EP0688020A1 - Abgedichtete Andockeinrichtung zwischen zwei umweltisolierten Gehäusen - Google Patents

Abgedichtete Andockeinrichtung zwischen zwei umweltisolierten Gehäusen Download PDF

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Publication number
EP0688020A1
EP0688020A1 EP95401275A EP95401275A EP0688020A1 EP 0688020 A1 EP0688020 A1 EP 0688020A1 EP 95401275 A EP95401275 A EP 95401275A EP 95401275 A EP95401275 A EP 95401275A EP 0688020 A1 EP0688020 A1 EP 0688020A1
Authority
EP
European Patent Office
Prior art keywords
enclosure
flange
door
cam
external
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95401275A
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English (en)
French (fr)
Other versions
EP0688020B1 (de
Inventor
Bernard Saint Martin
Christiane Lipp-Prioult
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
I D C - Isolateur Denominateur Commun
Original Assignee
I D C - Isolateur Denominateur Commun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I D C - Isolateur Denominateur Commun filed Critical I D C - Isolateur Denominateur Commun
Publication of EP0688020A1 publication Critical patent/EP0688020A1/de
Application granted granted Critical
Publication of EP0688020B1 publication Critical patent/EP0688020B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/02—Air-pressure chambers; Air-locks therefor
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F7/00—Shielded cells or rooms
    • G21F7/005—Shielded passages through walls; Locks; Transferring devices between rooms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S292/00—Closure fasteners
    • Y10S292/33—Metallic casement window fasteners
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T292/00—Closure fasteners
    • Y10T292/20—Clamps
    • Y10T292/205—Ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T292/00—Closure fasteners
    • Y10T292/20—Clamps
    • Y10T292/225—Cam-operating means

