EP0084102A1 - Plaque de micro-titrage pour diagnostique du groupe sanguin - Google Patents

Plaque de micro-titrage pour diagnostique du groupe sanguin Download PDF

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Publication number
EP0084102A1
EP0084102A1 EP82111063A EP82111063A EP0084102A1 EP 0084102 A1 EP0084102 A1 EP 0084102A1 EP 82111063 A EP82111063 A EP 82111063A EP 82111063 A EP82111063 A EP 82111063A EP 0084102 A1 EP0084102 A1 EP 0084102A1
Authority
EP
European Patent Office
Prior art keywords
wells
antisera
blood group
plate according
plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82111063A
Other languages
German (de)
English (en)
Other versions
EP0084102B1 (fr
Inventor
Horst Dr. Dipl.-Chem. Uthemann
Hans Dr. Dipl.-Chem. Schleussner
Dieter Dr. Dipl.-Chem. Merz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest AG
Original Assignee
Biotest Serum Institut GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Serum Institut GmbH filed Critical Biotest Serum Institut GmbH
Priority to AT82111063T priority Critical patent/ATE16320T1/de
Publication of EP0084102A1 publication Critical patent/EP0084102A1/fr
Application granted granted Critical
Publication of EP0084102B1 publication Critical patent/EP0084102B1/fr
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S422/00—Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
    • Y10S422/906—Plasma or ion generation means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S422/00—Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
    • Y10S422/907—Corona or glow discharge means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays

Definitions

  • the invention relates to a microtiter plate for blood group diagnostics.
  • the application includes determinations in the ABO, Rh and other systems and if necessary includes the antihuman globulin test. The execution of serum cross-tests is also described.
  • microtiter plates represent an improvement on the conventional methods, they all have in common that liquid antisera are either poured into the wells provided for this purpose immediately prior to the examination or are poured in and frozen in stock.
  • the object of the invention was therefore to provide a microtiter plate with which blood group determinations can be simplified considerably and can be automated to a certain extent.
  • a microtiter plate for blood group diagnosis consisting of a flat-bottom plate (1) made of a transparent, rigid plastic, which is equipped with a large number of cells (2), which is characterized in that the cell bases (3) have firmly adhering dry layers (4) consist of essentially pure antisera and the wells consist of a protein-binding plastic.
  • antisera adhere perfectly to rigid, transparent, protein-binding plastic without any adhesion-promoting additives.
  • Antisera which are introduced into the wells form a firmly adhering layer on the bottoms of the wells. Simulated transport conditions could not cause the layer to peel off.
  • ready-to-use microtiter plates coated with dried antiserum are thus provided, in which the use and filling in of liquid antisera is dispensed with.
  • Rehydration is unnecessary before use. Only a drop of saline suspension is added to the blood to be examined, and the antisera dissolve by shaking gently. After a short centrifugation (e.g. 2 minutes at 1000 rpm) - without previous incubation - the mixture is shaken and evaluated.
  • this plate has a large number of lengthways and crossways in wells arranged next to each other on one level. This offers a variety of options
  • the plates or well bases according to the invention are coated at least with antisera for blood group determination in the ABO and Rh systems.
  • the antisera for the ABO system are characterized by high avidity, while chemically modified antisera (e.g. Anti-D or Anti-CDE) are used for the Rh system, which also agglutinate quickly in the saline environment.
  • Chemically modified IgG molecules in which disulfide bridges in the hinge region have been partially reductively split and alkylated, are characterized by a high degree of flexibility, which is why antisera based on the modified molecules are based on the usual addition of supplements (e.g. albumin, Dextran, gelatin, AB serum, etc.) can be dispensed with.
  • supplements e.g. albumin, Dextran, gelatin, AB serum, etc.
  • the chemical modification converts incomplete antibodies into agglutinins that have similar properties to ABO test sera.
  • anti-D D (Rh o ) -positive erythrocytes in saline solution or in compatible serum or plasma are agglutinated with modified IgG of specificity.
  • Pirofsky B In Pirofsky B.
  • the anti-D reagent dried on the plastic cup wells and without having to be dissolved with water beforehand, after stirring with D (Rh o ) positive blood after a short reaction time (approx. 1 minute) provides agglutination images comparable in strength to the ABO system. Since neither the reagent itself contains any supplements, nor does it require highly polymeric, adhesion-promoting additives to dry on the well bottom, there is no need for a control.
  • the anti-D reagent with its low protein concentration which corresponds to the concentration of normal human serum, leads to false positive reactions with IgG and / or complement-loaded erythrocytes in autoimmune diseases or Erythroblastosis of the newborn leads, which however are frequently observed with incomplete anti-Rh sera, which contain bovine albumin or other high-molecular substances as enhancement medium.
  • the plates can expediently also be coated with Anti-AB, AB-Serum, Anti-Kell and other systems.
  • the plate should therefore have a sufficient number of cells in order to be able to carry out coatings with all desired systems. At least 7 to 8 wells should be arranged transversely next to each other. Commercially available plates have 96 cells, i.e. 8 rows of cells arranged side by side in the transverse direction and 12 side by side in the longitudinal direction.
  • the antisera layers can be colored differently.
  • the ready-to-use sheets are individually sealed in aluminum bags and stored at 2 to 8 ° C.
  • Fig. 1 shows a plan view of a flat-bottom plate (1) with a plurality of cylindrical cups (2) attached to one another, the bases of which are provided with an antiserum layer (4).
  • a frame (5) extends around the entire well arrangement, which is provided with a shoulder (6) on which a lid can be placed.
  • the longitudinal rows of cells are designated with A, B, C, etc. and the transverse rows of cells with 1, 2, 3, etc.
  • Fig. 2 shows a section AA through Fig. 1, wherein the cylindrical cups (2) with bottoms (3) and antiserum layer (4) can be seen, which are surrounded by frame (5) with paragraph (6) on the the lid (7) can be put on.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP82111063A 1981-12-28 1982-11-30 Plaque de micro-titrage pour diagnostique du groupe sanguin Expired EP0084102B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82111063T ATE16320T1 (de) 1981-12-28 1982-11-30 Mikrotiterplatte zur blutgruppendiagnostik.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19818137962U DE8137962U1 (de) 1981-12-28 1981-12-28 Mikrotiterplatte zur blutgruppendiagnostik
DE8137962U 1981-12-28

