EP0440715A1 - Topische salbe - Google Patents

Topische salbe

Info

Publication number
EP0440715A1
EP0440715A1 EP89912240A EP89912240A EP0440715A1 EP 0440715 A1 EP0440715 A1 EP 0440715A1 EP 89912240 A EP89912240 A EP 89912240A EP 89912240 A EP89912240 A EP 89912240A EP 0440715 A1 EP0440715 A1 EP 0440715A1
Authority
EP
European Patent Office
Prior art keywords
weight
percent
cholesterol
ointment
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP89912240A
Other languages
German (de)
English (en)
French (fr)
Inventor
Gabriele Flender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weck Wolfgang Dr-Med
Original Assignee
Weck Wolfgang Dr-Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weck Wolfgang Dr-Med filed Critical Weck Wolfgang Dr-Med
Publication of EP0440715A1 publication Critical patent/EP0440715A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Definitions

  • the invention relates to a topical ointment for the treatment of dermatoses, in particular psoriasis (psoriasis), based on petroleum jelly, jojoba oil and beeswax as an ointment base.
  • psoriasis psoriasis
  • ointments for the treatment of dermatological disorders are known which are applied to the diseased skin areas.
  • ointments are preferably used which contain corticosteroids or salicylic acid as pharmaceutically active substances.
  • corticosteroids or salicylic acid as pharmaceutically active substances.
  • corticosteroids or salicylic acid as pharmaceutically active substances.
  • striae stripes
  • infections worsening and other permanent skin damage telangiectasias.
  • Other possible side effects of conventional ointments and creams are: so-called steroid acne, blotchy to surface skin bleeding and skin ulcers in the area of the application.
  • DE-PS 638 859 discloses a process for the preparation of an aqueous-alcoholic solution which contains cholesterol and is said to be suitable for therapeutic purposes, in particular for the treatment of the scalp.
  • DE-OS 35 26 669 discloses in Example 6 there a moisturizing cream which has petroleum jelly oil and cholesterol as components. Such an emulsion system can be used for the production of cosmetic and pharmaceutical emulsions.
  • DE-OS 31 25 710 describes a cosmetic agent, inter alia in the form of oil-in-water dispersions.
  • Example 4 there relates to a nourishing fluid which also contains cholesterol, among other things.
  • Cosmetic products which contain cholesterol dissolved in oil are also known from FR-PS 9 280 337.
  • DE-OS 37 13 492 proposes a concentrate for the treatment of irritated skin which, in addition to a lipid, water and glycerol, also contains cholesterol.
  • DE-OS 33 19 304 describes a medicament with an antineoplastic effect which, in addition to a lipophilic solvent, also contains cholesterol.
  • CH-PS 1 43 520 describes the cosmetic properties of cholesterol, which is contained in an aqueous or aqueous-alcoholic solution.
  • the object of the present invention is therefore to create a highly effective ointment free of side effects for the treatment of dermatoses, in particular psoriasis.
  • the ointment according to the invention consists of 10 to 50 percent by weight of petroleum jelly, 10 to 50 percent by weight of jojoba oil, 1 to 10 percent by weight of cholesterol, 1 to 10 percent by weight of beeswax or walnut or walnut substitute, and 10 to 40 percent by weight of water.
  • Vaseline is a soft to ointment-like mixture of solid and liquid petroleum hydrocarbons with a melting range between 35 and 60 degrees Celsius.
  • Yellow petroleum jelly (Vaselinum flavum) and bleached white petroleum jelly (Vaselinum album) are commercially available.
