EP0332914B1 - Moyen pour l'ouverture d'ampoules - Google Patents

Moyen pour l'ouverture d'ampoules Download PDF

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Publication number
EP0332914B1
EP0332914B1 EP89103415A EP89103415A EP0332914B1 EP 0332914 B1 EP0332914 B1 EP 0332914B1 EP 89103415 A EP89103415 A EP 89103415A EP 89103415 A EP89103415 A EP 89103415A EP 0332914 B1 EP0332914 B1 EP 0332914B1
Authority
EP
European Patent Office
Prior art keywords
ampoule
membrane
sleeve
opening
ampoules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP89103415A
Other languages
German (de)
English (en)
Other versions
EP0332914A1 (fr
Inventor
Gerhard Dr. Wieland
Klaus Steckenreuter
Wolfgang Gernand
Helmut Simgen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP0332914A1 publication Critical patent/EP0332914A1/fr
Application granted granted Critical
Publication of EP0332914B1 publication Critical patent/EP0332914B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
    • B65D51/228—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being removed from the container after the opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/569—Glassware
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0015—Upper closure of the 41-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/0093—Membrane
    • B65D2251/0096—Membrane integral with the container
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/902—Vent

Definitions

  • the invention relates to opening aids for ampoules, which ensure a safe and safe opening of the ampoules and at the same time a quick, loss-free transfer of the entire ampoule contents into a vessel, e.g. a volumetric flask or a beaker.
  • a vessel e.g. a volumetric flask or a beaker.
  • the ampoules to be opened are primarily plastic ampoules with concentrated solutions for the production of standard, standard and buffer solutions.
  • the most well-known opening aids for these ampoules are glass rods.
  • the glass rod In the sense of the device safety law, the glass rod is a device that carries dangers. When using the up to 30 cm long glass rods, they can break through for different reasons and the pressing hand gets into the splintered glass stump.
  • plastic-coated glass rods have a number of disadvantages: the runoff behavior of water and aqueous solutions is unfavorable; the casing can peel off at the glass / plastic transition point; these glass rods are disproportionately expensive.
  • plastic and metal rods cannot be used against the cleaning agents used in the dimensional analysis (ethanolic potassium hydroxide solution or chromosulfuric acid) for repeated use.
  • the metal rod is also unusable for work in the field of trace analysis of metals because it contaminates the standard solutions.
  • Another opening aid for ampoules on the market is a plastic knife.
  • this aid also has disadvantages: loss of the ampoule content because the knife cannot be rinsed off; Loss of the ampoule contents when the ampoule opened on one side is turned over; if you put the volumetric flask on the ampoule before turning it around and turn both of them together, there is a risk that the volumetric flask will break during this cumbersome operation; If the opening at the end of the ampoule is too small, the contents run out very slowly and there are difficulties when rinsing the ampoule.
  • DE-OS 35 31 071 describes an opening aid for ampoules sealed with plastic membranes, but this embodiment has a number of disadvantages: To open the ampoule, the membrane must be pressed in from the outside. Since the membrane cannot be completely removed in this way, a dead volume is created behind the pressed-in membrane, in which liquid collects that cannot be completely rinsed out; quantitative rinsing is therefore not guaranteed. The liquid must also flow out through an inner tube, the diameter of which must naturally be smaller than the ampoule neck itself. A dead volume is created between the two tubes, which makes quantitative rinsing impossible. A welding of the Cutting with the membrane, as proposed in DE-OS 35 31 071, likewise does not represent a satisfactory solution to the problem. Holes are formed in the membranes in a high proportion of the ampoules. The opening to be reached by the spot welding of the cutting edge is also very small, so that a rapid outflow is impossible.
