EP0731834B1 - Enzyme stabilization by block-copolymers - Google Patents

Enzyme stabilization by block-copolymers Download PDF

Info

Publication number
EP0731834B1
EP0731834B1 EP95904182A EP95904182A EP0731834B1 EP 0731834 B1 EP0731834 B1 EP 0731834B1 EP 95904182 A EP95904182 A EP 95904182A EP 95904182 A EP95904182 A EP 95904182A EP 0731834 B1 EP0731834 B1 EP 0731834B1
Authority
EP
European Patent Office
Prior art keywords
block
composition
copolymer
enzyme
polyol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95904182A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0731834A1 (en
Inventor
James C. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buckman Laboratories International Inc
Original Assignee
Buckman Laboratories International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22578792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0731834(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Buckman Laboratories International Inc filed Critical Buckman Laboratories International Inc
Publication of EP0731834A1 publication Critical patent/EP0731834A1/en
Application granted granted Critical
Publication of EP0731834B1 publication Critical patent/EP0731834B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3703Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707Polyethers, e.g. polyalkyleneoxides
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/72Ethers of polyoxyalkylene glycols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663Stabilised liquid enzyme compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
EP95904182A 1993-12-03 1994-12-01 Enzyme stabilization by block-copolymers Expired - Lifetime EP0731834B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16086593A 1993-12-03 1993-12-03
US160865 1993-12-03
PCT/US1994/013744 WO1995015371A1 (en) 1993-12-03 1994-12-01 Enzyme stabilization by block-copolymers

Publications (2)

Publication Number Publication Date
EP0731834A1 EP0731834A1 (en) 1996-09-18
EP0731834B1 true EP0731834B1 (en) 2000-05-24

Family

ID=22578792

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95904182A Expired - Lifetime EP0731834B1 (en) 1993-12-03 1994-12-01 Enzyme stabilization by block-copolymers

Country Status (16)

Country Link
US (1) US5780283A (zh)
EP (1) EP0731834B1 (zh)
JP (1) JPH09506127A (zh)
CN (1) CN1064074C (zh)
AT (1) ATE193319T1 (zh)
BR (1) BR9408185A (zh)
CA (1) CA2177997C (zh)
CZ (1) CZ154996A3 (zh)
DE (1) DE69424683T2 (zh)
ES (1) ES2148479T3 (zh)
FI (1) FI118341B (zh)
NO (1) NO962263L (zh)
PT (1) PT731834E (zh)
SK (1) SK68996A3 (zh)
WO (1) WO1995015371A1 (zh)
ZA (1) ZA949653B (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551794B1 (en) * 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
MX9707487A (es) * 1996-01-31 1997-11-29 Gist Brocades Bv Uso de composiciones que comprenden compuestos efectivos biologicamente estabilizados.
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
CA2294839A1 (en) * 1997-07-02 1999-01-14 Saroj Rai Dishwashing compositions comprising a phospholipase and an amylase
US6455620B1 (en) * 1999-08-10 2002-09-24 Eastman Chemical Company Polyether containing polymers for oxygen scavenging
JP2004501293A (ja) 2000-06-16 2004-01-15 バックマン・ラボラトリーズ・インターナショナル・インコーポレーテッド 繊維中の有機夾雑物の制御方法
CN1294246C (zh) * 2001-10-08 2007-01-10 邬静文 内窥镜清洗液及清洗方法
US7125471B2 (en) * 2001-11-29 2006-10-24 Buckman Laboratories International, Inc. Papermaking process using enzyme-treated sludge, and products
US20060048908A1 (en) * 2004-09-08 2006-03-09 Enzymatic Deinking Technologies, Llc System for control of stickies in recovered and virgin paper processing
US8308900B2 (en) 2006-09-15 2012-11-13 Buckman Laboratories International, Inc. Methods to control lipophilic extractives in acacia wood pulp and fiber
CN101680172B (zh) * 2007-05-16 2013-04-17 巴科曼实验室国际公司 控制纤维中的有机污染物的方法
US9051692B2 (en) * 2009-01-06 2015-06-09 Enzymatic Deinking Technologies, L.L.C. Method of increasing enzyme stability and activity for pulp and paper production
AU2011215742B2 (en) 2010-02-12 2016-06-02 Kemira Oyj Method for removing ink from paper
EP2580388B1 (en) 2010-06-08 2018-01-17 Buckman Laboratories International, Inc Methods to degrade sludge from pulp and paper manufacturing
WO2012068455A1 (en) * 2010-11-19 2012-05-24 Isp Investments Inc. A stable and aqueous concentrated preservative composition of dehydroacetic acid (dha) and methylisothiazolinone (mit)
CN103998680B (zh) * 2011-10-27 2017-04-26 巴克曼实验室国际公司 用于酶降解处理造纸纤维的方法和组合物及由其制成的纸制品
CN102561044A (zh) * 2011-12-31 2012-07-11 湖南利尔康生物有限公司 纤维素酶制剂增效稳定剂
US20130180677A1 (en) 2012-01-12 2013-07-18 Buckman Laboratories International, Inc. Methods To Control Organic Contaminants In Fibers
CN102766540B (zh) * 2012-07-20 2014-06-18 山西大学 液体酶稳定化添加剂及其制备方法和应用
WO2015026507A1 (en) 2013-08-20 2015-02-26 Buckman Laboratories International, Inc. Methods to control organic contaminants in fibers using zeolites

