EP0398316A1 - Verpackung für medizinische Behälter - Google Patents

Verpackung für medizinische Behälter Download PDF

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Publication number
EP0398316A1
EP0398316A1 EP90109291A EP90109291A EP0398316A1 EP 0398316 A1 EP0398316 A1 EP 0398316A1 EP 90109291 A EP90109291 A EP 90109291A EP 90109291 A EP90109291 A EP 90109291A EP 0398316 A1 EP0398316 A1 EP 0398316A1
Authority
EP
European Patent Office
Prior art keywords
lid
package
heat
sealed
layer formed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP90109291A
Other languages
English (en)
French (fr)
Inventor
Shunji Kawatsu
Yasushi Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of EP0398316A1 publication Critical patent/EP0398316A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/10—Container closures formed after filling
    • B65D77/20—Container closures formed after filling by applying separate lids or covers, i.e. flexible membrane or foil-like covers
    • B65D77/2024—Container closures formed after filling by applying separate lids or covers, i.e. flexible membrane or foil-like covers the cover being welded or adhered to the container
    • B65D77/2028—Means for opening the cover other than, or in addition to, a pull tab
    • B65D77/2032—Means for opening the cover other than, or in addition to, a pull tab by peeling or tearing the cover from the container
    • B65D77/2036—Means for opening the cover other than, or in addition to, a pull tab by peeling or tearing the cover from the container the seal having a stress concentrating portion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2577/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks, bags
    • B65D2577/10—Container closures formed after filling
    • B65D2577/20—Container closures formed after filling by applying separate lids or covers
    • B65D2577/2041—Pull tabs
    • B65D2577/205—Pull tabs integral with the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2577/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks, bags
    • B65D2577/10—Container closures formed after filling
    • B65D2577/20—Container closures formed after filling by applying separate lids or covers
    • B65D2577/2066—Means on, or attached to, container flange facilitating opening, e.g. non-bonding region, cut-out

