WO1994028959A9 - Inhalateur - Google Patents

Inhalateur

Info

Publication number
WO1994028959A9
WO1994028959A9 PCT/EP1994/001815 EP9401815W WO9428959A9 WO 1994028959 A9 WO1994028959 A9 WO 1994028959A9 EP 9401815 W EP9401815 W EP 9401815W WO 9428959 A9 WO9428959 A9 WO 9428959A9
Authority
WO
WIPO (PCT)
Prior art keywords
inhalation device
container
lid
vessel
handle
Prior art date
Application number
PCT/EP1994/001815
Other languages
German (de)
English (en)
Other versions
WO1994028959A1 (fr
Filing date
Publication date
Priority claimed from DE4318389A external-priority patent/DE4318389B4/de
Priority claimed from DE9401140U external-priority patent/DE9401140U1/de
Application filed filed Critical
Priority to EP94921612A priority Critical patent/EP0705115A1/fr
Priority to AU72274/94A priority patent/AU7227494A/en
Priority to PL94311868A priority patent/PL175402B1/pl
Priority to SK1519-95A priority patent/SK284063B6/sk
Priority to HU9503409A priority patent/HU219392B/hu
Publication of WO1994028959A1 publication Critical patent/WO1994028959A1/fr
Publication of WO1994028959A9 publication Critical patent/WO1994028959A9/fr