  • the white, highly purified petroleum jelly preferred here serves as an inert carrier substance for the ointment.
  • the oil obtained from the jojoba plant also serves, together with the petroleum jelly, as a carrier, but also has a healing effect.
  • the essential pharmaceutically active substance is cholesterol, which is contained in the ointment with a relatively high proportion by weight.
  • Cholesterol as a pharmaceutical active ingredient in a topical ointment for the treatment of dermatoses, in particular psoriasis, is not known from the prior art document dealt with above. Chemically, cholesterol is a steroid but does not have the anti-inflammatory activity of the adrenal gland hormones derived from steroids. This does not mean that their well-known side effects are acceptable.
  • the cholesterol is preferably used in a highly pure form (Cholesterinum purissimum). Cholesterol obtained from wool fat in the form of crystallized powder can be used to produce the ointment.
  • the cholesterol contained in the ointment of the composition according to the invention acts as a lipid emulsifying.
  • the ointment according to the invention thus represents the ideal alternative preparation for the treatment of dermatoses for those patients who cannot tolerate any of the conventional preparations on the skin.
  • the proposed ointment represents a new perspective.
  • the ointment according to the invention is the only option known until now of achieving therapeutic effects without side effects.
  • An ointment consisting of 20 to 40 percent by weight of petroleum jelly, 25 to 45 percent by weight of jojoba oil, 2 to 6 percent by weight of cholesterol, 2 to 8 percent by weight of beeswax, walnut or walnut substitute and 15 to 30 percent has proven particularly effective for the treatment of psoriasis Weight pro there is water.
  • a composition of 25 to 35 percent by weight of petroleum jelly, 35 to 42 percent by weight of jojoba oil, 3 to 5 percent by weight of cholesterol, 4 to 7 percent by weight of beeswax, walnut or walnut substitute and 20 to 25 percent by weight of water is preferred.
  • the ointment is produced in the usual way by carefully mixing the ingredients at elevated temperature.
  • Vaseline, jojoba oil, cholesterol and beeswax are preferably heated together to about 75 degrees Celsius. With careful stirring, a thin, two-phase mixture is formed. Depending on the desired consistency, a corresponding amount of distilled water is added. The subsequent cooling to ambient temperature should be carried out with constant stirring.
  • Devices suitable for this manufacturing process are known and include heat exchangers and mixers.
  • the ointment according to Example 1 above was tested in tests carried out under medical supervision on patients suffering from chronic therapy-resistant psoriasis.
  • a total of 27 patients were treated in a first clinical examination.
  • one half of the patient's body was treated at the affected skin areas with ointment of the composition given in Example 1, while the other half of the body was treated with a salicylic ointment.
  • the ointment was applied twice a day.
  • the success of the treatment was checked by the investigator after one, two and three weeks. Of the 27 patients treated, 24 were free of symptoms after one or two weeks. Although the other three patients showed an effect, there was no complete healing of the skin changes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP89912240A 1988-10-31 1989-10-26 Topische salbe Pending EP0440715A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3836971 1988-10-31
DE3836971A DE3836971C1 (cs) 1988-10-31 1988-10-31