Definitions

  • the invention relates to a sealed junction device between two enclosures normally isolated from an external environment and capable of being put into communication without contact, even momentary, with said external environment.
  • the invention applies more particularly to such a sealed junction device the elements of which are distributed between a mobile or transportable container constituting one of the abovementioned enclosures and a fixed installation designed to be permanently isolated from the external environment and constituting the another aforementioned enclosure, the sealed junction device allowing transfers of objects or fluids between the two enclosures without contamination of or from said external environment.
  • Such a system implements two doors, each of them hermetically closing an opening of the corresponding enclosure delimited by an annular flange.
  • the doors are provided with cooperating assembly means making it possible to apply them one against the other in a hermetic manner, before placing in communication, in order to mutually isolate their external faces.
  • the assembly of the two doors is replaced in the respective housings provided in their flanges and the two enclosures are separated. In this way, the external faces of the two doors cannot be contaminated or contaminating because they had isolated each other during the transfer. They can therefore again be brought into contact with the outside environment.
  • the invention relates to a new concept for such sealed junction devices between two isolated enclosures, applicable to many fields where the products handled are sterile and must be kept sterile, or on the contrary polluting, even dangerous, and must be handled without communication. with the outside environment.
  • the invention therefore relates to a sealed junction device between two enclosures isolated from an external environment and each provided with a door capable of hermetically sealing an opening of the corresponding enclosure delimited by an annular flange, each door being delimited with an internal face in contact with the interior of the enclosure and with an external face in contact with said external medium and said doors being provided with cooperating assembly means making it possible to apply them one against the other so hermetic in order to isolate their external faces mutually, characterized in that one of the two enclosures being of the single-use type, it comprises means for final locking of its own door, controlled by first actuation means installed on the other enclosure.
  • At least part of the wall of said single-use enclosure is made of flexible material and attached directly or indirectly to the rigid annular flange on which the corresponding door is mounted.
  • the entire enclosure except for the flange and the door, will take the form of a bag of flexible material.
  • said single-use enclosure may include means for initial locking of its own door, arranged to be inhibited by second actuation means installed on said other enclosure.
  • FIG. 1 there is partially shown a sealed junction device 11 established between two enclosures 14, 16, the components of the device in question being carried in part by the enclosure 14, which is here a container or a room or any other fixed installation, designed to be permanently isolated from the outside environment and partly by enclosure 16 which is here a simple container of relatively low capacity compared to that of enclosure 14.
  • enclosure 16 is designed as a single-use enclosure. More specifically, the two enclosures 14 and 16 each comprise an aperture 18, 20 bounded by an annular flange 18, 20a, respectively. Each opening 18, 20 is provided with a door 22, 23, respectively. In the example, the flanges have a circular outline, but this is by no means imperative.
  • the sealed junction device is designed to manage the assembly and separation of the doors 22, 23 and the communication of the two enclosures according to a procedure avoiding any contact of the contents of one or the other enclosure with the external environment.
  • the door 22 of the enclosure 14 is defined with an internal face 22 a normally in contact with the interior of the enclosure 14 and in any case never in contact with the outside environment while the door 23 of the enclosure 16 is defined with an internal face 23 a normally in contact with the interior of the enclosure 16 and in any case never in contact with the external environment.
  • the door 22 is defined with an external face 22 b normally in contact with the external environment and in any case never in contact with the interior of one or the other enclosure while the door 23 is defined with a external face 23 b normally in contact with the external environment and in any case never in contact with inside one or the other enclosure.
  • the two doors are provided with cooperating assembly means making it possible to assemble them one against the other in a hermetic manner so as to mutually isolate their external faces 22b , 23b .
  • the door 22 is provided with an annular seal 26 made of elastomeric material on which a projecting external edge of the door 23 is applied.
  • the flange 20 has enclosure for use one 16 is provided at its periphery with an annular seal 27 which abuts on the edge of the flange 18a of the enclosure 14, adjacent the seal 26.