  • the present invention has for its object to provide opening aids that allow rapid and quantitative emptying of the ampoule contents with little subsequent rinsing and with which the disadvantages described above do not occur.
  • the invention relates to opening aids for ampules sealed with plastic membranes in the form of a funnel-shaped sleeve, which are characterized in that the sleeve contains a membrane welded to the plastic membrane. This membrane is located at the lower end of the sleeve. It is connected to the sleeve via at least two webs. Opening aid and ampoule are designed so that a rotary movement is converted into an axial movement via a thread.
  • FIG. 1 shows a preferred embodiment of the ampoule with the opening aid according to the invention.
  • Figure 2 shows the lower part of the ampoule in the open state, the webs (5) and the thread (6) can be seen.
  • FIG. 3 shows a top view of the upper funnel-shaped sleeve (7), which carries an upward-pointing mandrel (7c) which is held over at least two webs (7a, 7b) in such a way that liquid can flow through the spaces (7d).
  • the actual ampoule-like liquid container (2) is preferably cylindrical. He carries in the lower part a device suitable for guiding the lower sleeve, preferably a thread or a bolt.
  • the ampoule has ampoule necks on the top and underside, the diameter of which is smaller than that of the ampoule body itself, in particular the neck located at the outlet point of the ampoule has such a diameter that the contents of the ampoule can also be emptied into a measuring flask with normal ground joint NS 14/23 can.
  • the ampoule necks are sealed with plastic membranes that have to be destroyed to empty the container.
  • the funnel-shaped sleeve (3) has a device adapted to the guide element on the ampoule, for example a counter thread or a guide groove, and carries a membrane (4) held on the lower funnel neck by at least 2, preferably 3, webs.
  • the sleeve (3) is welded to this membrane over the surface (4) with the ampoule (2), preferably with the formation of an annular predetermined breaking point.
  • All parts of the ampoule and the opening aids according to the invention consist of plastics such as polyethylene, polypropylene, polyvinylidene difluoride or methylpentene polymers.
  • the dimensions can be chosen according to the desired amount of liquid.
  • a 100 cc ampoule is e.g. including the tubular lugs about 160-200 mm long and about 25-35 mm in diameter.
  • the ampoule body (2) and the funnel-shaped lower sleeve (3) are coupled via the thread (6).
  • an axially directed force acts on the weld, which causes the membrane to tear.
  • a circular hole (8) is created, the diameter of which corresponds practically to the diameter of the ampoule neck.
  • the contents of the ampoule can be emptied into the container, generally into a volumetric flask, through the openings (9) of the sleeve (3).
  • the upper membrane is opened by pressing in by means of the mandrel (7c) located in the sleeve (7).
  • the funnel is removed and turned over. After opening the membrane, the funnel is returned to its original position.
  • the ampoule can be rinsed or rinsed through the openings (7d) of the funnel.
  • the opening aid according to the invention ensures safe opening of the ampoule and rapid, complete and loss-free transfer of the ampoule contents into a volumetric flask or into a beaker. To open the ampoule, no further aids, which may be dangerous or impair the contents of the ampoule, are required.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Devices For Opening Bottles Or Cans (AREA)