Definitions

  • the present invention relates to a package for medical container. More particularly, it relates to a blister package for holding medicine-containing containers of flexible synthetic resin, which package exhibits highly satisfactory peelability at the time of its opening and retains highly satisfactory airtightness in its sealed state.
  • an anticoagulant for transfusion or blood such as the ACD solution or CPD solution is contained.
  • the blood at the time of its collection or transfusion is prevented from coagulation.
  • the medical containers containing the anticoagulant are stored in an airtight container of synthetic resin adapted for preservation.
  • the so-called blister package which comprises a tray part having a flange part formed along the edge of an opening part thereof and a lid heat-sealed to the flange part in such a manner as to be freely peeled to open the package through the medium of an adhesive layer fit for heat sealing has been finding extensive utility recently.
  • the conventional blister package of the kind described above uses the tray part which is made of synthetic resin, it is produced in a circular shape by reason of the convenience of molding.
  • this package is required to be produced in a square or rectangular shape for the convenience of medical container to be contained therein, the corner parts thereof are given a curved contour. As illustrated in Fig.
  • the lid except for the part used for starting separation thereof by peeling is identical in shape with the flange part whose corners are formed parallelly to the curved contours mentioned above.
  • the idea of forming one or three extended edges in the part for facilitating the start of separation of the heat-sealed part has been proposed (JP-­A-59-199,463)
  • the blister package of this class has suffered from a disadvantage that the heat-sealed part thereof in the corners except for the part for starting the separation has no sufficient shock resistance and the heat-­sealed part in the part for starting the separation has no fully satisfactory strippability.
  • An object of the present invention is to provide a novel package for medical containers.
  • Another object of this invention is to provide a package for medicine-containing containers of flexible synthetic resin, which offers highly satisfactory shock resistance and exhibits excellent strippability of the lid at the time of opening.
  • a package for medical containers of flexible synthetic resin comprising a tray part formed in a generally rectangular shape containing four curved corners and provided along the edge of an opening thereof with a flange part having an edge parallel to the shape and a lid heat-sealed with the flange part through the medium of an adhesive layer in such a manner as to be freely peeled, which package is characterized by the fact that the four corner parts of the lid are projected from the imaginary line of the outer edge parallel to the shape of the flange part of the tray part and, at the same time, two projections are formed in at least one curved part as the part for starting separation of the heat-sealed part.
  • the present invention further discloses a package for medicine-containing containers of flexible synthetic resin, wherein the tray part and the lid are made of synthetic resin and the lid has formed on the innermost surface thereof an adhesive layer capable of aiding in heat-­sealing the tray part and the lid and, after the formation of the heat-sealed part, allowing separation of the heat-­sealed part of the package.
  • the present invention further discloses a package for medicine-containing containers of flexible synthetic resin, wherein the tray part comprises an outer layer using polypropylene as a main component, an intermediate layer formed of an ethylene-vinyl alcohol copolymer, and an inner layer using polypropylene as a main component and the lid comprises an outer layer formed of polyethylene terephthalate, a first intermediate layer formed of polyvinylidene chloride, a second intermediate layer formed of nylon, and an adhesive layer formed of polypropylene incorporated with polyethylene.
  • the present invention is directed to a package for medical containers of flexible synthetic resin, comprising a tray part formed in a generally rectangular shape containing four curved corners and provided along the edge of an opening thereof with a flange part having an edge parallel to the aforementioned shape and a lid heat-sealed with the flange part through the medium of an adhesive layer in such a manner as to be freely peeled, wherein the four corner parts of the lid are projected from (the imaginary line of) the outer edge parallel to the aforementioned shape of the flange part of the tray part and, at the same time, two projections are formed in at least one curved part as the part for starting separation of the heat-sealed part, the heat-sealed part of the package in all of the four corners truly excels in shock resistance and the heat-sealed part of the package in the part for starting the separation of the lid exhibits highly satisfactory strippability.
  • the package not only excels in seal strength but also retains seal strength and strippability substantially intact in spite of possible variation in the sealing temperature and the sealing time.
  • this package contains medicine-containing vials of soft synthetic resin such as, for example, blood bags, it is capable of preserving its contents in a sterilized state for a long time without sustaining breakage.
  • a package 11 of the present invention comprises a tray part 15 produced by molding a synthetic resin sheet in the form of a rectangular platter possessing four curved corners and having formed along the edge of an opening thereof a flange part 14 possessing an outer edge 13 parallel to the contour of the platter and a sheetlike lid 16 made of synthetic resin.
  • the tray part 15 and the lid 16 are airtightly heat-­sealed in a strip 17 of a prescribed width through the medium of an adhesive layer formed on the inner surface of the lid 16.
  • the lid 16 mentioned above is required to be formed so that all of the four corners thereof will protrude from the outer edge 13 of the flange part 14 of the tray part 15.
  • the protruding parts are formed, for example, by causing the four corners of the rectangular lid 16 to be curved in a smaller than the corresponding corners in the imaginary line 13 of the outer edge of the flange part 14 parallel to the edge of the opening in the ray.
  • a part 18 for starting separation of the heat-sealed part by peeling is formed in at least one of the four corners mentioned above as illustrated in Fig. 4, so that the strip of heat-­sealed part will thrust out in two places relative to the line X-X′ of peeling force exerted on the lid 16.
  • the formation of the part 18 for starting the separation can be accomplished by imparting this shape to the die to be used for the heat-sealing.
  • the desirability of the shape of the part for starting separation increases in proportion as the sharpness of the leading ends of the protruding parts increases.
  • the part for starting the separation is preferable to be so shaped that, at the time of starting the separation, the length of the heat-­sealed part which falls on a straight perpendicular to the line of the peeling strength is shortened.
