EP0738136B1 - Verfahren zur herstellung von tabletten - Google Patents
Verfahren zur herstellung von tabletten Download PDFInfo
- Publication number
- EP0738136B1 EP0738136B1 EP95905039A EP95905039A EP0738136B1 EP 0738136 B1 EP0738136 B1 EP 0738136B1 EP 95905039 A EP95905039 A EP 95905039A EP 95905039 A EP95905039 A EP 95905039A EP 0738136 B1 EP0738136 B1 EP 0738136B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- additive
- process according
- lubricant
- additives
- compression chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
Definitions
- the invention relates to a method of manufacture of tablets using a press that at least one press chamber with an upper and lower stamp and a lubrication device with at least one two-substance nozzle has the lubricant on the bale chamber walls emitted on a spray cone.
- the invention has for its object a method to specify the manufacture of tablets in the case of additives at any time without changing the structure of the press can be added.
- the lubricant applied to the press chamber walls is applied, at least one additive attached. It is through this measure according to the invention possible without interfering with the structure of the press, additives, whose dosage must be exact, into the tablet to bring in the manufacturing process, or on the Apply tablet.
- additives can include flavorings, such as commercial sweeteners (claim 3) be.
- bitter substances as additives in a water-soluble preparation on the tablet to incite the children from abuse the tablets are supposed to hold. In the instructions for use would then be an indication that the tablets before the intended use would have to be washed off in order to thus removing the bitter substance.
- the flavor or flavors in mixed a carrier and then mixed the lubricant attached.
- a preferred possibility is characterized in claim 5, like the additive and especially one or more Flavors applied to the surface as a film can be:
- the flavor is mixed with a film former and then the lubricant together with the film former added.
- the mixture is then, for example, with the in DE 41 03 413 Cl device described on the Surface or on selected surface areas of the Press chamber or the active tool of the press chamber applied.
- a nozzle with is particularly suitable for use piezoelectric proportional valve in the feed device, with that even at high temperatures and high Pressing can be worked precisely.
- Such a valve works in proportion to the control and guaranteed by adjustable flow rate and adjustable cross-section exact dosage.
- the control is preferably carried out via a computer or via an electronic control unit that transmits its signals for example via sensors for pressure and / or temperature receive.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Seasonings (AREA)
- Formation And Processing Of Food Products (AREA)
Description
Claims (7)
- Verfahren zur Herstellung von Tabletten unter Verwendung einer Presse, die wenigstens eine Preßkammer mit einem Ober- und Unterstempel und eine Schmiervorrichtung mit wenigstens einer Zweistoffdüse aufweist, die das Schmiermittel auf die Preßkammerwände auf einem Sprühkegel emittiert,
dadurch gekennzeichnet, daß dem Schmiermittel wenigstens ein Zusatzstoff, der beim Herstellungsvorgang der Tabletten in diese einzubringen bzw. auf diese aufzubringen ist, beigefügt wird. - Verfahren nach Anspruch 1,
dadurch gekennzeichnet, daß der Zusatzstoff ein Geschmacksstoff ist. - Verfahren nach Anspruch 2,
dadurch gekennzeichnet, daß der Geschmacksstoff in einen Träger gemischt und dann dem Schmiermittel beigefügt wird. - Verfahren nach einem der Ansprüche 1 bis 3,
dadurch gekennzeichnet, daß der Zusatzstoff ein Süßstoff und/oder ein Bitterstoff ist. - Verfahren nach einem der Ansprüche 1 bis 4,
dadurch gekennzeichnet, daß der Zusatzstoff dadurch als Film auf die Oberfläche der Tablette aufgebracht wird, daß er mit einem Filmbildner gemischt und dann zusammen mit dem Filmbildner dem Schmiermittel zugesetzt wird. - Verfahren nach einem der Ansprüche 1 bis 5,
dadurch gekennzeichnet, daß die Zusatzstoffe in Form einer Schmelze auf die Preßkammerwände mit Hilfe wenigstens einer heizbaren Zweistoffdüse aufgetragen werden. - Verfahren nach einem der Ansprüche 1 bis 6,
dadurch gekennzeichnet, daß zur Dosierung des bzw. der Zusatzstoffe ein Proportionalventil verwendet wird, das die Dosierung des bzw. der Zusatzstoffe vor der Zweistoffdüse steuert.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4400111A DE4400111C2 (de) | 1994-01-04 | 1994-01-04 | Verfahren zur Herstellung von Tabletten |
DE4400111 | 1994-01-04 | ||
PCT/DE1995/000011 WO1995018596A1 (de) | 1994-01-04 | 1995-01-04 | Verfahren zur herstellung von tabletten |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0738136A1 EP0738136A1 (de) | 1996-10-23 |
EP0738136B1 true EP0738136B1 (de) | 1998-04-15 |
Family
ID=6507452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95905039A Expired - Lifetime EP0738136B1 (de) | 1994-01-04 | 1995-01-04 | Verfahren zur herstellung von tabletten |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0738136B1 (de) |
JP (1) | JPH09509589A (de) |
AT (1) | ATE164996T1 (de) |
DE (2) | DE4400111C2 (de) |
WO (1) | WO1995018596A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2829933B3 (fr) * | 2001-09-21 | 2004-03-12 | Ellipse Pharmaceuticals | Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3518343A (en) * | 1967-10-02 | 1970-06-30 | Miles Lab | Effervescent tablet and process for making same |
DD136026A5 (de) * | 1977-04-20 | 1979-06-13 | Thomae Gmbh Dr K | Verfahren zum bespruehen der verdichtungswerkzeuge mit schmiermitteln |
DE3312634A1 (de) * | 1983-04-08 | 1984-10-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Verbessertes verfahren und vorrichtungen zum bepunkten von formwerkzeugen mit troepfchen fluessiger oder suspendierter schmiermittel bei der herstellung von formlingen in pharma-, lebensmittel- oder katalysatorenbereich |
DE3811260A1 (de) * | 1988-04-02 | 1989-10-26 | Thomae Gmbh Dr K | Gezielte abgabe dosierter mengen von feinverteilten feststoffen mit venturi-duese und geregelter ansteuerung |
DE4103413C1 (de) * | 1991-02-05 | 1992-11-12 | Gunter M. 8918 Diessen De Voss |
-
1994
- 1994-01-04 DE DE4400111A patent/DE4400111C2/de not_active Expired - Fee Related
-
1995
- 1995-01-04 AT AT95905039T patent/ATE164996T1/de not_active IP Right Cessation
- 1995-01-04 JP JP7518264A patent/JPH09509589A/ja active Pending
- 1995-01-04 DE DE59501912T patent/DE59501912D1/de not_active Expired - Lifetime
- 1995-01-04 EP EP95905039A patent/EP0738136B1/de not_active Expired - Lifetime
- 1995-01-04 WO PCT/DE1995/000011 patent/WO1995018596A1/de active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO1995018596A1 (de) | 1995-07-13 |
JPH09509589A (ja) | 1997-09-30 |
DE59501912D1 (de) | 1998-05-20 |
DE4400111A1 (de) | 1995-07-06 |
DE4400111C2 (de) | 2003-06-18 |
EP0738136A1 (de) | 1996-10-23 |
ATE164996T1 (de) | 1998-05-15 |
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