
SG11201602261VA (en) | 2013-09-27 | 2016-04-28 | Chugai Pharmaceutical Co Ltd | Method for producing polypeptide heteromultimer |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
CA2926087C (en) | 2013-10-10 | 2023-03-14 | Beth Israel Deaconess Medical Center, Inc. | Tm4sf1 binding proteins and methods of using same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
EP3733868A3 (en) | 2013-10-28 | 2021-01-13 | DOTS Technology Corp. | Allergen detection |
SG10201803288RA (en) | 2013-10-31 | 2018-05-30 | Sanofi Sa | Specific anti-cd38 antibodies for treating human cancers |
CA2929547C (en) | 2013-11-06 | 2023-02-28 | Astute Medical, Inc. | Assays for igfbp7 having improved performance in biological samples |
CA2929044A1 (en) | 2013-11-11 | 2015-05-14 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified antibody variable region |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
MX2016007312A (en) | 2013-12-04 | 2017-01-13 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules. |
EP3080161B1 (en) | 2013-12-09 | 2021-03-24 | New York University | Compositions and methods for phagocyte delivery of anti-staphylococcal agents |
WO2015088346A1 (en) | 2013-12-13 | 2015-06-18 | Rijksuniversiteit Groningen | Antibodies against staphylococcus aureus and uses thereof. |
US20150190506A1 (en) | 2013-12-17 | 2015-07-09 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
AU2014364601A1 (en) | 2013-12-17 | 2016-07-07 | Genentech, Inc. | Methods of treating HER2-positive cancers using PD-1 axis binding antagonists and anti-HER2 antibodies |
US20150210772A1 (en) | 2013-12-17 | 2015-07-30 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
US10640569B2 (en) | 2013-12-19 | 2020-05-05 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
RU2732032C2 (en) | 2013-12-20 | 2020-09-10 | Дженентек, Инк. | Double specificity antibodies |
JP2017500017A (en) | 2013-12-20 | 2017-01-05 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
EP3087098B1 (en) | 2013-12-24 | 2020-04-08 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
ES2756175T3 (en) | 2013-12-27 | 2020-04-27 | Chugai Pharmaceutical Co Ltd | Fgfr guardian mutant genes and drugs that target them |
MY181081A (en) | 2013-12-27 | 2020-12-17 | Chugai Pharmaceutical Co Ltd | Method for purifying antibody having low isoelectric point |
EP2893939A1 (en) | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
WO2016114819A1 (en) | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
EP3094352B1 (en) | 2014-01-16 | 2020-09-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
CA2937539A1 (en) | 2014-02-04 | 2015-08-13 | Genentech, Inc. | Mutant smoothened and methods of using the same |
EP3105252B1 (en) | 2014-02-12 | 2019-07-24 | Michael Uhlin | Bispecific antibodies for use in stem cell transplantation |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
CA2940196C (en) | 2014-03-19 | 2023-03-07 | Wayne Marasco | Immunogenetic restriction on elicitation of antibodies |
US11124760B2 (en) | 2014-03-24 | 2021-09-21 | Biogen Ma Inc. | Methods for overcoming glutamine deprivation during mammalian cell culture |
SI3122799T1 (en) | 2014-03-25 | 2020-06-30 | F. Hoffmann-La Roche Ag | Methods of preparing a poloxamer for use in cell culture medium |
TWI687428B (en) | 2014-03-27 | 2020-03-11 | 中央研究院 | Reactive labelling compounds and uses thereof |
EP3126386A1 (en) | 2014-03-31 | 2017-02-08 | F. Hoffmann-La Roche AG | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
CA2943405A1 (en) | 2014-03-31 | 2015-10-08 | Debiopharm International Sa | Fgfr fusions |
JP6614582B2 (en) | 2014-04-04 | 2019-12-04 | バイオノミクス インコーポレイテッド | Humanized antibody that binds to LGR5 |
EP3804745A1 (en) | 2014-04-25 | 2021-04-14 | The Brigham and Women's Hospital, Inc. | Methods to manipulate alpha-fetoprotein (afp) |
US10131704B2 (en) | 2014-04-25 | 2018-11-20 | Dana-Farber Cancer Institute, Inc. | Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof |
EP3137910B1 (en) | 2014-04-30 | 2019-09-25 | Klinikum rechts der Isar der Technischen Universität München | Diagnosis of multiple sclerosis |
JP6832709B2 (en) | 2014-05-16 | 2021-02-24 | メディミューン,エルエルシー | Molecules with modified neonatal Fc receptor binding for enhanced therapeutic and diagnostic properties |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
AU2015267052A1 (en) | 2014-05-27 | 2016-12-15 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
AU2015267045B2 (en) | 2014-05-27 | 2021-02-25 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
KR20220151036A (en) | 2014-05-27 | 2022-11-11 | 아카데미아 시니카 | Anti-cd20 glycoantibodies and uses thereof |
US10155818B2 (en) | 2014-05-28 | 2018-12-18 | Agenus Inc. | Anti-GITR antibodies and methods of use thereof |
US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
WO2015189816A1 (en) | 2014-06-13 | 2015-12-17 | Friedrich Miescher Institute For Biomedical Research | New treatment against influenza virus |
TWI695011B (en) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | Monoclonal antibodies against her2 epitope and methods of use thereof |
TW201625299A (en) | 2014-06-20 | 2016-07-16 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii |
EP3157535A1 (en) | 2014-06-23 | 2017-04-26 | Friedrich Miescher Institute for Biomedical Research | Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas |
WO2016001830A1 (en) | 2014-07-01 | 2016-01-07 | Friedrich Miescher Institute For Biomedical Research | Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma |
AU2015287760B2 (en) | 2014-07-09 | 2019-06-20 | Genentech, Inc. | pH adjustment to improve thaw recovery of cell banks |
WO2016011052A1 (en) | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
CN116617401A (en) | 2014-07-15 | 2023-08-22 | 豪夫迈·罗氏有限公司 | Compositions for treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
CN106536559B (en) | 2014-07-17 | 2021-04-27 | 诺和诺德股份有限公司 | Site-directed mutagenesis of TREM-1 antibodies to reduce viscosity |
AR101669A1 (en) | 2014-07-31 | 2017-01-04 | Amgen Res (Munich) Gmbh | ANTIBODY CONSTRUCTS FOR CDH19 AND CD3 |
TW201609812A (en) | 2014-07-31 | 2016-03-16 | 安美基研究(慕尼黑)公司 | Optimized cross-species specific bispecific single chain antibody constructs |
AR101400A1 (en) | 2014-07-31 | 2016-12-14 | Amgen Res (Munich) Gmbh | INDIVIDUAL CHAIN INDIVIDUAL CHAIN ANTIBODY CONSTRUCTION WITH IMPROVED FABRIC DISTRIBUTION |
US20170240631A1 (en) | 2014-08-08 | 2017-08-24 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
EP3185004A4 (en) | 2014-08-20 | 2018-05-30 | Chugai Seiyaku Kabushiki Kaisha | Method for measuring viscosity of protein solution |
EP3183002B1 (en) | 2014-08-21 | 2021-03-03 | Walter Reed Army Institute of Research | Monoclonal antibodies for treatment of microbial infections |
SG11201701328XA (en) | 2014-09-02 | 2017-03-30 | Immunogen Inc | Methods for formulating antibody drug conjugate compositions |
CN107001404B (en) | 2014-09-08 | 2021-06-29 | 中央研究院 | Activation of human iNKT cells using glycolipids |
WO2016040767A2 (en) | 2014-09-12 | 2016-03-17 | Amgen Inc. | Chrdl-1 epitopes and antibodies |
EP3193932B1 (en) | 2014-09-15 | 2023-04-26 | F. Hoffmann-La Roche AG | Antibody formulations |
WO2016046768A1 (en) | 2014-09-24 | 2016-03-31 | Friedrich Miescher Institute For Biomedical Research | Lats and breast cancer |
MA40764A (en) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT INDUCING CYTOTOXICITY |
MY180054A (en) | 2014-09-30 | 2020-11-20 | Neurimmune Holding Ag | Human-derived anti-dipeptide repeats (dprs) antibody |
JP2017531427A (en) | 2014-10-03 | 2017-10-26 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Glucocorticoid-induced tumor necrosis factor receptor (GITR) antibody and method of use thereof |
CN107250160B (en) | 2014-10-06 | 2022-01-11 | 达纳-法伯癌症研究所公司 | Humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof |
MA41685A (en) | 2014-10-17 | 2017-08-22 | Biogen Ma Inc | COPPER SUPPLEMENT FOR THE REGULATION OF GLYCOSYLATION IN A MAMMAL CELL CULTURE PROCESS |
JP6946182B2 (en) | 2014-10-22 | 2021-10-06 | エクステンド バイオサイエンシズ インコーポレーテッドExtend Biosciences, Inc | Therapeutic Vitamin D Conjugate |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
EP3215168B1 (en) | 2014-10-31 | 2023-08-02 | The Trustees of the University of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
EP3217989B1 (en) | 2014-10-31 | 2022-01-05 | The Trustees of the University of Pennsylvania | Compositions and methods of stimulating and expanding t cells |
ES2832711T3 (en) | 2014-10-31 | 2021-06-11 | Abbvie Biotherapeutics Inc | Anti-CS1 Antibodies and Antibody Drug Conjugates |
MA40864A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES |
RU2739500C2 (en) | 2014-11-05 | 2020-12-25 | Дженентек, Инк. | Methods for producing double-stranded proteins in bacteria |
AU2015342961B2 (en) | 2014-11-05 | 2021-08-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
KR102626877B1 (en) | 2014-11-05 | 2024-01-19 | 애넥슨, 인코포레이티드 | Humanized Anti-Complement Factor C1Q Antibodies and Uses Thereof |
SG11201703376QA (en) | 2014-11-06 | 2017-05-30 | Genentech Inc | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