Links

Definitions

  • the invention relates to an inhalation device with a container containing the inhalant and with a lid, which contributes to the evaporation and distribution of the inhalant.
  • the cover is provided with a substantially central opening and a plurality of openings arranged annularly around the central opening.
  • the inhalation agent is arranged there near the lid openings and is vaporized during inhalation by the air flow generated during the suction, which enters the vessel through the holes. The resulting mixture of air and inhalant is inhaled through the central opening by the user.
  • This known device has proven itself. It works practically with hand warmth and / or ambient temperature. A temperature regarded as favorable for the evaporation, which is equal to or higher than the body temperature, is effected or maintained over a longer period of time by making the container double-walled and filled with heat-containing agents.
  • the invention has for its object to provide a novel inhalation tion device whose evaporation properties are further improved.
  • This object is achieved by the invention described in claim 1.
  • Further developments of the invention are defined in the subclaims.
  • the invention consists in that the evaporation in a Tempe ⁇ ratur Scheme between 38 ° C and 65 °, preferably between 38 ° and 50 ° C is performed.
  • an evaporation of the water is achieved in the small steam particles are generated for the steam, which entrain during their movement, especially during, ascend, small particles of the inhalant.
  • These small particles are inhaled as a mixture and penetrate deeply into the airways. This is extremely desirable, for example, for asthma treatment.
  • the inhalation device can be used not only for preventive or healing inhalation, as with the known device described above, but also for the medical treatment of diseases such as asthma.
  • the use of aerosols has been customary for such medical treatments until now.
  • the respectively required amount of the inhalant together with a liquid, in particular water is subjected to a heat of essentially 38 ° C. to 50 ° C. at which the water evaporates with small particle size or Evaporates and so the inhalation particles reach deep into the respiratory tract.
  • the rising from the warming in the vessel mixture of evaporating or evaporating water and inhalant is mixed with the intake through the holes fresh air and supplied to the respiratory tract.
  • the construction of the container is made so that the cold air entering when inhaled into the container can not significantly affect the evaporation temperature.
  • this is achieved by the water and the inhalant spatially on the opposite side of the lid, the bottom portion of the vessel angeord ⁇ net.
  • the cold air flow which is sucked into the vessel during inhalation through the openings can therefore not spread over the inhalation medium and reduce the evaporation temperature.
  • this is achieved by the lid penetrating the intake manifold for inhalation of the inhalation mixture led into the area in which the water and the inhalant are arranged, and therefore sucks the evaporated mixture near the evaporation point au.f.
  • the also sucked fresh air enters through holes in the upper part of the nozzle, there is swirled with the mixture and therefore can not affect the temperature for the evaporation or evaporation of the mixture also.
  • the water and the inhalant are absorbed by means of a sponge in this in the finest distribution, the construction makes it permeable to air through a plurality of pores.
  • This sponge is placed at a distance from the side walls and the bottom of the vessel, that the fresh air sucked initially along the heated vessel walls and then penetrates from the outside through the sponge, together with the vaporized mixture in the associated with the intake manifold sponge interior passes and from this through the intake manifold to the user.
  • the sponge is attached to the intake manifold.
  • the sponge can also be carried by a flat support with a handle arranged perpendicular to its surface, which extends to a lid inserted in a carrier inserted into the vessel.
  • the carrier is then facing with its top of the mixture Verwirbelungsraum between the carrier and the lid.
  • a sponge or the like is arranged between the bottom of the vessel and the carrier, preferably attached to the carrier.
  • the inhalant can be arranged or applied on the upper side of the carrier in order to dissolve there under the action of the steam and be entrained particle by particle by the evaporated upwardly rising water particles.
  • the handle may be formed hollow and be provided at its end facing the carrier with suction.
  • the handle with the nozzle penetrating the lid can be made in one piece, the lid being closed in the end position of the handle-carrier sponge construction, e.g. is screwed.
  • the handle at its upper opening is also produced.
  • the sucked through the lid openings fresh air enters through additional openings in the handle and / or by a non-sealing connection between the nozzle and handle in the airway «Finally, the fresh air sucked in only on the sponge and the bottom opening of the nozzle in this nozzle occur.
  • the nozzle can be closed above the sponge, so there suck in no fresh air.
  • the wall of the vessel can now be warmed or heated in several different ways. It can be filled as a double wall with hot water or another suitable hot liquid. It can be heated electrically. It can be used in a heater. The temperature can be adjusted or adjusted so that on the one hand, the evaporation takes place at the optimum temperature. But it can also heat the mixture already produced by evaporation and generated with cold, sucked fresh air so that it is supplied to the respiratory tract at the optimum temperature. In the interior of the vessel between the bottom of the vessel and Verwirbelungsraum the temperature is calculated so that a temperature between 50 ° and 38 °, averaged 45 ° is maintained.
  • the sucked cold fresh air can be warmed before its Verwirbelung with the steam during their Strei ⁇ chen along the vessel wall.
  • the handle of the wearer can be formed on its outside and / or inside strömungs ⁇ low so that the rising vapors are optimally mixed with the incoming air, for example, as upwardly tapering rod with spherical conclusion or as a nozzle with upwardly magnifying Diameter.
  • a particular advantage of the device according to the invention is its environmental compatibility. It allows for the deep penetration of the inhalants into the respiratory tract, which could hitherto only be achieved by the use of aerosols, ie by containers with fine atomization by the CFCs which are today undesirable.
  • FIG. 2 shows a development of the arrangement shown in FIG. 1 with the carrier inserted
  • FIG. 3 shows a development of the carrier of FIG. 2
  • Fig. 4 shows a vessel according to Fig. 1 with electric heating.
  • Fig. 5 shows a device with inductive power supply to the heating cable in the vessel.
