NO962057L - Joderte derivater, fremstilling og anvendelse som röntgen kontrastmidler - Google Patents

Joderte derivater, fremstilling og anvendelse som röntgen kontrastmidler

Info

Publication number
NO962057L
NO962057L NO962057A NO962057A NO962057L NO 962057 L NO962057 L NO 962057L NO 962057 A NO962057 A NO 962057A NO 962057 A NO962057 A NO 962057A NO 962057 L NO962057 L NO 962057L
Authority
NO
Norway
Prior art keywords
pct
formula
contrast agents
date
meanings
Prior art date
Application number
NO962057A
Other languages
English (en)
Other versions
NO962057D0 (no
Inventor
Gael Le Lem
Dominique Meyer
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of NO962057D0 publication Critical patent/NO962057D0/no
Publication of NO962057L publication Critical patent/NO962057L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Polyjoderte derivater med formel (I) U | ' ? (l) _/~\_, <"> -/ v, (in X&4-A-Z**! l Zb hvor A er en rest av et aromatisk eller alifatisk molekyl, Za, Zb, Zc og Zd er Tz-Qz-Vz hvor Tz og Vz kan være O, COND eller NDCO, D kan være H, C,-C6-alkyl eller -hydroksyalkyl, og Qz kan være alkylen eller hydroksyalkylen med 1 til 6 karbonatomer, eller hvor Vz har de ovenfor angitte betydninger eller Qz og/eller Tz er fraværende, Xa. Xb, Xc og Xd, som er like eller forskjellige, er (II) hvor Ar og Ar1 er tri- eller tetrajodinerte lenylgrupper med en eller to amidgrupper substituert med eventuelt hydroksylerte alkylgrupper, og T, Q og V har en av betydningene angitt for Tz, Qz eller Vz, eller X er (II'), hvor Ap og Ap1 har formel (II) og T, Q og V har en av betydningene angitt for Tz, Qz eller Vz. Derivatene har anvendelse som røntgenkontrastmidler.
NO962057A 1994-09-22 1996-05-21 Joderte derivater, fremstilling og anvendelse som röntgen kontrastmidler NO962057L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9411326 1994-09-22
PCT/FR1995/001213 WO1996009281A1 (fr) 1994-09-22 1995-09-20 Derives iodes, leur preparation et leur application comme agents de contraste en radiologie x

Publications (2)

Publication Number Publication Date
NO962057D0 NO962057D0 (no) 1996-05-21
NO962057L true NO962057L (no) 1996-07-19

Family

ID=9467178

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962057A NO962057L (no) 1994-09-22 1996-05-21 Joderte derivater, fremstilling og anvendelse som röntgen kontrastmidler

Country Status (14)

Country Link
US (1) US5709846A (no)
EP (1) EP0730573B1 (no)
JP (1) JPH09505833A (no)
CN (1) CN1046704C (no)
AT (1) ATE181729T1 (no)
AU (1) AU3524295A (no)
BR (1) BR9506372A (no)
CA (1) CA2174870A1 (no)
DE (1) DE69510527T2 (no)
ES (1) ES2135764T3 (no)
FI (1) FI962142A0 (no)
NO (1) NO962057L (no)
PL (1) PL314490A1 (no)
WO (1) WO1996009281A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2135086T3 (es) * 1994-09-22 1999-10-16 Guerbet Sa Compuestos poliyodados, su preparacion, y su aplicacion en radiologia.
CA2478924A1 (en) * 2002-03-14 2003-09-18 Qlt Inc. Cancer associated araf1 protein kinase and its uses
US20060292077A1 (en) * 2005-03-18 2006-12-28 Zhao Jonathon Z Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
US20070048803A1 (en) * 2005-08-25 2007-03-01 Lee Peter P Immune profiling of lymph nodes associated with cancer
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
FR2635327B1 (fr) * 1988-08-10 1990-11-16 Guerbet Sa Polymeres iodes, a squelette dextrane, leurs procedes de preparation et leurs applications comme produits de contraste
DE4111914A1 (de) * 1991-04-12 1992-10-15 Peter Neuenschwander Werkstoff
JPH07506085A (ja) * 1991-12-04 1995-07-06 ゲルベ　エス．アー． 新規なヨード含有ポリアミン系巨大分子化合物，その調製法，およびその造影剤としての応用
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
IT1264690B1 (it) * 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi

Also Published As

Publication number Publication date
BR9506372A (pt) 1997-09-16
WO1996009281A1 (fr) 1996-03-28
AU3524295A (en) 1996-04-09
CN1135749A (zh) 1996-11-13
DE69510527T2 (de) 2000-01-27
DE69510527D1 (de) 1999-08-05
EP0730573A1 (fr) 1996-09-11
CA2174870A1 (fr) 1996-03-28
FI962142A (fi) 1996-05-21
JPH09505833A (ja) 1997-06-10
ATE181729T1 (de) 1999-07-15
NO962057D0 (no) 1996-05-21
PL314490A1 (en) 1996-09-16
EP0730573B1 (fr) 1999-06-30
ES2135764T3 (es) 1999-11-01
FI962142A0 (fi) 1996-05-21
US5709846A (en) 1998-01-20
CN1046704C (zh) 1999-11-24

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