EP0588028B1 - Ampulle - Google Patents

Ampulle Download PDF

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Publication number
EP0588028B1
EP0588028B1 EP93111821A EP93111821A EP0588028B1 EP 0588028 B1 EP0588028 B1 EP 0588028B1 EP 93111821 A EP93111821 A EP 93111821A EP 93111821 A EP93111821 A EP 93111821A EP 0588028 B1 EP0588028 B1 EP 0588028B1
Authority
EP
European Patent Office
Prior art keywords
ampoule
neck
longitudinal
syringe
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP93111821A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0588028A3 (enrdf_load_stackoverflow
EP0588028A2 (de
Inventor
Bernd Dipl.-Ing. Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0588028A2 publication Critical patent/EP0588028A2/de
Publication of EP0588028A3 publication Critical patent/EP0588028A3/xx
Application granted granted Critical
Publication of EP0588028B1 publication Critical patent/EP0588028B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules

Definitions

  • the invention relates to an ampoule made of plastic for a liquid, which the ampoule is removed by means of a syringe body, which on its in the end of the ampoule to be inserted has a shoulder with a one Marking defining the longitudinal central plane and at least one longitudinal channel in the inner wall of the ampoule neck in that intended for the attachment of the approach Area for the intake of air when removing the liquid, the longitudinal channel in the circumferential direction of the ampoule neck compared to the Longitudinal median plane of the ampoule is arranged offset.
  • Such ampoules are made in one of two mirror images of the same design Parts of the existing mold are blow molded. After graduation of the molding process, the two parts of the mold become the parting plane in one perpendicular direction separated from each other to the ampoule or if multiple ampoules are molded simultaneously, the ampoule block of the mold to be able to remove.
  • the division of the form leads to markings of the Ampoules that define a median longitudinal plane.
  • the object of the invention based on developing an ampoule of the type mentioned in such a way that they are particularly good for use with syringes with a so-called Luer approach is suitable.
  • each existing longitudinal channel is preferably opposite the median longitudinal plane of the ampoule, because this position of the longitudinal channel in Particularly advantageous with regard to removing the ampoule from the mold is.
  • the shape of the outer surface of the ampoule neck then corresponds with the shape of the inner surface.
  • Ampoule is the ampoule neck with means, preferably an external thread, for an engagement of the internal thread of a couplable with the ampoule neck Luer lock approach provided a syringe, so that the luer lock approach Do not put the syringe on the neck of the ampoule, but screw it on can.
  • One blow molded plastic using one in one Contains dimensionally stable ampoule 101 produced in the longitudinal center plane a pharmaceutical liquid to be injected by means of a syringe 108.
  • On the neck of ampoule 101 designated as a whole by 102, closes in usual and not shown a one-piece trained with him Head on, which in turn is integrally formed with a molded gag is.
  • the ampoule body is mixed with the liquid for reasons of sterility filled while it is still in the blow mold.
  • the neck 102, the head and the gag are made in a known manner following the filling of the Ampoule body shaped, the ampoule 101 being closed at the same time becomes.
  • the head Connects to the end of the ampoule body opposite the bottom neck 102, whose diameter is smaller than that of the ampoule body.
  • the head can be removed from the head by twisting or tilting it Separate neck 102 along a predetermined breaking point so as to contain the contents of the ampoule body to release.
  • the ampoule neck 102 is radially inward projecting annular bead 112, the inner diameter of the Ring bead 112 to the outer diameter of the usually as a Luer approach designated pin or cone 107 of the syringe 108 is adapted.
  • the annular bead 112 is outside of the one in the production with the parting plane the shape coinciding longitudinal plane of the ampoule 101, which is defined by a circumferential marking 110, in one opposite this Longitudinal median plane rotated by 90 ° with two diametrically arranged Provide interruptions that each form a longitudinal channel 111.
  • the shape and the cross section of the longitudinal channels 111 are taking into account the viscosity the liquid contained in the ampoule selected such that on the one hand the Liquid can be removed at the desired speed and on the other hand, the liquid does not exit through the longitudinal channels 111, either when, as is often the case, the liquid is removed from the ampoule 101 in one position with her neck 102 facing down. It sticks out for you
  • the removal process of the cones or cones 107 of the syringe 108 is so far in into the ampoule neck 102 until it lies close to the annular bead 112.
  • the ampoule neck is in the exemplary embodiment 102 provided at the level of the annular bead 112 with a circumferential annular groove 113, whose cross-sectional shape corresponds to that of the annular bead 112.
  • This annular groove 113 can with one on each of the two longitudinal channels 111 aligned break. It then corresponds to the Shape of the outer surface of the ampoule neck 102 with the inner surface.
  • syringes with a Luer lock approach are used the pin or cone 107 also concentrically spaced from one another Surround integrally formed with the syringe 108 socket 114, the inside can be provided with a two-start thread, both of which Threads are designated 114 'and 114' '.
  • the ampoule neck 102 then has a corresponding external thread 102 'with which the Engages threads 114 'and 114' '.
  • the socket 114 of the Luer lock approach the syringe 108 is therefore not attached to the neck of the ampoule, but screwed on.
  • the external thread 102 ' others can also Means can be provided for thread-like engagement of the threads Allow 114 'and 114' '.
  • the axial length of the bush 114 is less than that of the pin or Cone 107.
  • the outer diameter of the neck 102 is the entire length of the neck 102 is chosen only slightly smaller than the inside diameter of the Syringe 108 socket 114.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
  • Packaging Frangible Articles (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Coating Apparatus (AREA)
EP93111821A 1992-09-12 1993-07-23 Ampulle Expired - Lifetime EP0588028B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4230645A DE4230645C2 (de) 1992-09-12 1992-09-12 Ampulle
DE4230645 1992-09-12

