EP0736481A2 - Dispositif et procédé pour retirer ou dévisser des fermetures de récipients ainsi que mandrin de maintien de fermetures - Google Patents

Dispositif et procédé pour retirer ou dévisser des fermetures de récipients ainsi que mandrin de maintien de fermetures Download PDF

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Publication number
EP0736481A2
EP0736481A2 EP96105314A EP96105314A EP0736481A2 EP 0736481 A2 EP0736481 A2 EP 0736481A2 EP 96105314 A EP96105314 A EP 96105314A EP 96105314 A EP96105314 A EP 96105314A EP 0736481 A2 EP0736481 A2 EP 0736481A2
Authority
EP
European Patent Office
Prior art keywords
closure
vessel
holding device
gripping jaws
vessels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP96105314A
Other languages
German (de)
English (en)
Other versions
EP0736481A3 (fr
EP0736481B1 (fr
Inventor
Peter Kraft
Horst Menzler
Hans Dr. Schels
Peter Dr. Wenzig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH, Boehringer Mannheim GmbH filed Critical Roche Diagnostics GmbH
Publication of EP0736481A2 publication Critical patent/EP0736481A2/fr
Publication of EP0736481A3 publication Critical patent/EP0736481A3/fr
Application granted granted Critical
Publication of EP0736481B1 publication Critical patent/EP0736481B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67BAPPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00Hand- or power-operated devices for opening closed containers
    • B67B7/18Hand- or power-operated devices for opening closed containers for removing threaded caps
    • B67B7/182Hand- or power-operated devices for opening closed containers for removing threaded caps power-operated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67BAPPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00Hand- or power-operated devices for opening closed containers
    • B67B7/02Hand- or power-operated devices for opening closed containers for removing stoppers