WO2016073157A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Anti-ang2 antibodies and methods of use thereof |
HUE061672T2 (en) | 2014-11-12 | 2023-08-28 | Seagen Inc | Glycan-interacting compounds and methods of use |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
CN106999583A (en) | 2014-11-17 | 2017-08-01 | 豪夫迈·罗氏有限公司 | Combination treatment comprising OX40 combinations activator and the axle binding antagonists of PD 1 |
EP3221358B1 (en) | 2014-11-18 | 2021-07-21 | Janssen Pharmaceutica, N.V. | Cd47 antibodies, methods, and uses |
WO2016079219A1 (en) | 2014-11-19 | 2016-05-26 | Koninklijke Philips N.V. | Diagnostic method employing hnl |
EP3221445B1 (en) | 2014-11-20 | 2021-07-14 | The Regents of The University of California | Compositions and methods related to hematologic recovery |
US11033637B2 (en) | 2014-11-21 | 2021-06-15 | University Of Maryland, Baltimore | Targeted structure-specific particulate delivery systems |
CN107206088A (en) | 2014-12-05 | 2017-09-26 | 豪夫迈·罗氏有限公司 | It is used for the method and composition for the treatment of cancer using the axle antagonists of PD 1 and HPK1 antagonists |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
KR20170087500A (en) | 2014-12-11 | 2017-07-28 | 피에르 파브르 메디카먼트 | Anti-C10ORF54 antibodies and uses thereof |
JP6827928B2 (en) | 2014-12-19 | 2021-02-10 | ユニヴェルシテ・ドゥ・ナント | Anti-IL-34 antibody |
JP7211703B2 (en) | 2014-12-22 | 2023-01-24 | ザ ロックフェラー ユニバーシティー | Anti-MERTK agonist antibody and use thereof |
EP3242893A1 (en) | 2015-01-08 | 2017-11-15 | Biogen MA Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
SG10201906471PA (en) | 2015-01-14 | 2019-09-27 | Brigham & Womens Hospital Inc | Treatment of cancer with anti-lap monoclonal antibodies |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccination regimens |
KR20170104617A (en) | 2015-01-24 | 2017-09-15 | 아카데미아 시니카 | Novel glycan conjugates and methods for using them |
KR102630294B1 (en) | 2015-01-24 | 2024-01-26 | 아카데미아 시니카 | Cancer markers and how to use them |
JP2018506275A (en) | 2015-01-28 | 2018-03-08 | ジェネンテック, インコーポレイテッド | Gene expression markers and treatment of multiple sclerosis |
TWI717333B (en) | 2015-01-30 | 2021-02-01 | 中央研究院 | Compositions and methods relating to universal glyoforms for enhanced antibody efficacy |
EP4223873A3 (en) | 2015-01-31 | 2023-09-06 | The Trustees of the University of Pennsylvania | Compositions and methods for t cell delivery of therapeutic molecules |
JP2018512597A (en) | 2015-02-04 | 2018-05-17 | ジェネンテック, インコーポレイテッド | Mutant smoothened and method of using the same |
CN114773469A (en) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | Antibodies comprising an ion concentration-dependent antigen-binding domain, FC region variants, IL-8-binding antibodies and uses thereof |
US10988534B2 (en) | 2015-02-09 | 2021-04-27 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof |
AU2016222928B2 (en) | 2015-02-26 | 2021-05-13 | Merck Patent Gmbh | PD-1 / PD-L1 inhibitors for the treatment of cancer |
JP6130983B2 (en) | 2015-02-27 | 2017-05-17 | 中外製薬株式会社 | Composition for treating IL-6 related diseases |
AU2016227493B2 (en) | 2015-03-03 | 2022-01-20 | Kymab Limited | Antibodies, uses & methods |
US10711067B2 (en) | 2015-03-03 | 2020-07-14 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
US11155601B2 (en) | 2015-03-06 | 2021-10-26 | CSL Behring Lengnau AG | Modified von Willebrand factor having improved half-life |
WO2016146702A1 (en) | 2015-03-16 | 2016-09-22 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Trispecific binding molecules for treating hbv infection and associated conditions |
IL296062A (en) | 2015-03-17 | 2022-10-01 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
WO2016149621A1 (en) | 2015-03-18 | 2016-09-22 | The Johns Hopkins University | Novel monoclonal antibody inhibitors targeting potassium channel kcnk9 |
EP3274724A1 (en) | 2015-03-25 | 2018-01-31 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of factor d of the alternative complement pathway |
WO2016151557A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of c5 convertase of the alternative complement pathway |
US10167334B2 (en) | 2015-04-03 | 2019-01-01 | Xoma Technology Ltd. | Treatment of cancer using anti-TGF-BETA and PD-1 antibodies |
US10849992B1 (en) | 2015-04-07 | 2020-12-01 | Alector Llc | Methods of screening for sortilin binding antagonists |
ES2899227T3 (en) | 2015-04-07 | 2022-03-10 | Alector Llc | Anti-sortilin antibodies and methods of using them |
CN107750253B (en) | 2015-04-08 | 2022-10-04 | 达纳-法伯癌症研究所公司 | Humanized influenza monoclonal antibodies and methods of use thereof |
CN116063541A (en) | 2015-04-17 | 2023-05-05 | 安进研发(慕尼黑)股份有限公司 | Bispecific antibody constructs for CDH3 and CD3 |
MX2017010734A (en) | 2015-04-17 | 2017-12-04 | Hoffmann La Roche | Combination therapy with coagulation factors and multispecific antibodies. |
US9901574B2 (en) | 2015-04-20 | 2018-02-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
AU2016253957C1 (en) | 2015-04-27 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | High throughput BH3 profiling: a rapid and scalable technology to BH3 profile on low numbers of cells |
EP3288977B1 (en) | 2015-05-01 | 2021-11-17 | Dana-Farber Cancer Institute, Inc. | Methods of mediating cytokine expression with anti ccr4 antibodies |
TWI820377B (en) | 2015-05-07 | 2023-11-01 | 美商艾吉納斯公司 | Anti-ox40 antibodies and methods of use thereof |
CN116196414A (en) | 2015-05-11 | 2023-06-02 | 豪夫迈·罗氏有限公司 | Compositions and methods for treating lupus nephritis |
IL295002A (en) | 2015-05-12 | 2022-09-01 | Genentech Inc | Therapeutic and diagnostic methods for cancer comprising a pd-l1 binding antagonist |
ES2962885T3 (en) | 2015-05-15 | 2024-03-21 | Massachusetts Gen Hospital | Tumor necrosis factor receptor superfamily antagonist antibodies |
CN111349118B (en) | 2015-05-18 | 2023-08-22 | 住友制药肿瘤公司 | Avicenna prodrugs with increased bioavailability |
EP3718569B1 (en) | 2015-05-22 | 2023-05-03 | Translational Drug Development, LLC | Benzamide and active compound compositions and methods of use |
LT3303394T (en) | 2015-05-29 | 2020-10-12 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
KR20180012753A (en) | 2015-05-29 | 2018-02-06 | 제넨테크, 인크. | Treatment and Diagnosis Methods for Cancer |
RU2715597C2 (en) | 2015-05-29 | 2020-03-02 | Эббви Инк. | Antibodies to cd40 and methods of use thereof |
CA3026154A1 (en) | 2015-06-03 | 2016-12-08 | The University Of Queensland | Mobilizing agents and uses therefor |
US11174313B2 (en) | 2015-06-12 | 2021-11-16 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
CA2988982A1 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
TW201710286A (en) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | Binding proteins against VEGF, PDGF, and/or their receptors |
EP3310810A1 (en) | 2015-06-16 | 2018-04-25 | Merck Patent GmbH | Pd-l1 antagonist combination treatments |
KR20180018538A (en) | 2015-06-17 | 2018-02-21 | 제넨테크, 인크. | Methods for the treatment of locally advanced or metastatic breast cancer using PD-1 axis-binding antagonists and taxanes |
WO2016207717A1 (en) | 2015-06-24 | 2016-12-29 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
CN108473573A (en) | 2015-06-29 | 2018-08-31 | 豪夫迈·罗氏有限公司 | II type anti-CD 20 antibodies are used in organ transplant |
TWI829617B (en) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for flt3 and cd3 |
TWI796283B (en) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for msln and cd3 |
TWI717375B (en) | 2015-07-31 | 2021-02-01 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for cd70 and cd3 |
TWI744242B (en) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for egfrviii and cd3 |
TW202346349A (en) | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for dll3 and cd3 |
CA2993659A1 (en) | 2015-08-03 | 2017-02-09 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
TW202340452A (en) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | Taurine supplemented cell culture medium and methods of use |
WO2017024285A2 (en) | 2015-08-06 | 2017-02-09 | Xoma (Us) Llc | Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia |
MA45352A (en) | 2015-08-07 | 2018-06-13 | Univ Birmingham | IDENTIFICATION OF GLYCOPEPTIDES ASSOCIATED WITH CATEGORY I HCM AS TARGETS FOR CANCER IMMUNOTHERAPY |
CN105384825B (en) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | A kind of bispecific chimeric antigen receptor and its application based on single domain antibody |
WO2017031353A1 (en) | 2015-08-19 | 2017-02-23 | Rutgers, The State University Of New Jersey | Novel methods of generating antibodies |
ES2734807T3 (en) | 2015-08-20 | 2019-12-12 | Hoffmann La Roche | Particle based immunoassay using a specific pegylated analyte binding agent |
EP3341411A1 (en) | 2015-08-28 | 2018-07-04 | Alector LLC | Anti-siglec-7 antibodies and methods of use thereof |
PE20181322A1 (en) | 2015-09-01 | 2018-08-14 | Agenus Inc | ANTI-PD1 ANTIBODY AND ITS METHODS OF USE |
WO2017041027A1 (en) | 2015-09-04 | 2017-03-09 | Obi Pharma, Inc. | Glycan arrays and method of use |
CA2993423C (en) | 2015-09-18 | 2024-03-12 | Chugai Seiyaku Kabushiki Kaisha | Il-8-binding antibodies and uses thereof |