  • the locking elements 28 operating herein by contact are respectively integral with the external faces 22b , 23b , at the centers thereof.
  • These joining elements 28 are for example magnetic or adhesive plates or means using suction cups or other similar elements. Each plate fixed to the center of a door is likely to come to stick against the other. These elements could also be replaced by mechanical systems, for example with hooks.
  • said assembly means are completed by cam mechanisms 25 arranged at the edge of the opening of the enclosure 14.
  • Each mechanism comprises a shaft 24 mounted rotating in the thickness of the flange 18 a and two cams 24A, 24B, respectively exterior and interior, with angularly offset angles of action.
  • the outer cam 24A makes it possible to secure the flange 20 to the chamber for single use to that of the enclosure 14 while the inner cam 24B makes it possible to secure the door 22 of the enclosure 14 to the flange 18 has this one.
  • Each shaft carrying the two aforementioned cams is provided with an operating handle 21.
  • the flange 20 a has an external annular flange 17 provided with three notches 17 a , radial where the external cams 24A are received when approaching the flange 20 a of the flange 18 a .
  • the outer cams 24A extend substantially radially and, as can be seen, the inner cams 24B are in a position such that they firmly hold the door 22 in application against its seat defined in the flange 18 a .
  • the internal cams 24B have flats 25 such that when the handles are rotated, first of all, the external flange 17 of the flange 20 a is made to join against the flange 18 a , before releasing the door 22 by releasing the interior cams.
  • the enclosure 16 is of the single-use type and therefore it comprises means for final locking of its own door 23, controlled by first actuation means installed on the other enclosure.
  • said final locking means comprise at least one arrangement 30 defined in the door 23 and the flange 20 a and comprising a hole 32 passing through the flange 20 a , a blind hole 34 extending in the thickness of the door 23 of the single-use enclosure 16, normally in the extension of the hole 32 of the flange and a pin 36 or the like, engaged in the hole 32 and having a length greater than the thickness of the flange 20 a .
  • said pin 36 projects outside the flange 20 a and is not engaged in the blind hole 34.
  • said first actuation means comprise, in the vicinity of each pin 36, an element 38 forming a shaft, mounted to pivot about its own axis in the flange 18 a , near the edge of the opening 18 of the enclosure 14
  • This shaft is fitted with a cam 37 capable of cooperating with the pin 36 next to it and driving it into the blind hole 34.
  • This element 38 is provided with a handle 39 making it possible to maneuver the cam 37.
  • the single-use enclosure 16 also comprises means for initial locking of its own door 23, arranged to be inhibited by second actuation means installed on the enclosure 14.
  • These initial locking means comprise at least one arrangement 40 defined in the door 23 and the flange 20 a and comprising a hole 42 passing through the flange 20 a , a blind hole 44 extending in the thickness of the door 23 of the disposable enclosure 16, normally in the extension of the hole 42 of the bridle and two pins or anal ogues, respectively an internal pin 46 and an external pin 47 engaged in the extension of one another, in these two holes.
  • two arrangements 40, diametrically opposed, have been provided.
  • the internal pin 46 is engaged both in the flange 20 a and in the door 23 while the external pin 47 projects from the flange 20 a ( Figure 3).
  • the lengths of the pins 46, 47 are such that their ends in contact can come to be placed at the interface of the flange 20 a and the door 23 (FIG. 4) when said second actuation means are exerted on the external pin 47.
  • These second actuation means comprise a cam 48 able to cooperate with the pin 47 to push it into the flange 20 a (FIG. 4).
  • This cam is integral with the same element 38 forming a shaft, provided with a handle 39.
  • said first and second actuation means are combined and distributed over two diametrically opposite assemblies.
  • the flange 17 is provided with cutouts to accommodate the elements 38 and the corresponding cams 37, 48.
  • the pins are mounted so as to guarantee hermetic contact with the walls of the holes in which they are installed, forming kinds of plugs.
  • the fields of the flanges 18 a , 20 a and those of the doors 22, 23 which are mounted therein respectively are conical or have conical portions.
  • the conical portions of the flanges thus form annular seats for said doors.
  • Said conical parts have the same conicity and the diameters of the external faces 22 b , 23 b are equal so that once assembled, the doors have only one conical part without any solution of continuity.
  • the ends of the flanges intended to come into contact have equal diameters so that the conical parts of the flanges are in the extension of one another after assembly and form only one conical section without solution of continuity.
  • the precise circumferential positioning of the flange 20 a with respect to the flange 18 a is ensured by three pins 50 integral with the flange 18 a and distributed circumferentially at 120 °, cooperating with notches 51 formed in the flange 17.
