EP0084102A1 - Plaque de micro-titrage pour diagnostique du groupe sanguin - Google Patents
Plaque de micro-titrage pour diagnostique du groupe sanguin Download PDFInfo
- Publication number
- EP0084102A1 EP0084102A1 EP82111063A EP82111063A EP0084102A1 EP 0084102 A1 EP0084102 A1 EP 0084102A1 EP 82111063 A EP82111063 A EP 82111063A EP 82111063 A EP82111063 A EP 82111063A EP 0084102 A1 EP0084102 A1 EP 0084102A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- wells
- antisera
- blood group
- plate according
- plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S422/00—Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
- Y10S422/906—Plasma or ion generation means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S422/00—Chemical apparatus and process disinfecting, deodorizing, preserving, or sterilizing
- Y10S422/907—Corona or glow discharge means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
Definitions
- the invention relates to a microtiter plate for blood group diagnostics.
- the application includes determinations in the ABO, Rh and other systems and if necessary includes the antihuman globulin test. The execution of serum cross-tests is also described.
- microtiter plates represent an improvement on the conventional methods, they all have in common that liquid antisera are either poured into the wells provided for this purpose immediately prior to the examination or are poured in and frozen in stock.
- the object of the invention was therefore to provide a microtiter plate with which blood group determinations can be simplified considerably and can be automated to a certain extent.
- a microtiter plate for blood group diagnosis consisting of a flat-bottom plate (1) made of a transparent, rigid plastic, which is equipped with a large number of cells (2), which is characterized in that the cell bases (3) have firmly adhering dry layers (4) consist of essentially pure antisera and the wells consist of a protein-binding plastic.
- antisera adhere perfectly to rigid, transparent, protein-binding plastic without any adhesion-promoting additives.
- Antisera which are introduced into the wells form a firmly adhering layer on the bottoms of the wells. Simulated transport conditions could not cause the layer to peel off.
- ready-to-use microtiter plates coated with dried antiserum are thus provided, in which the use and filling in of liquid antisera is dispensed with.
- Rehydration is unnecessary before use. Only a drop of saline suspension is added to the blood to be examined, and the antisera dissolve by shaking gently. After a short centrifugation (e.g. 2 minutes at 1000 rpm) - without previous incubation - the mixture is shaken and evaluated.
- this plate has a large number of lengthways and crossways in wells arranged next to each other on one level. This offers a variety of options
- the plates or well bases according to the invention are coated at least with antisera for blood group determination in the ABO and Rh systems.
- the antisera for the ABO system are characterized by high avidity, while chemically modified antisera (e.g. Anti-D or Anti-CDE) are used for the Rh system, which also agglutinate quickly in the saline environment.
- Chemically modified IgG molecules in which disulfide bridges in the hinge region have been partially reductively split and alkylated, are characterized by a high degree of flexibility, which is why antisera based on the modified molecules are based on the usual addition of supplements (e.g. albumin, Dextran, gelatin, AB serum, etc.) can be dispensed with.
- supplements e.g. albumin, Dextran, gelatin, AB serum, etc.
- the chemical modification converts incomplete antibodies into agglutinins that have similar properties to ABO test sera.
- anti-D D (Rh o ) -positive erythrocytes in saline solution or in compatible serum or plasma are agglutinated with modified IgG of specificity.
- Pirofsky B In Pirofsky B.
- the anti-D reagent dried on the plastic cup wells and without having to be dissolved with water beforehand, after stirring with D (Rh o ) positive blood after a short reaction time (approx. 1 minute) provides agglutination images comparable in strength to the ABO system. Since neither the reagent itself contains any supplements, nor does it require highly polymeric, adhesion-promoting additives to dry on the well bottom, there is no need for a control.
- the anti-D reagent with its low protein concentration which corresponds to the concentration of normal human serum, leads to false positive reactions with IgG and / or complement-loaded erythrocytes in autoimmune diseases or Erythroblastosis of the newborn leads, which however are frequently observed with incomplete anti-Rh sera, which contain bovine albumin or other high-molecular substances as enhancement medium.
- the plates can expediently also be coated with Anti-AB, AB-Serum, Anti-Kell and other systems.
- the plate should therefore have a sufficient number of cells in order to be able to carry out coatings with all desired systems. At least 7 to 8 wells should be arranged transversely next to each other. Commercially available plates have 96 cells, i.e. 8 rows of cells arranged side by side in the transverse direction and 12 side by side in the longitudinal direction.
