EP0261446B2 - Mehrlumige Schlauchanordnung sowie Verfahren zu ihrer Herstellung - Google Patents

Mehrlumige Schlauchanordnung sowie Verfahren zu ihrer Herstellung Download PDF

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Publication number
EP0261446B2
EP0261446B2 EP87112616A EP87112616A EP0261446B2 EP 0261446 B2 EP0261446 B2 EP 0261446B2 EP 87112616 A EP87112616 A EP 87112616A EP 87112616 A EP87112616 A EP 87112616A EP 0261446 B2 EP0261446 B2 EP 0261446B2
Authority
EP
European Patent Office
Prior art keywords
hose
individual hoses
hose arrangement
hoses
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP87112616A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0261446A3 (en
EP0261446B1 (de
EP0261446A2 (de
Inventor
Hans-Jürgen Dr. Dipl.-Phys. Neumann
Wolfram Dipl.-Ing. Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius SE and Co KGaA
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6310120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0261446(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Publication of EP0261446A2 publication Critical patent/EP0261446A2/de
Publication of EP0261446A3 publication Critical patent/EP0261446A3/de
Publication of EP0261446B1 publication Critical patent/EP0261446B1/de
Application granted granted Critical
Publication of EP0261446B2 publication Critical patent/EP0261446B2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y10T29/49881—Assembling or joining of separate helix [e.g., screw thread]