Definitions

  • Devices for removing closures from vessels are used in particular in the field of clinical analysis, since a large number of sample vessels are obtained here, which are closed with stoppers or screw caps, which have to be removed before an analysis is carried out.
  • This apparatus has a holding device for the sample vessels, as well as a mechanism by means of which the stoppers are encompassed by two opposing holding jaws. When the holding jaws are moved together, thorns are also inserted into the stopper, which enable secure holding. The stopper is removed by removing the device with the holding jaws upward from the sample vessel.
  • the object of the invention was to propose a device with which both the removal of plugs and screw caps is possible. It was a further object of the invention to propose a device with which any sample vessels used in practice can be freed from their closures.
  • a sample vessel is held in the vessel receiving device in such a way that a closure can be removed. This presupposes that the vessel receiving device forms a re-bearing against the forces occurring when pulling out or twisting off.
  • the vessel receiving device must accordingly be designed so that both rotational movements and linear movements of the vessels are largely prevented.
  • the sample tubes used are usually test tubes made of glass or plastic. The vessel receiving device must therefore be designed so that it without exerting excessive pressure on the sample vessel, a holder is used to prevent the sample vessel from being destroyed.
  • a suitable device for holding test tubes is described, for example, in EP-B-0 264 456.
  • a vessel receiving device was found to be particularly suitable in which the reagent vessels between holding jaws made of relatively elastic material, e.g. B. rubber, are clamped.
  • the holding jaws are in turn attached to adjusting jaws via an axis in such a way that they can be tilted relative to the axis of the vessel. It has proven to be particularly simple if the adjusting jaws are moved toward or away from one another via a spindle drive in order to open and close the vessel receiving device.
  • Such a spindle drive for a pair of adjusting jaws can advantageously be operated with a single motor if the spindle drive for both adjusting jaws is accommodated on a single threaded rod which has a right-hand thread on one section and a left-hand thread on the other section.
  • the described vessel holding devices can be operated together with racks for sample vessels.
  • racks used in practice, several reagent vessels are arranged linearly one after the other.
  • Such a rack can be operated together with a vessel receiving device by pushing the rack between the holding jaws of the vessel receiving device. If the rack is designed so that the sample vessels are accessible from the side, the sample vessels can be held by the holding jaws without the sample vessels having to be removed to remove the closure.
  • a sample rack is pushed onto a conveyor belt, through which the individual vessels are moved one after the other under the closure holding device.
  • a container which is located under the closure holder, is lifted by a gripper arm and the closure of the container is guided into the closure holder. It has been shown that it is favorable to make the gripper mechanically relatively simple and to provide a separate holding device for holding the vessel during the calibration process.
  • This vessel holding device can be arranged fixed in space due to the additional gripper.
  • the rotors for sample vessels used by some devices in which the sample vessels are arranged on a circular line, can also be used together with the described vessel receiving devices, provided that the vessels are accessible from the side.
  • a vessel receiving device has been found to be advantageous which consists of two vessel receiving devices which are fastened together on a rotary arm.
  • One of each of these two receptacle receptacles is in a position accessible to the closure holding device, usually below the closure holding device.
  • the second vessel receiving device is in a position in which it can be equipped with closed sample vessels. If the vessel in the first position has been opened and a closed vessel is in the second position, the rotary arm performs a rotation with which the two positions are interchanged. Now the still closed vessel can be opened and the already opened vessel can be transported on for subsequent analysis.
  • the device described is particularly suitable for incorporating it into a transport system in which the sample vessels individually pass through a multiplicity of stations, in which, for example, labels are stuck on, pipetting, dilution and centrifugation steps are carried out.
  • a closure holding device is equipped with holding elements which serve to hold a closure.
  • the device described in FIGS. 11 to 15 of the European patent EP-B-0 264 456 or a similar device can be used as the closure holding device.
  • the invention includes a new closure holding device which has proven to be particularly advantageous for the specific application.
  • This closure holding device according to the invention has a plurality of gripping jaws, preferably 4 to 8 and particularly preferably 6.
  • the gripping jaws are arranged around a center essentially on one level.
  • the gripping jaws can be moved by a drive from a first position to a second position, wherein in the first position there is an intermediate space between the gripping jaws which is sufficiently large to accommodate the respective closure.
  • a distance between the gripping jaws of more than 19 mm is suitable for the closure diameters of 11 to 19 mm that occur in clinical practice.
