ES2135764T3 - Derivados yodados, su preparacion y su aplicacion como agentes de contraste en radiologia x. - Google Patents

Derivados yodados, su preparacion y su aplicacion como agentes de contraste en radiologia x.

Info

Publication number
ES2135764T3
ES2135764T3 ES95932035T ES95932035T ES2135764T3 ES 2135764 T3 ES2135764 T3 ES 2135764T3 ES 95932035 T ES95932035 T ES 95932035T ES 95932035 T ES95932035 T ES 95932035T ES 2135764 T3 ES2135764 T3 ES 2135764T3
Authority
ES
Spain
Prior art keywords
pct
formula
date
meanings
radiology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932035T
Other languages
English (en)
Inventor
Lem Gael Le
Dominique Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Application granted granted Critical
Publication of ES2135764T3 publication Critical patent/ES2135764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS POLIYODADOS DE FORMULA (I), EN LA QUE A ES UN RESTO DE UNA MOLECULA AROMATICA O ALIFATICA, ZA, ZB, ZC, ZD REPRESENTAN TZ-QZ-VZ, PUDIENDO TZ Y VZ SER O, COND, O NDCO, PUDIENDO D SER H, ALQUILO O HIDROXIALQUILO TENIENDO DE 1 A 6 ATOMOS DE CARBONO Y QZ ALQUILENO O HIDROXIALQUILENO TENIENDO DE 1 A 6 ATOMOS DE CARBONO O TENIENDO VZ LA SIGNIFICACION ANTERIOR O QZ Y/O TZ NO EXISTEN, XA, XB, XC, XD, IDENTICOS O DIFERENTES REPRESENTAN (II) EN LA QUE AR Y AR'' SON GRUPOS FENILOS TRI O TETRAYODADOS Y QUE LLEVAN UNO O DOS GRUPOS AMIDAS SUSTITUIDAS POR ALQUILOS, EVENTUALMENTE HIDROXILADOS, Y LOS T, Q, V TIENEN UNA DE LAS SIGNIFICACIONES DE LOS TZ, QZ, VZ O LOS X REPRESENTAN (II''), EN LA QUE AP Y A''P REPRESENTAN LA FORMULA (II) ANTERIOR Y LOS T, Q, V TIENEN UNA DE LAS SIGNIFICACIONES DE LOS TZ, QZ, VZ. APLICACION DE ESTOS PRODUCTOS COMO AGENTES DE CONTRASTE PARA LA RADIOLOGIA POR RAYOS X.
ES95932035T 1994-09-22 1995-09-20 Derivados yodados, su preparacion y su aplicacion como agentes de contraste en radiologia x. Expired - Lifetime ES2135764T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9411326 1994-09-22

Publications (1)

Publication Number Publication Date
ES2135764T3 true ES2135764T3 (es) 1999-11-01

Family

ID=9467178

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932035T Expired - Lifetime ES2135764T3 (es) 1994-09-22 1995-09-20 Derivados yodados, su preparacion y su aplicacion como agentes de contraste en radiologia x.

Country Status (14)

Country Link
US (1) US5709846A (es)
EP (1) EP0730573B1 (es)
JP (1) JPH09505833A (es)
CN (1) CN1046704C (es)
AT (1) ATE181729T1 (es)
AU (1) AU3524295A (es)
BR (1) BR9506372A (es)
CA (1) CA2174870A1 (es)
DE (1) DE69510527T2 (es)
ES (1) ES2135764T3 (es)
FI (1) FI962142A (es)
NO (1) NO962057L (es)
PL (1) PL314490A1 (es)
WO (1) WO1996009281A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69510460T2 (de) * 1994-09-22 2000-01-13 Guerbet, Villepinte Iodo-verbindungen, ihre herstellung und verwendung als kontrastmittel für röntgen-radiologie
US20060099142A1 (en) * 2002-03-14 2006-05-11 Delaney Allen D Cancer associated araf1 protein kinase and its uses
US20060292077A1 (en) 2005-03-18 2006-12-28 Zhao Jonathon Z Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
US20070048803A1 (en) * 2005-08-25 2007-03-01 Lee Peter P Immune profiling of lymph nodes associated with cancer
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
FR2635327B1 (fr) * 1988-08-10 1990-11-16 Guerbet Sa Polymeres iodes, a squelette dextrane, leurs procedes de preparation et leurs applications comme produits de contraste
DE4111914A1 (de) * 1991-04-12 1992-10-15 Peter Neuenschwander Werkstoff
WO1993010824A1 (fr) * 1991-12-04 1993-06-10 Guerbet S.A. Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
IT1264690B1 (it) * 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi

Also Published As

Publication number Publication date
US5709846A (en) 1998-01-20
PL314490A1 (en) 1996-09-16
FI962142A0 (fi) 1996-05-21
DE69510527T2 (de) 2000-01-27
EP0730573A1 (fr) 1996-09-11
DE69510527D1 (de) 1999-08-05
JPH09505833A (ja) 1997-06-10
NO962057L (no) 1996-07-19
BR9506372A (pt) 1997-09-16
AU3524295A (en) 1996-04-09
FI962142A (fi) 1996-05-21
ATE181729T1 (de) 1999-07-15
WO1996009281A1 (fr) 1996-03-28
CN1046704C (zh) 1999-11-24
EP0730573B1 (fr) 1999-06-30
NO962057D0 (no) 1996-05-21
CN1135749A (zh) 1996-11-13
CA2174870A1 (fr) 1996-03-28

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