Publications (2)

Publication Number Publication Date
EP0084102A1 true EP0084102A1 (fr) 1983-07-27
EP0084102B1 EP0084102B1 (fr) 1985-10-30

Family

ID=6734273

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82111063A Expired EP0084102B1 (fr) 1981-12-28 1982-11-30 Plaque de micro-titrage pour diagnostique du groupe sanguin

Country Status (4)

Country Link
US (1) US4770856A (fr)
EP (1) EP0084102B1 (fr)
AT (1) ATE16320T1 (fr)
DE (2) DE8137962U1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177352A1 (fr) * 1984-10-04 1986-04-09 The State Of Victoria Immuno-essai enzymatique (ELISA)
DE3619107A1 (de) * 1985-07-01 1987-01-08 Jenoptik Jena Gmbh Probenkoerper zur diskreten analyse fluessiger analysenansaetze
EP0331808A1 (fr) * 1988-01-28 1989-09-13 Biotest AG Méthode d'essai immunologique pour déterminer des groupes sanguins
EP0363510A1 (fr) * 1988-10-12 1990-04-18 Biotest AG Procédés de recherche et d'identification des anticorps d'érythrocyte à l'aide d'une méthode à phase solide
DE9015317U1 (fr) * 1990-11-07 1991-03-14 Panitz, Norbert, Dr., 6500 Mainz, De
EP0522134A1 (fr) * 1991-01-11 1993-01-13 COBE Laboratories, Inc. Procede de detection de types anticorpaux en circulation a l'aide de cellules ou matieres cellulaires sechees ou lyophilisees
US5213963A (en) * 1988-10-12 1993-05-25 Biotest Aktiengesellschaft Procedure for finding and identifying red cell antibodies by means of the solid phase method
FR2694809A1 (fr) * 1992-08-11 1994-02-18 Mikralgen Dispositif réactionnel pour identifier un produit, et son procédé d'obtention.
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells

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DE3323645A1 (de) * 1983-07-01 1985-01-10 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Diagnostisches testsystem
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US4977078A (en) * 1987-12-22 1990-12-11 Olympus Optical Co., Ltd. Plate substrate immunoassay device and method for performing a multi-test immunoassay on a specimen
US5229163A (en) * 1989-12-21 1993-07-20 Hoffmann-La Roche Inc. Process for preparing a microtiter tray for immunometric determinations
US5041266A (en) * 1989-12-21 1991-08-20 Hoffmann-La Roche Inc. Tray for immunometric determinations
US5188965A (en) * 1991-03-18 1993-02-23 Difco Laboratories Reagent source for chemiluminescent reactions, test kit, and method for use
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DE4416640A1 (de) * 1994-05-11 1995-11-16 A I D Autoimmun Diagnostika Gm Objektträger für die mikroskopische Diagnose aus Kunststoffmaterial, Herstellungsverfahren und Verwendung
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KR101489804B1 (ko) * 2005-12-21 2015-02-05 메소 스케일 테크놀러지즈, 엘엘시 분석 시약을 갖는 분석 모듈 및 그것의 제조 및 사용 방법
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DE2636616A1 (de) * 1975-08-14 1977-02-24 Sinai School Medicine Monolayer von irreversibel auf einem festen traeger gebundenen zellen, verfahren zu seiner herstellung und seine verwendung zur durchfuehrung immunologischer reaktionen
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177352A1 (fr) * 1984-10-04 1986-04-09 The State Of Victoria Immuno-essai enzymatique (ELISA)
DE3619107A1 (de) * 1985-07-01 1987-01-08 Jenoptik Jena Gmbh Probenkoerper zur diskreten analyse fluessiger analysenansaetze
EP0331808A1 (fr) * 1988-01-28 1989-09-13 Biotest AG Méthode d'essai immunologique pour déterminer des groupes sanguins
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells
EP0363510A1 (fr) * 1988-10-12 1990-04-18 Biotest AG Procédés de recherche et d'identification des anticorps d'érythrocyte à l'aide d'une méthode à phase solide
US5213963A (en) * 1988-10-12 1993-05-25 Biotest Aktiengesellschaft Procedure for finding and identifying red cell antibodies by means of the solid phase method
DE9015317U1 (fr) * 1990-11-07 1991-03-14 Panitz, Norbert, Dr., 6500 Mainz, De
EP0522134A1 (fr) * 1991-01-11 1993-01-13 COBE Laboratories, Inc. Procede de detection de types anticorpaux en circulation a l'aide de cellules ou matieres cellulaires sechees ou lyophilisees
EP0522134A4 (fr) * 1991-01-11 1994-01-26 Cryopharm Corporation
FR2694809A1 (fr) * 1992-08-11 1994-02-18 Mikralgen Dispositif réactionnel pour identifier un produit, et son procédé d'obtention.

Also Published As

Publication number Publication date
US4770856A (en) 1988-09-13
EP0084102B1 (fr) 1985-10-30
DE3267183D1 (en) 1985-12-05
ATE16320T1 (de) 1985-11-15
DE8137962U1 (de) 1982-06-16

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