  • the gripping jaws In the second position, the gripping jaws have moved towards each other so far that they hold the respective closure that is between them. From the aim of the invention, different types of To be able to handle closures, it follows that said second position is not fixed, but must adapt to the size of the respective closure. For the sake of simplicity, however, the first position is usually chosen so large that all closures that occur in practice fit between the gripping jaws.
  • the drive of the gripping jaws can be, for example, a pressure cylinder or a spindle drive. According to the invention, however, a drive has been found that moves all gripping jaws simultaneously in a simple manner.
  • This drive has two plates arranged parallel to each other, which can be rotated against each other with a plate drive perpendicular to their plane. These two plates preferably have circular recesses in the region of the axis of rotation.
  • Each of the gripping jaws is rotatably connected to the first plate via a connecting axis and can be rotated about its connecting axis to the first plate with pins which are attached to the second plate.
  • the pins of the second plate preferably engage in recesses in the gripping jaws, which serve as a guide rail.
  • the guide rail and the connecting axis are arranged so that the tips of the gripping jaws move away from the center for receiving the closure when the plates are rotated against one another so that the connecting axes on the first plate and the pins on the second plate move away from one another.
  • the gripper jaws can be moved towards their common center by an opposite rotation, so as to catch a closure which is located between them. It has proven to be advantageous if the edges or surfaces of the gripping jaws that press against the closure have teeth. It has also proven to be particularly advantageous if there are needles or spikes on the gripping jaws which at least partially penetrate into the closure when it is held.
  • the closure holding device is located on a movement device which can both move the closure holding device essentially parallel to the vessel axis and also enables rotation of the closure holding device around the vessel axis.
  • This movement device can be a robot arm, for example, which carries out the corresponding movements with the closure holding device.
  • the movement device consists of a fixed rack, on which the closure holder can be moved up and down via a gear drive, while a separate motor ensures the rotation of the closure holder.
  • a particularly simple solution for the movement device has been found, in which a single motor drives a screw on which the closure holding device is located.
  • This screw is located in a nut, so that when the motor rotates, the closure holding device both rotates about the screw axis and a linear movement in the direction of Executes screw axis.
  • the rotation of the closure holding device is 400 ° and the screw mentioned is selected such that the advance of the closure holding device during this rotation is 9 mm. Good results could also be achieved with the device if the angle of rotation of the vessel receiving device is above 300 ° and the advance of the vessel receiving device is at least 5 mm.
  • the above-mentioned embodiment could be further improved in that the nut in which the screw of the closure holding device runs is rotatably mounted and can be locked in place by a pin which engages in a toothing on the outer edge of the nut.
  • a pin which engages in a toothing on the outer edge of the nut.
  • the closure holder In order to lower the closure holding device to a closure, it may be necessary for the closure holder to have to travel relatively large distances in the direction of the vessel axis. In this case, it can be provided that the nut in which the screw of the closure holding device is located is additionally moved in the direction of the vessel axis.
  • a vessel must be located in a vessel receiving device in such a way that its upper end, at which the closure is located, is accessible to the closure holding device, that is to say the closure must protrude from the vessel receiving device and there must be no circumferential surface of the closure disruptive device components.
  • the closure holding device is first lowered onto the closure or the closure is inserted into the closure holding device so that the closure is located in the center between the gripping jaws.
  • a particularly simple method for the suitable positioning of the vessels for the purpose of unblocking has also been found. This is done by a gripper with holding jaws encircling the vessel, then a slight opening of the holding jaws and the gripper being moved upwards, as a result of which the gripping jaws come to rest below the edge of the vessel opening or below the closure.
  • the gripper now introduces the closure into the closure holding device in such a way that the gripping jaws come to rest a few millimeters above the holding jaws of the gripper. Practical tests have shown that this is a very simple and efficient method for feeding the closures to the closure holding device in a suitable position without the need for time-consuming position detection of the closures.
  • the scanning of the sample vessel can be spatially separated from the device according to the invention, since the scanning of the sample vessels is generally one of the first Represents steps because the data obtained with the scanning can be used for many different steps of the processing line.
  • a microprocessor can advantageously be used, which processes data which is obtained when the sample vessels are scanned and controls the individual movements, such as lowering, rotation and raising of the closure holding device.
  • a microprocessor the ones that are common in practice can also advantageously be used Types of sample vessels and closures are stored, so that identification of the sample vessel and the closure is possible with a relatively inexpensive optical or mechanical scanning device and the parameters not determined during the scanning process, such as, for. B. Diameter of the closure and elasticity of the closure, can be found in a table.
