Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K49/00—Preparations for testing in vivo
  • A61K49/04—X-ray contrast preparations
  • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K49/00—Preparations for testing in vivo
  • A61K49/04—X-ray contrast preparations
  • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
  • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group

Definitions

• plastics in industry, agriculture, medicine or other fields of application are often associated with the question of the ability to be localized and the material being tested during its use.
• the implanted or applied plastics not only have to be securely localizable, but also have the property that they can be removed from the human or animal body after a certain time. The removal usually requires further (surgical) intervention.
• Plastics which are easy to locate are known, but are chemically stable and can therefore only be removed from the human body by a surgical procedure.
• plastics are known that dissolve after a certain time when they have fulfilled their task. However, the latter plastics cannot be easily located.
• the object of the invention is to create a material which, on the one hand, can be localized with high accuracy and, on the other hand, can also be degraded in the human or animal body.
• radiopaque polyurethanes are particularly well suited for the tasks described above.
• X-ray-tight polyurethanes are particularly suitable for the production of temporary or permanent polyurethane applications in connection with X-ray identification.
• the polyurethane In the solid aggregate state, devices, structures, films, foils, tubes, hoses, screws, rods or other three-dimensional elements are seared from the polyurethanes to make compact or hollow structures, and the polyurethane is also used for coatings on structures, insulation, seals and suitable as a drug carrier.
• the polyurethane can used to fill empty or filled biological or technical cavities for therapeutic and / or diagnostic, medical or technical purposes.
• the polyurethane can be used to coat structures for the additional purpose of X-ray identification.
• the polyurethane can also be used in the form of sprays, dispersions or as dispersants. Workpieces can be coated with this polyurethane, and topical application is not excluded. Thereby solidification takes place with external energy.
• the plastic to be used has some special properties, such as. E.g .: a) Biocompatibility
• b) be soluble in non-toxic or only slightly toxic solvents, such as alcohol, dimethyl sulfoxide, DMI or mixtures thereof
• c) be insoluble in an aqueous environment (water, blood, etc.)
• polyurethanes are suitable in which one of their two basic components, here the diol component, is wholly or partly by the glyceryl monoester (1) of a triiodobenzoic acid derivative (2, 3, 4, 5) or a pyridone-4 derivative, for example iopydol (6) , is replaced.
• polyester diols based on II-V are produced by reversing the corresponding higher molecular weight polyesters with ethylene glycol, diaethylene glycol and triaethylene glycol with simultaneous cleavage to macrodiols with average molecular weights between M n 500 and 10,000.
• TMDI 2,2,4-trimethylhexamethylene diisocyanate
• the condensation of the components takes place in solution in a mixture of dioxane / dimethylformamide with a mixing ratio between 1: 1 to 20: 1 at temperatures between 40 ° and 100 ° with or without a catalyst.
• the polymers are isolated by precipitation in water.
• the cleaning is done by repeatedly dissolving the polymer and precipitating in water.
• polymer made from the components described above can be illustrated by the following formula:

Landscapes

• Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Polyurethanes Or Polyureas (AREA)
• Materials For Medical Uses (AREA)
• Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Applications Claiming Priority (2)

Publications (1)

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Family Applications (1)

Country Status (5)

Families Citing this family (23)

Family Cites Families (10)

• 1991
  • 1991-04-12 DE DE4111914A patent/DE4111914A1/de active Granted
• 1992
  • 1992-04-10 JP JP4507940A patent/JPH06506494A/ja active Pending
  • 1992-04-10 EP EP92908385A patent/EP0579683A1/de not_active Ceased
  • 1992-04-10 WO PCT/DE1992/000294 patent/WO1992018167A1/de not_active Application Discontinuation
  • 1992-04-10 US US07/956,881 patent/US5319059A/en not_active Expired - Fee Related

Non-Patent Citations (1)

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