CA3000386A1 (en) | 2015-09-30 | 2017-04-06 | Merck Patent Gmbh | Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer |
AU2016334051B2 (en) | 2015-10-06 | 2023-10-26 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
WO2017072669A1 (en) | 2015-10-28 | 2017-05-04 | Friedrich Miescher Institute For Biomedical Research | Tenascin-w and biliary tract cancers |
CN116003596A (en) | 2015-10-29 | 2023-04-25 | 艾利妥 | anti-SIGLEC-9 antibodies and methods of use thereof |
AR106543A1 (en) | 2015-11-02 | 2018-01-24 | Netris Pharma | NTN1 NEUTRALIZING AGENT COMBINATION THERAPY WITH DRUGS THAT INHIBIT EPIGENTICAL CONTROL |
CN108350078A (en) | 2015-11-03 | 2018-07-31 | 默克专利股份公司 | Bispecific antibody and application thereof for improving tumor-selective and inhibition |
CN116217729A (en) | 2015-11-12 | 2023-06-06 | 思进公司 | Glycan interaction compounds and methods of use |
JP6931329B2 (en) | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | Combination therapy using T cell redirection antigen-binding molecule for cells with immunosuppressive function |
JP6925278B2 (en) | 2015-11-18 | 2021-08-25 | 中外製薬株式会社 | Method of enhancing humoral immune response |
FI3380525T3 (en) | 2015-11-25 | 2024-01-30 | Immunogen Inc | Pharmaceutical formulations and methods of use thereof |
ES2810755T3 (en) | 2015-11-30 | 2021-03-09 | Abbvie Inc | Anti-human lrrc15 drug-antibody conjugates and methods for their use |
WO2017095808A1 (en) | 2015-11-30 | 2017-06-08 | Abbvie Inc. | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
US10875920B2 (en) | 2015-12-02 | 2020-12-29 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof |
EP3383908A1 (en) | 2015-12-02 | 2018-10-10 | Stsciences, Inc. | Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator) |
EP3184544A1 (en) | 2015-12-23 | 2017-06-28 | Julius-Maximilians-Universität Würzburg | Glycoprotein v inhibitors for use as coagulants |
EP3395835B1 (en) | 2015-12-25 | 2021-02-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
SG10202103844WA (en) | 2015-12-30 | 2021-06-29 | Genentech Inc | Use of tryptophan derivatives for protein formulations |
AU2016380988B2 (en) | 2015-12-30 | 2022-07-21 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
WO2017114975A1 (en) | 2015-12-31 | 2017-07-06 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating gastric cancer |
JP6962920B2 (en) | 2015-12-31 | 2021-11-05 | プロガストリン、エ、カンセル、エス、アー エル、エルProgastrine Et Cancers S.A R.L. | Compositions and Methods for Detection and Treatment of Ovarian Cancer |
US11789021B2 (en) | 2015-12-31 | 2023-10-17 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating esophageal cancer |
CA3009768A1 (en) | 2015-12-31 | 2017-07-06 | Syncerus S.A R.L. | Compositions and methods for assessing the risk of cancer occurrence |
WO2017120536A1 (en) | 2016-01-08 | 2017-07-13 | Apg Therapeutics, Inc. | Polyethylenimine (pei)-polypeptide conjugates and methods of use thereof |
EP3862365A1 (en) | 2016-01-08 | 2021-08-11 | F. Hoffmann-La Roche AG | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
EA039859B1 (en) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Bispecific antibody constructs binding egfrviii and cd3 |
WO2017134158A1 (en) | 2016-02-03 | 2017-08-10 | Amgen Research (Munich) Gmbh | Psma and cd3 bispecific t cell engaging antibody constructs |
DK3411402T3 (en) | 2016-02-03 | 2022-02-07 | Amgen Res Munich Gmbh | BCMA AND CD3 BISPECIFIC T-CELL INVOLVING ANTIBODY CONSTRUCTIONS |
CN109071625A (en) | 2016-02-04 | 2018-12-21 | 柯瑞斯公司 | Smooth mutant and its application method |
US11262359B2 (en) | 2016-02-05 | 2022-03-01 | NanoView Biosciences, Inc. | Detection of exosomes having surface markers |
MX2018009800A (en) | 2016-02-12 | 2018-11-09 | Janssen Pharmaceutica Nv | Anti-vista (b7h5) antibodies. |
AU2017225854B2 (en) | 2016-02-29 | 2020-11-19 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
WO2017156032A1 (en) | 2016-03-07 | 2017-09-14 | Charlestonpharma, Llc | Anti-nucleolin antibodies |
AU2017231749A1 (en) | 2016-03-08 | 2018-09-20 | Academia Sinica | Methods for modular synthesis of N-glycans and arrays thereof |
RU2746754C2 (en) | 2016-03-14 | 2021-04-20 | Чугаи Сейяку Кабусики Кайся | Cell damage inducing therapeutic medicinal product for anticancer therapy |
CN109476756B (en) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | Multi-specificity Fab fusion protein and application thereof |
CA3016474A1 (en) | 2016-03-15 | 2017-09-21 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
JP6430025B2 (en) | 2016-03-15 | 2018-11-28 | 中外製薬株式会社 | Methods of treating cancer using PD-1 binding antagonists and anti-GPC3 antibodies |
RS61412B1 (en) | 2016-03-17 | 2021-03-31 | Tillotts Pharma Ag | Anti-tnf alpha-antibodies and functional fragments thereof |
WO2017158084A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
WO2017158079A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
RS61374B1 (en) | 2016-03-17 | 2021-02-26 | Tillotts Pharma Ag | Anti-tnf alpha-antibodies and functional fragments thereof |
CA3016870A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnf.alpha.-antibodies and functional fragments thereof |
CN108697799A (en) | 2016-03-22 | 2018-10-23 | 生态学有限公司 | The application of anti-LGR5 monoclonal antibodies |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
CN109071653A (en) | 2016-03-29 | 2018-12-21 | 詹森生物科技公司 | Psoriasis is treated with the increased anti-antibody administration of IL12 and/or -23 interval |
CN109311995A (en) | 2016-03-29 | 2019-02-05 | 台湾浩鼎生技股份有限公司 | Antibody, pharmaceutical composition and method |
US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
MX2018012492A (en) | 2016-04-15 | 2019-06-06 | Genentech Inc | Methods for monitoring and treating cancer. |
AU2017248766A1 (en) | 2016-04-15 | 2018-11-01 | Genentech, Inc. | Methods for monitoring and treating cancer |
JOP20170091B1 (en) | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia |
KR20180128496A (en) | 2016-04-22 | 2018-12-03 | 오비아이 파머 인코퍼레이티드 | Cancer immunotherapy by immune activation or immunomodulation through glycosylated antigen |
CN114703244A (en) | 2016-05-10 | 2022-07-05 | 豪夫迈·罗氏有限公司 | Method for reducing trisulfide bonds during recombinant production of polypeptides |
TW201808336A (en) | 2016-05-11 | 2018-03-16 | 賽諾菲公司 | Treatment regimen using anti-MUC1 maytansinoid immunoconjugate antibody for the treatment of tumors |
TWI794171B (en) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-l1 inhibitors |
TWI808055B (en) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Combination therapies of hdac inhibitors and pd-1 inhibitors |
LT3458102T (en) | 2016-05-17 | 2020-08-25 | Abbvie Biotherapeutics Inc. | Anti-cmet antibody drug conjugates and methods for their use |
CN109415441B (en) | 2016-05-24 | 2023-04-07 | 英斯梅德股份有限公司 | Antibodies and methods of making same |
BR112018073920A2 (en) | 2016-05-26 | 2019-02-26 | Merck Patent Gmbh | pd-1 / pd-l1 inhibitors for cancer treatment ". |
EP3464362B1 (en) | 2016-05-27 | 2020-12-09 | AbbVie Biotherapeutics Inc. | Anti-4-1bb antibodies and their uses |
KR102543118B1 (en) | 2016-05-27 | 2023-06-14 | 아게누스 인코포레이티드 | Anti-tim-3 antibodies and methods of use thereof |
SG10201914132RA (en) | 2016-05-27 | 2020-03-30 | Abbvie Biotherapeutics Inc | Anti-cd40 antibodies and their uses |
EP3325513A4 (en) | 2016-06-13 | 2018-12-19 | I-Mab | Anti-pd-l1 antibodies and uses thereof |
MX2018015755A (en) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof. |
EP3481864A1 (en) | 2016-07-08 | 2019-05-15 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
JP2018035137A (en) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | Novel anti-fibroblast activated protein (FAP) binding agent and use thereof |
WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
WO2018018039A2 (en) | 2016-07-22 | 2018-01-25 | Dana-Farber Cancer Institute, Inc. | Glucocorticoid-induced tumor necrosis factor receptor (gitr) antibodies and methods of use thereof |
WO2018022479A1 (en) | 2016-07-25 | 2018-02-01 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
CN110072545A (en) | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | Immunogenicity/therapeutic glycan pool object and application thereof |
JP7121724B2 (en) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ,インコーポレイテッド | Human antibodies, pharmaceutical compositions and methods |
NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
JP7148493B2 (en) | 2016-08-01 | 2022-10-05 | ゾーマ (ユーエス) リミテッド ライアビリティ カンパニー | Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof |
NL2017270B1 (en) | 2016-08-02 | 2018-02-09 | Aduro Biotech Holdings Europe B V | New anti-hCTLA-4 antibodies |
WO2018029124A1 (en) | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
EP3496752B1 (en) | 2016-08-12 | 2022-05-18 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a vegf inhibitor |
CN109963868B (en) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | Antibodies, binding fragments, and methods of use |
WO2018045379A1 (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders |
MX2019002696A (en) | 2016-09-06 | 2019-09-27 | Dana Farber Cancer Inst Inc | Methods of treating or preventing zika virus infection. |
