EP0169183A2 - Récipient à usage unique rempli d'un liquide et procédé de fabrication - Google Patents

Récipient à usage unique rempli d'un liquide et procédé de fabrication Download PDF

Info

Publication number
EP0169183A2
EP0169183A2 EP85850220A EP85850220A EP0169183A2 EP 0169183 A2 EP0169183 A2 EP 0169183A2 EP 85850220 A EP85850220 A EP 85850220A EP 85850220 A EP85850220 A EP 85850220A EP 0169183 A2 EP0169183 A2 EP 0169183A2
Authority
EP
European Patent Office
Prior art keywords
container
filling
containers
liquid
plastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85850220A
Other languages
German (de)
English (en)
Other versions
EP0169183A3 (fr
Inventor
Anders Tore Kers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Lakemedel AB filed Critical Astra Lakemedel AB
Publication of EP0169183A2 publication Critical patent/EP0169183A2/fr
Publication of EP0169183A3 publication Critical patent/EP0169183A3/fr
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D29/00—Sacks or like containers made of fabrics; Flexible containers of open-work, e.g. net-like construction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/02—Machines characterised by the incorporation of means for making the containers or receptacles
    • B65B3/022—Making containers by moulding of a thermoplastic material

Definitions

  • the present invention is directed to new one way containers filled with liquid and made of plastic and a new process for the preparation of such containers.
  • the new containers are small plastic bags.
  • the bags are filled with a sterile solution and are used to administer drugs parenterally.
  • Such bags on the market are often called minibags.
  • Minibags are most often filled with a physiological solution of NaCl and are being used in the administration of drugs, e.g. antibiotics, to patients, who are being fed by infusion.
  • drugs e.g. antibiotics
  • the drawbacks of the minibag, most commonly used are several.
  • US-A-3 913 299 it is known to produce plastic containers by extrusion, filling and sealing. According to the process described therein a heat treatment in three chambers must be performed in order to obtain an acceptable product.
  • US-A-3 190 441, US-A-3 269 079 and DK-B-118 998 describe methods to produce one way containers, where the tube is being sealed in its lower part, filled and sealed in its upper part. As the tubes are sealed in their lower part before filling, none of the described processes is continuous.
  • DE-A-2 817 291 describes a process for filling with milk containers made of plastic. Also in that process the lower part of the container is sealed before the container is filled and thus nor is the latter process continuous.
  • plastic containers e.g. minibags, which are filled with a liquid
  • a plastic granulate is fed into an extruder, from which a plastic tube or profile is extruded, moulded, filled, sealed by welding and cut into containers of suitable size.
  • the container is furnished with one or more openings, "ports" directly on the container.
  • the opening is laminated on the container when it is being moulded.
  • a tube is extruded vertically through a die, which has a filling drain through its middle.
  • the filling drain can easily be removed and replaced in order to undergo special treatment, e.g. sterilization.
  • the diameter of the drain may vary in diameter between 2 and 40 mm. From a tank and through the filling drain the liquid contents are introduced continuously in such a way that the liquid level is kept at a constant location, which may vary between two fixed locations, one being the lowest possible location and the other being the highest possible location.
  • the filling drain ends under the highest possible location but above the lowest possible location and may thus end within the liquid or above the liquid level.
  • Above the level of the liquid there is a gas cushion, which may be sterile filtered inert gas.
  • the moulding of the tube is performed in a hot state.
  • the plastic, being extruded has a temperature of 200°C and is completely sterile. Evacuation of the air in the mould is performed in order to avoid air entrapment between the plastic and any peaks of the mould profile, in which the tube is moulded. It is not necessary with complete vacuum, only a difference in the pressure between the outside and the inside of the container just being moulded. If desired a vibrator is connected to the system in order to eliminate air-bubbles from the liquid.
  • the process from extrusion to filling is a completely closed system when in use. As a result the contents of the produced container can if desired be maintained aseptic.
  • the filled tube obtained is sealed and cut into containers of the desired size, e.g.
  • the container is not filled through the opening but through the sides dividing the bags from each other, which after the filling are welded together. Also the welding is performed within the closed system. The welding can be performed by the use of one or more welding devices depending on the capacity desired. After the welding the tube is cut at the welds to obtain separate containers.
  • two containers may be moulded simultaneously.
