EP0395758A1 - Behälter für getrennte lagerung - Google Patents

Behälter für getrennte lagerung Download PDF

Info

Publication number
EP0395758A1
EP0395758A1 EP88908369A EP88908369A EP0395758A1 EP 0395758 A1 EP0395758 A1 EP 0395758A1 EP 88908369 A EP88908369 A EP 88908369A EP 88908369 A EP88908369 A EP 88908369A EP 0395758 A1 EP0395758 A1 EP 0395758A1
Authority
EP
European Patent Office
Prior art keywords
piercing
storage container
separate storage
chamber
container according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP88908369A
Other languages
English (en)
French (fr)
Other versions
EP0395758B1 (de
EP0395758A4 (en
Inventor
Norisuke Kira
Kazuhiko Sudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of EP0395758A1 publication Critical patent/EP0395758A1/de
Publication of EP0395758A4 publication Critical patent/EP0395758A4/en
Application granted granted Critical
Publication of EP0395758B1 publication Critical patent/EP0395758B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts

Definitions

  • the present invention relates to a container for separately containing two or more substances, and more particularly, to a separate storage container in which a solvent, such as a solution, in a storage chamber is fed into a solute containing member which contains a solute, such as a powered or liquid medicine, so that the solute, such as the powdered or liquid medicine, can be mixed and sterilely dissolved.
  • a solvent such as a solution
  • solute such as a powered or liquid medicine
  • a suitable amount of a solution such as a physiological saline solution or 5 % grape sugar injection solution, is sucked in by means of an injector, and the needle of the injector is stuck into a solute vessel containing a powdered medicine, thereby injecting the solution. After the powdered medicine is dissolved, the solution is sucked in again to give a patient an injection.
  • a solution such as a physiological saline solution or 5 % grape sugar injection solution
  • a solute vessel containing a powdered medicine and a bag stuffed with a solution are sterilely connected by means.of an adapter which constitutes communication means holding a piercing needle and a frangible portion, the solution is injected into the solute vessel which contains the powdered medicine, thereby dissolving the powdered medicine, and the resulting solution is returned to the bag to subject a patient to an intravenous drip.
  • a sleeve which is disposed so as to surround the piercing needle and is formed of a flexible material which expands and contracts as the needle moves.
  • a solute vessel containing a powdered medicine, a bag stuffed with a solution, and an empty bag are sterilely connected to one another by means of an adapter which includes a needle and a frangible portion.
  • the solution is put into the solute vessel to dissolve the powdered medicine, whereupon an antibiotic or the like is fully dissolved by using the empty bag as an air vent.
  • the resulting solution is returned to the bag to subject a patient to an intravenous drip.
  • vessels must be provided separately for the solution, injector, and powdered medicine, and must be operated in equipment for sterile work, such as a clean bench, so that the operation is troublesome, and there is a possibility of external bacterial contamination.
  • equipment for sterile work such as a clean bench
  • there is no need of the sterile equipment, such as a clean bench since no means is provided for positively keeping the prick portion of the solute vessel containing the powdered medicine separated from the piercing needle on the adapter when not in use in a normal state, so the solute vessel and the adapter may possibly be connected by mistake.
  • the connecting operation is troublesome for an operator, and the construction of the adapter is complicated.
  • the object of the present invention is to provide a medicine storage container which eliminates the various problems of the prior art separate storage containers described above, and which,despite its simple construction, can positively keep a piercing section of one containing member containing one substance separated from a piercing element capable of piercing the piercing section as required, when not in use in a normal state, and can enable an operator to perform the piercing operation easily and securely, when in use, so that a chamber for the one containing member and a chamber for the other containing member containing the other substance are sterilely connected to effect required mixing (dissolution), and which is easy to handle.
  • the present invention is based on the common arrangement disclosed in the second and third prior art examples.