  • the heat-sealed part is desired to have the shape illustrated in Fig. 4.
  • the leading ends of the protruding parts 19 are thrust out at an angle in the range of 90 to 120 degrees.
  • the material of which the package of the present invention is formed is synthetic resin.
  • the outer layer and the inner layer thereof each use polypropylene as a main component and each have a thickness in the range of 10 to 70 ⁇ m, preferably 30 to 50 ⁇ m. Owing to the material and the thickness described above, the tray part is allowed to possess a fully satisfactory shape-retaining property.
  • the inner layer of the tray part exhibits a fully satisfactory heat-sealing property with the lid of the quality to be described specifically hereinafter.
  • the intermediate layer is formed of an ethylene-vinyl alcohol copolymer in a thickness in the range of 10 to 50 ⁇ m, preferably 20 to 30 ⁇ m. Owing to this intermediate layer, the tray part possesses fully satisfactory moisture proofness and sparing permeability to gas.
  • the outer layer is formed of polyethylene terephthalate in a thickness in the range of 5 to 30 ⁇ m, preferably 10 to 15 ⁇ m. Owing to this outer layer, the lid exhibits satisfactory mechanical strength mainly in respect to the resistance to the impact exerted by a pointed object.
  • the first intermediate layer adjoining the outer layer is formed of polyvinylidene chloride in a thickness in the range of 10 to 50 ⁇ m, preferably 20 to 30 ⁇ m. It enables the lid to retain moistureproofness and sparing permeability to gas.
  • the second intermediate layer adjoining the first intermediate layer is formed of nylon, preferably biaxially stretched nylon, in a thickness in the range of 10 to 50 ⁇ m, preferably 20 to 30 ⁇ m.
  • the adhesive layer adjoining the second intermediate layer is polypropylene layer incorporating with polyethylene.
  • the weight ratio of polypropylene to polyethylene is from 80 : 20 to 50 : 50.
  • the overall thickness of this adhesive layer is in the range of 20 to 100 ⁇ m, preferably 40 to 60 ⁇ m.
  • the term "medicine-containing container of flexible synthetic resin” as used in the present invention refers to a blood bag made of flexible vinyl chloride resin and adapted to contain therein such an anticoagulant as an ACD solution or CPD solution or a transfusion bag made of flexible vinyl chloride resin and adapted to contain therein a transfusion solution.
  • This invention manifests an outstanding effect particularly when the package accomodates blood bags.
  • a rectangular tray possessing a flange along the edge of the opening having curves (curvature 41 mm) formed one each in the four corners thereof as illustrated in Figs. 1 to 4 was formed of a laminate composed of an outer layer formed of polypropylene in a thickness of 40 ⁇ m, an intermediate layer formed of an ethylene-vinyl alcohol copolymer in a thickness of 25 ⁇ m, and an inner layer formed of polypropylene in a thickness of 40 ⁇ m.
  • a laminate lid composed of an outer layer formed of polyethylene terephthalate in a thickness of 12 ⁇ m, a first intermediate layer formed of polyvinylidene chloride in a thickness of 25 ⁇ m, a second intermediate layer formed of biaxially stretched nylon in a thickness of 25 ⁇ m, and an adhesive layer (50 ⁇ m in thickness) formed polypropylene incorporating with polyethylene (weight ratio of polypropylene to polyethylene is 60 : 40) was thermally fused in a width of about 3 mm to the flange part in such a manner that two projections (about 110° in angle) were thrust out as the part for starting separation of the heat-­sealed part expected to be formed in the curved corners mentioned above as illustrated in Fig.
  • the curvature of the lid in the corner in which the part for starting separation was formed was 10 mm and the curvature of the lid in the other corners was 20 mm.
  • the lid measured 311 mm in length and 184 mm in width.
  • the lid and the flange part were jointly trimmed in such a manner that the parallel part (vertical part) of the flange acquired a width of about 9 mm and the four corners of the lid protruded from the imaginary line 13 of the outer edge parallel to the contour of the edge of the opening as illustrated in Figs. 1 to 4, to complete a package.
  • the curvature of the corners on the separation-starting part side was 10 mm and the curvature of the remaining corners was 20 mm and the lid measured 265 mm in length and 158 mm in width.
  • a package was obtained by following the procedure of Example 1, except that the shape of the lid in the corners in which the part for starting separation was not formed was substantially identical curvature 49 mm) with the outer edge of the flange part of the tray part as illustrated in Fig. 11.
  • one corner in which the part for starting separation was not formed was subjected to the same pressure test as in the working example.
  • the results of this test were as shown in Table 1.
  • the corner in which the part for starting separation was formed was subjected to the same test as shown in Fig. 5 (C). The results were as shown in Table 1.
  • a package was obtained by following the procedure of the working example, except that the fusion of the part for starting separation was formed in the form of three crests as shown in Fig. 7A.
  • a corner cut off the package was subjected to a peeling test with a tester (produced by Shimazu Seisakusho Ltd. and marketed under trademark designation of "Autograph DSS-100") at a stretching rate of 200 mm/min at room temperature.
  • the results of this test were as shown in Table 3.
  • the values given in the table each represent an average obtained of 20 samples.
  • the sample of the working example excelled the sample of Control 2 in separability of heat-sealed part.
  • a package was obtained by following the procedure of the working example, except that the lid was composed of an outer layer formed of polyvinylidene chloride-coated polyethylene terephthalate in a thickness of 12 ⁇ m, a first intermediate layer formed of polyvinylidene chloride-coated biaxially stretched polypropylene in a thickness of 20 ⁇ m, a second intermediate layer formed of biaxially stretched nylon in a thickness of 15 ⁇ m, and an inner layer formed of linear low-density polyethylene in a thickness of 50 ⁇ m.
  • a middle portion between the corners of the package obtained as described above was cut off.
  • the lid member and the tray part member of the cut portion of package were pulled away each other with a tester (produced by Shimazu Seisakusho Ltd. and marketed under trademark designation of "Autograph DSS-10") at a drawing rate of 200 mm/min at room temperature to determine the force (seal strength) necessary for causing separation.
  • the results were as shown in Table 4. This test was performed on five sets each of four cut pieces from a given package. The results shown in the table each represent an average of the values obtained of the five sets.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
EP90109291A 1989-05-16 1990-05-16 Verpackung für medizinische Behälter Withdrawn EP0398316A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1120471A JP2786882B2 (ja) 1989-05-16 1989-05-16 医療容器収納用包装容器
JP120471/89 1989-05-16

