Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
  • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
  • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/04—Centrally acting analgesics, e.g. opioids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/06—Antimigraine agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/04—Antibacterial agents

Definitions

• the present invention relates, as new products, to the piperidinyl thio indole derivatives of general formula (I) below and their addition salts, in particular the pharmaceutically acceptable addition salts.
• the compounds in question have a very interesting pharmacological profile insofar as they are endowed with analgesic properties. They will therefore be particularly indicated for the treatment of pain.
• the present invention also relates to the process for the preparation of said products and their applications in therapy.
• X- ⁇ and X2 independently represent: - the hydrogen atom
• R-i a sulfonamidomethyl group and can be in position 4, 5, 6 or 7 of the indole ring, R-i represents:
• R' represents the hydrogen atom or a lower alkyl radical of 1 to 6 carbon atoms
• n is an integer from 0 to 4,
• R2 represents:
• R 3 represents:
• n being an integer from 0 to 4
• p is an integer from 0 to 2.
• lower alkyl means a hydrocarbon chain having from 1 to 6 carbon atoms, linear or branched.
• a lower alkyl radical is for example a methyl, ethyl, propyl, isopropyl, butyl radical. isobutyl, tertiobutyl, pentyl, isopentyl, hexyl, isohexyl.
• Halogen means a chlorine, bromine, iodine or fluorine atom.
• Ph phenyl Phenethyl: 2-phenylethyl nBu: butyl tBu: tertiobutyl (1, 1-dimethyl ethyl)
• iPr isopropyl (1-methyl ethyl) Me: methyl Et: ethyl
• - X-i represents the chlorine atom in position 5 of the indole cycle
• - X- ⁇ represents the bromine atom in position 5 of the indole cycle
• R 3 represents the hydrogen atom - R3 represents a methyl radical - p is zero
• the particularly preferred compounds of the invention are those which are chosen from the products of formula:
• R represents a lower alkyl radical of 1 to 6 carbon atoms, a benzyl radical, a phenethyl radical, a protective group -COOtBu or a methoxy group .
• the derivatives of formula (III) where R represents the hydrogen atom will be prepared from the derivatives of formula (III) where R represents a methyl radical by the action of ethyl chloroformate in acetone, followed by a second treatment with ethyl chloroformate in toluene at reflux then by treatment with hydrochloric acid in acetic acid at reflux, according to the scheme:
• This reaction is carried out in the presence of a sodium, potassium or lithium alcoholate in the corresponding alcohol or in tetrahydrofuran or also by phase transfer in the presence of sodium or potassium carbonate and tetrabutylammonium iodide in toluene at temperatures between 20 and 130 * C.
• phenyhydrazines are commercial or can be prepared according to conventional methods known to those skilled in the art, for example by diazotization of commercial anilines of formula (IX):
• R 3 is defined as above and X represents a halogen atom, in liquid ammonia and / or tetrahydrofuran in the presence of sodium amide at a temperature of -40 "C which is allowed to return to ambient temperature.
• R representing a lower alkyl radical of 1 to 6 carbon atoms, benzyl, phenethyl or the hydrogen atom.
• Ri is defined as above and X represents an optimally chlorine, bromine or iodine halogen atom, to lead to the compounds of formula (I) in which p is equal to zero, this reaction being carried out in the presence of a tertiary base such as triethylamine or pyridine or sodium or potassium carbonate in an inert solvent such as toluene or dichloromethane at a temperature between ambient and 130 ° C, except where Ri is the group CHO , for which the compounds of formula (XII) where R represents the hydrogen atom will be reacted with formic acid in dichloromethane in the presence of dicyclohexylcarbodiimide, and where Ri represents the group CSSR ", for which the compounds of formula (XII) where R represents the hydrogen atom will be reacted with carbon sulfide in basic medium, the salt obtained then reacting with an alkyl halide.
• a tertiary base such as triethylamine or pyridine
• mposés of formula (I) where Xi or X 2 represents a nitrile group can be obtained from the compounds of formula (I) where Xi or X2 represents a halogen, preferably bromine or iodine, by reflux in N-methyl pyrrolidone with cuprous cyanide.