  • the invention is premised on an arrangement which comprises a first containing member including a first chamber having a discharge port and containing a first substance therein; a second containing member containing second sub'stance and including a piercing section; and communication means including a piercing element capable of piercing the piercing section of the second containing member with a predetermined piercing resistance, as required, and a closing section extending into the first chamber and adapted normally to cut off the communication between the first chamber and the piercing element, the closing section being separable as required so that the communication is allowed when the closing section is separated, whereby sterile communication between the first and second chambers is effected as required.
  • a separate storage container which is characterized by comprising: holding means disposed between the second containing member and the first chamber and surrounding the piercing element, and adapted normally to keep the piercing section of the second containing member and the piercing element separated and to undergo plastic deformation in the axial direction of the piercing element when subjected to an external force of a value grater than a predetermined value in the axial direction, thereby allowing the piercing element to pierce the piercing section and maintaining the pierced state, whereby the closing section of the communication means is separated after the piercing section is pierced by the piercing element, so that the sterile communication between the first and second chambers is effected through the communication means.
  • the holding means can positively keep the piercing element of the communication means separated from the piercing section of the second containing member, so that an unexpected wrong piercing operation can be prevented.
  • the holding means is plastically deformed by somewhat strongly applying the external force or an operator's manual force to a value greater than the predetermined value, so that the piercing operation can be effected, and the pierced state can be securely maintained by the plastically deformed holding means.
  • the separate storage container of the present invention is simple in construction due to its few components, and its communicating portion, which constitute the communication means, is sealed to be kept sterile. Further, a guide cover, which constitutes the holding means, cannot be plastically deformed unless it is subjected to an axial external force of a value greater than the predetermined value, so that a piercing needle, which constitutes the piercing element of the communicating portion, can hardly be unexpectedly run through the piercing section by mistake. Since there is no empty bag or the like, moreover, the dissolving operation is easy.
  • the predetermined value of the external force to subject the holding means to the plastic deformation is set to be greater than the piercing resistance of the piercing element piercing the piercing section, e.g., to 3 kgf or more, preferably within the range of 3 kgf to 5 kgf, further preferably to 3.5 kgf.
  • the holding means is composed of a bellows-like guide cover integrally formed from thermoplastic resin by blow molding, for example.
  • blow molding in particular, outwardly projecting crest portions of the bellows-like guide cover can be easily formed thinner than inwardly recessed bottom portions, so that a desirable property for the guide cover can be obtained.
  • Figs. 1 to 4 show one embodiment of the present invention, in which Fig. 1 is a perspective view of a medicine storage container wrapped in a package, Fig. 2 is an enlarged perspective view of the medicine storage container with the package of Fig. 1 removed therefrom, Fig. 3 is an enlarged longitudinal sectional view of the medicine storage container shown in Fig. 2, especially portions corresponding to a guide cover and communication means and Fig. 4(a), 4(b), 4(c) and 4(d) are illustrative diagrams for individually showing states of operation of the medicine storage container; and
  • Fig. 5 is a perspective view of a medicine storage container according to another embodiment of the present invention.
  • Fig. 1 is a perspective view of a medicine storage container as a separate storage container of the present invention wrapped in a package
  • Fig. 2 is a perspective view of the medicine storage container.
  • numeral 1 denotes the medicine storage container
  • the medicine storage container 1 comprises a storage chamber 2 and a housing chamber 3 which are integrally formed of a flexible synthetic resin sheet and are independent of each other.
  • This medicine storage container 1 is entirely covered by a rectangular package 4, which ensures the stability of a solution S (mentioned later) for use as a solvent sealed in the storage chamber 2.