  • Fig. 6 shows an embodiment of the handle as a suction and mixing chamber
  • FIG. 7 shows a modification of the power supply for the container according to FIG. 4
  • FIG. 8 shows a modification of the power supply according to FIG. 7
  • FIG. 10 is a detail of FIG. 9
  • a vessel 1 is shown, which is provided with a preferably ointment-like inhalant 1a.
  • Commercially available containers can be used for such containers. However, they can also be designed to be optimized for the particular application.
  • a lid 2 is screwed onto the container Lid 2 can already be present as a closure on delivery of the vessel. In this case, the vessel 1 is initially sealed, for example by a hot-melt adhesive film (not shown), which is removed before being put into operation.
  • the lid 2 can also be supplied or used as a replacement for the originally present closure lid.
  • the lid 2 is provided with a substantially centrally disposed opening 3 which is annularly surrounded by a plurality of openings.
  • the central opening 3 is formed by a tube 31 penetrating the disk-shaped cover surface. This ensures that the opening 3 on the one hand can be used as a connection for a breathing tube or breathing apparatus and on the other hand in a réelle ⁇ certain position to the surface of the inhalation means 1a can be performed.
  • the tube 31 may be fixed, but may also be arranged so as to be longitudinally displaceable in order to adjust the distance from the surface of the inhalation device. This can be connected to optimize the starting temperature of the mixture by means of a screw thread 21 with the vessel 1, which is provided with a similar thread. It can also be pluggable. In this case, it is advantageous to provide a detent position.
  • the tube 31 is provided with mouth or Nasenadaptern or connectable. In such a form of use, the user holds the container 1 in his hand and inhales the inhalant directly via one of the adapters. This form of use is particularly advantageous for travel purposes.
  • the central opening 3 can be connected or connectable to a separate non-illustrated breathing valve or to a breathing mask.
  • breathing valves are offered for example by the company Heraeus under the trade name AMBU.
  • the tube 31 of the lid 2 is designed so that the breathing valve can be plugged or screwed onto the tube 31.
  • Such a breathing valve when combined with the container 1 via the lid 2, permits easy inhalation of the inhalant evaporated in the container and unimpeded lightness Exhale via the valve section of the breathing valve.
  • the container wall 1b, 1d is formed double-walled with an arranged between the walls means 1c for generating and / or maintaining the desired for the evaporation of the inhalant heat.
  • the agent may in the simplest case be hot water or an agent such as tetradocanol which can maintain a desired temperature for a long time.
  • the inhalation agent 1a is applied or arranged on a carrier 5, which can be inserted into the container 1 by means of a handle 6, but can also be arranged only or additionally on the bottom 1B of the container 1 or on walls or in intermediate layers of a sponge,
  • the container 1 is formed so deep and the handle 6 so long that the carrier 5 is positioned in the region of the - bottom of the container, in which although the outgoing from the container wall heat, but less the inhalation through the openings 4 penetrating cool incoming air can get.
  • Below the carrier 5, an evaporation liquid 7, in particular water is arranged below the carrier 5, an evaporation liquid 7, in particular water is arranged. In the evaporation process, the water and the inhalant are evaporated at the same time. The water vapor tears the particles of the inhalant with it in the direction of the opening 3 and is mixed there with the supply air.
  • openings 51 are provided, through which the water vapor can pass.
  • the temperature in the area of the bottom 1B and in the areas near the ground is such that it remains in the optimum temperature range for the evaporation for a predetermined or predeterminable period of time.
  • the temperature range is about 38 ° C to 50 ° C. Rapid deployment and rapid achievement of the desired temperatures can be easily achieved with the necessary measures to sterilize the container. For this purpose, namely, the container is rinsed with almost boiling water and therefore already has a high initial temperature, which iat even after filling the container with boiling water and inhalant again insignificant. By temperature insulation, the temperature can be kept substantially constant over the desired short period of time.
  • the water may be filled loosely into the container 1 up to the carrier 5 arranged at a distance from the container bottom.
  • the carrier 5 may, however, also be provided or connected on its underside with a water container 8.
  • This water tank 8 is preferably a sponge.
  • the mixture of the vapor formed by water and inhalant and the inflowing air from the outside passes through the respiratory tract of the user when inhaled. Temperature and mixing ratio can be adjusted so that the treatment success desired by the user or by the doctor can be achieved.
  • the effective temperature for the evaporation and the thermal insulation of the wall are such that evaporation and inhalation of the total mixture in the desired temperature range of 50 ° to about 65 ° can be maintained over the usual for inhalations period of 5-7 minutes.
  • the desired period of time can be reached or extended when the interior of the container 1 facing wall 1 b dimensioned with high thermal conductivity and the outer wall 1 d is dimensioned with high thermal insulation.
  • Fig. 2 shows a development of the arrangement shown in Fig. 1.
  • the carrier 5 is provided with a handle 6, which tapers towards the top in accordance with a wall formed with a favorable flow and is formed on its upper side in a spherical shape such that the handle 6 can be easily gripped.
  • the spherical configuration of the upper side of the handle 6 may additionally be dimensioned or modified such that the outside air flowing in through the openings 4 of the lid 2 is swirled in the upper part of the container 1 and can not reach the lower evaporation region of the container 1. This effect can be favored if the tube 31 projects only slightly or not at all into the container 1.
  • Fig. 3 shows a development of the carrier 5 with handle 6, with which the swirling in the upper container space favors wir.d.
  • a closable opening 10 is provided in the space 1c of the container 1 between the walls 1b and 1d.
  • This opening 10 can be closed by a separate screw 11 or by the lid 2 itself.
  • the water filling of the room 1c is often sufficient to maintain the evaporation temperature for the required time. Therefore, even the relatively simple basic construction is sufficient to replace the hitherto customary medical devices for inhalation of dosing aerosols usingmaschine ⁇ on the mediums to be rejected for environmental reasons FKCW basis.
