EP0673246A1 - Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter - Google Patents
Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacterInfo
- Publication number
- EP0673246A1 EP0673246A1 EP94902761A EP94902761A EP0673246A1 EP 0673246 A1 EP0673246 A1 EP 0673246A1 EP 94902761 A EP94902761 A EP 94902761A EP 94902761 A EP94902761 A EP 94902761A EP 0673246 A1 EP0673246 A1 EP 0673246A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydrogen
- alkyl
- alkoxy
- benzimidazole
- thio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Definitions
- R4 is hydrogen or 1-4C-alkyl
- R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, halogen, trifluoromethyl, completely or predominantly fluorine-substituted 1-4C-alkoxy, chlorodifluoroethoxy, 2-chloro-1, 1,2-trifluoroethoxy or together with R3 desired at most means completely or partially substituted by fluorine-substituted 1-2C-alkylene-dioxy or chlorotrifluoroethylene-dioxy,
- Rl is hydrogen, 1-4C-alkyl or 1-4C-alkoxy
- R5 means 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-alkenyl, aryl or arylmethyl, where aryl is phenyl which is substituted by R51 and R52 and where R51 is hydrogen, 1-4C-alkyl, Hydroxy, 1-4C-alkoxy, halogen, nitro,
- the invention also relates to a process for the preparation of the new compounds of the formula I.
- the process is characterized in that appropriately substituted starting compounds analogous to those in European Patent No. 150 586 are reacted in a manner known per se.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Des composés de la formule (I), dans laquelle R1, R2, R3, R4, R5, R6 et n ont la signification donnée dans la description, sont utiles pour combattre des bactéries helicobacter.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH378192 | 1992-12-10 | ||
CH378092 | 1992-12-10 | ||
CH377892 | 1992-12-10 | ||
CH378292 | 1992-12-10 | ||
CH377992 | 1992-12-10 | ||
CH3779/92 | 1992-12-10 | ||
CH3782/92 | 1992-12-10 | ||
CH3778/92 | 1992-12-10 | ||
CH3781/92 | 1992-12-10 | ||
CH3780/92 | 1992-12-10 | ||
PCT/EP1993/003503 WO1994013290A1 (fr) | 1992-12-10 | 1993-12-10 | Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0673246A1 true EP0673246A1 (fr) | 1995-09-27 |
Family
ID=27509157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94902761A Withdrawn EP0673246A1 (fr) | 1992-12-10 | 1993-12-10 | Utilisation d'alkylthiopyridines pour combattre des bacteries helicobacter |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0673246A1 (fr) |
AU (1) | AU5699594A (fr) |
WO (1) | WO1994013290A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5504082A (en) * | 1992-06-01 | 1996-04-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and pharmaceutical compostions |
CN1070192C (zh) * | 1994-06-10 | 2001-08-29 | 比克·古尔顿·劳姆贝尔格化学公司 | 杀灭螺杆菌用的硫代吡啶 |
DE59510667D1 (de) * | 1994-07-20 | 2003-06-05 | Altana Pharma Ag | Pyridylthioverbindungen zur bekämpfung von helicobacter-bakterien |
RU2449805C1 (ru) | 2011-01-27 | 2012-05-10 | Общество С Ограниченной Ответственностью "Гармония" | Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
AU4057189A (en) * | 1988-08-23 | 1990-03-23 | Aktiebolaget Hassle | Treatment of glaucoma and related disorders in the human eye with pyridinylmethyl (sulfinyl or thio)benzimidazoles |
JP2694361B2 (ja) * | 1989-02-09 | 1997-12-24 | アストラ アクチエボラグ | 抗菌剤 |
ATE114114T1 (de) * | 1989-02-10 | 1994-12-15 | Takeda Chemical Industries Ltd | Verwendung von benzimidazol-derivaten als antibakterielle mittel. |
GB9018603D0 (en) * | 1990-08-24 | 1990-10-10 | Smith Kline French Lab | Compositions |
WO1992012976A1 (fr) * | 1991-01-16 | 1992-08-06 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de pyridine utilise comme medicament selectif et nouveau compose de pyridine |
-
1993
- 1993-12-10 EP EP94902761A patent/EP0673246A1/fr not_active Withdrawn
- 1993-12-10 AU AU56995/94A patent/AU5699594A/en not_active Abandoned
- 1993-12-10 WO PCT/EP1993/003503 patent/WO1994013290A1/fr not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9413290A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994013290A1 (fr) | 1994-06-23 |
AU5699594A (en) | 1994-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950608 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19951123 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19970715 |