Definitions

  • the invention relates to a multi-lumen tube arrangement for use in a centrifuge free of mechanical seals, comprising a plurality of individual tubes of approximately the same length, which are rotated around the longitudinal axis of the tube arrangement at least in some areas and arranged in a fixed position, and a method for their production.
  • Centrifuges without sliding seals are known, for example, from DE-A-21 14 161 and DE-A-26 12 988.
  • a hose arrangement extends from a stationary point around the separation container to the other side of the separation container, which is set in rotation by a drive unit.
  • the hose is connected to the drive unit, which rotates at half the angular velocity in relation to the separation container. Because of the connection to the drive unit, the hose is continuously rotated around the separation container and, due to the special different drive speeds, is twisted between the drive unit and the separation container. In this respect, twisting or even tearing of the hose is effectively prevented.
  • FIGS. 5, 8 and 9 a multi-lumen tube is used in the centrifuge, which has several liquid channels in a single tube.
  • such a multi-lumen tube has several disadvantages, among others: the relatively complex production and thus a price disadvantage compared to conventional hoses. Since the multi-lumen tube has several channels, it has a relatively large diameter and is therefore already relatively stiff, so that a material must be used which has a relatively low Shore hardness. For this purpose, soft PVC is used, which due to its relatively soft properties is stretched when centrifuged in the centrifuge mentioned above. As a result, the known multi-lumen tube is limited to a speed of at most 1600 rpm, since otherwise the errors in the tube routing become too large. Furthermore, such a soft material tends to deform the individual channels when spinning in the centrifuge, which can lead to a partial closure or slight blockage of these channels.
  • the multi-lumen tube is continuously untwisted when it is carried along by the drive unit.
  • the radially further outside of the tube comes to lie on the inside after half a turn in the centrifuge due to the untwisting treatment, while on the other hand the inside comes to lie on the outside.
  • the hose itself is radially curved, it always undergoes a flexing treatment during this untwisting treatment, since the hose is continuously elongated on the outside and compressed on the inside.
  • the energies occurring here are relatively large and lead to an increase in the temperature of the hose. In this respect, this energy must be dissipated either through the centrifugation material or through guide tubes.
  • Such guide hoses include also necessary because of the soft properties of the attached tube and lead to the disadvantage that closed centrifugation systems, for example a separation chamber with attached tubes and supply bags, cannot be inserted into the centrifuge, or only with great difficulty, since either the separation container or the rest of the tube system must thread through the guide device.
  • a further hose arrangement is known from WO 82/01321, in which individual hose regions are reinforced in terms of material in order to be more resistant to flexing and bending stress.
  • US Pat. No. 4,082,217 discloses a multi-lumen hose arrangement in which a number of hoses are intertwined or twisted. This publication does not give any indication of how the arrangement should be more resistant to flexing and bending due to the interweaving.
  • the invention has for its object to develop the above-mentioned hose arrangement so that the stress caused by flexing or bending during centrifugation is kept as low as possible.
  • the individual tubes are arranged torsionally about their own tube longitudinal axis, are each fixed in two areas and are freely movable in the area in between, and in that one end is n + 1/2 opposite the other end Rotations, where n is zero or an integer, are rotated.
  • a method of manufacture is set out in claim 11.
  • the multi-lumen hose arrangement consists of a plurality of individual hoses which are combined to form the hose arrangement according to the invention. This eliminates the complicated manufacture of a one-piece multi-lumen arrangement, so that the hose arrangement according to the invention is generally much cheaper to produce.
  • the individual hoses are either rotated around the longitudinal axis of the hose arrangement or to a parallel axis to this longitudinal axis.
  • This rotated arrangement improves the stability of the hoses with one another, so that the individual hoses cannot be fanned out and thus mutual interference in the movement cannot occur, which could otherwise quickly lead to twisting and tearing.
  • the individual hoses are fixed to one another at their ends in this tortuous state without tension. This has the consequence that the individual tube is not twisted about its own longitudinal axis in the rotated state, so that the entire arrangement remains in the rotated state after being fixed. In this respect, there is therefore no risk that the hoses will return to their untwisted initial state.
  • the hoses are of substantially the same length.
  • all hoses are rotated, at least in partial areas, to approximately equal proportions about the longitudinal axis of the hose arrangement or else to a parallel axis thereto.
  • one tube serves as an auxiliary carrier for the other tubes, which absorbs all the forces during the centrifugation treatment.
  • Such a disadvantageous arrangement is shown, for example, in the aforementioned DE-A-21 14 161, in which the auxiliary carrier is used for stabilization and for power transmission.
  • the auxiliary carrier is used for stabilization and for power transmission.
  • the hoses used according to the invention consist of a polymeric material, in particular polyamide, polyethylene, polypropylene, polyurethane or PVC, which should be used in particular for medical purposes. Of these materials, polyamide is preferred.
  • this material should be relatively rigid, the Shore hardness R should be between 60 and 80, in particular approximately R 70, i. H. the hoses should be semi-rigid to almost rigid.
  • the individual hoses can have an inner diameter of approximately 2 mm and an outer diameter of approximately 3.2 mm.
  • the individual hoses used according to the invention are notable for high strength, for. B. against elongation, kinking or twisting. Furthermore, the inner diameter of the individual hoses can be kept substantially constant over the entire length of the hose, so that there is no risk of clogging.
  • the hose arrangement according to the invention usually has 2-5 individual hoses, preferably 3 or 4 individual hoses.
  • these individual hoses are rotated at least in partial areas around the longitudinal axis of the hose arrangement or around a parallel axis, so that a bundle twisted in itself is produced.
  • the twisting takes place according to the usual methods of stranding, coiling, twisting or braiding.