EP3510046A4 (en) | 2016-09-07 | 2020-05-06 | The Regents of the University of California | Antibodies to oxidation-specific epitopes |
TW201825674A (en) | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | Oncolytic virus expressing bispecific engager molecules |
CA3035932A1 (en) | 2016-09-14 | 2018-03-22 | Abbvie Biotherapeutics Inc. | Anti-pd-1 antibodies and their uses |
JP7256116B2 (en) | 2016-09-19 | 2023-04-11 | アイ-エムエービー バイオファーマ (ハンジョウ) カンパニー リミテッド | ANTI-GM-CSF ANTIBODY AND USES THEREOF |
KR20240035625A (en) | 2016-09-21 | 2024-03-15 | 넥스트큐어 인코포레이티드 | Antibodies for siglec-15 and methods of use thereof |
JOP20190009A1 (en) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | Antibodies against signal-regulatory protein alpha and methods of use |
MX2019003543A (en) | 2016-09-28 | 2019-06-17 | Xoma Us Llc | Antibodies that bind interleukin-2 and uses thereof. |
BR112019005815A2 (en) | 2016-09-29 | 2019-06-25 | Genentech Inc | methods of treating an individual with breast cancer, breast cancer treatment kit, and breast cancer therapy drug combination |
KR20190059305A (en) | 2016-09-30 | 2019-05-30 | 얀센 바이오테크 인코포레이티드 | A safe and effective way to treat psoriasis with anti-IL23-specific antibodies |
CA3036714A1 (en) | 2016-10-03 | 2018-04-12 | Abbott Laboratories | Improved methods of assessing uch-l1 status in patient samples |
KR20190072528A (en) | 2016-10-06 | 2019-06-25 | 제넨테크, 인크. | Treatment and Diagnosis Methods for Cancer |
CN109843324A (en) | 2016-10-06 | 2019-06-04 | 辉瑞公司 | AVELUMAB therapeutic regimen for treating cancer |
WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
US10844119B2 (en) | 2016-10-11 | 2020-11-24 | Agenus Inc. | Anti-LAG-3 antibodies and methods of use thereof |
WO2018081531A2 (en) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Methods for human t-cell activation |
JP7100030B2 (en) | 2016-10-28 | 2022-07-12 | アスチュート メディカル,インコーポレイテッド | Use of antibody against TIMP-2 to improve renal function |
KR20190107656A (en) | 2016-11-02 | 2019-09-20 | 이뮤노젠 아이엔씨 | Combination treatment with antibody-drug conjugates and PARP inhibitors |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
JP2020503256A (en) | 2016-11-04 | 2020-01-30 | ノビミューン エスアー | Anti-CD19 antibodies and methods of using them |
KR102539159B1 (en) | 2016-11-07 | 2023-06-02 | 주식회사 뉴라클사이언스 | Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof |
WO2018093841A1 (en) | 2016-11-16 | 2018-05-24 | Janssen Biotech, Inc. | Method of treating psoriasis with anti-il-23 specific antibody |
US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
CA3044274A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
EP3544601B1 (en) | 2016-11-23 | 2024-03-20 | Translational Drug Development, LLC | A composition comprising a benzamide and a tnfrsf agonist binding to 4-1bb or gitr, and the use thereof in the treatment of cancer. |
TWI776827B (en) | 2016-11-28 | 2022-09-11 | 日商中外製藥股份有限公司 | Ligand-binding molecules capable of modulating ligand-binding activity |
IL307242A (en) | 2016-12-07 | 2023-11-01 | Agenus Inc | Anti-ctla-4 antibodies and methods of use thereof |
CN110300599A (en) | 2016-12-07 | 2019-10-01 | 艾吉纳斯公司 | Antibody and its application method |
AR110526A1 (en) | 2016-12-15 | 2019-04-10 | Abbvie Biotherapeutics Inc | ANTI-OX40 ANTIBODIES AND THEIR USES IN CANCER TREATMENT |
MX2019007332A (en) | 2016-12-19 | 2019-11-18 | Tolero Pharmaceuticals Inc | Profiling peptides and methods for sensitivity profiling. |
KR20210126136A (en) | 2016-12-27 | 2021-10-19 | 에프. 호프만-라 로슈 아게 | Novel biotin-specific monoclonal antibody and use thereof |
CN110088130A (en) | 2016-12-27 | 2019-08-02 | 豪夫迈·罗氏有限公司 | New biotin monoclonal antibody specific and application thereof |
CN110088129A (en) | 2016-12-27 | 2019-08-02 | 豪夫迈·罗氏有限公司 | New biotin monoclonal antibody specific and application thereof |
EA039433B1 (en) | 2017-01-05 | 2022-01-27 | Нетрис Фарма | Combined treatment with netrin-1 interfering drugs and immune checkpoint inhibitors drugs |
US11773182B2 (en) | 2017-01-05 | 2023-10-03 | The Johns Hopkins University | Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA) |
CN117586401A (en) | 2017-01-20 | 2024-02-23 | 大有华夏生物医药集团有限公司 | anti-PD-1 antibodies and uses thereof |
KR20180093088A (en) | 2017-01-24 | 2018-08-20 | 아이-맵 | Anti-CD73 antibody and its use |
WO2018140510A1 (en) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
CA3051484A1 (en) | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
WO2018140121A1 (en) | 2017-01-30 | 2018-08-02 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis |
JOP20190189A1 (en) | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
JP7068323B2 (en) | 2017-02-02 | 2022-05-16 | エフ.ホフマン-ラ ロシュ アーゲー | Immunoassay using at least two pegged analyte-specific binders |
KR20240038148A (en) | 2017-02-07 | 2024-03-22 | 얀센 바이오테크 인코포레이티드 | Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
CN108456251A (en) | 2017-02-21 | 2018-08-28 | 上海君实生物医药科技股份有限公司 | Anti- PD-L1 antibody and its application |
CA3052670A1 (en) | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
EP3589319A4 (en) | 2017-03-03 | 2021-07-14 | Seagen Inc. | Glycan-interacting compounds and methods of use |
TWI808963B (en) | 2017-03-22 | 2023-07-21 | 法商賽諾菲公司 | Treatment of lupus using humanized anti-cxcr5 antibodies |
CA3052513A1 (en) | 2017-03-23 | 2018-09-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
CA3057808A1 (en) | 2017-03-24 | 2018-09-27 | Zenyaku Kogyo Co., Ltd. | Anti-igm/b cell surface antigen bispecific antibody |
EP3601347B1 (en) | 2017-03-30 | 2021-11-03 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule |
JP7166278B2 (en) | 2017-03-30 | 2022-11-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Combination of anti-PD-L1 antibody and DNA-PK inhibitor for cancer treatment |
US11913958B2 (en) | 2017-03-30 | 2024-02-27 | Ecs-Progastrin Sa | Compositions and methods for detecting lung cancer |
EP3603670A4 (en) | 2017-03-31 | 2021-03-10 | Public University Corporation Nara Medical University | Medicinal composition usable for preventing and/or treating blood coagulation factor ix abnormality, comprising multispecific antigen binding molecule replacing function of blood coagulation factor viii |
US10722589B2 (en) | 2017-04-03 | 2020-07-28 | Covagen Ag | FGFR3 binding molecules |
WO2018187453A1 (en) | 2017-04-05 | 2018-10-11 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
JP7297672B2 (en) | 2017-04-13 | 2023-06-26 | アジェナス インコーポレイテッド | ANTI-CD137 ANTIBODY AND METHODS OF USE THEREOF |
JP7344797B2 (en) | 2017-04-15 | 2023-09-14 | アボット・ラボラトリーズ | Methods to aid in hyperacute diagnosis and determination of traumatic brain injury in human subjects using early biomarkers |
WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
CN110799529A (en) | 2017-04-22 | 2020-02-14 | 免疫治疗有限公司 | Improved LAMP constructs |
EP3615052B1 (en) | 2017-04-27 | 2023-01-25 | The University of Hong Kong | Use of hcn inhibitors for treatment of cancer |
US20200109390A1 (en) | 2017-04-27 | 2020-04-09 | Chugai Seiyaku Kabushiki Kaisha | Coagulation factor ix with improved pharmacokinetics |
JP7080899B2 (en) | 2017-04-28 | 2022-06-06 | アボット・ラボラトリーズ | Methods to aid in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
HUE062927T2 (en) | 2017-05-01 | 2023-12-28 | Agenus Inc | Anti-tigit antibodies and methods of use thereof |
JP7185884B2 (en) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | METHOD FOR PREDICTING AND DETERMINING THERAPEUTIC EFFECT OF IL-6 AND NEUTROPHIL-RELATED DISEASE |
KR20240027895A (en) | 2017-05-02 | 2024-03-04 | 이뮤노믹 쎄라퓨틱스, 인크. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
UY37726A (en) | 2017-05-05 | 2018-11-30 | Amgen Inc | PHARMACEUTICAL COMPOSITION THAT INCLUDES BISPECTIFIC ANTIBODY CONSTRUCTIONS FOR IMPROVED STORAGE AND ADMINISTRATION |
US10865238B1 (en) | 2017-05-05 | 2020-12-15 | Duke University | Complement factor H antibodies |
JOP20190256A1 (en) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | Newcastle disease viruses and uses thereof |
WO2018213316A1 (en) | 2017-05-16 | 2018-11-22 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
US10914729B2 (en) | 2017-05-22 | 2021-02-09 | The Trustees Of Princeton University | Methods for detecting protein binding sequences and tagging nucleic acids |
EP3630830A1 (en) | 2017-05-23 | 2020-04-08 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Novel cd73 antibody, preparation and uses thereof |
AU2018272054A1 (en) | 2017-05-25 | 2019-09-26 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
JP7220161B2 (en) | 2017-05-26 | 2023-02-09 | ノビミューン エスアー | Anti-CD47x anti-mesothelin antibodies and methods of using same |
BR112019025313A2 (en) | 2017-05-30 | 2020-06-23 | Abbott Laboratories | METHODS FOR ASSISTANCE IN DIAGNOSIS AND EVALUATION OF A LIGHT TRAUMATIC BRAIN INJURY IN A HUMAN INDIVIDUAL USING HEART TROPONIN I |
KR20200024158A (en) | 2017-05-31 | 2020-03-06 | 주식회사 에스티큐브앤컴퍼니 | How to treat cancer using antibodies and molecules that immunospecifically bind to BTN1A1 |
EP3630835A1 (en) | 2017-05-31 | 2020-04-08 | STCube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