  • the storage chamber 2 contains 50 to 100 ml of the solution S, e.g., a physiological saline solution or 5 % grape sugar solution.
  • a discharge port 5 is provided at the lower portion of the storage chamber 2, and further, an aluminum cap 6 is fitted on the discharge port 5 so that the solution S cannot run out.
  • a hole la which is used to hang the container 1 on a hanger 14 of a transfusion stand 13 mentioned later, is formed at one end portion of the container, and a boundary portion lb for dividing the two chambers 2 and 3 is formed at the middle portion.
  • a communicating section 9 as communication means is disposed between the upper portion of the storage chamber 2 and the lower portion of the housing chamber 3.
  • the communicating section 9 has a separable closing section 7 located in the storage chamber 2 and a bottle needle or piercing needle 8 as a piercing element at the distal end thereof which is located in the housing chamber 3.
  • This communicating section is in the form of a cylinder closed at its end portion in the storage chamber 2, and a notch is formed in the inner peripheral surface so that the closing section 7 can be easily broken by means of an external force.
  • the bottle needle 8 is provided with an angled edge 8a, which cannot be easily drawn out once it is passed through a piercing section 11 mentioned later. Further, the middle portion of the cylindrical communicating section 9 is held by means of the boundary portion lb.
  • a glass or plastic vial or solute vessel 10, which constitutes a solute containing member, is housed in the housing chamber 3, and an antibiotic A as a powdered solute is contained in a chamber 10b in the vial 10.
  • a mouth 10a of the vial 10 is fitted with a rubber stopper 11 for use as the piercing section through which the aforesaid bottle needle 8 can be run, and the stopper 11 is fixed by means of a mouthpierce lla (Fig. 3).
  • a bellows-like guide cover 12 is provided between the mouth 10a of the vial 10 and a bottom portion 3a of the housing chamber 3 defined by the boundary portion lb as in Fig. 2. This guide cover 12 constitutes holding means.
  • the guide cover 12 is formed of a material, e.g., a metal material such as aluminum or a thermoplastic resin such as polypropylene, which undergoes plastic deformation when subjected to an external force of a value greater than a predetermined value in the axial direction of the bottle needle 8, that is, in a direction such that the bottle needle 8 of the communicating section 9 pierces the rubber stopper 11 fitted in the mouth 10a of the vial 10, by an operator's hand, for example. Unless subjected to an axial force of a value greater than the predetermined value, therefore, the bottle needle 8 is kept at an off position, as shown in Fig. 3, in which it never pierces the rubber stopper 11, and the solution S cannot enter the vial 10 by mistake.
  • a material e.g., a metal material such as aluminum or a thermoplastic resin such as polypropylene
  • the bottle needle 8 is guided by the guide cover 12 so that it is prevented from misguidedly piercing any other object than the rubber stopper 11. Once the guide cover 12 is deformed and contracts, moreover, it maintains the deformed state as a result of the plastic deformation, so that the penetration of the bottle needle 8 can be secured.
  • one end portion 12a of the guide cover 12 surrounds the mouth 10a of the vial and the rubber stopper 11 and is fixed to the vial 10.
  • the other end portion 12b of the guide cover 12 extends in the axial direction of the bottle needle 8 so as to surround the needle, and is fixed to the bottom portion 3a.
  • the guide cover 12 is blow-molded from the a thermoplastic resin, it can get better expansion and contraction because crest portions 12c of the guide cover 12, which project radially outward, are thinner than bottom portions 12d which are recessed radially inward, as shown in Fig. 3.
  • the predetermined value of the external force which causes the plastic deformation of the guide cover 12 should be set to a value equal to or greater than the resistance against the needle 8 piercing the rubber stopper 11 of the vial 10, that is, piercing resistance.
  • the predetermined value for the guide cover 12 is preferably set to 3 kgf as a minimum value.
  • the upper limit of this predetermined value corresponds to the external force the operator can apply.
  • the predetermined value is set within the range of 3 kgf to 5 kgf, preferably to 3.5 kgf.
  • the guide cover 12 is formed from a metal material, the method of press-molding is preferably used.
  • the package 4 covering the medicine storage container 1, as shown in Fig. 1, is removed.
  • the bottle needle 8 of the communicating section 9 is run (see Fig. 4(a)) through the rubber stopper 11 in the mouth 10a of the vial 10 in the housing chamber 3 by axially contracting the guide cover 12 through plastic deformation by means of an external force of a value greater than the predetermined value.