  • the individual tubes are stranded in the following way:
  • the one ends of the individual hoses are fixed in a first adapter, for example by gluing or jamming.
  • the other ends of the loose individual hoses are inserted into a second adapter, which has corresponding receiving bores (fitting holes) for the respective hose end.
  • These hose ends are each freely movable about their hose axis in the fitting hole, d. H. the diameter of a fitting hole is slightly larger than the outside diameter of the hose.
  • the second adapter is rotated about the longitudinal axis of the tube arrangement while the first adapter is held in place.
  • the rotation of the second adapter relative to the first adapter (n + 1/2) times, where n represents zero or an integer.
  • the second adapter is either with a half, one and a half times ... rotation compared to the first adapter.
  • a 3.5-fold twisting of the individual tubes is particularly preferred.
  • the individual hoses themselves can remain stationary in this rotation due to their loose fit within the receiving bores. H. the individual hoses do not make any rotation about their own longitudinal axis, thus turning in opposite directions within the receiving bores during this turning treatment.
  • the individual hoses are firmly connected to the second adapter, for example by an adhesive treatment. After connecting, the individual tubes remain in the rotated arrangement.
  • the individual hoses can of course be clamped in corresponding device parts, which are then rotated against each other.
  • hoses can then be glued directly to each other at their ends, without the use of adapters.
  • first ends of the tubes can also be connected to the inlet and outlet ports of the separation chamber to be used in the centrifuge, the other ends then being able to be rotated in relation to these fixed ends in the manner described above.
  • the untwisting treatment of the individual tubes in the receiving bores can be promoted in the following way: The loose second adapter is pushed in the direction of the fixed adapter before or after twisting, the twisting treatment is carried out if necessary, and the second adapter is then moved back to the second ends. If necessary, this displacement treatment can be carried out several times in order to further promote untwisting of the individual tubes.
  • the hose arrangement according to the invention is shown at 10 in FIG. 1.
  • This hose arrangement consists of two individual tubes 12 and 14, which are shown in the unscrewed state according to the embodiment shown in Fig. 1a. These individual tubes each have a first end 16 and 18 and a second end 20 and 22.
  • the individual tubes consist of a polymeric material in the dimensions and Shore hardness degrees mentioned above.
  • ends are spoken of according to the invention, those tube ends are meant from which the tube regions which participate in the centrifugation treatment extend.
  • the second ends end on the one hand when the hose arrangement emerges from the centrifuge and on the other hand when the hose is returned to the central axis of the centrifuge, from which the individual hoses are closed extend the separation containers.
  • first ends 16 and 18 split, since here the hose arrangement is returned to the axis of rotation of the centrifuge and there is no longer any need to subject the hose arrangement 10 to a twisting treatment.
  • the tube areas are arranged between the first ends 16 and 18 and the second ends 20 and 22, which have to be subjected to the untwisting treatment in the centrifuge which is free of sliding seals.
  • the first ends 16 and 18 are fixed in a first holding piece 24 which has corresponding bores 26 for receiving the individual hoses 12 and 14.
  • the hoses 12 and 14 are glued into the bores 26, for example by thermal or solvent welding.
  • the second ends 20 and 22 are located in a second holding piece 30, which has corresponding bores 32 and 34 for receiving the tubes 12 and 14. These holes 32 and 34 are shown in broken lines in Fig. 1a.
  • the diameter of the bores 32 and 34 is somewhat larger than the outside diameter of the hoses 12 and 14, so that the hoses 12 and 14 can move and twist freely therein.
  • FIG. 1b the embodiment shown in FIG. 1a is now shown stranded along the longitudinal axis of the hose arrangement 10.
  • the second holding piece is rotated counterclockwise, while the first holding piece is prevented from rotating by holding. Since the Hoses 12 and 14 can freely rotate in the bores 32 and 34, only the hoses make the rotation about the common longitudinal axis, but do not twist themselves about their own axis.
  • the hose length between the two holding pieces 24 and 30 remains the same for both individual hoses 12 and 14.
  • the second holding piece 30 is advanced along the common longitudinal axis to the first holding piece 24 and then pulled back again to the starting point without the rotation being canceled, the second ends 20 and 22 are also firmly connected to the second holding piece 30, which in turn can be done by welding or pinching.
  • the hose arrangement 10 then remains in the rotated position of the two individual hoses 12 and 14.
  • FIG. 2 shows a further embodiment in which four individual tubes 36, 38, 40, 42 with a degree of stranding of 3.5 are arranged between a first holding piece 44 and a second holding piece 46.
  • the protruding ends of the individual hoses 36 - 42 have been omitted in FIG. 2.
  • Such an arrangement can be used, for example, for the separation of blood, the first tube for introducing the whole blood into the separation chamber and the other three tubes for withdrawing erythrocytes, the buffy-coat and the plasma.
  • the first and second holding pieces 44 and 46 again have corresponding bores, which are not shown in FIG. 2 for reasons of clarity. However, they can be seen in FIG. 3, in which the second holding piece 46 is shown in a top view.
  • the hose arrangement 35 shown in FIG. 2 has in turn been stranded with a degree of stranding of 3.5, so that the production method of this hose arrangement 35 corresponds to the production method of the hose arrangement 10 according to FIG. 1. In this respect, reference is made to this.
  • the second holding piece is shown in plan view.
  • This second holding piece consists of a cylindrical part 48, which is adjoined by a collar 50, of which in turn a cylinder part 52 with a smaller, compared to the collar however, the cylindrical part 48 has a larger diameter.
  • the cylindrical part 48, the collar 50 and the cylinder part 52 are provided with through holes 54 - four in the example case - in order to receive the individual hoses 36 - 42.
  • the collar 50 has a square design and is arranged in a correspondingly designed recess in the lid, not shown, of a centrifuge during the separation treatment. On the one hand, this ensures the correct position of the hose arrangement 35 and at the same time prevents the hose arrangement from twisting during centrifugation.