Publications (3)

Publication Number Publication Date
EP0588028A2 EP0588028A2 (de) 1994-03-23
EP0588028A3 EP0588028A3 (enrdf_load_stackoverflow) 1994-08-03
EP0588028B1 true EP0588028B1 (de) 1999-02-24

Family

ID=6467873

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93111821A Expired - Lifetime EP0588028B1 (de) 1992-09-12 1993-07-23 Ampulle

Country Status (11)

Country Link
US (1) US5897008A (enrdf_load_stackoverflow)
EP (1) EP0588028B1 (enrdf_load_stackoverflow)
JP (1) JP2622347B2 (enrdf_load_stackoverflow)
AU (1) AU664302B2 (enrdf_load_stackoverflow)
CA (1) CA2104363C (enrdf_load_stackoverflow)
DE (1) DE4230645C2 (enrdf_load_stackoverflow)
DK (1) DK0588028T3 (enrdf_load_stackoverflow)
ES (1) ES2127770T3 (enrdf_load_stackoverflow)
FI (1) FI105451B (enrdf_load_stackoverflow)
MX (1) MX9305493A (enrdf_load_stackoverflow)
NO (1) NO307167B1 (enrdf_load_stackoverflow)

Families Citing this family (45)

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US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US6540154B1 (en) 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
WO1996000556A1 (fr) * 1994-06-28 1996-01-11 Daniel Vuille Ampoule medicale avec cone luer femelle incorpore
DE29502782U1 (de) * 1995-02-20 1996-06-20 THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte, 82229 Seefeld Behälter, insbesondere für Dentalpräparate
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
FR2804940B1 (fr) * 2000-02-10 2002-08-30 Au Liegeur Ets J Pontneau Deni Bouchon pour bouteilles a vins effervescents et procede de fabrication d'un tel bouchon
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6948491B2 (en) 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
MXPA02010884A (es) 2000-05-05 2003-03-27 Aerogen Ireland Ltd Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US6764463B1 (en) * 2000-06-27 2004-07-20 Barry Farris Method and needleless apparatus for the storage of a first substance followed by subsequent mixing with a second substance and transfer without ambient air incursion
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
AU2003202925B2 (en) 2002-01-07 2008-12-18 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
AU2003203043A1 (en) 2002-01-15 2003-07-30 Aerogen, Inc. Methods and systems for operating an aerosol generator
EP1509259B1 (en) 2002-05-20 2016-04-20 Novartis AG Apparatus for providing aerosol for medical treatment and methods
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
USD548834S1 (en) * 2004-09-21 2007-08-14 Bernd Hansen Bottle with liquid and air compartments
JP5064383B2 (ja) 2005-05-25 2012-10-31 エアロジェン，インコーポレイテッド 振動システムと方法
CN101663206B (zh) * 2007-04-27 2011-05-11 大和制罐株式会社 聚酯树脂制带有待破裂部的容器及其制造方法
USD618339S1 (en) * 2007-05-22 2010-06-22 Bernd Hansen Ampule with handling and data tab
EP2269558B1 (en) 2008-04-25 2015-03-04 Nippon Zoki Pharmaceutical Co., Ltd. Plastic ampule
AU2009256148B2 (en) 2008-06-04 2014-11-27 Butamax(Tm) Advanced Biofuels Llc A method for producing butanol using two-phase extractive fermentation
BRPI0909989A2 (pt) 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
