EP0705115A1 - Inhalateur - Google Patents

Inhalateur

Info

Publication number
EP0705115A1
EP0705115A1 EP94921612A EP94921612A EP0705115A1 EP 0705115 A1 EP0705115 A1 EP 0705115A1 EP 94921612 A EP94921612 A EP 94921612A EP 94921612 A EP94921612 A EP 94921612A EP 0705115 A1 EP0705115 A1 EP 0705115A1
Authority
EP
European Patent Office
Prior art keywords
container
inhalation device
inhalation
handle
lid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94921612A
Other languages
German (de)
English (en)
Inventor
Barthold Von Schrader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4318389A external-priority patent/DE4318389B4/de
Priority claimed from DE9401140U external-priority patent/DE9401140U1/de
Application filed by Individual filed Critical Individual
Publication of EP0705115A1 publication Critical patent/EP0705115A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/045—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters using another liquid as heat exchanger, e.g. bain-marie

Definitions

  • the invention relates to an inhalation device with a
  • a known inhalation device EP 0 559 971 A1
  • the cover is provided with an essentially central opening and several openings arranged in a ring around the central opening.
  • the inhalation agent is arranged there close below the lid openings and is vaporized during inhalation by the air flow generated during suction and entering the vessel through the holes.
  • the resulting mixture of air and inhalant is inhaled by the user through the central opening.
  • This known device has proven itself. It works practically with hand warmth and / or ambient temperature. A temperature considered favorable for evaporation, which is the same as or higher than body temperature, is brought about or maintained over a longer period of time by the container being double-walled and filled with heat-containing agents.
  • the invention has for its object to provide a novel inhalation device, the evaporation properties of which are further improved. This object is achieved by the invention described in claim 1. Further developments of the invention are defined in the subclaims.
  • the invention consists in that the evaporation is carried out in a temperature range between 38 ° C and 65 °, preferably between 38 ° and 50 ° C. Evaporation of the water is thereby achieved, in which small water particles are generated for the steam, which entrain small particles of the inhalation agent when they move, in particular when they rise. These small ⁇ * particles are inhaled as a mixture and penetrate deep into the airways. This is extremely desirable, for example, for asthma treatment.
  • the inhalation device can be used not only for preventive or healing inhalation, as with the known device described at the beginning, but also for the medical treatment of diseases such as asthma Use of aerosols common.
  • the amount of the inhalant required in each case, together with a liquid, in particular water, is exposed to a heat of essentially 38 ° C. to 50 ° C., in which the water with a small particle size evaporates or evaporates, allowing the inhalation particles to penetrate deep into the airways.
  • the mixture of evaporating or evaporating water and inhalation agent, which rises due to the heating in the vessel, is mixed with the fresh air entering through the holes during suction and supplied to the airways.
  • the construction of the container is so made that the cold air entering by inhalation in the container may not significantly affect the evaporation temperature.
  • this is achieved by arranging the water and the inhalation agent spatially on the side opposite the lid, the bottom region of the vessel. The cold air flow sucked through the openings into the vessel during inhalation cannot therefore sweep over the inhalation agent and lower the vaporization temperature.
  • this is achieved in that the suction nozzle penetrating the cover for the inhalation of the inhalation mixture leads into the area in which the water and the inhalation agent are arranged, and therefore sucks up the evaporated mixture near the evaporation point.
  • the fresh air which is also drawn in, enters through holes in the upper part of the nozzle, is swirled there with the mixture and therefore cannot influence the temperature for the evaporation or evaporation of the mixture.
  • the water and the inhalation agent are sucked up in a finest distribution by means of a sponge, the construction of which makes it permeable to air through a large number of pores.
  • This sponge is arranged at a distance from the side walls and the bottom of the vessel so that the sucked-in fresh air first sweeps along the heated vessel walls and then penetrates through the sponge from the outside, together with the vaporized mixture into the sponge interior connected to the suction nozzle arrives and from this through the intake manifold to the user.
  • the sponge is attached to the intake manifold.
  • the sponge can, however, also be carried by a flat carrier with a handle arranged perpendicular to its surface, which extends to the lid when a carrier is inserted into the vessel. The top of the carrier then faces the mixture swirling space between the carrier and the lid.
  • a sponge or the like is arranged between the bottom of the vessel and the carrier, preferably attached to the carrier.
  • the inhalation agent can be arranged or applied on the top of the carrier in order to dissolve there under the action of the water vapor and to be carried away in particles by the evaporated water particles rising upwards.
  • a vessel has proven itself in which the inhalant has been arranged below the sponge on the bottom of the vessel.