  • the closing section 7 of the communicating section 9 is broken or separated so that the vial 10 and the storage chamber 2 are caused to communicate by means of the communicating section 9 (see Fig. 4(b)).
  • the solution S sealed in the storage chamber 2 is injected through the communicating section 9 into the vial 10 by holding the storage chamber 2 above the vial 10, whereby the powdered antibiotic A in the vial 10 is dissolved.
  • the resulting solution of the powdered antibiotic A is returned to the storage chamber 2 by holding the vial 10 above the storage chamber 2. By repeating such operation, the powdered antibiotic A in the vial 10 is fully dissolved (see Fig. 4(c)).
  • the medicine storage container 1 is hung on the hanger 14 of the transfusion stand 13 in a manner such that the hanger 14 is passed through the hole la of the medicine storage container 1 (see Fig. 4(d)).
  • the medicine storage container 1 is hung on the hanger 14 so that the storage chamber 2, which contains the solution of the powdered antibiotic A, is on the bottom side.
  • a transfusion set 15 comprises a bottle needle 16 piercing the discharge port 5, a drip cylinder 17, a clamp 18, an intravenous needle 19 to be stuck into a vein or the like of a patient M, and a tube 20 connecting these elements.
  • the intravenous needle 19 of the transfusion set 15 is stuck into the vein or the like of the patient M, the bottle needle 16 is run through the discharge port 5 after removing the aluminum cap 6 fitted on the discharge port 5, and the clamp 18 is adjusted so that the solution of the powdered antibiotic A in the storage chamber 2 of the medicine storage container 1 can be administered to the patient M by an intravenous drip.
  • the package 4 (Fig. 1) may be removed after the antibiotic A is dissolved in the solution S by the aforementioned piercing operation and before the setting on the transfusion stand 13.
  • Fig. 5 shows another embodiment of the present invention. Since this embodiment is constructed substantially in the same manner as the embodiment shown in Fig. 2, like reference numerals are used to designate the same portions, and a description of those portions is omitted.
  • the medicine storage container 1 comprises the storage chamber 2 and the housing chamber 3 which are integrally formed of the flexible synthetic resin sheet and are independent of each other. In the present embodiment, however, the storage chamber 2 and a housing chamber 30 are formed separately.
  • the housing chamber 30 is in the form of a cylinder having a bellows-like portion 30a formed on the outer peripheral surface thereof.
  • a hanging ring 21 is attached to an end face of the housing chamber 30.
  • Other arrangements and functions of this embodiment are the same as those of the embodiment shown in Fig. 2, so that a description thereof is omitted.
  • the bellows-like portion 30a serves to secure the axial plastic deformation of the guide cover 12 and the piercing state of the piercing element 8.
  • the piercing section and the piercing element may be disposed on the storage-chamber side and on the solute-vessel side, respectively, in contrast with the arrangement of the storage chamber 2 and the solute vessel 10 disclosed in connection with the embodiments described above.
  • various modifications may be effected in the present invention without departing from the spirit thereof, and the invention is not limited to the arrangements of the embodiments.
  • the separate storage container according to the present invention is suitably used as a drip bag adapted to be connected to a transfusion set, whereby a medicine is administered to a patient by an intravenous drip.
  • the separate storage container of the invention may be also widely utilized in other fields where powdered or liquid solutes, as well as medicines, must be sterilely dissolved in solvents.
  • the present invention may be applied to any other fields than the medical field in which medicines and the like are handled.
  • the medicine storage container is disclosed as an example of the separate storage container of the present invention, in connection with the embodiments, the range of application of the invention is not limited to the field associated with "medicines" in a narrow sense.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP88908369A 1987-09-28 1988-09-27 Behälter für getrennte lagerung Expired - Lifetime EP0395758B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP243080/87 1987-09-28
JP24308087A JPS6485653A (en) 1987-09-28 1987-09-28 Drug receiving container
PCT/JP1988/000980 WO1989002730A1 (en) 1987-09-28 1988-09-27 Separate storage container