  • One of the pins 50 at least passes through the wall of the flange 18 a and extends inside the enclosure 14.
  • a peripheral flange of the door 22 has a hole 51 or a similar cut, capable of ensuring precise circumferential positioning of the two doors compared to flanges assembled when the two doors are replaced before proceeding to separate the two enclosures.
  • the single-use enclosure 16 or at least part of it is made of flexible material.
  • the part made of flexible material is attached to the rigid annular flange 20 a on which the door 23 is mounted.
  • the enclosure 16 can consist of a simple bag of flexible material connected, for example welded, to the flange 20 a (see Figure 6).
  • the entire enclosure 16 is made up of elements made of inexpensive material.
  • the flange 20a and the door 23 can be made of rigid plastic and the rest of the enclosure (forming the flexible bag) can be made of flexible plastic.
  • the arrangements 30 and 40 of the single-use enclosure have the configuration illustrated in FIG. 3.
  • the lever 39 When the lever 39 is oriented radially, nothing prevents the positioning of the flange 20 a on the flange 18 a and to the assembly of the two doors 22, 23. However the position of the pins 46 prevents opening of the door 23.
  • the operator actuates the three cam mechanisms 25 which has the effect of firmly securing the flange 20 a on the flange 18 a and then unlocking the door 22. Then, the operator rotates the two handles 39 to pass from the situation illustrated in Figure 3 to that shown in Figure 4.
  • FIGS. 8 to 10 illustrate a variant in which the structural elements similar to those of FIGS. 1 to 5 bear the same numerical references increased by 100.
  • This embodiment differs from the previous one in that the assembly means, in particular the cam mechanisms 125 are combined with said first actuation means comprising a cam 137 and with said second actuation means comprising a cam 148. In this way, the connection and locking-unlocking operations are simplified and the risks of error maneuvers are considerably reduced.
  • the cam mechanisms shown in FIG. 1 are reduced to two and grouped with the shafts 138 and the handles 121 of the said first and second actuation means already combined in the previous example.
  • the inner and outer cams which said assembly means included are transferred to the shafts 138, an inner cam 124B being installed at the inner end of each of them and the outer cams here being combined with the cams 148 of said second means d actuation of the above-mentioned initial locking means 140.
  • the cams 148 (or 124A) and 124B are integral with the shaft 138 and have angularly offset action angles as in the previous example, to ensure the same functions.
  • the outer cam 124A are used to secure the flange 120 has the single-use enclosure to that of said other enclosure while the inner cam 124B allow securing the chamber door 114 to the flange thereof.
  • cams 148 are capable of cooperating at the end of the travel, in a direction of rotation of the operating handles 121, with the pins 142 of said initial locking means.
  • each operating handle 121 is not directly linked to the corresponding shaft 138; it is integral with an operating sleeve 160 which covers the shaft 138.
  • This sleeve carries a cam 137 of said first actuation means, capable of cooperating with a pin 136 of said final locking means.
  • the sleeve 160 comprises a coupling light 161 or the like and the shaft 138 comprises a protruding pin 162, extending perpendicular to its axis of rotation and engaged in said coupling light 161.
  • each handle By operating each handle from the neutral position ( Figure 8) to the first extreme position, the operator first causes the single-use enclosure to be attached (by cooperation of the cam 148 with the flange 170), then, at the end of the race, the release of the door of the enclosure 114 and the unlocking of the door 123. After use, the operator maneuvers each handle towards its other extreme position, and the coupling described makes it possible to permanently lock the door 123 of the single-use enclosure before the cam 148 is released from the flange of the single-use enclosure. The same movement causes the enclosure 114 door to be blocked by the cams 124B. To release the single-use enclosure, the operator returns the handles 121 to the neutral position.
  • FIGS. 11 to 22 illustrate mobile single-use enclosures, most often with a flexible wall or part of a wall and with particular characteristics and / or equipment giving the enclosure a specific function.
  • the structural elements similar to those described with reference to Figures 1 to 7 have the same reference numerals.
  • FIG. 11 as a whole represents a single-use enclosure 16 with a flexible wall in the form of a waterproof bag connected to the flange, the latter being closed by the door 23.
  • the flange and the door are equipped with pins allowing first the initial unlocking and later the final and final locking.
  • the part made of flexible material forming a bag can be made of perfectly waterproof plastic, in particular if the enclosure is intended to receive contaminated or polluting products and if it is intended to be destroyed, for example by incineration, with its content.
  • the wall can also be porous, which allows sterilization by autoclaving before or after use.