  • FIG. 4 shows a further development of the arrangements according to FIGS. 1 and 2, in which an electric heater is arranged in the wall or walls of the container.
  • This electric heating contains a resistor wire 12 which is let into the wall or into the interspace 1 c and which is supplied with power by a power supply unit 13 or a battery or rechargeable battery as required via a switch 15.
  • the heating wire is preferably arranged in the region of the container bottom and can be extended as far as the carrier 5. But it is also possible to provide the Verwirbelungs Scheme or even the respiratory tract with preheating heating wire.
  • An expedient embodiment is formed in the manner of the razor so aus ⁇ that in the bottom region of the container 1 a Steckeinrich ⁇ device 16 is provided, in which the plug of a power cord 17 is inserted.
  • Power supply unit, switch and heating wire are integrated in container 1.
  • the power cord can also be adapted for connection to the power supply of a motor vehicle to allow use while driving.
  • Fig. 5 shows an embodiment in which a stationary housing 20 with mains connection 210,211 has an opening 22 into which the container 1 can be inserted.
  • the primary winding 24 of a transformer 25th incorporated, which cooperates with one or more secondary windings 26 which are arranged in the container walls 1 b, c, d.
  • One of the secondary windings 26 feeds a battery 27, another a heating wire 28, which constantly heats the container interior.
  • An unillustrated thermostat prevents overheating of the container.
  • Fuses especially fuses, respond to excessive currents. Adjusting devices such as an adjustable thermostat allow a temperature setting in the range of 55 ° - 65 ° C. An adjustable closure plate 9 allows adjustment of the supply air required in each case.
  • the container 1 Before use, the container 1 is filled with water and inhalant and sealed inserted into the opening. When the desired temperature is reached, it is displayed optically or acoustically. For the container removed from the opening, the charged rechargeable battery continues to heat the or another heating wire and thus allows a considerable prolongation of the inhalation period.
  • the inner wall of the container is preferably made of a fine-walled acrylic.
  • the outer wall is designed to be highly heat-insulating and can even be double-walled.
  • the inner container may have the character of conventional spray cans, the outer wall may be made of soft material as in plastic packaging.
  • the intermediate space 1c of the container 1 can be filled in all embodiments with a tetradecanol to ensure an approximately gleich ⁇ moderate temperature.
  • the carrier 5 is arranged at 38mm0 about 30mm above the container bottom; the handle about 35 mm.
  • a handle 6 which is so hollow latest available air.
  • Holes 62 are provided, through which the fresh air entering the container 1 when sucked into the container 60 reaches the interior 60 of the handle and is swirled with the evaporation mixture.
  • the upper side 63 of the handle 6 is designed so that it practically extends the intake nozzle 31 forms. In this case, the joint 64 between the nozzle 31 and handle 6 itself represent an opening for the penetration of fresh air.
  • the wall 61 of the handle 6 may be made with the intake manifold 31 also in one piece.
  • This unit of nozzle 31 and handle 6 may be movable relative to the lid 2, so that first the unit 6, 31 is inserted into the container 1 and then pushed the cover 2 provided with a corresponding opening for the nozzle over the nozzle and to close the Be Strukturer1 is screwed with this.
  • the sponge 8 is darge provides that t here me hreren discs 81, 82, 83 h best, which each may be provided for with a layer of the substance to be inhaled.
  • Fig. 7 is a container, shown with the inner container 1c 1, wherein are used instead of the embodiment shown in Fig. 4 heating wires on the bottom 1B of the container 1 between the inner container and outer container 1 1e heating elements 12.
  • These heating elements 12 consist of a multiplicity of individual stacked resistor plates made of ceramic, in particular barium titanate. Such resistance plates are usually called a PTC thermistor.
  • PTC thermistor Such resistance plates are usually called a PTC thermistor.
  • These known elements have a temperature-dependent resistance behavior. When cold start flows due to negligible resistance, a very high current, the ceramic element When exceeding a certain temperature, the resistance increases sharply, the current becomes smaller and the temperature drops accordingly. The temperature thus settles on a bestimm ⁇ th area a «In this way, the temperature behavior for the container 1 can be accurately adjusted.
  • these heating elements can not only be used in a variety of forms. They can also be used optimally in their power requirements by using special insulating foils. For example, under the trade name Kapton known film allows outward optimal isolation and thus low power losses.
  • Kapton known film allows outward optimal isolation and thus low power losses.
  • the heating elements are shown as a large area. Since the ceramic elements are mostly offered as small platelets, it is expedient to form stacks of small platelets and to arrange these stacks either transversely or in parallel. A ring arrangement which is shown laterally from the inner container can also be achieved by columns arranged annularly around the inner container.
  • FIGS. 7 and 8 show a film 12a which seals off the heating elements 12 to the outside.
  • the network connections are simply omitted. But they are available. Because of the so-called PTC heating elements own control behavior is an additional control of the temperature unnecessary.
  • FIG. 9 shows an exemplary embodiment of the invention with net connecting cord 17 and watertight inlet of the container 1 for this cord 17.
  • the intake stub 31 is extended far into the container 1 and formed as a carrier for the sponge 8.
  • a viscose sponge made of regenerated cellulose is preferably used. This sponge is offered kar ⁇ porous in the pressed state and is particularly absorbent and permeable to air in this form.
  • the sponge 8 is pushed in particular in several discs 8 a, b, c on the intake and / or fixed. Its length and diameter are dimensioned so that between its lateral walls and lateral container walls and between the container bottom and front side are given small distances for the fresh air supply.
  • the air preheated on the container wall reaches the mixture of water and inhalant, which evaporates at 38-50 ° due to heat.
  • This evaporation and air turbulence is dissolved particularly advantageously in this example, because the mixture is exposed in the finest distribution with the greatest possible surface area of the heat and the air and thus is particularly productive for the user.
  • the dimensions of the sponge receiving container are about 40mm 0 at a length of 65-75 mm. The sponge largely fills the container "With these dimensions, a volume of water of 25-30 mL is enough for a period of 15-20 minutes.