Publications (3)

Publication Number Publication Date
EP0395758A1 true EP0395758A1 (de) 1990-11-07
EP0395758A4 EP0395758A4 (en) 1990-12-27
EP0395758B1 EP0395758B1 (de) 1994-07-20

Family

ID=17098480

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88908369A Expired - Lifetime EP0395758B1 (de) 1987-09-28 1988-09-27 Behälter für getrennte lagerung

Country Status (4)

Country Link
EP (1) EP0395758B1 (de)
JP (1) JPS6485653A (de)
DE (1) DE3850781T2 (de)
WO (1) WO1989002730A1 (de)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002724A1 (en) * 1991-07-30 1993-02-18 Baxter International Inc. Needleless vial access device
EP0536841A1 (de) * 1991-10-07 1993-04-14 INGE S.p.A. Mischbehälter mit Irrigator für einmalige Verwendung
EP0538891A1 (de) * 1991-10-25 1993-04-28 Fujisawa Pharmaceutical Co., Ltd. Infusionsbehälter
EP0554988A1 (de) * 1992-02-04 1993-08-11 Material Engineering Technology Laboratory, Inc. Vorrichtung zum Vermischen
DE4314090A1 (de) * 1993-04-29 1994-11-03 Wolfgang Dr Vilmar Medizinisches Besteck zur Herstellung einer Medikamentenlösung
GB2327409A (en) * 1997-07-16 1999-01-27 Inibsa Lab A cartridge
US5976115A (en) * 1997-10-09 1999-11-02 B. Braun Medical, Inc. Blunt cannula spike adapter assembly
WO2005030111A1 (en) 2003-09-30 2005-04-07 Coloplast A/S A wound care device
US7520919B2 (en) 2004-06-22 2009-04-21 Gambro Lundia Ab Transducer-protector device for medical apparatus
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
WO2013020989A1 (en) 2011-08-11 2013-02-14 Fresenius Medical Care Deutschland Gmbh Container for dialysis
US20150005734A1 (en) * 2011-12-29 2015-01-01 Otsuka Pharmaceutical Factory, Inc. Exposure prevention cover, exposure prevention cover module provided with same, drug solution supply system, and drug solution supply method
EP2962676A1 (de) 2014-07-02 2016-01-06 Paolo Gobbi Frattini S.r.l. Flexible verpackung mit abgedichteter steriler kammer zur rekonstitution und verabreichung von flüssigen, in den körper eines patienten einflössbaren medizinischen substanzen oder nährstoffsubstanzen
US9527627B2 (en) 2011-05-18 2016-12-27 Fresenius Medical Care Deutschland Gmbh Connector for dialysis container, container equipped with such connector, manufacturing and filling method for such connectors and containers
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US9999703B2 (en) 2012-06-12 2018-06-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
EP3427781A3 (de) * 2017-07-11 2019-05-01 Pharma Resources GmbH Arzneimittel und vorrichtungssystem für druckbeaufschlagte aerosoltherapien in einem säugetierhohlraum
EP3355847A4 (de) * 2015-09-29 2019-07-03 Siemens Medical Solutions USA, Inc. Aseptisches zusammensetzen von pharmazeutischen behältern
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN112020345A (zh) * 2018-04-13 2020-12-01 费森尤斯卡比股份公司 提供用于肠外营养物的制剂的设备和方法
CN112020344A (zh) * 2018-04-13 2020-12-01 费森尤斯卡比股份公司 用于混合系统的容器、用于肠外营养物的混合系统以及混合方法
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3834566A1 (de) * 1988-10-11 1990-04-12 Fresenius Ag Behaelter zur sterilen, getrennten aufbewahrung mindestens zweier substanzen und zur vermischung derselben
JPH077965Y2 (ja) * 1990-11-14 1995-03-01 昭和電工株式会社 輸液バッグ
US5776125A (en) 1991-07-30 1998-07-07 Baxter International Inc. Needleless vial access device
JP3146465B2 (ja) * 1992-03-13 2001-03-19 株式会社ニッショー 薬液注入装置
JP3256583B2 (ja) * 1992-12-10 2002-02-12 株式会社リコー 電子写真用トナー及びその製法
US5547797A (en) * 1993-08-05 1996-08-20 Minolta Co., Ltd. Developer for developing electrostatic latent images
US6071270A (en) 1997-12-04 2000-06-06 Baxter International Inc. Sliding reconstitution device with seal
AR021220A1 (es) 1998-09-15 2002-07-03 Baxter Int DISPOSITIVO DE CONEXIoN PARA ESTABLECER UNA COMUNICACIoN FLUíDA ENTRE UN PRIMER RECIPIENTE Y UN SEGUNDO RECIPIENTE.
DE10005813A1 (de) * 2000-02-10 2001-08-23 Wolfgang Vilmar Mischbesteck
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
ATE448808T1 (de) * 2001-12-21 2009-12-15 Ferrosan As Hämostatische garnitur, verfahren zum zubereiten eines hämostatischen mittels und verfahren zur blutstillung
CA2509914A1 (en) 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
US7048724B2 (en) * 2002-12-17 2006-05-23 Denver Biomedicals, Inc. Device for withdrawing body fluids
JP2007519450A (ja) 2004-01-30 2007-07-19 フェロサン アー／エス 止血用のスプレーおよび組成物
DE102004021990B3 (de) * 2004-05-04 2005-11-10 Fresenius Kabi Deutschland Gmbh Medizinischer Behälter zum Verabreichen einer Flüssigkeit aus einer Trägerlösung und einem zugemischten Medikament
CN101001649B (zh) 2004-07-09 2011-08-31 弗罗桑医疗设备公司 包括透明质酸的止血组合物及其制备方法
WO2007136791A2 (en) 2006-05-18 2007-11-29 Maej, Llc Delivery device with separate chambers connectable in fluid communication when ready for use, and related method
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
JP7003493B2 (ja) * 2017-08-28 2022-02-04 ニプロ株式会社 透析液分析用標準試薬キット
WO2018043492A1 (ja) * 2016-08-30 2018-03-08 ニプロ株式会社 透析液分析用標準試薬キットならびに標準試薬用、透析液用および人工腎臓用補液用の水溶液
JP6642339B2 (ja) * 2016-08-30 2020-02-05 ニプロ株式会社 透析液分析用標準試薬キット