  • the bag connected to the flange is made of water-soluble material. It is thus possible to recover dirty and / or contaminated clothing, place it in the single-use enclosure and introduce it into a washing machine. The water-soluble bag dissolves there at the start washing and clean clothes can be retrieved at the end of the washing cycle.
  • Figure 12 is similar to that of Figure 11 but a portion 16a only of the flexible wall is made of a porous material adapted to allow sterilization by impregnating a gas such as oxide ethylene. Sterilization is done by placing the enclosure in an atmosphere of ethylene oxide under pressure.
  • a gas such as oxide ethylene
  • the embodiment of Figure 13 also allows sterilization by ethylene oxide.
  • said single-use enclosure comprises a connection end piece 50 for its connection to a source of gaseous ethylene oxide or to another source of sterilization gas.
  • a membrane filter 51 is interposed between the nozzle 50 and the internal volume of the enclosure 16. This filter simultaneously forms a shutter which prevents subsequent contamination of the interior volume of the enclosure.
  • the single-use enclosure consists of a part made of flexible material 16 b and a rigid jar 53.
  • the part made of flexible material is connected in a sealed manner to the jar on the one hand and on the flange 20 a on the other hand.
  • the example of FIG. 15 is that of a bag 55 containing powder.
  • the part made of flexible material comprises at least one tubular sleeve 56 connected between the flange on the one hand and the bag on the other hand. It is also possible that this part is a bag as in the example in FIG. 8 containing another bag, the latter containing the powder. In both cases, the single-use enclosure or the inner bag has an inner sleeve 57 made of flexible material which makes it possible to easily pour the powder.
  • the part which contains the powder is connected to the flange by the sleeve made of flexible material, the connection to the fixed enclosure without being bothered by the often significant weight of the powder bag.
  • FIG. 16 illustrates another embodiment making it possible to transfer a sterilizable solution by filtration.
  • the wall of the single-use enclosure 16 is hermetically traversed by a connecting tube 59 and a filter 60, connected to this tube, is housed in said single-use enclosure.
  • This enclosure can therefore be connected to another fixed enclosure containing the liquid product to be sterilized by filtration, extract this product by filtering it and discard and / or destroy the filter 60 in said single-use enclosure, after transfer.
  • FIG. 17 illustrates another embodiment comprising two flanges 20 a provided with respective doors 23 and respectively connectable to other enclosures 14.
  • the two parts are connected by a tube 63 which forms a element of a fluid circuit. Thanks to this arrangement, it is thus possible to establish a circulation of fluid between two enclosures normally isolated from one another, the double enclosure for single use containing the connection tube 63 being intended to be destroyed after use.
  • FIG. 18 also shows a single-use enclosure comprising two flanges 20a provided with respective doors 23, which can be connected to other fixed enclosures.
  • the flexible material part is connected to the two flanges by its respective ends so that a communication sleeve 65 is thus defined between the two fixed enclosures.
  • the single-use enclosure comprises a flexible duct element 68, the two ends of which open out inside the bag made of flexible material.
  • a U-shaped section of said conduit element extends outside of this bag.
  • This device produces a disposable peristaltic pump element.
  • the two ends of the flexible conduit can be connected to two parts a circuit established inside the fixed enclosure while it is possible to couple the motor and the eccentrics of the peristaltic pump to the part of the flexible conduit which extends outside the bag. After use, the two ends of the flexible conduit are confined to the interior of the single-use enclosure and the assembly can be destroyed.
  • FIG. 20 describes a single-use enclosure which is not provided with a wall made of flexible material but which constitutes an air filter or more generally a single-use gas filter, intended to be connected to a fixed enclosure.
  • the flange 20a is connected by a rigid pipe 69 to a housing 70 containing a dry filter 71, the air filter type, low pressure.
  • Figures 21 and 22 illustrate a last embodiment in which the flexible material part of the single-use enclosure consists of an inverted glove 73 ( Figure 21) connected by the sleeve to a flange 20 a provided with its door 23
  • Figure 21 the flexible material part of the single-use enclosure consists of an inverted glove 73 ( Figure 21) connected by the sleeve to a flange 20 a provided with its door 23
  • the user can introduce his hand into the glove 73 and engage it in the fixed enclosure (FIG. 22) to carry out manipulations there. .
EP95401275A 1994-06-17 1995-06-01 Abgedichtete Andockeinrichtung zwischen zwei umweltisolierten Behältnissen und Behältnis dafür zum einmaligen Gebrauch Expired - Lifetime EP0688020B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9407430A FR2721289B1 (fr) 1994-06-17 1994-06-17 Dispositif de jonction étanche entre deux enceintes isolées d'un milieu extérieur.
FR9407430 1994-06-17