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950277A (en) * 1973-07-25 1976-04-13 The Procter & Gamble Company Laundry pre-soak compositions
EP0274044A1 (en) * 1986-11-29 1988-07-13 Horsell Graphic Industries Limited Method of Developing Lithographic plates
US5209865A (en) * 1990-01-25 1993-05-11 Ciba-Geigy Corporation Conditioning solution for contact lenses and a method of using the same

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078315A (en) * 1955-09-02 1963-02-19 Union Carbide Corp Polyoxyalkylene products
US3676373A (en) * 1970-07-20 1972-07-11 Gulf Research Development Co Detergent compositions
US3950133A (en) * 1971-10-20 1976-04-13 Mallinckrodt, Inc. Reagent formulations for assaying biological specimens and methods of preparing and using same
US4169817A (en) * 1971-12-23 1979-10-02 Midwest Biochemical Corporation Liquid cleaning composition containing stabilized enzymes
US4064010A (en) * 1976-07-21 1977-12-20 Eastman Kodak Company Purification of uricase
JPS5913187B2 (ja) * 1978-07-04 1984-03-28 ノヴオ インダストリ エ−/エス プロテア−ゼ濃縮物
US4243546A (en) * 1979-03-23 1981-01-06 The Drackett Company Stable aqueous compositions containing enzymes
US4243543A (en) * 1979-05-11 1981-01-06 Economics Laboratory, Inc. Stabilized liquid enzyme-containing detergent compositions
US4261868A (en) * 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4318818A (en) * 1979-11-09 1982-03-09 The Procter & Gamble Company Stabilized aqueous enzyme composition
US4305837A (en) * 1980-10-30 1981-12-15 The Procter & Gamble Company Stabilized aqueous enzyme composition
JPS5950280B2 (ja) * 1980-10-24 1984-12-07 花王株式会社 酵素入り漂白剤組成物
US4578265A (en) * 1981-08-13 1986-03-25 Laclede Professional Products, Inc. Di-enzymatic dentifrice
EP0080748B1 (en) * 1981-11-13 1985-07-10 Unilever N.V. Enzymatic liquid cleaning composition
US4462922A (en) * 1981-11-19 1984-07-31 Lever Brothers Company Enzymatic liquid detergent composition
JPS591598A (ja) * 1982-06-25 1984-01-06 花王株式会社 洗浄剤組成物
US4529525A (en) * 1982-08-30 1985-07-16 Colgate-Palmolive Co. Stabilized enzyme-containing detergent compositions
US4490285A (en) * 1983-08-02 1984-12-25 The Procter & Gamble Company Heavy-duty liquid detergent composition
US4548727A (en) * 1983-10-06 1985-10-22 The Drackett Company Aqueous compositions containing stabilized enzymes
US4537707A (en) * 1984-05-14 1985-08-27 The Procter & Gamble Company Liquid detergents containing boric acid and formate to stabilize enzymes