  • the container is separated from the parallel container before filling and are then filled through two filling drains placed beside each other.
  • the two simultaneously formed containers are separated from each other they are still connected to each other and the sides between the containers below each filling drain are still open between each other. It is not until the filling has been completed that all the walls of the containers are closed by welding.
  • a V-or U-formed profile is extruded horisontally.
  • the containers are moulded in a continuous process.
  • the containers are moulded with an opening through which the liquid to be dispensed is introduced through a filling drain.
  • the walls between the containers are welded together before filling.
  • the filling drain and the containers move along the production line at the same rate.
  • the containers are sealed alternatively with welding or a cap.
  • the containers are separated from each other by cutting along the side walls.
  • two or more different liquids are filled into the containers and the containers are being furnished with arrangements for mixing the different liquids without destroying the sterility inside the container.
  • plastic material preferably polypropene and polyethylene
  • the mentioned material has the advantage that no harmful compounds are solved out into the liquid inside the container.
  • the containers can also be produced in two or more layers by using coextrusion.
  • the thickness of the extruded plastic is preferably 0.15 - 0.35 mm for small plastic bags such as minibags.
  • each container may be given a varying wall thickness by the moulding of thicker parts in the form of ribs simultaneously with the extrusion. This is carried out by using a die, which extrudates more plastic material at specific parts of the circumference of the die. It might also be appropriate to make one or more parts of the wall of the container thinner, whereby the collapse is facilitated when the container is being emptied. The thinner parts are made by stretching or blowing of the plastic material.
  • the container has thinner parts placed either directly opposite each other or dislocated on the sides.
  • the thinner parts may be placed along the whole length of the container.
  • Containers with varying thickness of the walls may also be formed by the coextrusion of different materials with different properties.
  • the produced containers have a smallest inner dimension of 5 mm and a biggest outer dimension of 400 mm.
  • the cross section may vary in form and be e.g. round, oval, square, e.g. rectangular or polygonal.
  • the length of the container is between 20-500 mm and the thickness of the walls between 0.15-1 mm.
  • the containers may if desired be packed into an outer package. This is especially desired when the container is small and as thin as 0.15 - 0.35 mm.
  • the containers hold between 2 ml and 10 1, especially between 50 ml and 5 1..
  • minibags Small plastic bags, minibags, are used when drugs are administered intermittently, i.e. the infusion is interrupted for a certain time and instead the drug is administered.
  • the minibag is therefore connected to an infusion set in connection with the infusion bag.
  • For use of the minibag it is punctured at the opening region. This is done by the tearing off of a tear-off patch covering the opening region, to expose a sterile area at which a sterile puncture may be performed.
  • the manufacture of the minibag is performed in a closed system and also the opening is laminated on under sterile conditions. Thereby high hygienic demands are met and usually no outer bag is needed for protecting the minibag.
  • An outer bag has the drawback that the time for sterilization is extended considerably.
  • the mould opposite the opening on the containers are provided with arrangements to punch a hole which suspends the container in use.
  • the hole is usually placed in the middle of the weld region on the side opposite the opening.
  • the small plastic bag according to the invention holds usually 50 - 100 ml of liquid. It is calculated that 4000 - 5000 units/hour shall be produced by the new method whereby the conventional method used at the moment only gives 1000 - 2000 units/hour.
  • Plastic granules are filled into an extruder.
  • a plastic tube (1) is extruded through a die (2, 3).
  • the plastic tube is formed in moulds and the opening (10) is laminated on the container.
  • a system which evacuates superfluous air (7) from the moulds is connected to the moulding process.
  • After moulding the containers, which still are connected to each other and form a tube having openings in the walls adjacent to the successive container are filled through a filling drain (4) with a sterile solution e.g. of isotonic sodium chloride.
  • a sterile solution e.g. of isotonic sodium chloride.
  • First when the containers are completely filled they are sealed in the two walls adjacent the container in front and the successive container, i.e. the walls at right angles to the wall having the laminated opening.
  • the sealing is made by e.g. ultrasonic welding through the liquid.
  • the containers may then whenever wanted be packed into an outer bag and autoclaved, in order to obtain the