• the compounds of formula (I) where Xi or X 2 represents an acid group can be obtained from the compounds of formula (I) where X- or X2 represents a halogen, preferably bromine or iodine, after metallation with nBuLi in tetrahydrofuran at -78 ° C followed by carbonation with carbon dioxide, taking care to protect, if necessary, indole nitrogen with a protective group such as a tosylate, COOtBu, COOBn or t-Butyl dimethyl silane and l piperidine nitrogen by COOtBu or COOBn for example.
• a protective group such as a tosylate, COOtBu, COOBn or t-Butyl dimethyl silane and l piperidine nitrogen by COOtBu or COOBn for example.
• the compounds of formula (I) where Xi or X 2 represents an amide group may be prepared under the same conditions as the previous case but by reacting the compound metalized with nBuLi on trimethyl silane isocyanate in place of carbonation ; they can also be obtained by transformation of the acid previously obtained into acid chloride, for example using thionyl chloride, then reaction of this acid chloride on an amine, for example ammonia.
• the compounds of formula (I) where Xi or X 2 represents an acid group may be reduced, for example by double aluminum and lithium hydride to obtain the compounds where Xi or X 2 represents a hydroxymethyl group.
• the compounds of formula (I) where Xi or X 2 represents a nitrile group may be reduced, for example by double aluminum and lithium hydride to obtain the compounds where Xi or X 2 represents an amino methyl group, these compounds which can react with a sulfonic acid chloride to lead to the compounds of formula (I) where Xi or X2 represents a sulfonamidomethyl group.
• Another access route to these latter compounds can be the reaction of the compounds of formula (I) where Xi or X 2 represents a hydroxymethyl group with mesyl chloride or tosyl chloride, the mesylate or tosylate thus obtained may react. with a sulfonamide previously metallized to yield these derivatives of formula (I) where Xi or X 2 represents a sulfonamidomethyl group.
• the compounds of formula (I) where R 3 represents the hydrogen atom and p is equal to zero may be substituted in position 1 of the indole according to methods known to those skilled in the art, for example by presence of a metallizing agent such as sodium amide, a hydride or an alcoholate of sodium, potassium or lithium, in a solvent such as liquid ammonia, tetrahydrofuran or dimethyl formamide at a temperature between -40 "C and 80 “C, or in the presence of sodium hydroxide and a phase transfer agent in toluene, using the derivatives of formula (XI).
• a metallizing agent such as sodium amide, a hydride or an alcoholate of sodium, potassium or lithium
• Formula (XIV) in which Xi, X2, Ri, R 2 . R 3 are as defined in formula (I) can be oxidized using an oxidizing agent such as meta chloroperbenzoic acid in a solvent such as chloroform or methylene chloride or such as potassium peroxy monosulfate (KHSO5) in an alcohol-water mixture, at a temperature between 0 and 30 "C, to yield the compounds of formula (I) where p is equal to 1 or 2.
• the addition salts of the compounds of formula (I) can be obtained by reaction of these compounds with a mineral or organic acid according to a method known per se.
• a mineral or organic acid Among the acids which can be used for this purpose, hydrochloric, hydrobromic, sulfuric, phosphoric, 4-toluene sulfonic, methane, sulfonic, cyclohexyl sulfamic, oxalic, succinic, formic, fumaric, maleic, citric, aspartic, cinnamic acids are cited.
• lactic, glutamic, N-acetylaspartic, N-acetylgiutamic, ascorbic, malic, benzoic, nicotinic and acetic are cited.
• the invention also covers a pharmaceutical composition, characterized in that it comprises a pharmaceutically effective amount of at least one compound of formula (I) as defined above or one of its pharmaceutically acceptable addition salts, optionally incorporated in a pharmaceutically acceptable excipient, vehicle or support.
• compositions can be administered by the oral, rectal, parenteral, transdermal, ocular, nasal or auricular route.
• compositions can be solid or liquid and can be presented in the pharmaceutical forms commonly used in human medicine such as, for example, simple or coated tablets, capsules, granules, suppositories, injectables, transdermal systems, eye drops, aerosols and sprays and ear drops. They are prepared according to the usual methods.