US4801544A (en) * 1984-09-12 1989-01-31 The Clorox Company Method of improving the storage life of liquid compositions containing enzymes
EG18543A (en) * 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
US4842758A (en) * 1986-10-31 1989-06-27 Colgate-Palmolive Company Stabilized enzyme system for use in aqueous liquid built detergent compositions
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
JPH0241398A (ja) * 1988-07-20 1990-02-09 Novo Ind As 安定化酵素液体洗剤組成物
EP0394470B1 (en) * 1988-09-09 1993-06-16 Sunstar Kabushiki Kaisha Composition for oral cavity
DD286181A5 (de) * 1988-12-28 1991-01-17 Adw Der Ddr,Zi Fuer Organische Chemie,De Fluessiges, enzymhaltiges waschmittel
US4908150A (en) * 1989-02-02 1990-03-13 Lever Brothers Company Stabilized lipolytic enzyme-containing liquid detergent composition
US5082585A (en) * 1989-02-02 1992-01-21 Lever Brothers Company, Division Of Conopco, Inc. Enzymatic liquid detergent compositions containing nonionic copolymeric stabilizing agents for included lipolytic enzymes
EP0385526A3 (en) * 1989-02-27 1991-09-11 Unilever N.V. Enzymatic liquid detergent composition
US5270194A (en) * 1989-08-31 1993-12-14 Instrumentation Laboratory Spa Stabilized glucose oxidase from Aspergillus Niger
US5156773A (en) * 1989-12-12 1992-10-20 Novo Nordisk A/S Stabilized enzymatic liquid detergent composition
US5073292A (en) * 1990-06-07 1991-12-17 Lever Brothers Company, Division Of Conopco, Inc. Heavy duty liquid detergent compositions containing enzymes stabilized by quaternary nitrogen substituted proteins
JPH0465494A (ja) * 1990-07-04 1992-03-02 Kao Corp 自動食器洗浄機用洗浄剤組成物
US5071586A (en) * 1990-07-27 1991-12-10 Lever Brothers Company, Division Of Conopco, Inc. Protease-containing compositions stabilized by propionic acid or salt thereof
US5169553A (en) * 1991-05-31 1992-12-08 Colgate Palmolive Company Nonaqueous liquid, phosphate-free, improved automatic dishwashing composition containing enzymes
JPH0525491A (ja) * 1991-07-19 1993-02-02 Fuji Kooraru Kk 酵素力価の安定した液体洗剤
DE4319908A1 (de) * 1993-06-16 1994-12-22 Solvay Enzymes Gmbh & Co Kg Flüssige Enzymzubereitungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950277A (en) * 1973-07-25 1976-04-13 The Procter & Gamble Company Laundry pre-soak compositions
EP0274044A1 (en) * 1986-11-29 1988-07-13 Horsell Graphic Industries Limited Method of Developing Lithographic plates
US5209865A (en) * 1990-01-25 1993-05-11 Ciba-Geigy Corporation Conditioning solution for contact lenses and a method of using the same