Landscapes

  • Centrifugal Separators (AREA)
  • Rigid Pipes And Flexible Pipes (AREA)
  • External Artificial Organs (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
  • Tires In General (AREA)
  • Reciprocating Pumps (AREA)
  • Joints Allowing Movement (AREA)
  • Making Paper Articles (AREA)
  • Supports For Pipes And Cables (AREA)
EP87112616A 1986-09-23 1987-08-29 Mehrlumige Schlauchanordnung sowie Verfahren zu ihrer Herstellung Expired - Lifetime EP0261446B2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3632241 1986-09-23
DE19863632241 DE3632241A1 (de) 1986-09-23 1986-09-23 Mehrlumige schlauchanordnung sowie verfahren zu ihrer herstellung

Publications (4)

Publication Number Publication Date
EP0261446A2 EP0261446A2 (de) 1988-03-30
EP0261446A3 EP0261446A3 (en) 1989-05-24
EP0261446B1 EP0261446B1 (de) 1991-06-26
EP0261446B2 true EP0261446B2 (de) 1995-07-12

Family

ID=6310120

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87112616A Expired - Lifetime EP0261446B2 (de) 1986-09-23 1987-08-29 Mehrlumige Schlauchanordnung sowie Verfahren zu ihrer Herstellung

Country Status (6)