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
EP85850220A 1984-07-19 1985-06-27 Récipient à usage unique rempli d'un liquide et procédé de fabrication Withdrawn EP0169183A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8403793A SE8403793D0 (sv) 1984-07-19 1984-07-19 Vetskefylld engangsbehallare samt forfarande for dess framstellning
SE8403793 1984-07-19

Publications (2)

Publication Number Publication Date
EP0169183A2 true EP0169183A2 (fr) 1986-01-22
EP0169183A3 EP0169183A3 (fr) 1987-02-04

Family

ID=20356571

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85850220A Withdrawn EP0169183A3 (fr) 1984-07-19 1985-06-27 Récipient à usage unique rempli d'un liquide et procédé de fabrication

Country Status (10)

Country Link
EP (1) EP0169183A3 (fr)
JP (1) JPS6147391A (fr)
KR (1) KR860000996A (fr)
AU (1) AU4474385A (fr)
DK (1) DK328985A (fr)
FI (1) FI852825L (fr)
IL (1) IL75684A0 (fr)
NO (1) NO852675L (fr)
PT (1) PT80834B (fr)
SE (1) SE8403793D0 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004405A1 (fr) * 1986-01-17 1987-07-30 Tore Kers Procede de production en continu de recipients remplis jetables
WO1988010186A1 (fr) * 1987-06-25 1988-12-29 Compex Ab Procede et agencement pour la fabrication de pieces en materiaux composites fibreux dans des moules
WO1994019240A1 (fr) * 1993-02-23 1994-09-01 Unifill S.P.A. Procede et installation de conditionnement de produits fluides ou semi-fluides dans des recipients en resine synthetique thermoformable
WO2005037647A1 (fr) * 2003-10-15 2005-04-28 Bernd Hansen Procede et dispositif pour produire au moins un recipient rempli d'un milieu

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639250A (en) * 1986-02-20 1987-01-27 Becton, Dickinson And Company Syringe barrel and hypodermic needle assembly

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2866488A (en) * 1956-03-07 1958-12-30 Harvey G Thompson Container
US3098601A (en) * 1958-12-31 1963-07-23 Procter & Gamble Tear tape for thermoplastic packaging materials
DE1180301B (de) * 1961-07-17 1964-10-22 Schmalbach Ag J A Verfahren und Vorrichtung zum konti-nuierlichen Herstellen gefuellter und verschlos-sener Behaelter aus thermoplastischem Kunststoff
DE1251009B (fr) * 1967-09-28
US3399508A (en) * 1964-07-10 1968-09-03 Shell Oil Co Apparatus for forming bottles or similar containers from thermoplastic material, filling them with liquid and subsequently sealing them in one operation
US3894381A (en) * 1973-06-21 1975-07-15 Inpaco Method and means for attaching fitments to a bag or pouch on a packaging machine
US3913299A (en) * 1973-05-21 1975-10-21 Alfa Laval Ab Apparatus for enveloping and treating substances
DE2720907A1 (de) * 1976-05-14 1977-11-24 Rondo Ag Allschwil Tubenartiger behaelter und verfahren zum fuellen und zum herstellen eines tubenartigen behaelters
DE3033821A1 (de) * 1980-09-09 1982-04-08 Gerhard 7166 Sulzbach-Laufen Hansen Verfahren und vorrichtung zum herstellen eines behaelters aus einem heisssiegelbaren kunststoffschlauch und durch das verfahren und mittels der vorrichtung hergestellter behaelter

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1251009B (fr) * 1967-09-28
US2866488A (en) * 1956-03-07 1958-12-30 Harvey G Thompson Container
US3098601A (en) * 1958-12-31 1963-07-23 Procter & Gamble Tear tape for thermoplastic packaging materials
DE1180301B (de) * 1961-07-17 1964-10-22 Schmalbach Ag J A Verfahren und Vorrichtung zum konti-nuierlichen Herstellen gefuellter und verschlos-sener Behaelter aus thermoplastischem Kunststoff
US3399508A (en) * 1964-07-10 1968-09-03 Shell Oil Co Apparatus for forming bottles or similar containers from thermoplastic material, filling them with liquid and subsequently sealing them in one operation
US3913299A (en) * 1973-05-21 1975-10-21 Alfa Laval Ab Apparatus for enveloping and treating substances
US3894381A (en) * 1973-06-21 1975-07-15 Inpaco Method and means for attaching fitments to a bag or pouch on a packaging machine
DE2720907A1 (de) * 1976-05-14 1977-11-24 Rondo Ag Allschwil Tubenartiger behaelter und verfahren zum fuellen und zum herstellen eines tubenartigen behaelters
DE3033821A1 (de) * 1980-09-09 1982-04-08 Gerhard 7166 Sulzbach-Laufen Hansen Verfahren und vorrichtung zum herstellen eines behaelters aus einem heisssiegelbaren kunststoffschlauch und durch das verfahren und mittels der vorrichtung hergestellter behaelter