• the active principle consisting of a pharmaceutically effective amount of at least one compound of formula (I) defined as above or one of its addition salts pharmaceutically acceptable, can be incorporated into excipients usually used in these pharmaceutical compositions, such as talc, gum arabic, lactose, starch, magnesium stearate, polyvidone, cellulose derivatives, cocoa butter , semi-synthetic glycerides, aqueous or non-aqueous vehicles, fatty substances of animal or vegetable origin, glycols, various wetting agents, dispersants or emulsifiers, silicone gels, certain polymers or copolymers, preservatives, flavors and dyes.
• excipients usually used in these pharmaceutical compositions, such as talc, gum arabic, lactose, starch, magnesium stearate, polyvidone, cellulose derivatives, cocoa butter , semi-synthetic glycerides, aqueous or non-aqueous vehicles, fatty substances of animal or vegetable origin, glycol
• the invention also covers a pharmaceutical composition with analgesic activity which makes it possible in particular to favorably treat pain, characterized in that it comprises a pharmaceutically effective amount of at least one compound of the abovementioned formula (I) or one of its pharmaceutically added salts. acceptable, optionally incorporated into a pharmaceutically acceptable excipient, vehicle or support.
• the invention also covers a process for the preparation of a pharmaceutical composition, characterized in that a pharmaceutically effective amount of at least one compound of formula (I) as defined above, or one of its salts, is incorporated. pharmaceutically acceptable addition to a pharmaceutically acceptable excipient, vehicle or carrier. According to one embodiment, a pharmaceutical composition with analgesic activity is prepared which makes it possible in particular to treat pain favorably.
• a composition is prepared formulated in the form of capsules or tablets dosed from 1 mg to 1000 mg or in the form of injectable preparations dosed from 0.1 mg to 500 mg.
• Formulations in the form of suppositories, ointments, creams, gels or aerosol preparations may also be used.
• the invention also covers a method for the therapeutic treatment of mammals, characterized in that a therapeutically effective amount of at least one compound of formula (I) as defined above, or one of its salts, is administered to this mammal. pharmaceutically acceptable addition.
• the compound of formula (I), either alone or in combination with a pharmaceutically acceptable excipient is formulated in capsules or tablets dosed from 1 mg to 1000 mg for administration by orally, or in the form of injectable preparations dosed from 0.1 to 500 mg or also in the form of suppositories, ointments, creams, gels or aerosol preparations.
• the compounds of formula (I) and their salts can be administered alone or in combination with a physiologically excipient. acceptable in any form, in particular orally in the form of capsules or tablets or parenterally in the form of an injectable solution.
• the compounds according to the invention can be administered in human therapy in the abovementioned indications orally in the form of tablets or capsules dosed from 1 mg to 1000 mg or parenterally in the form of injections dosed from 0.1 mg to 500 mg in one or more daily doses for an adult of average weight 60 to 70 kg.
• the daily dose that can be used is between 0.01 and 20 mg per kg.
• Example 3 4-mercap.o - i-piperidinecarboxy.ate of 1,1-dimet yl ethyl
• a suspension of 1- (phenylmethyl) -4-piperidinethiol (70 g, prepared in Example 1), chloroacetone (26.9 ml), sodium carbonate (71.6 g) and tetrabutylammonium iodide ( 31.2 g) in toluene (350 ml) is stirred at room temperature for 4 hours.
• the insoluble material is filtered and washed with toluene. After concentration, the filtrate is taken up in dichloromethane, washed with dilute soda and then with water saturated with sodium chloride.
• Example 10 4 - [(2-oxopropyl) thio] -1 - (2-phenylethyl) -piperidine
• Paratolylhydrazine hydrochloride (20 g) is added to a solution of 4 - [(2-oxopropyl) thio] -1- (phenylmethyl) -piperidine (33.2 g, prepared in Example 9) in isopropanol ( 150 ml) under nitrogen. After 30 minutes, the solution was cooled to 0 ° C and saturated with gaseous hydrochloric acid. After 4 hours at room temperature the precipitate formed is drained, washed with water and then taken up in hot ethanol.