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4589879A (en) * 1983-11-04 1986-05-20 Baxter Travenol Laboratories, Inc. Cannula assembly having closed, pressure-removable piercing tip

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS561559Y2 (de) * 1976-08-12 1981-01-14
CA1171030A (en) * 1979-11-05 1984-07-17 David Bellamy Fluid transfer assembly
JPS61260772A (ja) * 1985-05-14 1986-11-18 Mitsubishi Electric Corp 画像欠陥補償装置
JPH0614708Y2 (ja) * 1989-10-17 1994-04-20 ホシザキ電機株式会社 飲料の保温・保冷装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4589879A (en) * 1983-11-04 1986-05-20 Baxter Travenol Laboratories, Inc. Cannula assembly having closed, pressure-removable piercing tip

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8902730A1 *

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411499A (en) * 1988-01-25 1995-05-02 Baxter International Inc. Needleless vial access device
WO1993002724A1 (en) * 1991-07-30 1993-02-18 Baxter International Inc. Needleless vial access device
EP0536841A1 (de) * 1991-10-07 1993-04-14 INGE S.p.A. Mischbehälter mit Irrigator für einmalige Verwendung
US5383579A (en) * 1991-10-07 1995-01-24 Inge, S.P.A. Container for containing two flowable materials in separated compartments, but permitting the two materials to be mixed for dispensing, before the container is opened
EP0538891A1 (de) * 1991-10-25 1993-04-28 Fujisawa Pharmaceutical Co., Ltd. Infusionsbehälter
US5352191A (en) * 1991-10-25 1994-10-04 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
EP0554988A1 (de) * 1992-02-04 1993-08-11 Material Engineering Technology Laboratory, Inc. Vorrichtung zum Vermischen
US5380315A (en) * 1992-02-04 1995-01-10 Material Engineering Technology Laboratory Incorporated Mixing apparatus
DE4314090A1 (de) * 1993-04-29 1994-11-03 Wolfgang Dr Vilmar Medizinisches Besteck zur Herstellung einer Medikamentenlösung
GB2327409B (en) * 1997-07-16 1999-09-15 Inibsa Lab A cartridge
GB2327409A (en) * 1997-07-16 1999-01-27 Inibsa Lab A cartridge
US5976115A (en) * 1997-10-09 1999-11-02 B. Braun Medical, Inc. Blunt cannula spike adapter assembly
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
WO2005030111A1 (en) 2003-09-30 2005-04-07 Coloplast A/S A wound care device
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
US7520919B2 (en) 2004-06-22 2009-04-21 Gambro Lundia Ab Transducer-protector device for medical apparatus
US9527627B2 (en) 2011-05-18 2016-12-27 Fresenius Medical Care Deutschland Gmbh Connector for dialysis container, container equipped with such connector, manufacturing and filling method for such connectors and containers
US10022299B2 (en) 2011-08-11 2018-07-17 Fresenius Medical Care Deutschland Gmbh Container for dialysis
WO2013020989A1 (en) 2011-08-11 2013-02-14 Fresenius Medical Care Deutschland Gmbh Container for dialysis
US20150005734A1 (en) * 2011-12-29 2015-01-01 Otsuka Pharmaceutical Factory, Inc. Exposure prevention cover, exposure prevention cover module provided with same, drug solution supply system, and drug solution supply method
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US10799611B2 (en) 2012-06-12 2020-10-13 Ferrosan Medical Devices A/S Dry haemostatic composition
US9999703B2 (en) 2012-06-12 2018-06-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US10595837B2 (en) 2013-06-21 2020-03-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US11103616B2 (en) 2013-12-11 2021-08-31 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
EP2962676A1 (de) 2014-07-02 2016-01-06 Paolo Gobbi Frattini S.r.l. Flexible verpackung mit abgedichteter steriler kammer zur rekonstitution und verabreichung von flüssigen, in den körper eines patienten einflössbaren medizinischen substanzen oder nährstoffsubstanzen
US10010481B2 (en) 2014-07-02 2018-07-03 Paolo Gobbi Frattini S.R.L. Flexible package with a sealed sterile chamber for the reconsitution and administration of fluid medicinal or nutritional substances instillable into the body of a patient
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
EP3355847A4 (de) * 2015-09-29 2019-07-03 Siemens Medical Solutions USA, Inc. Aseptisches zusammensetzen von pharmazeutischen behältern
EP3427781A3 (de) * 2017-07-11 2019-05-01 Pharma Resources GmbH Arzneimittel und vorrichtungssystem für druckbeaufschlagte aerosoltherapien in einem säugetierhohlraum
CN112020345A (zh) * 2018-04-13 2020-12-01 费森尤斯卡比股份公司 提供用于肠外营养物的制剂的设备和方法
CN112020344A (zh) * 2018-04-13 2020-12-01 费森尤斯卡比股份公司 用于混合系统的容器、用于肠外营养物的混合系统以及混合方法
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Also Published As

