EP0679440A1 - Pipette de distribution à répétition - Google Patents

Pipette de distribution à répétition Download PDF

Info

Publication number
EP0679440A1
EP0679440A1 EP95104357A EP95104357A EP0679440A1 EP 0679440 A1 EP0679440 A1 EP 0679440A1 EP 95104357 A EP95104357 A EP 95104357A EP 95104357 A EP95104357 A EP 95104357A EP 0679440 A1 EP0679440 A1 EP 0679440A1
Authority
EP
European Patent Office
Prior art keywords
rack
actuating
path
syringe
actuating element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95104357A
Other languages
German (de)
English (en)
Other versions
EP0679440B1 (fr
Inventor
Herbert Belgardt
Klaus Ing. Schürbrock (grad.)
Rolf-Günter Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf Netheler Hinz GmbH
Eppendorf Geraetebau Netheler and Hinz GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf Netheler Hinz GmbH, Eppendorf Geraetebau Netheler and Hinz GmbH filed Critical Eppendorf Netheler Hinz GmbH
Publication of EP0679440A1 publication Critical patent/EP0679440A1/fr
Application granted granted Critical
Publication of EP0679440B1 publication Critical patent/EP0679440B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge

Definitions

  • the invention relates to a repeater pipette according to the preamble of claim 1.
  • a repeating pipette of the above type is known from DE 29 26 691 C2.
  • the syringe holder is a U-shaped groove with a lateral opening in a pipette housing, through which a syringe flange can be inserted.
  • the syringe flange is loaded in the receptacle by a compression spring in the direction of the dispensing opening.
  • the syringe plunger has a cylindrical actuating section which can be fixed in the receiving body by means of a clamping device.
  • the piston return device is a lever extending from the receiving body and protruding through a side slot in the housing.
  • the plunger can be pulled out of the syringe by pushing the lever away from the syringe holder.
  • the actuating element of the piston advancing device is an actuating lever which is pivotably mounted on the toothless side of the toothed rack and which has the pawl and an actuating end protruding from the housing on the toothed side of the toothed rack.
  • the restraining element of the increment setting device is a tongue, which more or less covers the toothing of the rack depending on the setting of a rotary knob. In the overlap area, the tongue prevents the pawl from engaging in the rack when the lever is actuated. In the area without overlap, the pawl engages in the toothing and takes it and the piston connected to it by one advance step. The width of the advance step and thus the volume dispensed by the syringe can therefore be adjusted by means of the rotary knob.
  • the actuation path of the actuation lever is composed of an idle path in which the pawl is prevented from engaging by the tongue and a work path in which the pawl engages in the toothing.
  • the free travel is the greater and the work route the smaller, the smaller the set step size and the smaller that volume of liquid to be dosed.
  • the object of the invention is to create a repeater pipette of the type mentioned at the outset with reduced actuation effort for an operator.
  • a path limiting device is provided for the actuating path of the actuating element.
  • the path limiting device is controlled by the step size setting device in such a way that the actuation path is increased with increasing step size and reduced with decreasing step size. Care is taken to ensure that the actuating element is always moved over the commute, but that a reduced free travel is covered with all the increments set.
  • the operation is always predominantly or exclusively serves to overcome the commute, ie pushes the syringe plunger forward.
  • the amount of actuation is reduced and adapted to the respective dosage amount.
  • the actuation path is matched to the respective work path, so that it is a measure of the dosing volume and gives the operator an additional indication of the pipette setting.
  • the path limiting device preferably has a stop which limits the actuating path of the actuating element at the beginning and which can be adjusted in the forward and backward movement direction of the actuating element by the step size adjusting device. To compensate for an increased free travel, the stop is adjusted in the direction of advance of the actuating element when the step size is reduced. When the step size for larger amounts of liquid is increased, the stop is moved in the return movement direction of the actuating element, so that a sufficient working path and possibly a desired free path is available.
  • the stop as the shoulder of the holding element can preferably be displaced along the rack, as a result of which a practically constant free travel is achieved.
  • the actuation path is corresponding to that by means of the holding element set travel distance reduced or enlarged.
  • the stop is preferably arranged at a distance from a front end of the holding element.
  • the holding element can be a sleeve guided on the rack.
  • the stop is preferably a lateral shoulder of the sleeve.
  • the actuating element extends across one side of the rack.
  • the holding element can have the shoulder on this side of the rack.
  • the actuating element can have two parallel legs on opposite sides of the rack and the retaining element can have the shoulder on both sides.
  • the actuating element can have a pivot bearing on one side of the rack and an actuating end on the other side of the rack.
  • the holding element has a laterally projecting guide cam, which acts as a setting element in a guide curve of a rotatable adjusting knob the step size setting is performed.