KR20200026209A (en) | 2017-06-06 | 2020-03-10 | 주식회사 에스티큐브앤컴퍼니 | How to treat cancer using antibodies and molecules that bind BTN1A1 or BTN1A1-ligand |
WO2019000223A1 (en) | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | Chimeric antibody immune effctor cell engagers and methods of use thereof |
AR112336A1 (en) | 2017-07-14 | 2019-10-16 | Pfizer | ANTIBODIES AGAINST MADCAM |
TWI823859B (en) | 2017-07-21 | 2023-12-01 | 美商建南德克公司 | Therapeutic and diagnostic methods for cancer |
US20210032364A1 (en) | 2017-07-27 | 2021-02-04 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
KR20200033798A (en) | 2017-08-03 | 2020-03-30 | 알렉터 엘엘씨 | Anti-CD33 antibodies and methods of use |
JP2020533948A (en) | 2017-08-03 | 2020-11-26 | アレクトル エルエルシー | Anti-TREM2 antibody and how to use it |
CA3072111A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Dynamic human antibody light chain libraries |
WO2019036842A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Dynamic human heavy chain antibody libraries |
MX2020002612A (en) | 2017-09-07 | 2020-07-13 | Univ Res Inst Inc Augusta | Antibodies to programmed cell death protein 1. |
WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | Treatment regimen for cancers that are insensitive to bcl-2 inhibitors using the mcl-1 inhibitor alvocidib |
WO2019059411A1 (en) | 2017-09-20 | 2019-03-28 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
AU2018335231B2 (en) | 2017-09-22 | 2022-03-24 | F. Hoffmann-La Roche Ag | Multivalent mono- or bispecific recombinant antibodies for analytic purpose |
TW201922780A (en) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | Safe and effective method of treating Lupus with anti-IL12/IL23 antibody |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
WO2019075270A1 (en) | 2017-10-12 | 2019-04-18 | Amesino Llc | Vegfr-antibody light chain fusion protein |
KR20200074160A (en) | 2017-10-20 | 2020-06-24 | 가꼬우호우징 효고 이카다이가쿠 | Pharmaceutical composition for inhibiting post-surgical adhesion containing anti-IL-6 receptor antibody |
WO2019083904A1 (en) | 2017-10-23 | 2019-05-02 | Chan Zuckerberg Biohub, Inc. | Measurement of afucosylated igg fc glycans and related treatment methods |
WO2019084460A1 (en) | 2017-10-26 | 2019-05-02 | The Regents Of The University Of California | Inhibition of oxidation-specific epitopes to treat ischemic reperfusion injury |
WO2019089594A1 (en) | 2017-10-31 | 2019-05-09 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and cytarabine |
JP7039694B2 (en) | 2017-10-31 | 2022-03-22 | スターテン・バイオテクノロジー・ベー・フェー | Anti-APOC3 antibody and how to use it |
AU2018359967A1 (en) | 2017-11-06 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
EP3717069A1 (en) | 2017-11-27 | 2020-10-07 | Purdue Pharma L.P. | Humanized antibodies targeting human tissue factor |
EP3719036A4 (en) | 2017-11-28 | 2021-09-08 | Chugai Seiyaku Kabushiki Kaisha | Ligand-binding molecule having adjustable ligand-binding activity |
PT3720879T (en) | 2017-12-05 | 2022-07-13 | Progastrine Et Cancers S A R L | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
KR20200096942A (en) | 2017-12-06 | 2020-08-14 | 마젠타 테라퓨틱스 인코포레이티드 | Dosing regimen for mobilization of hematopoietic stem and progeny cells |
CA3067057A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
BR112020010085A2 (en) | 2017-12-09 | 2020-10-13 | Abbott Laboratories | methods to assist in the diagnosis and assessment of a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
EP3724229A1 (en) | 2017-12-11 | 2020-10-21 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
PL3710484T3 (en) | 2017-12-20 | 2024-03-25 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding ctla-4 and uses thereof |
JP7314146B2 (en) | 2017-12-28 | 2023-07-25 | 中外製薬株式会社 | Cytotoxicity-inducing therapeutic agent |
KR20200104886A (en) | 2017-12-28 | 2020-09-04 | 난징 레전드 바이오테크 씨오., 엘티디. | Antibodies and variants against PD-L1 |
US11905327B2 (en) | 2017-12-28 | 2024-02-20 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
WO2019133902A2 (en) | 2017-12-28 | 2019-07-04 | Astute Medical, Inc. | Antibodies and assays for ccl14 |
UY38041A (en) | 2017-12-29 | 2019-06-28 | Amgen Inc | CONSTRUCTION OF BIESPECFIC ANTIBODY DIRECTED TO MUC17 AND CD3 |
SG11202004233UA (en) | 2018-01-15 | 2020-06-29 | Nanjing Legend Biotech Co Ltd | Single-domain antibodies and variants thereof against pd-1 |
BR112020013405A2 (en) | 2018-01-25 | 2020-12-01 | Acm Biolabs Pte Ltd. | polymerosomes comprising a soluble encapsulated antigen, as well as methods of its manufacture and use |
WO2019145537A1 (en) | 2018-01-26 | 2019-08-01 | Ecs-Progastrin Sa | Combination of progastrin detection with other cancer biomarkers in cancer diagnosis |
EP3747469A4 (en) | 2018-01-31 | 2022-03-23 | Motokazu Kato | Therapeutic agent for asthma containing il-6 inhibitor |
TW202000702A (en) | 2018-02-26 | 2020-01-01 | 美商建南德克公司 | Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies |
AU2019228339A1 (en) | 2018-02-27 | 2020-09-10 | Ecs-Progastrin Sa | Progastrin as a biomarker for immunotherapy |
WO2019169229A1 (en) | 2018-03-01 | 2019-09-06 | Nextcure, Inc. | Klrg1 binding compositions and methods of use thereof |
NL2020520B1 (en) | 2018-03-02 | 2019-09-12 | Labo Bio Medical Invest B V | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
JP2021515770A (en) | 2018-03-05 | 2021-06-24 | ヤンセン バイオテツク,インコーポレーテツド | Treatment of Crohn's disease using anti-IL-23 specific antibody |
MX2020009526A (en) | 2018-03-12 | 2020-10-28 | Zoetis Services Llc | Anti-ngf antibodies and methods thereof. |
RU2020128013A (en) | 2018-03-14 | 2022-04-15 | Бейцзин Сюаньи Фармасайенсиз Ко., Лтд. | ANTIBODIES AGAINST CLAUDIN 18.2 |
EP3765520A1 (en) | 2018-03-14 | 2021-01-20 | NovImmune SA | Anti-cd3 epsilon antibodies and methods of use thereof |
WO2019183266A1 (en) | 2018-03-21 | 2019-09-26 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
WO2019180272A1 (en) | 2018-03-23 | 2019-09-26 | Fundación Instituto De Investigación Sanitaria De Santiago De Compostela | Anti-leptin affinity reagents for use in the treatment of obesity and other leptin-resistance associated diseases |
SI3775909T1 (en) | 2018-03-26 | 2023-10-30 | Glycanostics S.R.O. | Means and methods for glycoprofiling of a protein |
SG11202006674QA (en) | 2018-03-30 | 2020-08-28 | Nanjing Legend Biotech Co Ltd | Single-domain antibodies against lag-3 and uses thereof |
SG11202009625WA (en) | 2018-04-02 | 2020-10-29 | Bristol Myers Squibb Co | Anti-trem-1 antibodies and uses thereof |
JP2021521273A (en) | 2018-04-12 | 2021-08-26 | メディアファーマ エス.アール.エル. | LGALS3BP antibody-drug conjugate and its use for cancer treatment |
SG11202010011RA (en) | 2018-04-17 | 2020-11-27 | Celldex Therapeutics Inc | Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs |
WO2019207159A1 (en) | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
EP3787683A1 (en) | 2018-05-04 | 2021-03-10 | Merck Patent GmbH | Combined inhibition of pd-1/pd-l1, tgf? and dna-pk for the treatment of cancer |
US20190345245A1 (en) | 2018-05-11 | 2019-11-14 | Janssen Biotech, Inc. | Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody |
JP2021523185A (en) | 2018-05-15 | 2021-09-02 | イミュノミック セラピューティックス, インコーポレイテッドImmunomic Therapeutics, Inc. | Improved LAMP constructs containing allergens |
WO2019222130A1 (en) | 2018-05-15 | 2019-11-21 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and flt3 inhibitors |
EP3797752A4 (en) | 2018-05-21 | 2022-03-02 | Chugai Seiyaku Kabushiki Kaisha | Lyophilized formulation sealed in glass vial |
MX2020011828A (en) | 2018-05-25 | 2021-02-09 | Alector Llc | Anti-sirpa antibodies and methods of use thereof. |
US20210364412A1 (en) | 2018-06-01 | 2021-11-25 | NanoView Biosciences, Inc. | Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles |
AU2019282264A1 (en) | 2018-06-05 | 2020-11-26 | Amgen Inc. | Modulating antibody dependent cellular phagocytosis |
WO2019236965A1 (en) | 2018-06-08 | 2019-12-12 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
KR20210040945A (en) | 2018-06-21 | 2021-04-14 | 유마니티 테라퓨틱스, 인크. | Composition and method for the treatment and prevention of neurological disorders |
US20200030443A1 (en) | 2018-06-23 | 2020-01-30 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
TW202035444A (en) | 2018-06-27 | 2020-10-01 | 台灣浩鼎生技股份有限公司 | Glycosynthase variants for glycoprotein engineering and methods of use |
US11884729B2 (en) | 2018-06-29 | 2024-01-30 | ApitBio, Inc | Anti-L1CAM antibodies and uses thereof |
ES2940311T3 (en) | 2018-07-13 | 2023-05-05 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
US20200025776A1 (en) | 2018-07-18 | 2020-01-23 | Janssen Biotech, Inc. | Sustained Response Predictors After Treatment With Anti-IL23 Specific Antibody |
KR20210034622A (en) | 2018-07-18 | 2021-03-30 | 제넨테크, 인크. | Lung cancer treatment method using PD-1 axis binding antagonist, anti-metabolite, and platinum agent |
JP2021531007A (en) | 2018-07-20 | 2021-11-18 | ピエール、ファーブル、メディカマン | Receptor for VISTA |
MX2021000933A (en) | 2018-07-27 | 2021-05-27 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof. |