Publications (1)

Publication Number Publication Date
EP0398316A1 true EP0398316A1 (de) 1990-11-22

Family

ID=14786995

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90109291A Withdrawn EP0398316A1 (de) 1989-05-16 1990-05-16 Verpackung für medizinische Behälter

Country Status (2)

Country Link
EP (1) EP0398316A1 (de)
JP (1) JP2786882B2 (de)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435493A2 (de) * 1989-12-20 1991-07-03 Eaton Forms Corporation Arzneimittelbehälter und Deckel dafür
EP0498760A1 (de) * 1991-02-04 1992-08-12 Alusuisse-Lonza Services Ag Verpackung
US5613617A (en) * 1994-09-27 1997-03-25 Da Vitoria Lobo; Luis J. Sealed container that is easily opened and mass-produced
WO2003055771A1 (de) * 2002-01-02 2003-07-10 Wipak Walsrode Gmbh & Co. Kg Verpackung mit einer speziellen siegelnaht
WO2011157705A1 (en) 2010-06-16 2011-12-22 Dsm Ip Assets B.V. A package comprising a sterilized content
EP2907759A1 (de) * 2014-02-12 2015-08-19 Cryovac, Inc. Verpackung für ein Produkt und Vorrichtung und Verfahren zur Verpackung eines Produkts
US10233009B2 (en) 2014-03-28 2019-03-19 Kyoraku Co., Ltd. Container for microwave oven and package for microwave oven
WO2022124114A1 (ja) 2020-12-09 2022-06-16 テルモ株式会社 医療器具用包装容器および包装された医療器具