  • This known setting device of the holding element is particularly advantageous if it also causes the stop to be displaced.
  • the rack is a rod with teeth, which can also be designed as a threaded rod or as a rod with circumferential grooves.
  • the repeater pipette has a housing 1, which acts as a handle executed middle section 2, a foot section 3 and a head section 4.
  • a syringe holder 5 is arranged for a syringe flange of a syringe 6, which is partially shown in broken lines.
  • the foot section 3 is provided with an end entry opening 7 for the syringe body.
  • the middle section 2 has a guide 8 inside, in which a receiving body 9 designed as a sliding block for the actuating end of the syringe plunger is guided.
  • the receiving body 9 has a - not shown - clamping device with which the inserted actuating end can be fixed.
  • the receiving body 9 has a push-back lever 10 which protrudes from a slot 11 in the left side of the housing.
  • the receptacle body 9 carries a toothed rack 13 on the end face 12 facing away from the receptacle 5, which extends through the central section 2 to the head section 4 of the housing 1.
  • the toothed rack 13 has a flat cross section, which is provided with sawtooth-shaped teeth 14 on a narrow side. The steeper flank of the toothing 14 faces the head section 4.
  • an actuating lever 17 is pivotably mounted on an axis 15 in a recess 16 on a housing side.
  • the actuating lever 17 has two parallel legs 18, 18 'and projects with one actuating end from a slot 19 in the opposite side of the housing.
  • a tension spring 20 acts between the actuating lever 17 and the housing 1 and biases the actuating lever towards the head section 4.
  • the actuating lever 17 pivotably supports a pawl 22 between its legs 18, 18 'on a pin 21 which, according to FIG. 1, engages in the toothing 14 with its engagement end.
  • the pawl 22 is biased toward the rack 13 by means of a leg spring which is supported on it and the actuating lever 17 and is not shown.
  • a holding element 23 in the form of a sleeve extends to the rack 13.
  • the sleeve 23 covers part of the toothing 14 with a holding surface 24. It can be moved along the rack 13.
  • it has a pin 25 near its end facing away from the rack 13, which engages in a guide curve 26 of a rotary knob 27 mounted on the head section 4.
  • the position of the sleeve 23 in the housing 1 and the extent of their overlap with the toothing 14 is adjustable by turning the rotary knob 27.
  • the sleeve 23 has on the side surfaces 28, 28 'outwardly projecting shoulders 29, 29'.
  • the shoulders 29, 29 ' form stops for the parallel legs 18, 18' of the lever 17, which receive the sleeve 23 or the rack 13 between them.
  • the stops 29, 29 ' have a taper 30, 30' towards the lever 17, which ensure a clear contact of the legs 18, 18 '.
  • the repeater pipette works as follows: First, a syringe 6 is inserted through the inlet opening 7 with its flange into the syringe holder 5 and with its actuating end into the receiving body 9. It is clamped in the syringe holder 5 and in the holder body 9 by means not shown. To fill the syringe 6, the receiving body 9 can be pushed back in the R direction by means of the push-back lever 10. 1 to 3 show the repeater pipette with the receiving body 9 withdrawn in the ready position for dispensing liquid.
  • the sleeve 23 is by means of the rotary knob 27 withdrawn in the reverse direction R at most.
  • the actuating lever 17 is pivoted back by the tension spring 20 as far as the slot 19 in the housing 1 allows.
  • the pawl 22 is just supported on the holding surface 24 of the sleeve 23.
  • the actuating lever 17 is actuated, the pawl 22 falls directly into the toothing 14 via the front end of the sleeve 23 and takes the toothed rack 13 with it in the advancing direction V. Practically the entire actuation path B of the actuation lever 17 is used as a work path for taking the toothed rack 13 and dosing liquid. After relieving the actuating lever 17, this returns under the influence of the tension spring 20 into the drawn starting position by itself, the pawl 22 moving out of the toothing 14. The pipette is then ready for a further dosing step.
  • the sleeve 23 is pushed as far as possible over the rack 13 by adjusting the rotary knob 27. Only four teeth of the teeth 14 are free to be taken along by the pawl 22.
  • the actuating lever 17 is pressed on its legs 18, 18 'by the shoulders 29, 29' of the sleeve 23 in the feed direction V.
  • the distance between the stops 29, 29 'from the front end of the sleeve 23 is such that the pawl 22 with a certain distance from the front end corresponding to an empty path on the holding surface 24 rests.
  • the lever 17 is actuated, the pawl 22 first slides along the idle path over the holding surface 24 and is prevented from engaging with the teeth.
  • the rest of the actuation path B is connected to latch engagement in the toothing 14 and is thus used as a work path.
  • FIG. 1 shows that the setting of a smaller step size is associated with a considerably reduced actuation path B.
  • the actuation path is changed in proportion to the work path.
  • the free travel is - as long as the lever 17 is not retained by the limitation of the slot 19 - practically constant and is determined by the distance of the stops 29, 29 'from the front end of the sleeve 23.
EP95104357A 1994-04-27 1995-03-24 Pipette de distribution à répétition Expired - Lifetime EP0679440B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4414744 1994-04-27
DE4414744A DE4414744C1 (de) 1994-04-27 1994-04-27 Repetierpipette

