EP0758888A1 - Matrixsystem für die transdermale verabreichung von ibuprofen und herstellungsverfahren - Google Patents

Matrixsystem für die transdermale verabreichung von ibuprofen und herstellungsverfahren

Info

Publication number
EP0758888A1
EP0758888A1 EP95920133A EP95920133A EP0758888A1 EP 0758888 A1 EP0758888 A1 EP 0758888A1 EP 95920133 A EP95920133 A EP 95920133A EP 95920133 A EP95920133 A EP 95920133A EP 0758888 A1 EP0758888 A1 EP 0758888A1
Authority
EP
European Patent Office
Prior art keywords
ibuprofen
matrix
weight
parts
adhesive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95920133A
Other languages
English (en)
French (fr)
Inventor
Antoine Sawaya
Marie-Christine Math
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires dHygiene et de Dietetique SA
Original Assignee
Laboratoires dHygiene et de Dietetique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires dHygiene et de Dietetique SA filed Critical Laboratoires dHygiene et de Dietetique SA
Publication of EP0758888A1 publication Critical patent/EP0758888A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

  • a self-adhesive transdermal matrix system for the percutaneous administration of ibuprofen is recommended, said matrix system, which comprises a support and a self-adhesive matrix, being characterized in that said matrix comprises:
  • these adhesive acrylate copolymers are in the form of solutions in a solvent system (consisting of a single organic solvent or better of a mixture of several organic solvents) and having a content of 25 to 55% w / v in copolymers such as for example the products marketed by the companies NATIONAL STARCH, AVERY DENNISON, UCB SA SEKISUI CHEMICAL CO, respectively under the names DUROTAK®, POLITEX ®, SOLUCRYL®, and TSR®.
  • a solvent system consisting of a single organic solvent or better of a mixture of several organic solvents
  • UCB SA SEKISUI CHEMICAL CO respectively under the names DUROTAK®, POLITEX ®, SOLUCRYL®, and TSR®.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP95920133A 1994-05-11 1995-05-10 Matrixsystem für die transdermale verabreichung von ibuprofen und herstellungsverfahren Withdrawn EP0758888A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9405818A FR2719770A1 (fr) 1994-05-11 1994-05-11 Système matriciel pour administration transdermique d'ibuprofène et procédé de préparation.
FR9405818 1994-05-11
PCT/FR1995/000611 WO1995031193A1 (fr) 1994-05-11 1995-05-10 Systeme matriciel pour administration transdermique d'ibuprofene et procede de preparation

Publications (1)

Publication Number Publication Date
EP0758888A1 true EP0758888A1 (de) 1997-02-26

Family

ID=9463130

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95920133A Withdrawn EP0758888A1 (de) 1994-05-11 1995-05-10 Matrixsystem für die transdermale verabreichung von ibuprofen und herstellungsverfahren

Country Status (10)

Country Link
EP (1) EP0758888A1 (de)
JP (1) JPH10500947A (de)
CA (1) CA2189970A1 (de)
CZ (1) CZ331496A3 (de)
FI (1) FI964500A (de)
FR (1) FR2719770A1 (de)
HU (1) HUT75863A (de)
NO (1) NO964743L (de)
PL (1) PL317156A1 (de)
WO (1) WO1995031193A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2196208T3 (es) * 1996-03-09 2003-12-16 Nitto Denko Corp Preparacion percutanea adhesiva.
DE19830649C2 (de) * 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
DE19830651A1 (de) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Steroidhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung
DE19834496B4 (de) * 1998-07-31 2004-02-26 Beiersdorf Ag Verbesserte Freisetzung von Ibuprofen aus Heißschmelzklebemassen in wirkstoffhaltigen Pflastern durch Zusatz von pharmazeutischen Hilfsstoffen und Verwendung von Hilfsstoffen zur Verbesserung der Freisetzung von Ibuprofen
US20030170195A1 (en) 2000-01-10 2003-09-11 Noven Pharmaceuticals, Inc. Compositions and methods for drug delivery
PT1061900E (pt) † 1999-01-14 2005-04-29 Noven Pharma Composicoes e metodos para libertacao de uma droga
KR100623077B1 (ko) * 2002-08-26 2006-09-18 지상철 에스(+)-이부프로펜을 함유하는 경피투여용 조성물 및이를 함유하는 경피투여용 패취제
ITMI20041628A1 (it) * 2004-08-06 2004-11-06 Bouty S P A Sistema terapeutico a rilascio controllato per uso topico transdermico
WO2006041911A2 (en) 2004-10-08 2006-04-20 Noven Pharmaceuticals, Inc. Device transdermal administration of drugs including acrylic polymers
CN107028920A (zh) * 2017-05-16 2017-08-11 蔡志浩 布洛芬巴布贴剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS596287B2 (ja) * 1980-11-28 1984-02-10 日東電工株式会社 医薬製剤
JPH0747535B2 (ja) * 1985-11-26 1995-05-24 日東電工株式会社 消炎鎮痛用貼付剤
DE3634016A1 (de) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
JP2638635B2 (ja) * 1989-01-31 1997-08-06 積水化学工業株式会社 経皮吸収製剤
ES2055291T5 (es) * 1989-12-28 2000-03-01 Nitto Denko Corp Material de gel acrilico y preparacion de gel acrilico.
DE4020144A1 (de) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen
JPH04120017A (ja) * 1990-09-11 1992-04-21 Lion Corp 粘膜投与用液剤
CA2077369A1 (en) * 1991-09-09 1993-03-10 Hitoshi Akemi Acrylic gel material and gel-based medical preparation for percutaneous absorption employing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9531193A1 *

Also Published As

Publication number Publication date
PL317156A1 (en) 1997-03-17
FI964500A0 (fi) 1996-11-08
FI964500A (fi) 1996-11-08
HUT75863A (en) 1997-05-28
CA2189970A1 (en) 1995-11-23
WO1995031193A1 (fr) 1995-11-23
NO964743D0 (no) 1996-11-08
FR2719770B1 (de) 1997-02-21
JPH10500947A (ja) 1998-01-27
NO964743L (no) 1996-11-08
HU9603108D0 (en) 1997-01-28
CZ331496A3 (en) 1997-02-12
FR2719770A1 (fr) 1995-11-17

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Legal Events

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