SG11202006674QA - Single-domain antibodies against lag-3 and uses thereof - Google Patents

Single-domain antibodies against lag-3 and uses thereof

Info

Publication number
SG11202006674QA
SG11202006674QA SG11202006674QA SG11202006674QA SG11202006674QA SG 11202006674Q A SG11202006674Q A SG 11202006674QA SG 11202006674Q A SG11202006674Q A SG 11202006674QA SG 11202006674Q A SG11202006674Q A SG 11202006674QA SG 11202006674Q A SG11202006674Q A SG 11202006674QA
Authority
SG
Singapore
Prior art keywords
antibodies against
domain antibodies
against lag
lag
domain
Prior art date
Application number
SG11202006674QA
Inventor
Wang Zhang
Shuai Yang
Shu Wu
Chuan-Chu Chou
Original Assignee
Nanjing Legend Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Legend Biotech Co Ltd filed Critical Nanjing Legend Biotech Co Ltd
Publication of SG11202006674QA publication Critical patent/SG11202006674QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
SG11202006674QA 2018-03-30 2019-03-29 Single-domain antibodies against lag-3 and uses thereof SG11202006674QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018081356 2018-03-30
PCT/CN2019/080528 WO2019185040A1 (en) 2018-03-30 2019-03-29 Single-domain antibodies against lag-3 and uses thereof

Publications (1)

Publication Number Publication Date
SG11202006674QA true SG11202006674QA (en) 2020-08-28

Family

ID=68060954

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006674QA SG11202006674QA (en) 2018-03-30 2019-03-29 Single-domain antibodies against lag-3 and uses thereof

Country Status (10)

Country Link
EP (1) EP3774917A4 (en)
JP (1) JP7346790B2 (en)
KR (1) KR20200138720A (en)
CN (1) CN111886254B (en)
AU (1) AU2019241350A1 (en)
CA (1) CA3093034A1 (en)
IL (1) IL276260A (en)
SG (1) SG11202006674QA (en)
TW (1) TW202003567A (en)
WO (1) WO2019185040A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7366908B2 (en) 2018-01-15 2023-10-23 ナンジン レジェンド バイオテック カンパニー，リミテッド Single domain antibodies against PD-1 and variants thereof
WO2020249071A1 (en) * 2019-06-12 2020-12-17 Nanjing GenScript Biotech Co., Ltd. Anti-pd-l1/anti-lag-3 multiple antigen binding proteins and methods of use thereof
US11124568B1 (en) * 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
WO2022109987A1 (en) * 2020-11-27 2022-06-02 Shanghai Benemae Pharmaceutical Corporation Novel anti-lag3 antibodies and methods of making and using the same
EP4019548A1 (en) * 2020-12-23 2022-06-29 Vrije Universiteit Brussel Anti lag3 vhhs and their use
KR102461837B1 (en) * 2022-01-13 2022-11-01 ㈜지아이이노베이션 Fusion protein comprising extracellular domain of cd80 and anti-lag3 antibody fragments and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013201422B2 (en) * 2012-01-23 2015-04-09 Ablynx Nv Sequences directed against hepatocyte growth factor (HFG) and polypeptides comprising the same for the treatment of cancers and/or tumors
CN113583129A (en) * 2014-03-14 2021-11-02 诺华股份有限公司 Antibody molecules against LAG-3 and uses thereof
JO3663B1 (en) * 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
CN104479015A (en) * 2014-12-04 2015-04-01 东南大学 Nano antibody aiming at NGAL epitope and application thereof
TWI773646B (en) * 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 Lag-3-binding molecules and methods of use thereof
WO2017015560A2 (en) * 2015-07-22 2017-01-26 Sorrento Therapeutics, Inc. Antibody therapeutics that bind lag3
US20190010231A1 (en) * 2015-08-07 2019-01-10 Pieris Pharmaceuticals Gmbh Novel fusion polypeptide specific for lag-3 and pd-1
DK3356401T3 (en) * 2015-09-30 2020-09-07 Igm Biosciences Inc BINDING MOLECULES WITH MODIFIED J-CHAIN
KR102220275B1 (en) * 2015-11-18 2021-02-26 머크 샤프 앤드 돔 코포레이션 Pd1 and/or lag3 binders
WO2017087901A2 (en) * 2015-11-19 2017-05-26 Sutro Biopharma, Inc. Anti-lag3 antibodies, compositions comprising anti-lag3 antibodies and methods of making and using anti-lag3 antibodies
CN107400166A (en) * 2016-05-19 2017-11-28 苏州康宁杰瑞生物科技有限公司 for CTLA4 single domain antibody and its derived protein
WO2018014260A1 (en) * 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2018068201A1 (en) * 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4

Also Published As

Publication number Publication date
WO2019185040A1 (en) 2019-10-03
CN111886254B (en) 2023-12-08
IL276260A (en) 2020-09-30
KR20200138720A (en) 2020-12-10
EP3774917A4 (en) 2022-01-19
US20210017279A1 (en) 2021-01-21
JP7346790B2 (en) 2023-09-20
EP3774917A1 (en) 2021-02-17
JP2021516951A (en) 2021-07-15
CN111886254A (en) 2020-11-03
AU2019241350A1 (en) 2020-07-30
CA3093034A1 (en) 2019-10-03
TW202003567A (en) 2020-01-16

Similar Documents

Publication Publication Date Title
IL275575A (en) Single-domain antibodies and variants thereof against tigit
EP3652212A4 (en) Antibodies binding lag-3 and uses thereof
IL275737A (en) Antibodies and variants thereof against tigit
IL276950A (en) Anti-cd73 antibodies and uses thereof
IL274438A (en) Single-domain antibodies and variants thereof against pd-l1
IL282968A (en) Anti-nkg2a antibodies and uses thereof
IL278846A (en) Anti-cd3 antibodies and uses thereof
SG11202100746WA (en) Anti-tigit antibody and use thereof
IL276260A (en) Single-domain antibodies against lag-3 and uses thereof
SG11202105885WA (en) Anti-claudin antibodies and uses thereof
IL275740A (en) Single-domain antibodies and variants thereof against pd-1
SG11202104240TA (en) Cll1-targeting antibody and application thereof
ZA202006066B (en) Anti-hla-g antibodies and use thereof
IL275826A (en) Anti-mct1 antibodies and uses thereof
IL281297A (en) Anti-npr1 antibodies and uses thereof
SG11202009772PA (en) Anti-dll3 antibodies and uses thereof
SG11202009625WA (en) Anti-trem-1 antibodies and uses thereof
IL280321A (en) Anti-cxcr2 antibodies and uses thereof
IL277330A (en) Anti-il-27 antibodies and uses thereof
IL283875A (en) Anti-il-27 antibodies and uses thereof
IL277075A (en) Anti-phf-tau antibodies and uses thereof
IL276548A (en) Bcma-binding antibodies and uses thereof
IL283926A (en) Anti-alpha-synuclein antibodies and uses thereof
IL281202A (en) Anti-tnfrsf9 antibodies and uses thereof
IL283890A (en) Anti-periostin antibodies and uses thereof