BR112012006939A2 (pt) 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides
KR20120099509A (ko) 2009-12-29 2012-09-10 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 재조합 숙주 세포에서 육탄당 키나아제의 발현
US20110312053A1 (en) 2010-06-18 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Supplementation of fatty acids for improving alcohol productivity
JP2013535956A (ja) 2010-06-18 2013-09-19 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー アルコール発酵の際のアルコールエステルの生成および原位置生成物除去
WO2014035935A1 (en) * 2012-08-27 2014-03-06 Ultradent Products, Inc. Ampoule dispenser
DE102012021525A1 (de) 2012-10-31 2014-04-30 Kocher-Plastik Maschinenbau Gmbh Dichtungsanordnung sowie einer solchen zugeordneter Behälter
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
AU2013202778A1 (en) 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
MX374231B (es) * 2013-09-12 2025-03-05 Fresenius Kabi Deutschland Gmbh Ampolla para líquido medicinal y método para producción de ampolla.
DE102017007443A1 (de) * 2017-08-05 2019-02-07 Kocher-Plastik Maschinenbau Gmbh Blasform-, Füll- und Schließverfahren sowie danach hergestelltes Behältererzeugnis, insbesondere Ampullenerzeugnis
JP7374077B2 (ja) * 2018-03-23 2023-11-06 テルモ株式会社 薬物充填済み合成樹脂製アンプルおよびそれに使用される合成樹脂製アンプル本体
DE102018007993A1 (de) * 2018-10-08 2020-04-09 Kocher-Plastik Maschinenbau Gmbh Dichtungsanordnung mit zugeordnetem Behälter und einem Dichtstoff
JP2021020739A (ja) * 2019-07-29 2021-02-18 ウェイラー エンジニアリング インコーポレイテッド 熱可塑性材料の気密封止容器
JP7575869B2 (ja) * 2019-10-31 2024-10-30 小林製薬株式会社 スクイズ容器

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US4046145A (en) * 1976-06-29 1977-09-06 American Hospital Supply Corporation Syringe connector
US4172457A (en) * 1977-10-06 1979-10-30 American Hospital Supply Corporation Plural component mixing system and method
US4192429A (en) * 1978-03-02 1980-03-11 Becton, Dickinson And Company Vented vacuum tube and stopper
US4641663A (en) * 1985-05-17 1987-02-10 Juhn Steven K Apparatus for collecting specimens
IT207944Z2 (it) * 1986-07-25 1988-03-14 Erba Farmitalia Dispositivo di bloccaggio di una siringa su di un corpo al quale la siringa deve essere accoppiata.
GB8800448D0 (en) * 1988-01-09 1988-02-10 Smiths Industries Plc Liquid containers
GB8801655D0 (en) * 1988-01-26 1988-02-24 Waverley Pharma Ltd Ampoules
GB8802349D0 (en) * 1988-02-03 1988-03-02 Waverley Pharma Ltd Ampoule with luer
DE3916840A1 (de) * 1988-09-21 1990-03-29 Bernd Hansen Ampulle

Also Published As

Publication number Publication date
EP0588028A3 (enrdf_load_stackoverflow) 1994-08-03
ES2127770T3 (es) 1999-05-01
DE4230645C2 (de) 1996-03-07
JP2622347B2 (ja) 1997-06-18
NO933244D0 (no) 1993-09-10
JPH06218025A (ja) 1994-08-09
NO307167B1 (no) 2000-02-21
CA2104363A1 (en) 1994-03-13
CA2104363C (en) 1998-06-16
US5897008A (en) 1999-04-27
AU4479293A (en) 1994-03-17
AU664302B2 (en) 1995-11-09
NO933244L (no) 1994-03-14
DE4230645A1 (de) 1994-03-17
FI105451B (fi) 2000-08-31
MX9305493A (es) 1994-03-31
DK0588028T3 (da) 1999-09-27
FI933933L (fi) 1994-03-13
EP0588028A2 (de) 1994-03-23
FI933933A0 (fi) 1993-09-08

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