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004405A1 (fr) * 1986-01-17 1987-07-30 Tore Kers Procede de production en continu de recipients remplis jetables
WO1988010186A1 (fr) * 1987-06-25 1988-12-29 Compex Ab Procede et agencement pour la fabrication de pieces en materiaux composites fibreux dans des moules
WO1994019240A1 (fr) * 1993-02-23 1994-09-01 Unifill S.P.A. Procede et installation de conditionnement de produits fluides ou semi-fluides dans des recipients en resine synthetique thermoformable
US5813197A (en) * 1993-02-23 1998-09-29 Unifull S.P.A. Process and plant for packaging fluid or semi-fluid products in thermoformable synthetic resin containers
WO2005037647A1 (fr) * 2003-10-15 2005-04-28 Bernd Hansen Procede et dispositif pour produire au moins un recipient rempli d'un milieu

Also Published As

Publication number Publication date
DK328985A (da) 1986-01-20
IL75684A0 (en) 1985-11-29
NO852675L (no) 1986-01-20
PT80834B (en) 1988-05-12
AU4474385A (en) 1986-01-23
DK328985D0 (da) 1985-07-19
KR860000996A (ko) 1986-02-22
FI852825A0 (fi) 1985-07-18
SE8403793D0 (sv) 1984-07-19
EP0169183A3 (fr) 1987-02-04
FI852825L (fi) 1986-01-20
JPS6147391A (ja) 1986-03-07
PT80834A (en) 1985-08-01

Similar Documents

Publication Publication Date Title
CA1197818A (fr) Systeme de manutention de produits pharmaceutiques secs
US4176153A (en) Unitary, hermetically-sealed but pierceable dispensing container
CN100396575C (zh) 具有一体化液滴分配器的气密容器
JP2001522634A (ja) 選択的に拡大可能なコンパートメントを有する可撓性の医療用容器及びその製造方法
JPH0788149A (ja) 医療用バッグ及びその製造方法と製造装置
US4547900A (en) Flexible container with integral ports and diaphragm
EP1002512A2 (fr) Récipient souple pour conserver et distribuer des liquides
US6200300B1 (en) Hangable container
GB2066210A (en) Flexible container with integral ports and diaphragm
JP2007508214A (ja) 媒体で充填された少なくとも１つの容器を形成する方法および装置
PT2125524E (pt) Dispositivo para minimizar o conteúdo de oxigénio
EP0539169A1 (fr) Article avec forme permettant de déterminer sa position; procédé et appareil pour la production et le traitement de cet article
EP0169183A2 (fr) Récipient à usage unique rempli d'un liquide et procédé de fabrication
US4441538A (en) Flexible container with integral ports and diaphragm
WO2000029301A9 (fr) Recipient accrochable
US3507666A (en) Process and design of aseptically filled infant nurser
US3589422A (en) Sealed bag for liquids
CN210139991U (zh) 一种中成药袋装冲剂生产系统
CN203507132U (zh) 一种非管口式灌装多层共挤膜大输液软袋
JP4500974B2 (ja) 医療用薬液封入用の可撓性容器の製造方法
JP3517919B2 (ja) 医療用容器及び成形金型
JP2005067730A (ja) 易開封型内容物入り複室容器の製造方法
JP2006513933A (ja) 二チャンバ一体型容器
JPH11171241A (ja) 円柱状包装体とその製造方法およびその装置
JPH0281621A (ja) 合成樹脂製容器およびその製造方法

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19870805

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KERS, ANDERS TORE