Publications (2)

Publication Number Publication Date
EP0688020A1 true EP0688020A1 (de) 1995-12-20
EP0688020B1 EP0688020B1 (de) 1998-09-09

Family

ID=9464331

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95401275A Expired - Lifetime EP0688020B1 (de) 1994-06-17 1995-06-01 Abgedichtete Andockeinrichtung zwischen zwei umweltisolierten Behältnissen und Behältnis dafür zum einmaligen Gebrauch

Country Status (8)

Country Link
US (1) US5853207A (de)
EP (1) EP0688020B1 (de)
JP (1) JP3929511B2 (de)
AT (1) ATE171006T1 (de)
CA (1) CA2151698C (de)
DE (1) DE69504581T2 (de)
ES (1) ES2120695T3 (de)
FR (1) FR2721289B1 (de)

Cited By (15)

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FR2787235A1 (fr) * 1998-12-11 2000-06-16 Becton Dickinson France Dispositif de liaison de portes entre deux enceintes isolees du milieu exterieur
WO2002017332A1 (en) * 2000-08-18 2002-02-28 Glaxosmithkline Biologicals S.A. System for providing communication between the interior and the exterior of a compartment
EP2091051A1 (de) 2008-02-12 2009-08-19 JCE Biotechnology Dichte Verbindungsvorrichtung zwischen zwei Behältern
WO2011023906A1 (fr) 2009-08-26 2011-03-03 Bernard Saint Martin Dispositif de jonction temporaire étanche à double porte
FR2951516A1 (fr) * 2009-10-20 2011-04-22 Sartorius Stedim Aseptics Perfectionnements aux systemes de transfert entre une enceinte et un conteneur.
WO2011061463A1 (fr) 2009-11-23 2011-05-26 Sartorius Stedim Aseptics Perfectionnements a la jonction etanche et au transfert etanche entre deux enceintes en vue d'un transfert aseptique entre elles.
WO2011061464A1 (fr) 2009-11-23 2011-05-26 Sartorius Stedim Aseptics Enceinte pour dispositif de jonction etanche et dispositif de transfert aseptique.
WO2011131870A1 (fr) 2010-04-20 2011-10-27 Sartorius Stedim Biotech S.A. Emballage biopharmaceutique stérilisable
FR2978363A1 (fr) * 2011-07-29 2013-02-01 Sartorius Stedim Aseptics Conteneur pour le transfert aseptique d'un produit biopharmaceutique.
WO2013017765A1 (fr) 2011-07-29 2013-02-07 Sartorius Stedim Aseptics Dispositif de jonction étanche pour le transfert aseptique d'un produit biopharmaceutique entre une enceinte et un conteneur
US8523436B2 (en) 2007-05-11 2013-09-03 Sartorius Stedim Aseptics Flexible shipping container and manufacturing process
WO2013160594A1 (fr) 2012-04-24 2013-10-31 Sartorius Stedim Biotech S.A. Ensemble unitaire stérile pour la production de produits biopharmaceutiques
WO2017109420A1 (fr) * 2015-12-23 2017-06-29 Sartorius Stedim Aseptics Procede de fabrication d'un recipient etanche
GB2555145A (en) * 2016-12-22 2018-04-25 Zennex Special Products Ltd Liner interface
WO2021123636A1 (fr) * 2019-12-20 2021-06-24 Abc Transfer Arrangement de porte equipant un premier volume clos permettant de reduire les risques de contamination lors du raccordement d'un deuxieme volume clos au premier volume clos