Publications (2)

Publication Number Publication Date
EP0679440A1 true EP0679440A1 (fr) 1995-11-02
EP0679440B1 EP0679440B1 (fr) 1998-03-04

Family

ID=6516601

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95104357A Expired - Lifetime EP0679440B1 (fr) 1994-04-27 1995-03-24 Pipette de distribution à répétition

Country Status (7)

Country Link
US (1) US5573729A (fr)
EP (1) EP0679440B1 (fr)
JP (1) JPH08150207A (fr)
AT (1) ATE163573T1 (fr)
CA (1) CA2147927A1 (fr)
DE (2) DE4414744C1 (fr)
FI (1) FI116202B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2838070B2 (ja) * 1996-03-07 1998-12-16 株式会社ニチリョー 反復式ピペット
DE20019821U1 (de) * 1999-12-09 2001-06-07 Brand Gmbh & Co Kg Dosiereinrichtung für Flüssigkeiten
ATE480330T1 (de) * 2001-10-16 2010-09-15 Matrix Technologies Corp Hand-pipettiervorrichtung
US20060027033A1 (en) * 2002-10-16 2006-02-09 Richard Cote Hand-held pipette employing voice recognition control
US7284454B2 (en) * 2004-05-27 2007-10-23 Matrix Technologies Corporation Hand held pipette
US7381371B2 (en) * 2004-01-16 2008-06-03 Heathrow Scientific Llc Pipette device with pivotable nozzle assembly
CN101163514B (zh) 2005-04-24 2012-01-25 诺和诺德公司 注射装置
CN101400394B (zh) * 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 具有传动部件的注射装置
JP5062768B2 (ja) 2006-03-10 2012-10-31 ノボ・ノルデイスク・エー／エス 注射装置および該装置のカートリッジを交換する方法
CN101641126B (zh) 2007-03-23 2014-06-04 诺沃-诺迪斯克有限公司 包括锁定螺母的注射装置
WO2011056127A1 (fr) * 2009-11-06 2011-05-12 Shl Group Ab Dispositif de délivrance de médicament
DE202010009747U1 (de) * 2010-07-01 2010-11-18 Brand Gmbh + Co Kg Pipette für ein Pipettensystem mit Pipette und Spritze
WO2014204587A1 (fr) * 2013-06-17 2014-12-24 Waters Technologies Corporation Micropipette d'aliquotage de petits volumes de liquide
JP6640998B2 (ja) 2015-06-05 2020-02-05 ミメタス ビー．ブイ． マイクロ流体プレート

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3051172A (en) * 1958-03-22 1962-08-28 Hauptner H Ampule syringe, particularly for veterinary use
US3110310A (en) * 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3141583A (en) * 1962-03-23 1964-07-21 William L Brickson Injection gun
DE2926691A1 (de) * 1979-07-02 1981-06-11 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Repetierpipette

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2768768A (en) * 1953-02-27 1956-10-30 Gibson Homans Company Calking gun
US3606085A (en) * 1968-08-26 1971-09-20 Ian Butler Spilman Dispensing gun for pastes and like substances
US4099548A (en) * 1976-08-25 1978-07-11 Oxford Laboratories Inc. Hand-held pipette for repetitively dispensing precise volumes of liquid
FI58875C (fi) * 1979-08-31 1981-05-11 Suovaniemi Finnpipette Pipett
DE3204178C2 (de) * 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipettiervorrichtung
US4467942A (en) * 1982-04-29 1984-08-28 Yuuji Oshikubo Repeating dispenser
DE3216644A1 (de) * 1982-05-04 1983-11-10 Nichiryo Co., Ltd., Tokyo Wiederholspender
EP0109913A3 (fr) * 1982-11-03 1984-09-12 Micro-Mega Seringue dentaire pour injections intra-ligamentaires
FI921648A0 (fi) * 1992-04-13 1992-04-13 Labsystems Oy Stegpipett.
US5323931A (en) * 1993-02-08 1994-06-28 Prince Castle Inc. Dispenser for extrudable material including dispensing from collapsible containers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3051172A (en) * 1958-03-22 1962-08-28 Hauptner H Ampule syringe, particularly for veterinary use
US3110310A (en) * 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3141583A (en) * 1962-03-23 1964-07-21 William L Brickson Injection gun
DE2926691A1 (de) * 1979-07-02 1981-06-11 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Repetierpipette

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism

Also Published As

Publication number Publication date
JPH08150207A (ja) 1996-06-11
US5573729A (en) 1996-11-12
DE4414744C1 (de) 1995-11-02
FI951977A0 (fi) 1995-04-26
ATE163573T1 (de) 1998-03-15
FI951977A (fi) 1995-10-28
EP0679440B1 (fr) 1998-03-04
DE59501519D1 (de) 1998-04-09
FI116202B (fi) 2005-10-14
CA2147927A1 (fr) 1995-10-28

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