  • Figure 1 shows the closure holding device (10) and the movement device (20) in side view.
  • the first plate (11) of the closure holder (10) is formed by the housing of the closure holder, while the second plate (12) is located inside the housing and has the shape of a circular ring with an outer ring gear. Rotation of the first plate (11) and the second plate (12) is achieved with the geared motor (13) which is mounted on the first plate (11) and which carries on its shaft a gearwheel which engages in the teeth of the second Engages plate (12).
  • Figure 2 shows the closure holding device according to the invention in cross section from the bottom (view X).
  • the gripping jaws (14) are rotatably connected to the first plate (11) via an axle (15) attached to their end.
  • the gripping jaws (14) have a recess (16) in which pins (17) run.
  • the pins (17) are in turn firmly attached to the second plate (12).
  • Figure 2A shows the closure retainer in an open position from which it is closed by rotating the second plate (12) clockwise.
  • FIG. 2B shows a state of the closure receiving device in which the gripping jaws (14) hold the closure (30).
  • Figure 2C shows a single gripping jaw (14) with the recess (16) and the teeth (18) on its arrow-shaped tip.
  • the teeth (18) at the tip of the gripper jaw have a relatively large distance between the teeth.
  • the distance between the teeth and also the size of the individual teeth decrease with increasing distance from the tip. This configuration of the toothing has proven to be particularly advantageous if both relatively small and relatively large closures are to be held with one and the same vessel holding device.
  • FIG 3 shows an arrangement (40) of two vessel receiving devices, which are mounted together on an axis (45).
  • Each of the vessel receiving devices has two holding jaws (41, 41 ') which are connected to the adjusting jaws (42, 42') via an axis (46).
  • the adjusting jaws (42, 42 ') lie displaceably on the rotary arm (45) and each have a thread in which a spindle (43, 43') is located.
  • Each of the spindles (43, 43 ') has both a left-hand and a right-hand thread.
  • the spindles are driven by a motor (44 or 44 ') in order to move the holding jaws (41, 41') towards and away from one another.
  • the entire arrangement of the two vessel holding devices can be pivoted via the rotating arm, which is rotatably arranged via an axis (47).
  • the device shown in FIG. 3 it is therefore possible to hold a closed sample vessel in one of the vessel holding devices in order to open it and to set a new, still closed sample vessel in the second vessel holding device at the same time or at different times.
  • the rotary arm (45) is rotated about the axis (47), so that the two vessel receiving devices are exchanged for one another.
  • the already opened vessel can now be removed from the vessel receiving device and the still closed vessel can be opened simultaneously or at different times.
  • FIG. 4 schematically shows the perspective view of a further embodiment with which an increased throughput of vessels can be achieved. Individual components of this second embodiment are shown separately in FIGS. 5 to 8.
  • the device in FIG. 4 has a left and a right tripod leg (50, 51).
  • a conveyor belt (52) runs between these tripod legs, on which frames with sample vessels can be transported.
  • the conveyor belt is arranged in such a way that the vessels located in a frame are moved one after the other below the vessel receiving device.
  • the conveyor belt (52) can be controlled so that it stops when a sample vessel is below the closure holder.
  • a gripper (53) which serves to remove vessels from a rack or to lift a vessel in the rack.
  • the gripper (53) is located, for example, on a spindle with which it can be moved up and down.
  • the gripper (53) moves so as to feed a closure to the closure holding device that it is above the holding jaws (54) of the vessel holding device.
  • the vessel holding jaws (54) hold the vessel in this position.
  • the height to which the gripper (53) lifts the vessel is chosen so that the closure holding device (10) can hold the closure.
  • Figure 4 shows schematically also a closure holding device (10) with a rotatably mounted nut (55) which carries recesses on its outer peripheral surface.
  • the plunger (56) can engage in these depressions and thus prevent the nut (55) from rotating.
  • the locking device (10) is driven in this embodiment by a motor (58) via a toothed belt (57).
  • Figure 4 also shows a catch device for twisted closures, which has a lever (60) on which there is a hose (61) made of elastic material.
  • Figure 5 shows a variant of the closure holding and moving device shown in Figure 1. No significant changes were made in the area of the closure holding device (10), so that reference is made to FIG. 1 for a description. In the area of the closure holding device (10), however, it can be seen that the holding jaws have spikes (70) which at least partially penetrate into the closure material when holding closures.
  • the locking device (10) is located here, as in the first embodiment, on a threaded rod or screw (21).
  • the nut (55) is, however, rotatably mounted in ball bearings (71).
  • the nut (55) has depressions on its outer circumferential surface, for example analogous to the toothing of a toothed wheel, so that the plunger (56) can engage in these depressions.
  • the plunger (56) is moved by a lifting magnet (72). In its rest position, the plunger (56) is largely inside the lifting magnet (72) and does not engage in the recesses in the nut (55).
  • the solenoid (72) is activated, the plunger (56) is moved into a recess in the nut (55).
  • the threaded rod (21), on which the holding device (10) is located, is driven by a motor (73) via a toothed belt (57).