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FR2777059B1 (fr) * 1998-04-03 2000-08-25 Becton Dickinson France Dispositif de mise en communication de deux enceintes, en preservant leur etancheite
FR2782071B1 (fr) * 1998-08-04 2000-11-03 Idc Isolateur Denominateur Com Conteneur a usage unique
FR2787190B1 (fr) * 1998-12-11 2001-02-16 Becton Dickinson France Dispositif de detection de l'etancheite de la liaison entre les elements d'un dispositif de jonction etanche de deux enceintes isolees du milieu exterieur
FR2808198B1 (fr) * 2000-03-29 2002-07-26 Isolateur Denominateur Commun Installation de sterilisation a autoclave
DE20117669U1 (de) 2001-10-29 2002-03-14 Gea Buck Valve Gmbh Abgedichtete Andockeinrichtung insbesondere für Säcke
US7051897B2 (en) * 2001-11-05 2006-05-30 Robbins & Myers Energy Systems, L.P. Closure for a pressure vessel and method
FR2833745B1 (fr) * 2001-12-14 2004-10-01 Becton Dickinson France Dispositif de protection pour enceinte sterile
FR2853552B1 (fr) * 2003-04-09 2008-02-29 Isolateur Denominateur Commun Procede et installation de traitement sterile de produits
DE10321814B4 (de) * 2003-05-15 2007-03-01 Gea Niro Gmbh Kopplungselement sowie Andockeinrichtung enthaltend ein Kopplungselement
DE10362131A1 (de) 2003-08-01 2006-06-14 Gea Buck Valve Gmbh Kupplungsverschlüsse sowie Andockeinrichtungen enthaltend diese Kupplungsverschlüsse
DE102004003511B4 (de) * 2004-01-23 2007-04-26 Gea Niro Gmbh Wiederverschließbarer Andockverschluss sowie Andocksystem, Mehrfachkupplungsverschluss, Mehrfachandocksystem, Fördermittel und Behältnis, enthaltend diesen Andockverschluss, und Verfahren zum Befüllen, Umfüllen und/oder Entleeren von solchen Behältnissen und/oder Fördermitteln
FR2883266B1 (fr) * 2005-03-15 2007-06-15 Isolateur Denominateur Commun Conteneur souple a element de guidage incorpore
JP2010512286A (ja) 2006-12-15 2010-04-22 ゲーエーアー ファーマ システムズ アーゲー 結合閉鎖具および２つの結合閉鎖具からなる連結装置
FR2927062B1 (fr) * 2008-02-04 2011-07-01 Arkema France Procede de remplissage securise de nanotubes de carbone, systeme de remplissage et installation industrielle mettant en oeuvre le procede.
DE102008026584A1 (de) * 2008-06-03 2009-12-10 Clariant International Limited Verbessertes Cyanfarbmittel
WO2010054031A1 (en) * 2008-11-05 2010-05-14 West Pharmaceutical Services, Inc. Barrier isolator port assembly
FR2956092B1 (fr) * 2010-02-10 2012-02-24 Sartorius Stedim Biotech Sa Procede et unite d'emplissage sterile d'un conteneur elementaire final avec un contenu destine au domaine biopharmaceutique.
FR3010119A1 (fr) * 2013-09-03 2015-03-06 Getinge La Calhene Dispositif de connexion etanche a securite de fonctionnement amelioree
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FR3010120B1 (fr) * 2013-09-03 2016-03-04 Getinge La Calhene Dispositif de connexion etanche entre deux volumes clos comportant des moyens de maintien prealablement a la connexion
WO2016140920A1 (en) 2015-03-02 2016-09-09 Delaware Capital Formation, Inc. Customizable mounting interface for a sealed transfer port
FR3034405B1 (fr) 2015-03-30 2017-04-07 Lourd'innov Sachet pour le transfert et l'emballage de composants d'une enceinte confinee
GB2542123A (en) 2015-09-08 2017-03-15 Chargepoint Tech Ltd Transfer device
FR3054126B1 (fr) * 2016-07-22 2019-07-26 Sartorius Stedim Fmt Sas Recipient biopharmaceutique, poche de recipient biopharmaceutique, procede de fabrication et d’utilisation de recipient biopharmaceutique
JP2020520309A (ja) 2017-05-08 2020-07-09 デラウェア・キャピタル・フォーメイション・インコーポレーテッドＤｅｌａｗａｒｅ Ｃａｐｉｔａｌ Ｆｏｒｍａｔｉｏｎ Ｉｎｃｏｒｐｏｒａｔｅｄ カバーを有するアクセスポート
FR3071725A1 (fr) 2017-10-03 2019-04-05 Sartorius Stedim Fmt Sas Dispositif de jonction etanche pour le transfert aseptique d’un produit biopharmaceutique entre une enceinte et un conteneur
CA3085289A1 (en) 2017-12-11 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Modular aseptic production system
DE102019003317A1 (de) * 2019-05-10 2020-11-12 Atec Pharmatechnik Gmbh Vorrichtung zur sterilen Übergabe von Gut zwischen einem Behälter und einem Isolator
WO2022084359A1 (en) * 2020-10-23 2022-04-28 Merck Patent Gmbh Transfer device for transferring a plurality of objects through a transfer port
DE102021201569A1 (de) * 2021-02-18 2022-08-18 Castus GmbH & Co. KG beta-Behälter für ein alpha-beta-Portsystem
DE102021114897A1 (de) 2021-06-09 2022-12-15 Pharmpur Gmbh Adapterplatte, Transferbeutel mit Adapterplatte sowie Transferschleuse und Schleusensystem für einen Sterilbereich und Verfahren zum sterilen Transfer eines in einem Transferbeutel steril verpackten Transferguts durch eine Transferschleuse in einen Sterilbereich
CN117500596A (zh) * 2021-06-18 2024-02-02 贝克顿迪金森法国公司 用于从容器转移无菌部件的柔性箱和刚性支撑件装置