MX2021001221A (en) | 2018-07-30 | 2021-06-23 | Amgen Res Munich Gmbh | Prolonged administration of a bispecific antibody construct binding to cd33 and cd3. |
KR20210042117A (en) | 2018-08-03 | 2021-04-16 | 암젠 리서치 (뮌헨) 게엠베하 | Antibody constructs against CLDN18.2 and CD3 |
JP2021533149A (en) | 2018-08-08 | 2021-12-02 | ジェネンテック, インコーポレイテッド | Use of tryptophan derivatives and L-methionine for protein formulations |
AU2019327155A1 (en) | 2018-08-27 | 2021-03-18 | Affimed Gmbh | Cryopreserved NK cells preloaded with an antibody construct |
JP2022500371A (en) | 2018-09-11 | 2022-01-04 | アムジエン・インコーポレーテツド | How to regulate antibody-dependent cellular cytotoxicity |
US20220105176A1 (en) | 2018-09-12 | 2022-04-07 | Acm Biolabs Pte Ltd | Polymersomes comprising a covalently bound antigen as well as methods of making and uses thereof |
JP2022501332A (en) | 2018-09-19 | 2022-01-06 | ジェネンテック, インコーポレイテッド | How to treat and diagnose bladder cancer |
ES2955032T3 (en) | 2018-09-21 | 2023-11-28 | Hoffmann La Roche | Diagnostic methods for triple negative breast cancer |
JP7359845B2 (en) | 2018-09-24 | 2023-10-11 | ヤンセン バイオテツク,インコーポレーテツド | A safe and effective method to treat ulcerative colitis with anti-IL12/IL23 antibodies |
KR20210066837A (en) | 2018-09-26 | 2021-06-07 | 메르크 파텐트 게엠베하 | Combination of PD-1 antagonists, ATR inhibitors and platinizing agents for the treatment of cancer |
US11505614B2 (en) | 2018-09-28 | 2022-11-22 | Amgen Inc. | Antibodies binding to soluble BCMA |
CN112969503A (en) | 2018-10-03 | 2021-06-15 | 斯塔滕生物技术有限公司 | Antibodies specific for human and cynomolgus macaques APOC3 and methods of use thereof |
WO2020076969A2 (en) | 2018-10-10 | 2020-04-16 | Tilos Therapeutics, Inc. | Anti-lap antibody variants and uses thereof |
AU2019356564A1 (en) | 2018-10-11 | 2021-04-29 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
EP3866785A1 (en) | 2018-10-15 | 2021-08-25 | Merck Patent GmbH | Combination therapy utilizing dna alkylating agents and atr inhibitors |
WO2020081767A1 (en) | 2018-10-18 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
US20220170097A1 (en) | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
CA3118453A1 (en) | 2018-11-02 | 2020-05-07 | The Regents Of The University Of California | Compositions and methods for treating brain injury |
JP2022506156A (en) | 2018-11-05 | 2022-01-17 | ジェネンテック, インコーポレイテッド | Method for producing double-stranded protein in prokaryotic host cell |
CN113039287A (en) | 2018-11-16 | 2021-06-25 | 豪夫迈·罗氏有限公司 | Streptavidin-coated solid phase with members of a binding pair |
CA3120237A1 (en) | 2018-11-20 | 2020-05-28 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il-23 specific antibody |
US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
US20220026445A1 (en) | 2018-12-07 | 2022-01-27 | Georgia Tech Research Corporation | Antibodies that bind to natively folded myocilin |
US20200197517A1 (en) | 2018-12-18 | 2020-06-25 | Janssen Biotech, Inc. | Safe and Effective Method of Treating Lupus with Anti-IL12/IL23 Antibody |
MX2021008434A (en) | 2019-01-14 | 2021-09-23 | Genentech Inc | Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine. |
WO2020148651A1 (en) | 2019-01-15 | 2020-07-23 | Janssen Biotech, Inc. | Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis |
MX2021008871A (en) | 2019-01-23 | 2021-08-19 | Janssen Biotech Inc | Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis. |
CA3124515A1 (en) | 2019-01-23 | 2020-07-30 | Genentech, Inc. | Methods of producing multimeric proteins in eukaryotic host cells |
EP3915581A4 (en) | 2019-01-24 | 2023-03-22 | Chugai Seiyaku Kabushiki Kaisha | Novel cancer antigens and antibodies of said antigens |
CA3125697A1 (en) | 2019-01-29 | 2020-08-06 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Treating the causative agent in adhesiogenesis |
AU2019427766A1 (en) | 2019-01-30 | 2021-09-16 | Nomocan Pharmaceuticals Llc | Antibodies to M(H)DM2/4 and their use in diagnosing and treating cancer |
WO2020163589A1 (en) | 2019-02-08 | 2020-08-13 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
JP2022520088A (en) | 2019-02-13 | 2022-03-28 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | Anti-peripheral lymph node addressin antibody and its use |
JP2022530301A (en) | 2019-02-22 | 2022-06-29 | 武▲漢▼友芝友生物制▲薬▼有限公司 | CD3 antigen-binding fragment and its use |
MA55080A (en) | 2019-02-26 | 2022-01-05 | Inspirna Inc | HIGH AFFINITY ANTI-MERTK ANTIBODIES AND ASSOCIATED USES |
MX2021010313A (en) | 2019-02-27 | 2021-09-23 | Genentech Inc | Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies. |
MX2021010404A (en) | 2019-02-28 | 2021-09-14 | Juntendo Educational Found | Antibody capable of binding to truncated mutant calreticulin, and diagnostic, prophylactic or therapeutic drug for myeloproliferative neoplasms. |
CA3133388A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
KR20210141990A (en) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | Methods of Preparation for Generating Anti-IL12/IL23 Antibody Compositions |
KR20210142002A (en) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | Methods of Preparation for Producing Anti-TNF Antibody Compositions |
WO2020183270A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
CA3158025C (en) | 2019-03-15 | 2023-07-11 | Yi Zhang | Anti-bcma chimeric antigen receptors |
WO2020188466A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Biotech, Inc. | Method of treating psoriasis in pediatric subjects with anti-il12/il23 antibody |
CN113613676A (en) | 2019-03-19 | 2021-11-05 | 中外制药株式会社 | Antigen binding molecule comprising antigen binding domain whose binding activity to antigen is changed by MTA and library for obtaining the same |
JP2022525149A (en) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | Treatment of Acute Myeloid Leukemia (AML) with Venetoclax Failure |
WO2020198413A1 (en) | 2019-03-27 | 2020-10-01 | The Trustees Of The University Of Pennsylvania | Tn-muc1 chimeric antigen receptor (car) t cell therapy |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
AU2020273072A1 (en) | 2019-04-10 | 2021-12-09 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying Fc region-modified antibody |
JPWO2020213665A1 (en) | 2019-04-17 | 2020-10-22 | ||
SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
WO2020226986A2 (en) | 2019-05-03 | 2020-11-12 | Genentech, Inc. | Methods of treating cancer with an anti-pd-l1 antibody |
US20200369759A1 (en) | 2019-05-23 | 2020-11-26 | Fibrogen, Inc. | Methods of treatment of muscular dystrophies |
CN113874073A (en) | 2019-05-23 | 2021-12-31 | 詹森生物科技公司 | Methods of treating inflammatory bowel disease with combination therapy of antibodies to IL-23 and TNF α |
MA56015A (en) | 2019-06-03 | 2022-04-06 | Janssen Biotech Inc | ANTI-TNF ANTIBODY COMPOSITIONS AND METHODS FOR TREATING PSORIATIC ARTHRITIS |
AU2020288404A1 (en) | 2019-06-03 | 2022-02-03 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, and methods for the treatment of active Ankylosing Spondylitis |
US20220324975A1 (en) | 2019-06-05 | 2022-10-13 | Chugai Seiyaku Kabushiki Kaisha | Antibody cleavage site binding molecule |
AU2020290573A1 (en) | 2019-06-13 | 2021-11-04 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
CA3148591A1 (en) | 2019-07-26 | 2021-02-04 | Amgen Inc. | Anti-il13 antigen binding proteins |
WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
KR20220053007A (en) | 2019-08-30 | 2022-04-28 | 아게누스 인코포레이티드 | Anti-CD96 antibodies and methods of use thereof |
CN117683133A (en) | 2019-09-03 | 2024-03-12 | 百奥泰生物制药股份有限公司 | anti-TIGIT immunosuppressant and application |
CR20220095A (en) | 2019-09-04 | 2022-06-06 | Genentech Inc | Cd8 binding agents and uses thereof |
MX2022002981A (en) | 2019-09-10 | 2022-04-06 | Amgen Inc | Purification method for bispecific antigen-binding polypeptides with enhanced protein l capture dynamic binding capacity. |
CN114340675A (en) | 2019-09-12 | 2022-04-12 | 豪夫迈·罗氏有限公司 | Compositions and methods for treating lupus nephritis |
WO2021062323A1 (en) | 2019-09-26 | 2021-04-01 | Stcube & Co. | Antibodies specific to glycosylated ctla-4 and methods of use thereof |
JP2022548978A (en) | 2019-09-27 | 2022-11-22 | ジェネンテック, インコーポレイテッド | Dosing for Treatment with Drugs Anti-TIGIT and Anti-PD-L1 Antagonist Antibodies |
WO2021072277A1 (en) | 2019-10-09 | 2021-04-15 | Stcube & Co. | Antibodies specific to glycosylated lag3 and methods of use thereof |
AU2020366515A1 (en) | 2019-10-18 | 2022-04-21 | Immunomic Therapeutics, Inc. | Improved lamp constructs comprising cancer antigens |
US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
KR20220095205A (en) | 2019-11-01 | 2022-07-06 | 아레스 트레이딩 에스.아. | Combination inhibition of PD-1, TGFβ and ATM with radiotherapy for the treatment of cancer |
US20230340122A1 (en) | 2019-11-05 | 2023-10-26 | Glaxosmithkline Intellectual Property (No. 4) Ltd. | Combined inhibition of pd-1, tgfb and tigit for the treatment of cancer |
IL292458A (en) | 2019-11-06 | 2022-06-01 | Genentech Inc | Diagnostic and therapeutic methods for treatment of hematologic cancers |
AU2020381536A1 (en) | 2019-11-13 | 2022-04-21 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