- the antisera layers can be colored differently.
- the ready-to-use sheets are individually sealed in aluminum bags and stored at 2 to 8 ° C.
- Fig. 1 shows a plan view of a flat-bottom plate (1) with a plurality of cylindrical cups (2) attached to one another, the bases of which are provided with an antiserum layer (4).
- a frame (5) extends around the entire well arrangement, which is provided with a shoulder (6) on which a lid can be placed.
- the longitudinal rows of cells are designated with A, B, C, etc. and the transverse rows of cells with 1, 2, 3, etc.
- Fig. 2 shows a section AA through Fig. 1, wherein the cylindrical cups (2) with bottoms (3) and antiserum layer (4) can be seen, which are surrounded by frame (5) with paragraph (6) on the the lid (7) can be put on.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT82111063T ATE16320T1 (de) | 1981-12-28 | 1982-11-30 | Mikrotiterplatte zur blutgruppendiagnostik. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19818137962U DE8137962U1 (de) | 1981-12-28 | 1981-12-28 | Mikrotiterplatte zur blutgruppendiagnostik |
DE8137962U | 1981-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0084102A1 true EP0084102A1 (fr) | 1983-07-27 |
EP0084102B1 EP0084102B1 (fr) | 1985-10-30 |
Family
ID=6734273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP82111063A Expired EP0084102B1 (fr) | 1981-12-28 | 1982-11-30 | Plaque de micro-titrage pour diagnostique du groupe sanguin |
Country Status (4)
Country | Link |
---|---|
US (1) | US4770856A (fr) |
EP (1) | EP0084102B1 (fr) |
AT (1) | ATE16320T1 (fr) |
DE (2) | DE8137962U1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0177352A1 (fr) * | 1984-10-04 | 1986-04-09 | The State Of Victoria | Immuno-essai enzymatique (ELISA) |
DE3619107A1 (de) * | 1985-07-01 | 1987-01-08 | Jenoptik Jena Gmbh | Probenkoerper zur diskreten analyse fluessiger analysenansaetze |
EP0331808A1 (fr) * | 1988-01-28 | 1989-09-13 | Biotest AG | Méthode d'essai immunologique pour déterminer des groupes sanguins |
EP0363510A1 (fr) * | 1988-10-12 | 1990-04-18 | Biotest AG | Procédés de recherche et d'identification des anticorps d'érythrocyte à l'aide d'une méthode à phase solide |
DE9015317U1 (de) * | 1990-11-07 | 1991-03-14 | Panitz, Norbert, Dr., 6500 Mainz | Doppelplatte |
EP0522134A1 (fr) * | 1991-01-11 | 1993-01-13 | COBE Laboratories, Inc. | Procede de detection de types anticorpaux en circulation a l'aide de cellules ou matieres cellulaires sechees ou lyophilisees |
US5213963A (en) * | 1988-10-12 | 1993-05-25 | Biotest Aktiengesellschaft | Procedure for finding and identifying red cell antibodies by means of the solid phase method |
FR2694809A1 (fr) * | 1992-08-11 | 1994-02-18 | Mikralgen | Dispositif réactionnel pour identifier un produit, et son procédé d'obtention. |
US5759774A (en) * | 1988-05-18 | 1998-06-02 | Cobe Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3323645A1 (de) * | 1983-07-01 | 1985-01-10 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Diagnostisches testsystem |
HU192513B (en) * | 1984-11-23 | 1987-06-29 | Human Oltoanyagtermelo | Quick diagnostic substance for determining blood group |
US4977078A (en) * | 1987-12-22 | 1990-12-11 | Olympus Optical Co., Ltd. | Plate substrate immunoassay device and method for performing a multi-test immunoassay on a specimen |
US5229163A (en) * | 1989-12-21 | 1993-07-20 | Hoffmann-La Roche Inc. | Process for preparing a microtiter tray for immunometric determinations |
US5041266A (en) * | 1989-12-21 | 1991-08-20 | Hoffmann-La Roche Inc. | Tray for immunometric determinations |