Also Published As

Publication number Publication date
NO962263D0 (no) 1996-05-31
JPH09506127A (ja) 1997-06-17
ATE193319T1 (de) 2000-06-15
CZ154996A3 (en) 1996-10-16
DE69424683T2 (de) 2000-10-05
FI962304A0 (fi) 1996-05-31
CN1064074C (zh) 2001-04-04
FI118341B (fi) 2007-10-15
NO962263L (no) 1996-05-31
CN1136823A (zh) 1996-11-27
CA2177997C (en) 2008-09-23
SK68996A3 (en) 1997-06-04
FI962304A (fi) 1996-05-31
PT731834E (pt) 2000-09-29
ZA949653B (en) 1995-10-04
EP0731834A1 (en) 1996-09-18
WO1995015371A1 (en) 1995-06-08
DE69424683D1 (de) 2000-06-29
ES2148479T3 (es) 2000-10-16
BR9408185A (pt) 1997-05-27
CA2177997A1 (en) 1995-06-08
US5780283A (en) 1998-07-14

Similar Documents

Publication Publication Date Title
EP0731834B1 (en) Enzyme stabilization by block-copolymers
EP0740697B1 (en) Enzymes for recreational water
EP0670894B1 (en) Stabilized liquid enzymatic compositions
EP0702712B1 (en) Synergistically stabilized liquid enzymatic compositions
EP0381262A2 (en) Enzymatic liquid detergent composition
EP0376705A1 (en) Enzymatic liquid detergent compositions
EP1056826B1 (en) Enzyme stabilizing polyamide oligomers
AU1297595A (en) Enzyme stabilization by block-copolymers
NZ330424A (en) Enzyme composition stabilised by a non-ionic poyether-polyol surfactant
US20020183230A1 (en) Enzymatic liquid cleaning composition exhibiting enhanced alpha-amylase enzyme stability
AU1730399A (en) Enzyme stabilazation by block-copolymers
CN117377758A (zh) 酶反应促进方法
WO2018224699A1 (en) Liquid detergent composition with surfactant-mixture and at least two enzymes
JP2006036928A (ja) 自動食器洗浄機用洗浄剤組成物
NZ314287A (en) Stabilized liquid enzyme compositions

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19960703

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: LT PAYMENT 960703;SI PAYMENT 960703

RAX Requested extension states of the european patent have changed

Free format text: LT PAYMENT 960703;SI PAYMENT 960703

17Q First examination report despatched

Effective date: 19960906

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: LT PAYMENT 19960703;SI PAYMENT 19960703

ITF It: translation for a ep patent filed

Owner name: STUDIO FERRARIO

LTIE Lt: invalidation of european patent or patent extension
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20000524

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20000524

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000524

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20000524

REF Corresponds to:

Ref document number: 193319

Country of ref document: AT

Date of ref document: 20000615

Kind code of ref document: T

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 69424683

Country of ref document: DE

Date of ref document: 20000629

ET Fr: translation filed
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20000824

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20000529

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2148479

Country of ref document: ES

Kind code of ref document: T3

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20001201

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20001201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 20001231

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

26 Opposition filed

Opponent name: HENKEL KGAA

Effective date: 20010222

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

PLBF Reply of patent proprietor to notice(s) of opposition

Free format text: ORIGINAL CODE: EPIDOS OBSO

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PLBO Opposition rejected

Free format text: ORIGINAL CODE: EPIDOS REJO

PLBN Opposition rejected

Free format text: ORIGINAL CODE: 0009273

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: OPPOSITION REJECTED

27O Opposition rejected

Effective date: 20021017

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20101203

Year of fee payment: 17

Ref country code: AT

Payment date: 20101122

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20101126

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20101123

Year of fee payment: 17

Ref country code: SE

Payment date: 20101122

Year of fee payment: 17

Ref country code: IT

Payment date: 20101218

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20101230

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20101213

Year of fee payment: 17

Ref country code: ES

Payment date: 20101213

Year of fee payment: 17

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20120601

BERE Be: lapsed

Owner name: *BUCKMAN LABORATORIES INTERNATIONAL INC.

Effective date: 20111231

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20111201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120601

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20120831

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69424683

Country of ref document: DE

Effective date: 20120703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111231

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120703

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111202

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111201

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 193319

Country of ref document: AT

Kind code of ref document: T

Effective date: 20111201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120102

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20130703

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111202