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FR2787235A1 (fr) * 1998-12-11 2000-06-16 Becton Dickinson France Dispositif de liaison de portes entre deux enceintes isolees du milieu exterieur
WO2000036610A1 (fr) * 1998-12-11 2000-06-22 Becton Dickinson France Dispositif de liaison de portes entre deux enceintes isolees du milieu exterieur
WO2002017332A1 (en) * 2000-08-18 2002-02-28 Glaxosmithkline Biologicals S.A. System for providing communication between the interior and the exterior of a compartment
AU2001291764B2 (en) * 2000-08-18 2005-08-11 Aseptic Technologies S.A. System for providing communication between the interior and the exterior of a compartment
US7192065B2 (en) 2000-08-18 2007-03-20 Smithkline Beecham Biologicals S.A. System for providing communication between the interior and the exterior of a compartment
US7431352B2 (en) 2000-08-18 2008-10-07 Glaxosmithkline Biologicals S.A. System for providing communication between the interior and the exterior of a compartment
CZ301748B6 (cs) * 2000-08-18 2010-06-09 Aseptic Technologies S.A. Systém pro spojení vnitrku komory s vnejškem komory, spojovací teleso, kryt a jejich kombinace pro tento systém a zpusob prenosu materiálu mezi vnitrkem a vnejškem komory
US8523436B2 (en) 2007-05-11 2013-09-03 Sartorius Stedim Aseptics Flexible shipping container and manufacturing process
EP2091051A1 (de) 2008-02-12 2009-08-19 JCE Biotechnology Dichte Verbindungsvorrichtung zwischen zwei Behältern
WO2011023906A1 (fr) 2009-08-26 2011-03-03 Bernard Saint Martin Dispositif de jonction temporaire étanche à double porte
US8893914B2 (en) 2009-08-26 2014-11-25 Lourd 'Innov SAS Temporary sealed double-door junction device
WO2011048295A1 (fr) 2009-10-20 2011-04-28 Sartorius Stedim Aseptics Perfectionnements aux systemes de transfert entre une enceinte et un conteneur
US9545628B2 (en) 2009-10-20 2017-01-17 Sartorius Stedim Aseptics Systems for the transfer between a chamber and a container
FR2951516A1 (fr) * 2009-10-20 2011-04-22 Sartorius Stedim Aseptics Perfectionnements aux systemes de transfert entre une enceinte et un conteneur.
WO2011061464A1 (fr) 2009-11-23 2011-05-26 Sartorius Stedim Aseptics Enceinte pour dispositif de jonction etanche et dispositif de transfert aseptique.
CN102821858A (zh) * 2009-11-23 2012-12-12 赛多利斯埃塞普蒂克公司 对两个壳体之间的密封连接和密封传递在两个壳体之间的无菌传递方面的改进
WO2011061463A1 (fr) 2009-11-23 2011-05-26 Sartorius Stedim Aseptics Perfectionnements a la jonction etanche et au transfert etanche entre deux enceintes en vue d'un transfert aseptique entre elles.
US9283556B2 (en) 2009-11-23 2016-03-15 Sartorius Stedim Aseptics Tight connection and tight transfer between two housings in view of an aseptic transfer therebetween
US9168520B2 (en) 2009-11-23 2015-10-27 Sartorius Stedim Aseptics Chamber for sealed junction device and aseptic transfer device
WO2011131870A1 (fr) 2010-04-20 2011-10-27 Sartorius Stedim Biotech S.A. Emballage biopharmaceutique stérilisable
WO2013017765A1 (fr) 2011-07-29 2013-02-07 Sartorius Stedim Aseptics Dispositif de jonction étanche pour le transfert aseptique d'un produit biopharmaceutique entre une enceinte et un conteneur
US9795956B2 (en) 2011-07-29 2017-10-24 Sartorius Stedium Fmt Sas Container for the aseptic transfer of a biopharmaceutical product
WO2013017766A1 (fr) 2011-07-29 2013-02-07 Sartorius Stedim Aseptics Conteneur pour le transfert aseptique d'un produit biopharmaceutique
US9440229B2 (en) 2011-07-29 2016-09-13 Sartorius Stedim Fmt Sas Leaktight joining device for the aseptic transfer of a biopharmaceutical product between a chamber and a container
US9446401B2 (en) 2011-07-29 2016-09-20 Sartorius Stedim Fmt Sas Container for the aseptic transfer of a biopharmaceutical product
FR2978363A1 (fr) * 2011-07-29 2013-02-01 Sartorius Stedim Aseptics Conteneur pour le transfert aseptique d'un produit biopharmaceutique.
US9963255B2 (en) 2012-04-24 2018-05-08 Sartorius Stedim Fmt Sas Sterile individual set for producing biopharmaceutical products
WO2013160594A1 (fr) 2012-04-24 2013-10-31 Sartorius Stedim Biotech S.A. Ensemble unitaire stérile pour la production de produits biopharmaceutiques
FR3046206A1 (fr) * 2015-12-23 2017-06-30 Sartorius Stedim Aseptics Procede de fabrication d'un recipient etanche
WO2017109420A1 (fr) * 2015-12-23 2017-06-29 Sartorius Stedim Aseptics Procede de fabrication d'un recipient etanche
US10843184B2 (en) 2015-12-23 2020-11-24 Sartorius Stedim Aseptics Method for manufacturing a leaktight container
GB2555145A (en) * 2016-12-22 2018-04-25 Zennex Special Products Ltd Liner interface
GB2555145B (en) * 2016-12-22 2021-11-24 Zennex Special Products Ltd Liner interface
WO2021123636A1 (fr) * 2019-12-20 2021-06-24 Abc Transfer Arrangement de porte equipant un premier volume clos permettant de reduire les risques de contamination lors du raccordement d'un deuxieme volume clos au premier volume clos
FR3105055A1 (fr) * 2019-12-20 2021-06-25 Abc Tranfer Arrangement de porte equipant un premier volume clos permettant de reduire les risques de contamination lors du raccordement d’un deuxieme volume clos au premier volume clos

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JPH0842694A (ja) 1996-02-16
ATE171006T1 (de) 1998-09-15
DE69504581D1 (de) 1998-10-15
US5853207A (en) 1998-12-29
FR2721289B1 (fr) 1996-08-30
CA2151698C (fr) 2005-11-29
JP3929511B2 (ja) 2007-06-13
FR2721289A1 (fr) 1995-12-22
CA2151698A1 (fr) 1995-12-18
DE69504581T2 (de) 1999-04-29
ES2120695T3 (es) 1998-11-01
EP0688020B1 (de) 1998-09-09

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