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4645175B2 (ja) * 2004-11-30 2011-03-09 東洋製罐株式会社 易開封性容器及びその製造方法
JP2012213416A (ja) * 2011-03-31 2012-11-08 Yasushi Matsumoto 消毒用具とその使用方法
JP6500269B2 (ja) * 2014-03-31 2019-04-17 キョーラク株式会社 電子レンジ用包装体
JP6387516B2 (ja) * 2014-03-28 2018-09-12 キョーラク株式会社 電子レンジ用包装体
JP6505032B2 (ja) * 2016-02-09 2019-04-24 大森機械工業株式会社 深絞り包装機
JP7008273B2 (ja) * 2017-09-27 2022-01-25 大日本印刷株式会社 積層体及び該積層体で構成される蓋材を用いた輸液容器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1480970A (en) * 1975-05-14 1977-07-27 Cawrse R Apparatus and method for applying lids to containers
EP0001094A1 (de) * 1977-09-12 1979-03-21 BEHRINGWERKE Aktiengesellschaft Heissversiegelbarer Behälter
EP0093797A1 (de) * 1982-05-06 1983-11-16 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Verpackung für medizinische Behälter
JPS59199463A (ja) * 1983-04-20 1984-11-12 テルモ株式会社 包装容器
GB2161782A (en) * 1984-07-17 1986-01-22 Toyo Seikan Kaisha Ltd Synthetic resin vessel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54104314U (de) * 1977-12-28 1979-07-23
JPH0698737B2 (ja) * 1985-10-03 1994-12-07 出光石油化学株式会社 多層容器

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1480970A (en) * 1975-05-14 1977-07-27 Cawrse R Apparatus and method for applying lids to containers
EP0001094A1 (de) * 1977-09-12 1979-03-21 BEHRINGWERKE Aktiengesellschaft Heissversiegelbarer Behälter
EP0093797A1 (de) * 1982-05-06 1983-11-16 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Verpackung für medizinische Behälter
JPS59199463A (ja) * 1983-04-20 1984-11-12 テルモ株式会社 包装容器
GB2161782A (en) * 1984-07-17 1986-01-22 Toyo Seikan Kaisha Ltd Synthetic resin vessel

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0435493A2 (de) * 1989-12-20 1991-07-03 Eaton Forms Corporation Arzneimittelbehälter und Deckel dafür
EP0435493B1 (de) * 1989-12-20 1994-09-21 Eaton Forms Corporation Arzneimittelbehälter und Deckel dafür
EP0498760A1 (de) * 1991-02-04 1992-08-12 Alusuisse-Lonza Services Ag Verpackung
CH683175A5 (de) * 1991-02-04 1994-01-31 Alusuisse Lonza Services Ag Verpackung.
US5613617A (en) * 1994-09-27 1997-03-25 Da Vitoria Lobo; Luis J. Sealed container that is easily opened and mass-produced
WO2003055771A1 (de) * 2002-01-02 2003-07-10 Wipak Walsrode Gmbh & Co. Kg Verpackung mit einer speziellen siegelnaht
WO2011157705A1 (en) 2010-06-16 2011-12-22 Dsm Ip Assets B.V. A package comprising a sterilized content
EP2907759A1 (de) * 2014-02-12 2015-08-19 Cryovac, Inc. Verpackung für ein Produkt und Vorrichtung und Verfahren zur Verpackung eines Produkts
WO2015121270A1 (en) * 2014-02-12 2015-08-20 Cryovac, Inc. Package for a product and apparatus and process for packaging a product
US10233009B2 (en) 2014-03-28 2019-03-19 Kyoraku Co., Ltd. Container for microwave oven and package for microwave oven
US10968028B2 (en) 2014-03-28 2021-04-06 Kyoraku Co., Ltd. Container for microwave oven and package for microwave oven
WO2022124114A1 (ja) 2020-12-09 2022-06-16 テルモ株式会社 医療器具用包装容器および包装された医療器具

Also Published As

Publication number Publication date
JPH03667A (ja) 1991-01-07
JP2786882B2 (ja) 1998-08-13

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