Publications (1)

Publication Number Publication Date
EP0440715A1 true EP0440715A1 (de) 1991-08-14

Family

ID=6366210

Family Applications (2)

Application Number Title Priority Date Filing Date
EP89912240A Pending EP0440715A1 (de) 1988-10-31 1989-10-26 Topische salbe
EP89119890A Expired - Lifetime EP0367103B1 (de) 1988-10-31 1989-10-26 Topische Salbe

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP89119890A Expired - Lifetime EP0367103B1 (de) 1988-10-31 1989-10-26 Topische Salbe

Country Status (11)

Country Link
US (1) US5179086A (cs)
EP (2) EP0440715A1 (cs)
JP (1) JPH0647544B2 (cs)
AT (1) ATE84216T1 (cs)
CA (1) CA2001797A1 (cs)
DE (2) DE3836971C1 (cs)
DK (1) DK7191A (cs)
ES (1) ES2053907T3 (cs)
GR (1) GR3007370T3 (cs)
PT (1) PT92148B (cs)
WO (1) WO1990004967A2 (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705030A1 (fr) * 1993-05-11 1994-11-18 Biodev Utilisation de composés stéroliques pour la fabrication d'un médicament anti-inflammatoire.
US5888984A (en) 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US5444092A (en) * 1994-07-20 1995-08-22 Collins; Jerry Method and composition for treating psoriasis
GB9814527D0 (en) * 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
EP1958961A3 (en) 1998-11-13 2008-09-03 Cyclacel Limited Transport Vectors
AU2745700A (en) 1999-02-01 2000-08-18 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US7879824B2 (en) * 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
TNSN02063A1 (en) * 2001-07-07 2005-12-23 Egyptian Natural Oil Co Natoil The medical effect of jojoba oil
US7048914B2 (en) * 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US20050002884A1 (en) * 2003-07-02 2005-01-06 Marsella Jefferson Hair treatment compositions
US7374754B2 (en) * 2003-09-02 2008-05-20 Essential Skincare, Llc Use of placental alkaline phosphatase to promote skin cell proliferation
US8455016B2 (en) * 2004-03-12 2013-06-04 Melbj Holdings, Llc Treatment for meibomian gland dysfunction or obstruction
WO2007075199A1 (en) * 2005-12-28 2007-07-05 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
CN102137713A (zh) * 2008-12-24 2011-07-27 生物制药开发股份有限公司 脂质体的制备方法及胆固醇溶解方法
JP5665861B2 (ja) 2010-04-28 2015-02-04 久光製薬株式会社 ドネペジル含有経皮吸収製剤
JP5654006B2 (ja) 2010-04-28 2015-01-14 久光製薬株式会社 皮膚刺激抑制剤及び経皮吸収製剤
EP2772252B1 (en) 2011-10-26 2020-03-18 Hisamitsu Pharmaceutical Co., Inc. Oxybutynin-containing transdermal absorption preparation
US9717741B2 (en) 2012-10-11 2017-08-01 Anaplasi Pharmaceuticals Llc Method and compositions for treating psoriasis
US9987361B1 (en) 2014-12-29 2018-06-05 Noven Pharmaceuticals, Inc. Compositions and method for sustained drug delivery by active transdermal technology
GB201814036D0 (en) 2018-08-29 2018-10-10 Ucl Business Plc New therapy
WO2020091703A1 (en) * 2018-11-01 2020-05-07 Yeditepe Universitesi A medicine for treatment of psoriasis and production method thereof
GB201918752D0 (en) * 2019-12-18 2020-01-29 Ucl Business Plc New therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE523144C (de) * 1927-09-11 1931-04-20 Friedrich Passek Verfahren zur Herstellung wasserreicher Cholesterinloesungen
DE638839C (de) * 1935-01-15 1936-11-24 Chem Fab Promonta G M B H Verfahren zur Herstellung waessrig-alkoholischer Cholesterinloesungen
FR928337A (fr) * 1946-05-20 1947-11-25 Procédé d'obtention de solutions stables de cholestérine, en vue de la préparation de produits cosmétiques et de beauté
FR2485921A1 (fr) * 1980-07-01 1982-01-08 Oreal Composition cosmetique a base d'une dispersion aqueuse de spherules lipidiques
IT8221553A0 (it) * 1982-05-28 1982-05-28 Gruppo Scient Revici Pacelli Composizioni farmaceutiche adattivita' antineoplastica.
DE3225849A1 (de) 1982-07-07 1984-01-19 Schering Ag Kortikoidhaltige zubereitung zur topischen applikation
FR2568142B1 (cs) * 1984-07-26 1989-11-17 Oreal
US4743597A (en) * 1986-01-27 1988-05-10 Javitt Norman B Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases
FR2597346B1 (fr) * 1986-04-22 1989-08-18 Oreal Procede pour faciliter la formation de niosomes en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9004967A2 *

Also Published As

Publication number Publication date
DE58903222D1 (de) 1993-02-18
ES2053907T3 (es) 1994-08-01
GR3007370T3 (cs) 1993-07-30
ATE84216T1 (de) 1993-01-15
JPH04501415A (ja) 1992-03-12
DK7191D0 (da) 1991-01-15
WO1990004967A2 (de) 1990-05-17
EP0367103A1 (de) 1990-05-09
EP0367103B1 (de) 1993-01-07
WO1990004967A3 (de) 1990-06-28
PT92148B (pt) 1995-06-30
DE3836971C1 (cs) 1990-05-17
PT92148A (pt) 1990-05-31
DK7191A (da) 1991-06-04
JPH0647544B2 (ja) 1994-06-22
CA2001797A1 (en) 1990-04-30
US5179086A (en) 1993-01-12

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Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT 89119890.5/0367103 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) VOM 15.10.91.