Claims (4)

1. Auxiliaire d'ouverture pour ampoules (2) avec des membranes en matière synthétique (1), configuré en forme de douille (3) en entonnoir, caractérisé en ce que la douille comprend une membrane (4) soudée avec une membrane en matière synthétique (1).
2. Auxiliaire d'ouverture selon la revendication 1, caractérisé en ce que la membrane (4) se trouve à l'extrémité inférieure de la douille (3).
3. Auxiliaire d'ouverture selon les revendications 1 et 2, caractérisé en ce que la membrane (4) est reliée à la douille (3) par au moins 2 nervures (5).
4. Auxiliaire d'ouverture selon les revendications 1 à 3, caractérisé en ce que l'auxiliaire d'ouverture et l'ampoule (2) présentent une configuration telle qu'un mouvement de rotation est transformé en un mouvement axial par un filet (6).
EP89103415A 1988-03-12 1989-02-27 Moyen pour l'ouverture d'ampoules Expired - Lifetime EP0332914B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3808308 1988-03-12
DE3808308A DE3808308A1 (de) 1988-03-12 1988-03-12 Oeffnungshilfe fuer ampullen

Publications (2)

Publication Number Publication Date
EP0332914A1 EP0332914A1 (fr) 1989-09-20
EP0332914B1 true EP0332914B1 (fr) 1992-03-04

Family

ID=6349583

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89103415A Expired - Lifetime EP0332914B1 (fr) 1988-03-12 1989-02-27 Moyen pour l'ouverture d'ampoules

Country Status (8)

Country Link
US (1) US4964521A (fr)
EP (1) EP0332914B1 (fr)
JP (1) JPH0271743A (fr)
CZ (1) CZ278215B6 (fr)
DE (2) DE3808308A1 (fr)
IL (1) IL89566A (fr)
SK (1) SK277749B6 (fr)
ZA (1) ZA891856B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT220069Z2 (it) * 1990-07-27 1993-06-09 Erba Carlo Spa "fiala per reagenti chimici"
CA2027690A1 (fr) * 1990-10-18 1992-04-19 Christian Laing Ampoule en plastique
FR2687066A1 (fr) * 1992-02-06 1993-08-13 Oreal Ampoule autocassable.
DE4204554C1 (fr) * 1992-02-15 1993-07-15 Riedel - De Haen Ag, 3016 Seelze, De
IT232769Y1 (it) * 1994-02-23 2000-01-19 Erba Carlo Reagenti Srl Fiala per reagenti chimici
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US7100600B2 (en) 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
EP1471960B1 (fr) 2002-01-07 2019-03-13 Novartis AG Dispositifs pour la nebulisation de fluides d'inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
EP1474196B1 (fr) * 2002-01-15 2016-08-17 Novartis AG Procedes et systemes de fonctionnement d'un generateur d'aerosol
AU2003256253A1 (en) 2002-05-20 2003-12-02 Aerogen, Inc. Aerosol for medical treatment and methods
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
CN101208123B (zh) 2005-05-25 2012-09-19 亚罗擎公司 振动系统和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331798A2 (fr) * 1988-03-11 1989-09-13 International Paper Company Goulotte auto-ouvrante et fermeture à vis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB601606A (en) * 1944-04-15 1948-05-10 Rupolph Adler Improvements relating to methods of packaging liquid chemical substances
FR1174993A (fr) * 1958-05-27 1959-03-18 Ampoule de verre pour produits pharmaceutiques ou autres produits similaires
US3784045A (en) * 1971-10-26 1974-01-08 Automatic Liquid Packaging Permanently sealed containers and end caps therefor
FR2209292A5 (en) * 1972-12-06 1974-06-28 Pichot Georges Opening and emptying cap for sealed ampoules - contg. liqs and granules, including circular rotatable barrel as breaking component
US3858739A (en) * 1973-03-05 1975-01-07 Barnes Hind Diagnostics Inc Breakaway neck container with integral cap
DE2653993C3 (de) * 1976-11-27 1980-05-14 Stella-Kg Werner Deussen, 6229 Walluf Behälter mit abbrechbarem Verschluß
MX150148A (es) * 1979-01-12 1984-03-20 Marcelo Chiquiar Arias Mejoras a envase profilactico para soluciones medicinales
GB8505237D0 (en) * 1985-02-28 1985-04-03 Schering Chemicals Ltd Bottles
DE3531071A1 (de) * 1985-08-30 1987-03-05 Merck Patent Gmbh Oeffnungshilfe fuer ampullen
US4747501A (en) * 1987-07-08 1988-05-31 National Plastics Limited Container closure method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331798A2 (fr) * 1988-03-11 1989-09-13 International Paper Company Goulotte auto-ouvrante et fermeture à vis

Also Published As

Publication number Publication date
IL89566A (en) 1995-03-30
IL89566A0 (en) 1989-09-10
EP0332914A1 (fr) 1989-09-20
US4964521A (en) 1990-10-23
DE3808308A1 (de) 1989-09-21
SK277749B6 (en) 1994-12-07
CZ278215B6 (en) 1993-10-13
DE58900884D1 (de) 1992-04-09
ZA891856B (en) 1989-11-29
JPH0271743A (ja) 1990-03-12

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