  • the sponge filled with hot water When the sponge filled with hot water is inserted into the vessel, the sponge is pressed against the bottom of the vessel and partially absorbs the dissolved inhalant when it is relieved. Because of the better use of heat near the ground, the evaporation of the water can be carried out in the optimal temperature range. This means that the particles of the inhalant are entrained in a fine distribution by the water particles.
  • the vessel is rinsed with boiling water for disinfection, the sponge of the carrier is filled with hot water and the bottom and / or top of the carrier with the required amount of inhalation provided agent.
  • the carrier is inserted into the vessel by means of the handle, the sponge is pressed against the bottom of the vessel by means of the handle, and the vessel is closed with the lid.
  • the handle can be hollow and can be provided with suction openings at its end facing the carrier.
  • the handle with the connecting piece penetrating the cover can consist of one piece, the cover being closed in the end position of the handle-carrier-sponge construction, e.g. is screwed.
  • the handle at its upper opening is a connector for a corresponding connector of the nozzle.
  • the connection is established at the same time.
  • the fresh air drawn in through the cover openings enters the airway through additional openings in the handle and / or through a non-sealing connection between the nozzle and the handle.
  • the fresh air drawn in can only enter this nozzle via the sponge and the bottom opening of the nozzle.
  • the nozzle can be closed above the sponge, so no fresh air can be drawn in there.
  • the wall of the vessel can now be warmed or heated in several different ways. It can be filled as a double wall with hot water or another suitable hot liquid. It can be heated electrically. It can be used in a heater.
  • the temperature can be set or set so that on the one hand the evaporation takes place at the optimal temperature. However, it can also heat the mixture that has already been generated by evaporation and that is generated with cold, sucked-in fresh air so that it is supplied to the airways at the optimal temperature.
  • the temperature in the interior of the vessel between the bottom of the vessel and the swirling space is such that a temperature between 50 ° and 38 °, on average -45 ° is maintained.
  • the cold fresh air drawn in can be warmed up before it is swirled with the steam when it is brushed along the wall of the vessel.
  • the handle of the carrier can be designed on its outside and / or inside in a flow-favorable manner in such a way that the rising vapors are optimally mixed with the inflowing air, for example as a rod tapering towards the top with a spherical end or as a nozzle with an enlarging shape upwards Diameter "A particular advantage of the device according to the invention is its environmental compatibility.” It enables the inhalation agents to penetrate deeply into the respiratory tract, which until now could only be achieved through the use of aerosols, that is, through containers with fine atomization from the CFCs that are undesirable today «
  • Fig. 1 shows a section through the lid and the vessel of an inhalation device according to the invention
  • FIG. 2 a development of the arrangement shown in FIG. 1 with the carrier inserted
  • FIG. 2 Fig. .3 a further development of the carrier from FIG. 2,
  • Fig. 4 a vessel according to FIG. 1 with electric heating.
  • Fig. 5 shows a device with inductive power supply
  • Heating line in the vessel. 6 shows a design of the handle as a suction and mixing space.
  • FIG. 7 shows a modification of the power supply for the container according to FIG. -4.
  • FIG. 8 shows a modification of the power supply according to FIG. 7
  • FIG. 9 shows another embodiment of the invention FIG Detail from Fig. 9
  • FIG. 1 shows a vessel 1 which is provided with a preferably ointment-like inhalation agent 1a.
  • Commercial vessels can be used for such vessels. However, they can also be of optimized design for the respective application.
  • a lid 2 is screwed onto the vessel.” Lid 2 can already be present as a closure when the vessel is delivered « . In this case, the vessel 1 is initially tightly closed, for example by means of a hot-melt film (not shown) which is removed before start-up.
  • the cover 2 can, however, also be supplied or used as a replacement for the closure cover originally present.
  • the lid 2 is provided with an essentially centrally arranged opening 3, which is surrounded by a plurality of openings -4 in a ring.
  • the central opening 3 is formed by a tube 31 penetrating the disk-shaped cover surface. It is thereby achieved that the opening 3 can be used on the one hand as a connection for an atera tube or for breathing apparatus and on the other hand can be guided into a predetermined position to the surface of the inhalation means 1a.
  • the tube 31 can be fixed, but can also be arranged so as to be longitudinally displaceable in order to adjust the distance from the surface of the inhalation means. To optimize the initial temperature of the mixture, this can be connected to the vessel 1 by means of a screw thread 21, which is provided with a similar thread. But it can also be pluggable. In this case, it is advantageous to provide a locking position.
  • the tube 31 is provided or connectable with mouth or nose adapters.
  • the user holds the container 1 in his hand and inhales the inhalant directly through one of the adapters.
  • This form of use is particularly advantageous for travel purposes.
  • the central opening 3 can be connected or connectable to a separate breathing valve (not shown) or to a breathing mask.
  • breathing valves are offered, for example, by Heraeus under the trade name AMBU.