• R-- Bn
• R 2 H
• R 3 H
• Xi 5-Br
• X 2 H
• p 0
• Example 55 By a similar method, the product of Example 55 is obtained, by reaction of iodoethane with 5-chloro-3- (4-piperidinylthio) -1 H-indole (prepared in Example 50):
• Meta chloroperbenzoic acid (2.79 g) is added in portions to 5-chloro-2-methyl-3- (4-piperidinylthio) -1 H-indole (3g, prepared in Example 18) in solution in dichloromethane (25 ml) at -40 ° C. After 4 hours at room temperature, the insoluble material is filtered. The filtrate is washed with soda and then with water. The aqueous phases are extracted with ether, then with ethyl acetate. The organic phases are combined, dried over magnesium sulfate and concentrated.
• Example 61 is prepared from the product of Example
• a suspension of copper cyanide (17.7 g) and 5-bromo-3 - [(1-methyl-4-piperidinyl) thio] -1 H-indole (35.5 g, prepared in Example 44) in 1-methyl-2-pyrrolidinone (45 ml) is brought to reflux for 24 hours. After dilution with water, the brown precipitate is separated, then taken up in a mixture of water (110 ml) and ethylenediamine (170 ml). The blue solution is extracted with ethyl acetate. The organic phase is dried over sodium sulfate and concentrated.
• Examples 66 to 69 are prepared from the products of Examples 49 and 50, by the action of acetyl chloride or ethyl, vinyl or phenyl chloroformates.
• Example 68 4 - [(5-chloro-1 H-indol-3-yl) thio] -1-vinyl piperidine carboxylate
• Example 70 3 - [(1-methoxy-4-piperidlnyl) thio] -1-methyl-1 H-indole-5-carboxylic acid
• Ci6 H2o 2 0 3 SF 170-172 ° C
• Example 72 ethyl 5-bromo-3 - [(1-carbethoxy-4-piperidinyl) thlo] -1 H-indole-1-carboxylate
• Ethyl chloroformate (4.4 ml) is added dropwise to a toluene solution (50 ml) at 90 ° C of 5-bromo-3 - [(1-methyl-4-piperidinyl) thio] -1 H -indole (5g, prepared in Example 44). After four hours of reflux, the insoluble material is filtered and the reaction mixture is concentrated. The orange oil obtained is taken up in ether and washed with a dilute solution of hydrochloric acid. The organic phase is dried over sodium sulfate and concentrated.
• the acid thus obtained (11 g) is added in portions to a suspension of double lithium aluminum hydride (LiAIH 4 , 1, 6 g) in anhydrous tetrahydrofuran (60 ml) at 0 ° C. After 4 hours at room temperature, the reaction mixture is cooled to 0 ° C and hydrolyzed with a saturated solution of sodium sulfate. The suspension is filtered through celite and then concentrated. After purification on silica gel (eluent: CH 2 CI 2 / ethanol, 80/20) 1-methyl-3 - [(1-methyl-4-piperidinyl) thio] -1H-indole-5-methanol (7, 5 g) is obtained in the form of an oil.
• silica gel eluent: CH 2 CI 2 / ethanol, 80/20
• Example 36 Prepared as in Example 36 by reaction of 4 - [(2,2-diethoxyethyl) thio] -1-methyl-piperidine (prepared in Example 12) with ethyl 4-hydrazino-benzoate hydrochloride.
• the analgesic activity of the examples was evaluated according to the method of stretching caused by phenylbenzoquinone in mice, described by Siegmund et al. (1957).
• the 0.02% phenylbenzoquinone solution in water is administered in a volume of 1 ml / 100 g.
• the products of the examples are administered orally one hour before the injection of phenylbenzoquinone.
• Stretching and twisting are counted for each mouse during an observation period of 5 minutes.
• results are expressed in the form of ID50, a dose which makes it possible to obtain a reduction of 50% in the number of painful reactions compared to the control animals.
• the first toxicology studies carried out show that the products of the examples do not induce any deleterious effect after oral abso ⁇ tion in rats of doses which can vary from 30 to 300 mg / kg.

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• 1993
  • 1993-05-18 FR FR9305966A patent/FR2705346B1/fr not_active Expired - Fee Related
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• 1994
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