EP3825330A1 (en) | 2019-11-19 | 2021-05-26 | International-Drug-Development-Biotech | Anti-cd117 antibodies and methods of use thereof |
MX2022006073A (en) | 2019-12-05 | 2022-08-04 | Alector Llc | Methods of use of anti-trem2 antibodies. |
US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
EP4073120A2 (en) | 2019-12-09 | 2022-10-19 | Genentech, Inc. | Anti-pd-l1 antibody formulations |
BR112022011337A2 (en) | 2019-12-12 | 2022-08-23 | Alector Llc | METHOD TO TREAT AND/OR DELAY THE PROGRESSION OF A DISEASE OR INJURY IN AN INDIVIDUAL |
UY38995A (en) | 2019-12-20 | 2021-06-30 | Amgen Inc | MESOTHELIN TARGETING CD40 AGONIST MULTI-SPECIFIC ANTIBODY CONSTRUCTS FOR THE TREATMENT OF SOLID TUMORS |
CA3160927A1 (en) | 2019-12-27 | 2021-07-01 | Affimed Gmbh | Method for the production of bispecific fcyriii x cd30 antibody construct |
CN115052663A (en) | 2020-01-08 | 2022-09-13 | 辛瑟斯治疗股份有限公司 | ALK5 inhibitor conjugates and uses thereof |
EP4093771A1 (en) | 2020-01-22 | 2022-11-30 | Amgen Research (Munich) GmbH | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
EP4096708A1 (en) | 2020-01-31 | 2022-12-07 | Genentech, Inc. | Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine |
CN113248611A (en) | 2020-02-13 | 2021-08-13 | 湖南华康恒健生物技术有限公司 | anti-BCMA antibody, pharmaceutical composition and application thereof |
CA3167851A1 (en) | 2020-02-24 | 2021-09-02 | Francesca CIGNARELLA | Methods of use of anti-trem2 antibodies |
WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
AU2021231890A1 (en) | 2020-03-06 | 2022-09-29 | Go Therapeutics, Inc. | Anti-glyco-CD44 antibodies and their uses |
MX2022011178A (en) | 2020-03-10 | 2023-01-04 | Massachusetts Inst Technology | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER. |
US20230146593A1 (en) | 2020-03-12 | 2023-05-11 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecific antibodies binding to cds x cancer cell and tnf alpha or il-6 inhibitor |
JP2023518225A (en) | 2020-03-19 | 2023-04-28 | アムジエン・インコーポレーテツド | Antibodies against mucin 17 and uses thereof |
WO2021193928A1 (en) | 2020-03-27 | 2021-09-30 | 株式会社PhotoQ3 | Pharmaceutical drug for destroying tumor cells |
WO2021202473A2 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Engineered antibodies |
CN115362171A (en) | 2020-03-31 | 2022-11-18 | 百奥泰生物制药股份有限公司 | Antibody for treating coronavirus, fusion protein and application thereof |
MX2022012182A (en) | 2020-04-03 | 2022-12-08 | Alector Llc | Methods of use of anti-trem2 antibodies. |
WO2021202959A1 (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
US20230149555A1 (en) | 2020-04-06 | 2023-05-18 | PhotoQ3 Inc. | Medicament for killing tumor cells |
WO2021207449A1 (en) | 2020-04-09 | 2021-10-14 | Merck Sharp & Dohme Corp. | Affinity matured anti-lap antibodies and uses thereof |
CA3175523A1 (en) | 2020-04-13 | 2021-10-21 | Antti Virtanen | Methods, complexes and kits for detecting or determining an amount of a .beta.-coronavirus antibody in a sample |
WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
JP2023106635A (en) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | Bispecific antigen binding molecules and compositions related thereto, uses, kits and methods for producing compositions |
MX2022013493A (en) | 2020-04-27 | 2023-02-22 | Magenta Therapeutics Inc | METHODS AND COMPOSITIONS FOR TRANSDUCING HEMATOPOIETIC STEM AND PROGENITOR CELLS <i>IN VIVO. |
WO2021222181A2 (en) | 2020-04-27 | 2021-11-04 | The Regents Of The University Of California | Isoform-independent antibodies to lipoprotein(a) |
WO2021222167A1 (en) | 2020-04-28 | 2021-11-04 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
CA3183756A1 (en) | 2020-05-19 | 2021-11-25 | Amgen Inc. | Mageb2 binding constructs |
KR20230014719A (en) | 2020-05-22 | 2023-01-30 | 추가이 세이야쿠 가부시키가이샤 | Antibodies that neutralize substances with coagulation factor VIII (F.VIII) alternative activity |
EP3915641A1 (en) | 2020-05-27 | 2021-12-01 | International-Drug-Development-Biotech | Anti-cd5 antibodies and methods of use thereof |
CA3183693A1 (en) | 2020-05-29 | 2021-12-02 | Amgen Inc. | Adverse effects-mitigating administration of a bispecific construct binding to cd33 and cd3 |
CN115803062A (en) | 2020-06-03 | 2023-03-14 | 博泰康医药公司 | Antibodies to trophoblast cell surface antigen 2 (TROP-2) |
WO2021249969A1 (en) | 2020-06-10 | 2021-12-16 | Merck Patent Gmbh | Combination product for the treatment of cancer diseases |
KR20230025691A (en) | 2020-06-16 | 2023-02-22 | 제넨테크, 인크. | Methods and compositions for treating triple negative breast cancer |
KR20230024368A (en) | 2020-06-18 | 2023-02-20 | 제넨테크, 인크. | Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists |
EP4174071A1 (en) | 2020-06-24 | 2023-05-03 | The University of Tokyo | Photosensitizing dye |
WO2022006562A1 (en) | 2020-07-03 | 2022-01-06 | Dana-Farber Cancer Institute, Inc. | Multispecific coronavirus antibodies |
JP2023534987A (en) | 2020-07-24 | 2023-08-15 | アムジエン・インコーポレーテツド | Immunogen derived from SARS-COV2 spike protein |
EP4190354A1 (en) | 2020-07-28 | 2023-06-07 | Chugai Seiyaku Kabushiki Kaisha | Prefilled syringe preparation with needle, provided with needle shield and including novel modified antibody |
IL300133A (en) | 2020-07-31 | 2023-03-01 | Genentech Inc | Anti-integrin beta7 antibody formulations and devices |
CN116194124A (en) | 2020-07-31 | 2023-05-30 | 中外制药株式会社 | Pharmaceutical composition comprising cells expressing chimeric receptors |
JP2023536602A (en) | 2020-08-03 | 2023-08-28 | ジェネンテック, インコーポレイテッド | Diagnostic and therapeutic methods for lymphoma |
WO2022031804A1 (en) | 2020-08-04 | 2022-02-10 | Abbott Laboratories | Improved methods and kits for detecting sars-cov-2 protein in a sample |
EP4194468A1 (en) | 2020-08-07 | 2023-06-14 | Bio-Thera Solutions, Ltd. | Anti pd-l1 antibody and application thereof |
WO2022036146A1 (en) | 2020-08-12 | 2022-02-17 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
CN114106173A (en) | 2020-08-26 | 2022-03-01 | 上海泰槿生物技术有限公司 | anti-OX 40 antibodies, pharmaceutical compositions and uses thereof |
WO2022045247A1 (en) | 2020-08-27 | 2022-03-03 | 学校法人順天堂 | Anti-truncated mutant calr-cd3 bispecific antibody and pharmaceutical composition |
JP2023539279A (en) | 2020-08-31 | 2023-09-13 | ジェネンテック, インコーポレイテッド | Method for producing antibodies |
WO2022051549A1 (en) | 2020-09-04 | 2022-03-10 | Rutgers, The State University Of New Jersey | Sars-cov-2 vaccines and antibodies |
US20230372484A1 (en) | 2020-09-14 | 2023-11-23 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
AU2021357841A1 (en) | 2020-10-08 | 2023-06-15 | Affimed Gmbh | Trispecific binders |
WO2022081436A1 (en) | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
WO2022087274A1 (en) | 2020-10-21 | 2022-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that neutralize type-i interferon (ifn) activity |
WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
EP4237435A1 (en) | 2020-11-02 | 2023-09-06 | Ares Trading S.A. | Combination treatment of cancer |
EP4237441A1 (en) | 2020-11-02 | 2023-09-06 | F. Hoffmann-La Roche AG | Sars-cov-2 nucleocapsid antibodies |
EP4237001A1 (en) | 2020-11-02 | 2023-09-06 | Ares Trading S.A. | Combination treatment of cancer |
KR20230098334A (en) | 2020-11-06 | 2023-07-03 | 암젠 리서치 (뮌헨) 게엠베하 | Polypeptide constructs that selectively bind to CLDN6 and CD3 |
CN116323671A (en) | 2020-11-06 | 2023-06-23 | 安进公司 | Multi-targeting bispecific antigen binding molecules with increased selectivity |
EP4240767A1 (en) | 2020-11-06 | 2023-09-13 | Amgen Inc. | Polypeptide constructs binding to cd3 |
EP4242232A1 (en) | 2020-11-06 | 2023-09-13 | Bio-Thera Solutions, Ltd. | Bispecific antibody and use thereof |
EP4240407A1 (en) | 2020-11-06 | 2023-09-13 | Amgen Inc. | Antigen binding domain with reduced clipping rate |
WO2022100694A1 (en) | 2020-11-12 | 2022-05-19 | 迈威(上海)生物科技股份有限公司 | Antibody and preparation method therefor |
US20220170948A1 (en) | 2020-12-01 | 2022-06-02 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi |
WO2023102384A1 (en) | 2021-11-30 | 2023-06-08 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2022140797A1 (en) | 2020-12-23 | 2022-06-30 | Immunowake Inc. | Immunocytokines and uses thereof |
EP4271998A1 (en) | 2020-12-30 | 2023-11-08 | Abbott Laboratories | Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample |
WO2022187591A1 (en) | 2021-03-05 | 2022-09-09 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
EP4294927A2 (en) | 2021-03-10 | 2023-12-27 | Immunowake Inc. | Immunomodulatory molecules and uses thereof |
KR20230156368A (en) | 2021-03-12 | 2023-11-14 | 추가이 세이야쿠 가부시키가이샤 | Pharmaceutical composition for the treatment or prevention of myasthenia gravis |
WO2022190033A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
WO2022190034A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
WO2022198192A1 (en) | 2021-03-15 | 2022-09-22 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
EP4308694A1 (en) | 2021-03-16 | 2024-01-24 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
CA3212599A1 (en) | 2021-03-22 | 2022-09-29 | Novimmune S.A. | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