  • the tube 31 of the cover 2 is designed such that the breathing valve can be plugged or screwed onto the tube 31.
  • Such a breathing valve allows in combination with the container 1 via the lid 2 easy inhalation of the inhaled vaporized in the container and an unimpeded, easy exhalation via the valve path of the Atemventi s.
  • the container wall 1b, 1d is double-walled with a means 1c arranged between the walls for generating and / or maintaining the heat desired for the evaporation of the inhalant.
  • the agent can be hot water or an agent such as tetradocanol, which can maintain a desired temperature for a long time.
  • the inhalation means 1a is applied or arranged on a carrier 5, which can be inserted into the container 1 by means of a handle 6, but can also be arranged only or additionally on the bottom 1B of the container 1 or on walls or in intermediate layers of a sponge, which is arranged between the carrier 5 and the floor 1B.
  • the container 1 is formed so deep and the handle 6 so long that the carrier 5 is positioned in the region of the bottom of the container, in which the heat emanating from the container wall, but less so, the cool air entering through the openings 4 when inhaled can reach.
  • An evaporation liquid 7, in particular water, is arranged below the carrier 5. During the evaporation process, the water and the inhalant are evaporated at the same time. The water vapor entrains the particles of the inhalation agent in the direction of the opening 3 and is mixed there with the supply air. Openings 51 are provided in the carrier 5, through which the water vapor can pass «
  • the temperature in the area of the floor 1B and in the areas near the floor is dimensioned such that it remains in the optimum temperature range for evaporation for a predetermined or predeterminable period of time.
  • the temperature range is about 38 ° C to 50 ° C.
  • a quick use and a quick reaching of the desired temperatures can easily be achieved with the necessary measures for the sterilization of the container.
  • the container is rinsed out with almost boiling water and therefore already has a high starting temperature, which even after filling the container with boiling water and inhalation agent has dropped only insignificantly. «The temperature can be kept largely constant over the desired short temperature insulation Period of time.
  • the water can be filled loosely into the container 1 up to the carrier 5 arranged at a distance from the container bottom.
  • the carrier 5 can also be provided or connected to a water container 8 on its underside.
  • This water container 8 is preferably a sponge.
  • the mixture of the steam formed by water and inhalation agent and the supply air flowing in from outside enters the user's airways when inhaled.
  • the temperature and mixing ratio can be set so that the treatment success desired by the user or by the doctor can be achieved.
  • the temperature effective for the evaporation and the thermal insulation of the wall are dimensioned such that evaporation and inhalation of the entire mixture are within the desired temperature range from 50 ° to about 65 ° over the period of 5-7 minutes that is usual for inhalations.
  • the desired period of time can be reached or extended if the wall 1 b facing the interior of the container 1 b is dimensioned with high thermal conductivity and the outer wall 1 d is dimensioned with high thermal insulation.
  • FIG. 2 shows a development of the arrangement shown in FIG. 1.
  • the carrier 5 is provided with a handle 6, which tapers towards the top in accordance with a streamlined wall and is designed spherically on its upper side in such a way that the handle 6 is easy to grasp.
  • the spherical design of the top of the handle 6 can additionally be dimensioned or modified such that the outside air flowing through the openings 4 of the lid 2 is swirled in the upper part of the container 1 and cannot reach the lower evaporation area of the container 1. This effect can be promoted if the tube 31 protrudes only slightly or not at all into the container 1.
  • Fig. 3 shows a development of the carrier 5 with handle 6, with which the vortexing in the upper container space is favored.
  • Hot water can be filled into the intermediate space 1c of the container 1 between the walls 1b and 1d.
  • a closable opening 10 is provided for this purpose. This opening 10 can be closed by a separate screw 11 or by the cover 2 itself.
  • the water filling of the room 1c is often sufficient to maintain the evaporation temperature for the required time. Therefore, the relatively simple basic construction is sufficient to replace the medical devices for inhaling dosing aerosols that have been customary up to now, using propellants on the FKCW basis, which is to be rejected for environmental reasons.
  • FIGS. 1 and 2 shows a development of the arrangements according to FIGS. 1 and 2, in which an electric heater is arranged in the wall or walls of the container.
  • This electric heating contains a resistance wire 12 embedded in the wall or in the intermediate space 1 c, which is supplied with power by a power supply unit 13 or a battery or rechargeable battery via a switch 15 if required.
  • the heating wire is preferably arranged in the area of the container bottom and can be extended up to the carrier 5. However, it is also possible to provide the swirling area or even the airways with preheating heating wire.
  • An expedient embodiment is designed in the manner of the razors in such a way that a plug device 16 is provided in the bottom region of the container 1, into which the plug of a mains cable 17 is inserted. Power pack, switch and heating wire are integrated in the container 1.
  • the power cord can also be adapted for connection to the power supply of a motor vehicle to enable use while driving.