Publication number Publication date
EP0395758B1 (de) 1994-07-20
DE3850781D1 (de) 1994-08-25
JPH0236261B2 (de) 1990-08-16
DE3850781T2 (de) 1995-02-23
EP0395758A4 (en) 1990-12-27
JPS6485653A (en) 1989-03-30
WO1989002730A1 (en) 1989-04-06

Similar Documents

Publication Publication Date Title
EP0395758B1 (de) Behälter für getrennte lagerung
EP0340880B1 (de) Spritze
EP1323446B1 (de) Spritzenartiger Behälter für ein flüssiges Medikament
EP0282545B1 (de) Verbinder sowie seine verwendung in einer wegwerfeinheit
JP2988661B2 (ja) バイアル及びアンプルからの流体にアクセスする流体移送装置及びその装置を使用して流体を移送する方法
JP4216466B2 (ja) 流体移転アセンブリ
US5454805A (en) Medicine vial link for needleless syringes
US4861335A (en) Syringe
US4838875A (en) Method and apparatus for dealing with intravenous fluids
US4568346A (en) Hypodermic syringe having a telescopic assembly between cartridge and medicament holder
US4336802A (en) Parenteral solution container for aseptic mixing
US5718690A (en) Hypodermic injector system and method for maintaining the sterility thereof prior to use
US20010000347A1 (en) Container closure system
WO1986005683A1 (en) Transfer device
AU7796400A (en) Device for reconstituting a therapeutic solution, suspension or dispersion
JPH06239352A (ja) 溶解液注入セット
WO2000063088A1 (fr) Couvercle pour recipient et adaptateur pour communication liquide
CN112105328B (zh) 用于将医用注射设备连接到容器的连接器
JPS6072561A (ja) 静脈表示能を有する２医薬成分注射器
AU771466B2 (en) Membrane port for a container
US3938518A (en) Syringe attachment device
EP0820779B1 (de) Vorrichtung zum Befüllen und zum Verabreichen des Inhalts von Spritzen
KR19980079298A (ko) 시린지 충전 및 운반 장치
US20220081147A1 (en) System and Method for Containing and Dispensing Fluids
JP4158446B2 (ja) 既充填蛇腹容器

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19900327

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE DE FR GB IT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19901107

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE DE FR GB IT SE

ITCL It: translation for ep claims filed

Representative=s name: FUMERO BREVETTI S.N.C.

EL Fr: translation of claims filed
DET De: translation of patent claims
17Q First examination report despatched

Effective date: 19920619

RBV Designated contracting states (corrected)

Designated state(s): DE FR IT

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE FR IT

REF Corresponds to:

Ref document number: 3850781

Country of ref document: DE

Date of ref document: 19940825

ITF It: translation for a ep patent filed

Owner name: FUMERO BREVETTI S.N.C.

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20050823

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20050922

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20060930

Year of fee payment: 19

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070403

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20070531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20061002

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070927