US5188965A (en) * | 1991-03-18 | 1993-02-23 | Difco Laboratories | Reagent source for chemiluminescent reactions, test kit, and method for use |
US5443743A (en) * | 1991-09-11 | 1995-08-22 | Pall Corporation | Gas plasma treated porous medium and method of separation using same |
US5221410A (en) * | 1991-10-09 | 1993-06-22 | Schering Corporation | Crystal forming device |
US5211182A (en) * | 1991-10-23 | 1993-05-18 | Deutsch Marshall E | Home ovulation test kit and method |
DE4209064C2 (de) * | 1992-03-20 | 1995-07-27 | Gerhard Dr Noss | Verfahren zum Zuführen von Waschflüssigkeit zu kleinen, transparenten, mit Zellkulturen beschichteten Testfeldern und zum Absaugen der Waschflüssigkeit von den Testfeldern |
US5319436A (en) * | 1992-05-28 | 1994-06-07 | Packard Instrument Company, Inc. | Microplate farming wells with transparent bottom walls for assays using light measurements |
FR2700010B1 (fr) * | 1992-12-24 | 1995-03-17 | Rocher Yves Biolog Vegetale | Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits. |
DE4416640A1 (de) * | 1994-05-11 | 1995-11-16 | A I D Autoimmun Diagnostika Gm | Objektträger für die mikroskopische Diagnose aus Kunststoffmaterial, Herstellungsverfahren und Verwendung |
US6297046B1 (en) | 1994-10-28 | 2001-10-02 | Baxter International Inc. | Multilayer gas-permeable container for the culture of adherent and non-adherent cells |
US5935847A (en) | 1994-10-28 | 1999-08-10 | Baxter International Inc. | Multilayer gas-permeable container for the culture of adherent and non-adherent cells |
US5922534A (en) | 1995-03-28 | 1999-07-13 | Hewlett-Packard Company | Dry biochemical assay plate and method for making the same |
IL113920A (en) * | 1995-05-30 | 1999-09-22 | Avraham Reinhartz | Apparatus and method for detection of analytes in a sample |
US6024220A (en) | 1995-06-07 | 2000-02-15 | Baxter International Inc. | Encapsulated seam for multilayer materials |
US6391404B1 (en) | 1995-06-07 | 2002-05-21 | Baxter International Inc. | Coextruded multilayer film materials and containers made therefrom |
US5766554A (en) * | 1996-07-19 | 1998-06-16 | Liu; Rui Ye | Immunoassay plates with desiccant housing |
US6229603B1 (en) | 1997-06-02 | 2001-05-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for spectroscopic measurements |
US6171780B1 (en) | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6063338A (en) * | 1997-06-02 | 2000-05-16 | Aurora Biosciences Corporation | Low background multi-well plates and platforms for spectroscopic measurements |
US5910287A (en) * | 1997-06-03 | 1999-06-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples |
US6426050B1 (en) | 1997-05-16 | 2002-07-30 | Aurora Biosciences Corporation | Multi-well platforms, caddies, lids and combinations thereof |
US6517781B1 (en) | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6096562A (en) * | 1997-10-27 | 2000-08-01 | Nalge Nunc International Corporation | Multi-slide assembly including slide, frame and strip cap, and methods thereof |
US6825042B1 (en) | 1998-02-24 | 2004-11-30 | Vertex Pharmaceuticals (San Diego) Llc | Microplate lid |
US6861035B2 (en) | 1998-02-24 | 2005-03-01 | Aurora Discovery, Inc. | Multi-well platforms, caddies, lids and combinations thereof |
US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
DE29811606U1 (de) * | 1998-06-29 | 1999-05-06 | Sension, biologische Detektions- und Schnelltestsysteme GmbH, 86167 Augsburg | Kombi-Vorrichtung zur simultanen Durchführung von Immunfiltrationstests |
US6399394B1 (en) | 1999-06-30 | 2002-06-04 | Agilent Technologies, Inc. | Testing multiple fluid samples with multiple biopolymer arrays |
US6635430B1 (en) * | 1999-07-16 | 2003-10-21 | Dupont Pharmaceuticals Company | Filtrate plate device and reversible-well plate device |