  • the toothed belt (57) runs over a first gear (74), which is located on the axis of the motor (73), and over a second gear (75), which is firmly connected to the threaded rod (21).
  • the lock receiving device (10) rotates without a superimposed linear movement. This can be used advantageously if the entire sample vessel is to be rotated before the closure is removed, for example for reading a bar code on the vessel or for determining the fill level. However, if the nut (55) is prevented from rotating by the plunger (56), the rotation of the The threaded rod (21) is partially converted into a linear movement and the closure holding device (10) carries out a linear and a rotary movement at the same time.
  • the advantages of removing closures by means of this form of movement have already been described in more detail in connection with the first embodiment.
  • FIG. 6 shows an improved embodiment of the vessel holding device. It has been found that it is of crucial importance for the proper functioning of the vessel holding device that the position of the vessel axis is precisely defined for each holding cycle and does not shift between individual holding cycles. It is therefore advantageous to use a single motor (80) for driving the vessel holding device, which motor transmits its rotational movement to the two vessel holding jaws (54). On the axis of the motor (80), a damping element (81) is attached, which prevents excessive mechanical stress on the vessels when the vessel holding device is closed. This damping element (81) is a flexible material, usually a plastic, which is located between two metal disks, which are firmly connected to the respective part of the drive axle.
  • This damping element (81) is a flexible material, usually a plastic, which is located between two metal disks, which are firmly connected to the respective part of the drive axle.
  • the elastic material of the damping element is twisted and destruction of the vessel is prevented.
  • a drive axle (82) on which two gear wheels are mounted, which in turn drive toothed belts.
  • toothed wheels are driven by these toothed belts, each of which is connected to a cone (83), on the peripheral surface of which a pin is located.
  • the vessel holding jaws (54) each have a cylinder which surrounds the cone (83) and has a groove on the inside, into which the pin of the cone engages.
  • the vessel holding jaws (54) are mounted in such a way that they can only carry out a linear movement and no rotation.
  • the vessel holding jaws (54) move towards or away from one another, depending on the direction of rotation of the cone, due to the interaction between the pin and the groove.
  • FIG. 7 shows a gripper (53), which has a relatively simple structure.
  • the two gripping jaws (90) each have a thread that runs on a threaded rod (91), the threaded rod having two threads oriented in opposite directions.
  • the threaded rod (91) is connected to the axis of a motor (92). By rotating the motor axis, the gripping jaws (90) are moved towards or away from one another, depending on the direction of rotation.
  • a damping element (81) can optionally be provided between the axis of the motor and the threaded rod (91).
  • the function of the gripper is to grasp a vessel and appropriately feed it to the closure holding device. It has proven to be advantageous if the gripper (53) first firmly encloses a vessel with the gripping jaws (90) and then loosens the grip slightly by moving the motor in opposite directions. The vessel can now be moved along the axis of the vessel between the gripping jaws (90) without falling out sideways. If the gripper (53) moves upward, the vessel slides along the longitudinal axis through the gripping jaws (90) until the edge of the vessel or the closure rests on the gripping jaws (90). Due to the position of the gripping jaws known to the device, the position of the closure can now also be determined with sufficient accuracy. It is therefore no longer necessary to separately detect the closure.
  • FIG. 8 shows a further improvement of the device according to the invention, with which disposal of twisted closures is possible in a simple and contamination-free manner.
  • the lever (60) is firmly connected on one side to the axis of a motor (93) and can be pivoted by the motor. On the other side, the lever has an annular opening which opens into a hose (61). A flag (95) is also attached to the lever and can be detected by light barriers (94).
  • the mode of operation of the collecting device is that, after unscrewing a closure from a vessel, the annular opening of the lever is moved under the closure holding device (10), the closure holding device releases the closure, so that it opens through the annular opening of the lever into the hose (61). falls.
  • the lever (60) is moved out of the area of the closure holding device in order not to impair subsequent process steps.
  • the lever must therefore be able to assume at least two positions, the first being located below the locking device and the second outside of this area. Light barriers serve to reliably detect these positions.
  • the hose (61) of the collecting device can consist, for example, of a plastic or a woven material.
  • the hose should be dimensioned such that closures that slide through it fall into a collecting zone in which they do not impair the functioning of the device and do not cause contamination.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Centrifugal Separators (AREA)
  • Devices For Opening Bottles Or Cans (AREA)
EP96105314A 1995-04-06 1996-04-03 Dispositif pour retirer ou dévisser des fermetures de récipients Expired - Lifetime EP0736481B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19512905A DE19512905A1 (de) 1995-04-06 1995-04-06 Vorrichtung zum Herausziehen oder Abdrehen von Verschlüssen von Gefäßen
DE19512905 1995-04-06