  • FIG. 5 shows an embodiment in which a stationary housing 20 with a mains connection 210, 211 has an opening 22 into which the container 1 can be inserted.
  • the primary winding 2-4 of a transformer 25 is in the wall 23 surrounding this opening 22 incorporated, which cooperates with one or more secondary windings 26 which are arranged in the container walls 1 b, c, d.
  • One of the secondary windings 26 feeds a battery 27, another a heating wire 28, which continuously heats the interior of the container.
  • a thermostat not shown, prevents the container from overheating.
  • Fuses in particular fuses, respond when the currents are too high. Adjustment devices such as an adjustable thermostat allow the temperature to be set in the range from 55 ° -65 ° C. An adjustable cover plate 9 allows the adjustment of the respectively required supply air.
  • the container 1 Before use, the container 1 is filled with water and inhalation agent and inserted closed into the opening. When the desired temperature is reached, this is indicated optically or acoustically. For the container removed from the opening, the charged rechargeable battery continues to heat the or another heating wire and thus allows the inhalation period to be considerably extended.
  • the inner wall of the container is preferably made of a fine-walled acrylic.
  • the outer wall is highly insulating and can even be double-walled.
  • the inner container can have the properties of conventional spray cans, and the outer wall can be made of a soft material like plastic packaging.
  • the space 1c of the container 1 can be filled with a tetradecanol in all versions in order to ensure an approximately uniform temperature.
  • the carrier 5 is arranged at 38mm0 about 30mm above the bottom of the container; the handle about 35 mm.
  • the 6 shows a handle 6 which is so hollow and shaped so that the vapor mixture formed during the evaporation of the inhalant 1a and the water rises inside 60 of the handle 6 and when inhaled through the Intake nozzle 31 is sucked.
  • Holes 62 are provided through which the fresh air entering the container 1 when it is sucked into the interior 60 of the handle and swirled with the evaporation mixture.
  • the top 63 of the handle 6 is designed so that it practically forms an extension of the intake port 31.
  • the joint 64 between the socket 31 and the handle 6 itself can represent an opening for the penetration of the fresh air.
  • the wall 61 of the handle 6 can also be made in one piece with the intake manifold 31.
  • This unit consisting of nozzle 31 and handle 6 can be movable relative to the cover 2, so that first the unit 6, 31 is inserted into the container 1 and then the cover 2 provided with a corresponding opening for the nozzle is pushed over the nozzle and is screwed to close the container 1.
  • the sponge 8 is darge provides, he d h ier consists of me hreren discs 81, 82, 83, which each may be provided for with a layer of the substance to be inhaled.
  • the wall 61 of the handle 6 can be cylindrical.
  • FIG. 7 shows a container .1 with an inner container 1c, in which heating elements 12 are used instead of the heating wires shown in FIG. -4 on the bottom 1B of the container 1 between the inner container 1c and the outer container 1.
  • These heating elements 12 consist of a large number of individual ceramic resistance plates, in particular barium titanate, which are layered one above the other. Such resistance plates are usually referred to as PTC thermistors.
  • PTC thermistors Such resistance plates are usually referred to as PTC thermistors.
  • these heating elements can not only be used in a variety of forms. In terms of their power requirements, they can also be optimally used thanks to special insulating foils.
  • Kapton the film known under the trade name Kapton enables optimum insulation from the outside and thus low power losses.
  • Fig. 7 the heating elements are shown as a large area. Since the ceramic elements are mostly offered as small plates, it is expedient to form stacks of small plates and to arrange these stacks either transversely or in parallel.
  • the ring arrangement shown to the side of the inner container can also be achieved by columns arranged in a ring around the inner container.
  • Fig. 9 shows an embodiment of the invention with Netzan ⁇ connection cord 17 and waterproof entrance of the container 1 for this cord 17- .
  • the suction port 31 is extended far into the container 1 and is designed as a carrier for the sponge 8.
  • a viscose sponge made from regenerated cellulose is preferably used as the sponge.
  • This sponge is offered as a medium pore in the pressed state and is particularly absorbent and air-permeable in this form.
  • the sponge 8 is pushed and / or fastened in particular in a plurality of disks 8 a, b, c onto the intake manifold. Its length and diameter are such that there are small clearances for the fresh air supply between its side walls and side container walls and between the container bottom and the end face.
  • the air thus preheated on the container wall passes through the pores to the mixture of water and inhalant evaporating at 38-50 ° due to the action of heat.
  • This evaporation and air swirling is solved particularly advantageously in this example because the mixture is exposed in the finest distribution with the largest possible surface area to the heat and the air and is therefore particularly economical for the user.
  • the dimensions of the container holding the sponge are approximately 40 mm 0 with a length of 65-75 mm.
  • the sponge largely fills the container. With these dimensions, a quantity of water of 25-30 mL is sufficient for a content of 15-20 minutes.