Country Link
US (1) US4865081A (es)
EP (1) EP0261446B2 (es)
JP (1) JPH07108378B2 (es)
AT (1) ATE64697T1 (es)
DE (2) DE3632241A1 (es)
ES (1) ES2022238T5 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251147B (it) * 1991-08-05 1995-05-04 Ivo Panzani Tubo multilume per separatore centrifugo particolarmente per sangue
US5327879A (en) * 1993-03-12 1994-07-12 Ferraro Frank A Cooking apparatus with supplemental heat source
DE4310975C2 (de) * 1993-04-03 1997-04-03 Fresenius Ag Schlauchanordnung für eine gleitdichtungsfreie Zentrifuge
US5514069A (en) * 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
US5918640A (en) * 1996-12-26 1999-07-06 Dana Corporation Twin tube air brake hose
US6344020B1 (en) 1997-04-11 2002-02-05 Baxter International Inc. Bearing and umbilicus gimbal with bearing retainer in blood processing system
US5989177A (en) * 1997-04-11 1999-11-23 Baxter International Inc. Umbilicus gimbal with bearing retainer
US7008366B1 (en) * 2000-10-27 2006-03-07 Zymequest, Inc. Circumferentially driven continuous flow centrifuge
EP1272277B1 (en) * 1999-10-28 2010-08-11 Velico Medical, Inc. Circumferentially driven continuous flow centrifuge
DE10129769A1 (de) * 2001-06-20 2003-01-09 Fresenius Hemocare Gmbh Schlauchanordnung und Verfahren zu ihrer Herstellung
US6857125B2 (en) 2001-12-10 2005-02-15 Akros Limited Contact member to optical disk, protecting film for optical disk and coating composition
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7476209B2 (en) 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US8157655B2 (en) * 2007-11-07 2012-04-17 Futurelogic, Inc. Secured gaming table device
US9909783B2 (en) * 2010-02-23 2018-03-06 Robert Jensen Twisted conduit for geothermal heat exchange
US8277369B2 (en) 2010-06-15 2012-10-02 Fenwal, Inc. Bearing and bearing assembly for umbilicus of a fluid processing system
US8257239B2 (en) * 2010-06-15 2012-09-04 Fenwal, Inc. Umbilicus for use in an umbilicus-driven fluid processing
DE102012002093A1 (de) * 2012-02-06 2013-08-08 Deckel Maho Pfronten Gmbh Leitungsführungssystem zur Aufnahme und Führung von Versorgungsleitungen sowie Werkzeugmaschine
US9383044B2 (en) 2013-02-15 2016-07-05 Fenwal, Inc. Low cost umbilicus without overmolding
US9517500B2 (en) * 2014-09-23 2016-12-13 Kennieth Neal Method and appraratus for forming a helical tube bundle
US9636733B2 (en) 2014-09-23 2017-05-02 Neal Technologies Ip Holdings, Llc Method and apparatus for forming a helical tube bundle
US9545637B2 (en) * 2015-04-22 2017-01-17 Fenwal, Inc. Bearing for umbilicus of a fluid processing system

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US2832374A (en) * 1955-03-10 1958-04-29 Breeze Corp Flexible tube assemblies
US2936791A (en) * 1955-09-21 1960-05-17 Flexonics Corp Flexible hydraulic hose
US3646972A (en) * 1970-02-27 1972-03-07 Kabel Metallwerke Ghh Multitubing system
DE2114161C3 (de) * 1971-03-24 1984-10-25 Dale A. Tucson Ariz. Adams Vorrichtung zur Übertragung von Energie zwischen einem rotierenden Bauteil und einem stationären Anschluß
DE2502122A1 (de) * 1973-08-27 1975-07-31 Separex Sa Zentrifuge
US4113173A (en) * 1975-03-27 1978-09-12 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus
DE2825937C2 (de) * 1978-06-14 1984-10-25 kabelmetal electro GmbH, 3000 Hannover Abstandswendel für koaxiale Rohrsysteme
US4344560A (en) * 1979-11-02 1982-08-17 Asahi Kasei Kogyo Kabushiki Kaisha Container, apparatus and method for separating platelets
JPS5680247U (es) * 1979-11-27 1981-06-29
JPS56113301A (en) * 1980-02-13 1981-09-07 Asahi Chem Ind Co Ltd Method and apparatus for separation of fluid
US4389206A (en) * 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4372484A (en) * 1981-02-04 1983-02-08 Gambro Ab Device for the separation of a liquid, especially whole blood
US4389207A (en) * 1981-03-16 1983-06-21 Baxter Travenol Laboratories, Inc. Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system
US4439178A (en) * 1982-12-30 1984-03-27 International Business Machines Corporation Sealless centrifuge processing channel and tube system
US4673553A (en) * 1986-09-08 1987-06-16 Camet, Inc. Metal honeycomb catalyst support having a double taper

Also Published As

Publication number Publication date
ATE64697T1 (de) 1991-07-15
ES2022238B3 (es) 1991-12-01
EP0261446A3 (en) 1989-05-24
JPH07108378B2 (ja) 1995-11-22
EP0261446B1 (de) 1991-06-26
ES2022238T5 (es) 1995-10-01
DE3632241A1 (de) 1988-06-09
DE3632241C2 (es) 1989-10-26
EP0261446A2 (de) 1988-03-30
JPS63205168A (ja) 1988-08-24
DE3771022D1 (de) 1991-08-01
US4865081A (en) 1989-09-12

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