Publications (3)

Publication Number Publication Date
EP0736481A2 true EP0736481A2 (fr) 1996-10-09
EP0736481A3 EP0736481A3 (fr) 1996-12-04
EP0736481B1 EP0736481B1 (fr) 1999-10-13

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EP96105314A Expired - Lifetime EP0736481B1 (fr) 1995-04-06 1996-04-03 Dispositif pour retirer ou dévisser des fermetures de récipients

Country Status (5)

Country Link
US (1) US5819508A (fr)
EP (1) EP0736481B1 (fr)
JP (1) JPH08276989A (fr)
DE (2) DE19512905A1 (fr)
ES (1) ES2139270T3 (fr)

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US8220225B1 (en) * 2011-03-03 2012-07-17 Closure Systems International, Inc. Capping chuck assembly
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EP3196655B1 (fr) 2016-01-22 2020-11-25 Roche Diagniostics GmbH Récipient pour échantillons de laboratoire et appareil de manipulation de support d'un système de laboratoire
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EP3196648B1 (fr) * 2016-01-22 2021-03-31 Roche Diagniostics GmbH Dispositif de levage d'un tube d'échantillon
EP3560477A1 (fr) * 2016-03-15 2019-10-30 Capsugel Belgium NV Appareil de scellement de gélule dure aseptique et procédés
EP3236267B1 (fr) * 2016-04-18 2021-09-08 Roche Diagnostics GmbH Décapsuleur et appareil
US10155318B2 (en) * 2017-03-16 2018-12-18 Perception Robotics, Inc. Systems and methods for post-treatment of dry adhesive microstructures
CN107055435A (zh) * 2017-04-01 2017-08-18 长沙开元仪器股份有限公司 一种旋压盖开启装置
WO2019109121A1 (fr) * 2017-12-06 2019-06-13 University Of Technology Sydney Dispositif de saisie
JP7104923B2 (ja) * 2018-07-17 2022-07-22 国立大学法人神戸大学 キャップ着脱装置、並びに、これを備えたサンプリング装置及び前処理装置
CN116476274B (zh) * 2023-06-05 2023-11-24 河津市津昌药包材有限公司 一种塑料瓶身瓶盖分离器

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EP0899233A1 (fr) * 1997-08-29 1999-03-03 Jauch & $Schmider GmbH Dispositif pour dévisser des capsules à vis de bouteilles de boissons
EP0972744A2 (fr) * 1998-07-14 2000-01-19 Bayer Corporation Dispositif de débouchage
EP0972744A3 (fr) * 1998-07-14 2000-08-02 Bayer Corporation Dispositif de débouchage
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WO2013030196A1 (fr) 2011-08-29 2013-03-07 Hamilton Bonaduz Ag Dispositif pour ouvrir automatiquement des récipients à fermeture filetée
DE102012213821A1 (de) 2012-08-03 2014-02-06 Hamilton Bonaduz Ag Vorrichtung zum automatisierten Herstellen und Lösen von Schraubverbindungen
WO2014020168A1 (fr) 2012-08-03 2014-02-06 Hamilton Bonaduz Ag Dispositif permettant de créer et de desserrer automatiquement des assemblages par vis
CN109110705A (zh) * 2018-06-27 2019-01-01 毛静玲 一种瓶装饮料自动开盖加热装置
CN110639638A (zh) * 2019-09-25 2020-01-03 中南大学湘雅二医院 一种血液样品预处理用试剂盒及其使用方法
CN110639638B (zh) * 2019-09-25 2021-06-25 中南大学湘雅二医院 一种血液样品预处理用试剂盒及其使用方法
CN115445515A (zh) * 2022-09-21 2022-12-09 山东省保利来日化科技有限公司 一种杀虫剂生产用高效混料装置
CN115445515B (zh) * 2022-09-21 2023-07-18 山东省保利来日化科技有限公司 一种杀虫剂生产用高效混料装置

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ES2139270T3 (es) 2000-02-01
EP0736481A3 (fr) 1996-12-04
EP0736481B1 (fr) 1999-10-13
DE59603319D1 (de) 1999-11-18
DE19512905A1 (de) 1996-10-10
US5819508A (en) 1998-10-13

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