Abstract

Un inhalateur comprend un récipient (1) contenant de l'eau et une substance à inhaler et un couvercle (2) pourvu d'une ouverture (3) sensiblement centrale et de plusieurs ouvertures (4) amenant l'air extérieur à l'intérieur du récipient. L'eau et la substance à inhaler sont évaporées ensemble dans le récipient à une température égale ou supérieure à la température du corps qui s'élève, au maximum, à 65 °C. L'air amené de l'extérieur fait tourbillonner le mélange de vapeur d'eau et de substance à inhaler.
EP94921612A 1993-06-03 1994-06-03 Inhalateur Withdrawn EP0705115A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4318389 1993-06-03
DE4318389A DE4318389B4 (de) 1993-06-03 1993-06-03 Inhalationseinrichtung
DE9401140U 1994-01-25
DE9401140U DE9401140U1 (de) 1994-01-25 1994-01-25 Inhalationseinrichtung
PCT/EP1994/001815 WO1994028959A1 (fr) 1993-06-03 1994-06-03 Inhalateur

Publications (1)

Publication Number Publication Date
EP0705115A1 true EP0705115A1 (fr) 1996-04-10

Family

ID=25926439

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94921612A Withdrawn EP0705115A1 (fr) 1993-06-03 1994-06-03 Inhalateur

Country Status (6)

Country Link
EP (1) EP0705115A1 (fr)
AU (1) AU7227494A (fr)
CZ (1) CZ287275B6 (fr)
HU (1) HU219392B (fr)
SK (1) SK284063B6 (fr)
WO (1) WO1994028959A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040234914A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Percussively ignited or electrically ingnited self-contained heating unit and drug-supply unit employing same
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
GB201707436D0 (en) * 2017-05-09 2017-06-21 British American Tobacco Investments Ltd Aerosol provision device and apparatus for a vessel

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GB191027593A (en) * 1910-11-28 1911-11-16 Claude Hamilton Verity Medicator for Medicated Steam or Hot Air Inhalations.
FR449781A (fr) * 1912-10-05 1913-03-07 Eugen Von Devoorde Dispositif pour l'introduction directe de vapeurs de plantes aromatiques dans les voies respiratoires
US1998327A (en) * 1933-04-10 1935-04-16 Mcguire Clarence Vane Inhalant device
FR793235A (fr) * 1934-08-03 1936-01-20 Appareil d'inhalation
GB509593A (en) * 1938-07-20 1939-07-19 Elmer Arthur Diamond Electric medicinal vapouriser
US4903850A (en) * 1989-03-14 1990-02-27 Bernard Frank Vaporizing device
DE9209050U1 (fr) * 1992-02-13 1992-10-01 Schrader, Barthold Von, 2400 Travemuende, De
DE9201793U1 (fr) * 1992-02-13 1992-05-14 Schrader, Barthold Von, 2400 Travemuende, De

Non-Patent Citations (1)

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Title
See references of WO9428959A1 *

Also Published As

Publication number Publication date
SK284063B6 (sk) 2004-09-08
HUT73218A (en) 1996-06-28
SK151995A3 (en) 1996-09-04
WO1994028959A1 (fr) 1994-12-22
CZ287275B6 (en) 2000-10-11
HU219392B (en) 2001-03-28
AU7227494A (en) 1995-01-03
CZ318095A3 (en) 1996-06-12
HU9503409D0 (en) 1996-01-29

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