EP0673246A1 - Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter - Google Patents

Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter

Info

Publication number
EP0673246A1
EP0673246A1 EP94902761A EP94902761A EP0673246A1 EP 0673246 A1 EP0673246 A1 EP 0673246A1 EP 94902761 A EP94902761 A EP 94902761A EP 94902761 A EP94902761 A EP 94902761A EP 0673246 A1 EP0673246 A1 EP 0673246A1
Authority
EP
European Patent Office
Prior art keywords
hydrogen
alkyl
alkoxy
benzimidazole
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94902761A
Other languages
German (de)
English (en)
Inventor
Bernhard Kohl
Jörg Senn-Bilfinger
Gerhard Grundler
Wolfgang Opferkuch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of EP0673246A1 publication Critical patent/EP0673246A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Definitions

  • R4 is hydrogen or 1-4C-alkyl
  • R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, halogen, trifluoromethyl, completely or predominantly fluorine-substituted 1-4C-alkoxy, chlorodifluoroethoxy, 2-chloro-1, 1,2-trifluoroethoxy or together with R3 desired at most means completely or partially substituted by fluorine-substituted 1-2C-alkylene-dioxy or chlorotrifluoroethylene-dioxy,
  • Rl is hydrogen, 1-4C-alkyl or 1-4C-alkoxy
  • R5 means 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-alkenyl, aryl or arylmethyl, where aryl is phenyl which is substituted by R51 and R52 and where R51 is hydrogen, 1-4C-alkyl, Hydroxy, 1-4C-alkoxy, halogen, nitro,
  • the invention also relates to a process for the preparation of the new compounds of the formula I.
  • the process is characterized in that appropriately substituted starting compounds analogous to those in European Patent No. 150 586 are reacted in a manner known per se.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des composés de la formule (I), dans laquelle R1, R2, R3, R4, R5, R6 et n ont la signification donnée dans la description, sont utiles pour combattre des bactéries helicobacter.
EP94902761A 1992-12-10 1993-12-10 Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter Withdrawn EP0673246A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CH377992 1992-12-10
CH3779/92 1992-12-10
CH3780/92 1992-12-10
CH3781/92 1992-12-10
CH378192 1992-12-10
CH378292 1992-12-10
CH377892 1992-12-10
CH378092 1992-12-10
CH3782/92 1992-12-10
CH3778/92 1992-12-10
PCT/EP1993/003503 WO1994013290A1 (fr) 1992-12-10 1993-12-10 Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter

Publications (1)

Publication Number Publication Date
EP0673246A1 true EP0673246A1 (fr) 1995-09-27

Family

ID=27509157

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94902761A Withdrawn EP0673246A1 (fr) 1992-12-10 1993-12-10 Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter

Country Status (3)

Country Link
EP (1) EP0673246A1 (fr)
AU (1) AU5699594A (fr)
WO (1) WO1994013290A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504082A (en) * 1992-06-01 1996-04-02 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and pharmaceutical compostions
CN1070192C (zh) * 1994-06-10 2001-08-29 比克·古尔顿·劳姆贝尔格化学公司 杀灭螺杆菌用的硫代吡啶
CA2195444A1 (fr) * 1994-07-20 1996-02-01 Bernhard Kohl Composes de thiopyridyle utiles pour combattre des bacteries helicobacter
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
WO1990002124A1 (fr) * 1988-08-23 1990-03-08 Aktiebolaget Hässle Traitement du glaucome et des troubles associes de l'×il chez l'homme au moyen de (sulfinyle ou thio)benzimidazoles de pyridinylmethyle
JP2694361B2 (ja) * 1989-02-09 1997-12-24 アストラ アクチエボラグ 抗菌剤
EP0382489B1 (fr) * 1989-02-10 1994-11-17 Takeda Chemical Industries, Ltd. Utilisation de dérivés du benzimidazole comme agents antibactériels
GB9018603D0 (en) * 1990-08-24 1990-10-10 Smith Kline French Lab Compositions
EP0567643A4 (fr) * 1991-01-16 1995-07-19 Yoshitomi Pharmaceutical Compose de pyridine utilise comme medicament selectif et nouveau compose de pyridine.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9413290A1 *

Also Published As

Publication number Publication date
WO1994013290A1 (fr) 1994-06-23
AU5699594A (en) 1994-07-04

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