IL305827A (en) | 2021-03-22 | 2023-11-01 | Novimmune Sa | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
JP2024513376A (en) | 2021-04-02 | 2024-03-25 | アムジエン・インコーポレーテツド | MAGEB2 binding construct |
JP2024513246A (en) | 2021-04-09 | 2024-03-22 | ジェネンテック, インコーポレイテッド | Combination treatment with RAF inhibitor and PD-1 axis inhibitor |
CN117440798A (en) | 2021-04-12 | 2024-01-23 | Acm 生物实验室私人有限公司 | Polymer vesicles comprising soluble encapsulated polynucleotides and ionizable lipids, methods of making and uses thereof |
EP4333900A2 (en) | 2021-05-03 | 2024-03-13 | Merck Patent GmbH | Her2 targeting fc antigen binding fragment-drug conjugates |
AU2022270075A1 (en) | 2021-05-04 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Multispecific fgf21 receptor agonists and their uses |
IL307672A (en) | 2021-05-06 | 2023-12-01 | Amgen Res Munich Gmbh | Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases |
WO2022235940A1 (en) | 2021-05-06 | 2022-11-10 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
AU2022279156A1 (en) | 2021-05-18 | 2023-11-02 | Abbott Laboratories | Methods of evaluating brain injury in a pediatric subject |
IL308818A (en) | 2021-05-25 | 2024-01-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
CN117858723A (en) | 2021-06-07 | 2024-04-09 | 阿雷斯贸易股份有限公司 | Combination therapy for cancer |
CA3222291A1 (en) | 2021-06-14 | 2022-12-22 | Jaime MARINO | Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind |
AU2022293999A1 (en) | 2021-06-14 | 2023-11-30 | argenx BV | Anti-il-9 antibodies and methods of use thereof |
IL309997A (en) | 2021-07-09 | 2024-03-01 | Janssen Biotech Inc | Manufacturing methods for producing anti-tnf antibody compositions |
AU2022306973A1 (en) | 2021-07-09 | 2024-02-22 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
KR20240032991A (en) | 2021-07-09 | 2024-03-12 | 얀센 바이오테크 인코포레이티드 | Manufacturing Methods for Producing Anti-TNF Antibody Compositions |
WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
IL308154A (en) | 2021-07-30 | 2023-12-01 | Affimed Gmbh | Duplexbodies |
WO2023014863A1 (en) | 2021-08-05 | 2023-02-09 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
IL310535A (en) | 2021-08-10 | 2024-03-01 | Byomass Inc | Anti-gdf15 antibodies, compositions and uses thereof |
AU2022330106A1 (en) | 2021-08-16 | 2024-03-21 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
AU2022328625A1 (en) | 2021-08-17 | 2024-03-21 | Eli Lilly And Company | Bispecific anti-flt3/cd3 antibodies and methods of use |
CA3230038A1 (en) | 2021-08-31 | 2023-03-09 | Hongwei Zhang | Methods and systems of diagnosing brain injury |
WO2023034571A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
AU2022339667A1 (en) | 2021-09-03 | 2024-04-11 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
CA3232176A1 (en) | 2021-09-30 | 2023-04-06 | Beth MCQUISTON | Methods and systems of diagnosing brain injury |
WO2023057871A1 (en) | 2021-10-04 | 2023-04-13 | Novartis Ag | Surfactant stabilizers |
CA3233924A1 (en) | 2021-10-08 | 2023-04-13 | Kengo ARAI | Method for preparing prefilled syringe formulation |
WO2023069421A1 (en) | 2021-10-18 | 2023-04-27 | Byomass Inc. | Anti-activin a antibodies, compositions and uses thereof |
WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
WO2023073615A1 (en) | 2021-10-29 | 2023-05-04 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
TW202334221A (en) | 2021-11-03 | 2023-09-01 | 德商安富美德有限公司 | Bispecific cd16a binders |
WO2023079493A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
WO2023081471A1 (en) | 2021-11-05 | 2023-05-11 | Dana-Farber Cancer Institute, Inc. | Human broadly crossreactive influenza monoclonal antibodies and methods of use thereof |
WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
WO2023084488A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
US20230159633A1 (en) | 2021-11-23 | 2023-05-25 | Janssen Biotech, Inc. | Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody |
WO2023097024A1 (en) | 2021-11-24 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Antibodies against ctla-4 and methods of use thereof |
WO2023114544A1 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Antibodies and uses thereof |
WO2023114543A2 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Platform for antibody discovery |
WO2023111168A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
WO2023114978A1 (en) | 2021-12-17 | 2023-06-22 | Abbott Laboratories | Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples |
WO2023122213A1 (en) | 2021-12-22 | 2023-06-29 | Byomass Inc. | Targeting gdf15-gfral pathway cross-reference to related applications |
US20230213536A1 (en) | 2021-12-28 | 2023-07-06 | Abbott Laboratories | Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan |
WO2023147107A1 (en) | 2022-01-31 | 2023-08-03 | Byomass Inc. | Myeloproliferative conditions |
WO2023150652A1 (en) | 2022-02-04 | 2023-08-10 | Abbott Laboratories | Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample |
WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2023169896A1 (en) | 2022-03-09 | 2023-09-14 | Astrazeneca Ab | BINDING MOLECULES AGAINST FRα |
WO2023170216A1 (en) | 2022-03-11 | 2023-09-14 | Astrazeneca Ab | A SCORING METHOD FOR AN ANTI-FRα ANTIBODY-DRUG CONJUGATE THERAPY |
EP4245772A1 (en) | 2022-03-18 | 2023-09-20 | Netris Pharma | Anti-netrin-1 antibody to treat liver inflammation |
WO2023178357A1 (en) | 2022-03-18 | 2023-09-21 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules and methods of use thereof |
EP4249509A1 (en) | 2022-03-22 | 2023-09-27 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
WO2023186968A1 (en) | 2022-03-29 | 2023-10-05 | Netris Pharma | Novel mcl-1 inhibitor and combination of mcl-1 and a bh3 mimetic, such as a bcl-2 inhibitor |
WO2023187707A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of treating mild to moderate psoriasis with il-23 specific antibody |
WO2023194539A1 (en) | 2022-04-07 | 2023-10-12 | Heidelberg Pharma Research Gmbh | Methods of improving the therapeutic index of amatoxin-antibody conjugates |
WO2023201201A1 (en) | 2022-04-10 | 2023-10-19 | Immunomic Therapeutics, Inc. | Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof |
WO2023215498A2 (en) | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
TW202346368A (en) | 2022-05-12 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
US20230374122A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for Evaluating and Treating Psoriatic Arthritis with IL23 Antibody |
WO2023235415A1 (en) | 2022-06-01 | 2023-12-07 | Genentech, Inc. | Method to identify a patient with an increased likelihood of chemotherapy-induced peripheral neuropathy |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2024006876A1 (en) | 2022-06-29 | 2024-01-04 | Abbott Laboratories | Magnetic point-of-care systems and assays for determining gfap in biological samples |
WO2024015953A1 (en) | 2022-07-15 | 2024-01-18 | Danisco Us Inc. | Methods for producing monoclonal antibodies |
WO2024039670A1 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against cldn4 and methods of use thereof |
WO2024039672A2 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against msln and methods of use thereof |
WO2024038165A1 (en) | 2022-08-18 | 2024-02-22 | Immunocore Ltd | T cell receptor fusion proteins specific for mage a4 |
WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
WO2024059708A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Biomarkers and methods for differentiating between mild and supermild traumatic brain injury |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002602A1 (en) * | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
WO1994025585A1 (en) * | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1996033735A1 (en) * | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5204244A (en) * | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
WO1991000906A1 (en) * | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
-
1995
- 1995-04-28 CA CA002219486A patent/CA2219486A1/en not_active Abandoned
- 1995-04-28 AU AU24668/95A patent/AU2466895A/en not_active Abandoned
- 1995-04-28 WO PCT/US1995/005500 patent/WO1996034096A1/en not_active Application Discontinuation
- 1995-04-28 EP EP95918935A patent/EP0823941A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002602A1 (en) * | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
WO1994025585A1 (en) * | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1996033735A1 (en) * | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
Non-Patent Citations (2)
Title |
---|
JAKOBOVITS A ET AL: "PRODUCTION OF ANTIGEN-SPECIFIC HUMAN ANTIBODIES FROM MICE ENGINEERED WITH HUMAN HEAVY AND LIGHT CHAIN YACS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,US,NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, vol. 764, 29 September 1995 (1995-09-29), pages 525 - 535, XP002067728, ISSN: 0077-8923 * |
See also references of WO9634096A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2466895A (en) | 1996-11-18 |
CA2219486A1 (en) | 1996-10-31 |
EP0823941A1 (en) | 1998-02-18 |
WO1996034096A1 (en) | 1996-10-31 |
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