Abstract

Un inhalateur comprend un récipient (1) contenant de l'eau et une substance à inhaler et un couvercle (2) pourvu d'une ouverture (3) sensiblement centrale et de plusieurs ouvertures (4) amenant l'air extérieur à l'intérieur du récipient. L'eau et la substance à inhaler sont évaporées ensemble dans le récipient à une température égale ou supérieure à la température du corps qui s'élève, au maximum, à 65 °C. L'air amené de l'extérieur fait tourbillonner le mélange de vapeur d'eau et de substance à inhaler.
PCT/EP1994/001815 1993-06-03 1994-06-03 Inhalateur WO1994028959A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP94921612A EP0705115A1 (fr) 1993-06-03 1994-06-03 Inhalateur
AU72274/94A AU7227494A (en) 1993-06-03 1994-06-03 Inhalator
PL94311868A PL175402B1 (pl) 1993-06-03 1994-06-03 Inhalator
SK1519-95A SK284063B6 (sk) 1993-06-03 1994-06-03 Inhalačné zariadenie
HU9503409A HU219392B (en) 1993-06-03 1994-06-03 Inhalator

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4318389A DE4318389B4 (de) 1993-06-03 1993-06-03 Inhalationseinrichtung
DEP4318389.1 1993-06-03
DEG9401140.0U 1994-01-25
DE9401140U DE9401140U1 (de) 1994-01-25 1994-01-25 Inhalationseinrichtung

Publications (2)

Publication Number Publication Date
WO1994028959A1 WO1994028959A1 (fr) 1994-12-22
WO1994028959A9 true WO1994028959A9 (fr) 1995-01-19

Family

ID=25926439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/001815 WO1994028959A1 (fr) 1993-06-03 1994-06-03 Inhalateur

Country Status (6)

Country Link
EP (1) EP0705115A1 (fr)
AU (1) AU7227494A (fr)
CZ (1) CZ287275B6 (fr)
HU (1) HU219392B (fr)
SK (1) SK284063B6 (fr)
WO (1) WO1994028959A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625335A2 (fr) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Unite de chauffage autonome a allumage optique ou electrique, et unite d'administration de medicament utilisant cette unite de chauffage
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2008112661A2 (fr) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Unité chauffante à utiliser dans un dispositif d'administration de médicament
GB201707436D0 (en) * 2017-05-09 2017-06-21 British American Tobacco Investments Ltd Aerosol provision device and apparatus for a vessel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191027593A (en) * 1910-11-28 1911-11-16 Claude Hamilton Verity Medicator for Medicated Steam or Hot Air Inhalations.
FR449781A (fr) * 1912-10-05 1913-03-07 Eugen Von Devoorde Dispositif pour l'introduction directe de vapeurs de plantes aromatiques dans les voies respiratoires
US1998327A (en) * 1933-04-10 1935-04-16 Mcguire Clarence Vane Inhalant device
FR793235A (fr) * 1934-08-03 1936-01-20 Appareil d'inhalation
GB509593A (en) * 1938-07-20 1939-07-19 Elmer Arthur Diamond Electric medicinal vapouriser
US4903850A (en) * 1989-03-14 1990-02-27 Bernard Frank Vaporizing device
DE9209050U1 (de) * 1992-02-13 1992-10-01 Schrader, Barthold von, 2400 Travemünde Inhalationseinrichtung
DE9201793U1 (de) * 1992-02-13 1992-05-14 Schrader, Barthold von, 2400 Travemünde Inhalationseinrichtung

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