US6555392B1 (en) * | 1999-09-13 | 2003-04-29 | Helena Laboratories Corporation | Antisera tray |
US7005029B2 (en) * | 1999-10-26 | 2006-02-28 | Nalge Nunc International Corporation | Method of making a multi-well test plate having adhesively secured transparent bottom panel |
US6455007B1 (en) * | 2000-06-13 | 2002-09-24 | Symyx Technologies, Inc. | Apparatus and method for testing compositions in contact with a porous medium |
US20040018615A1 (en) * | 2000-08-02 | 2004-01-29 | Garyantes Tina K. | Virtual wells for use in high throughput screening assays |
US6800491B2 (en) | 2001-06-08 | 2004-10-05 | Nalge Nunc International Corporation | Robotic reservoir without liquid hangup |
PL367715A1 (en) * | 2001-09-20 | 2005-03-07 | 3-Dimensional Pharmaceuticals, Inc. | Conductive microtiter plate |
AU2002353013A1 (en) * | 2001-12-03 | 2003-06-17 | Massachusetts Institute Of Technology | Microscale lyophilization and drying methods for the stabilization of molecules |
US6767401B2 (en) * | 2002-01-18 | 2004-07-27 | Neuro Probe Incorporated | Crystal forming apparatus and method for using same |
US7332029B2 (en) * | 2002-01-18 | 2008-02-19 | Neuro Probe Incorporated | Crystal forming apparatus and method for using same |
KR100719029B1 (ko) * | 2002-03-28 | 2007-05-16 | 대한제당 주식회사 | 마이크로-웰 플레이트 |
US7537936B2 (en) * | 2002-05-31 | 2009-05-26 | Agilent Technologies, Inc. | Method of testing multiple fluid samples with multiple biopolymer arrays |
JP2004045104A (ja) * | 2002-07-09 | 2004-02-12 | Futaba Corp | マイクロプレート |
WO2005025749A1 (fr) * | 2003-09-08 | 2005-03-24 | Irm, Llc | Recipients multi-puits, systemes, et procedes d'utilisation |
NL1024578C2 (nl) * | 2003-10-21 | 2005-04-22 | Univ Delft Tech | Inrichting voor het uitvoeren van een reactie. |
US20050173059A1 (en) * | 2004-02-11 | 2005-08-11 | Nalge Nunc International Corporation | Methods of making a multi-well test plate having an adhesively secured transparent bottom panel |
US7384779B2 (en) * | 2004-04-12 | 2008-06-10 | Corning Incorporated | Porous substrate plates and the use thereof |
GB0506183D0 (en) * | 2005-03-24 | 2005-05-04 | Univ Edinburgh | Antigen detection |
KR101423938B1 (ko) | 2005-12-21 | 2014-08-06 | 메소 스케일 테크놀러지즈, 엘엘시 | 분석 장치, 방법 및 시약 |
MX2008008280A (es) | 2005-12-21 | 2008-11-06 | Meso Scale Technologies Llc | Modulos de ensayo que tienen reactivos de ensayo y metodos para hacer y utilizar los mismos. |
US20080280310A1 (en) * | 2007-05-09 | 2008-11-13 | Louis Panagopoulos | Testing for Blood Group Immunological Reaction Without the Use of Anti-Human Globulin |
JP5282088B2 (ja) | 2007-06-21 | 2013-09-04 | ジェン−プロウブ インコーポレイテッド | 処理実行に使用する機器および容器 |
US9594019B1 (en) * | 2013-08-09 | 2017-03-14 | Lester F. Ludwig | Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications |
US20170189902A1 (en) * | 2014-09-12 | 2017-07-06 | Pinpoint Testing, Llc | Ready-to-constitute analytical platforms for chemical analyses and quantification |
WO2016117541A1 (fr) * | 2015-01-22 | 2016-07-28 | 株式会社村田製作所 | Structure de réseau de vide et son procédé de production |
CN107810277B (zh) * | 2015-04-21 | 2021-11-02 | 通用自动化实验技术公司 | 用于高通量微生物学应用的高分辨率系统、试剂盒、设备和方法 |
JP6842778B2 (ja) * | 2016-09-06 | 2021-03-17 | 学校法人慶應義塾 | 紫外線吸収剤又は赤外線遮断剤含有水性組成物の紫外線防御効果又は赤外線防御効果の測定方法及び測定用試料作成装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2152068A1 (de) * | 1970-10-19 | 1972-04-20 | Astec Inc | Vorrichtung zur Untersuchung der biologischen Wirksamkeit von Kontrollreagenzien |
DE2636616A1 (de) * | 1975-08-14 | 1977-02-24 | Sinai School Medicine | Monolayer von irreversibel auf einem festen traeger gebundenen zellen, verfahren zu seiner herstellung und seine verwendung zur durchfuehrung immunologischer reaktionen |
DE2938009A1 (de) * | 1979-09-20 | 1981-04-30 | Ernst Dr. 5300 Bonn Cohnen | Serco-spezial-tuepfelplatte zur blutgruppenbestimmung |
DE8029596U1 (de) * | 1980-11-06 | 1981-06-11 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Blutgruppenidentitaetskarte, insbesondere fuer den bed side-test |
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US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
GB1447493A (en) * | 1973-02-01 | 1976-08-25 | Ici Ltd | Coated synthetic film materials electric circuit arrangements for energising electromagnetic |
FR2296869A1 (fr) * | 1975-01-06 | 1976-07-30 | Al Marachy Pierre | Installation pour la determination du groupe sanguin |
US4154795A (en) * | 1976-07-23 | 1979-05-15 | Dynatech Holdings Limited | Microtest plates |
US4284725A (en) * | 1976-08-13 | 1981-08-18 | Dynasciences Corporation | Virus titration and identification system |
US4337104A (en) * | 1978-10-10 | 1982-06-29 | Becton, Dickinson And Company | Method for manufacturing a roller bottle |
US4613317A (en) * | 1983-11-07 | 1986-09-23 | Nissan Motor Co., Ltd. | Cardan universal joints |
-
1981
- 1981-12-28 DE DE19818137962U patent/DE8137962U1/de not_active Expired
-
1982
- 1982-11-30 AT AT82111063T patent/ATE16320T1/de not_active IP Right Cessation
- 1982-11-30 EP EP82111063A patent/EP0084102B1/fr not_active Expired
- 1982-11-30 DE DE8282111063T patent/DE3267183D1/de not_active Expired
-
1987
- 1987-10-29 US US07/114,891 patent/US4770856A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2152068A1 (de) * | 1970-10-19 | 1972-04-20 | Astec Inc | Vorrichtung zur Untersuchung der biologischen Wirksamkeit von Kontrollreagenzien |
DE2636616A1 (de) * | 1975-08-14 | 1977-02-24 | Sinai School Medicine | Monolayer von irreversibel auf einem festen traeger gebundenen zellen, verfahren zu seiner herstellung und seine verwendung zur durchfuehrung immunologischer reaktionen |
DE2938009A1 (de) * | 1979-09-20 | 1981-04-30 | Ernst Dr. 5300 Bonn Cohnen | Serco-spezial-tuepfelplatte zur blutgruppenbestimmung |
DE8029596U1 (de) * | 1980-11-06 | 1981-06-11 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Blutgruppenidentitaetskarte, insbesondere fuer den bed side-test |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0177352A1 (fr) * | 1984-10-04 | 1986-04-09 | The State Of Victoria | Immuno-essai enzymatique (ELISA) |
DE3619107A1 (de) * | 1985-07-01 | 1987-01-08 | Jenoptik Jena Gmbh | Probenkoerper zur diskreten analyse fluessiger analysenansaetze |
EP0331808A1 (fr) * | 1988-01-28 | 1989-09-13 | Biotest AG | Méthode d'essai immunologique pour déterminer des groupes sanguins |
US5759774A (en) * | 1988-05-18 | 1998-06-02 | Cobe Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells |
EP0363510A1 (fr) * | 1988-10-12 | 1990-04-18 | Biotest AG | Procédés de recherche et d'identification des anticorps d'érythrocyte à l'aide d'une méthode à phase solide |
US5213963A (en) * | 1988-10-12 | 1993-05-25 | Biotest Aktiengesellschaft | Procedure for finding and identifying red cell antibodies by means of the solid phase method |
DE9015317U1 (de) * | 1990-11-07 | 1991-03-14 | Panitz, Norbert, Dr., 6500 Mainz | Doppelplatte |
EP0522134A1 (fr) * | 1991-01-11 | 1993-01-13 | COBE Laboratories, Inc. | Procede de detection de types anticorpaux en circulation a l'aide de cellules ou matieres cellulaires sechees ou lyophilisees |
EP0522134A4 (fr) * | 1991-01-11 | 1994-01-26 | Cryopharm Corporation | |
FR2694809A1 (fr) * | 1992-08-11 | 1994-02-18 | Mikralgen | Dispositif réactionnel pour identifier un produit, et son procédé d'obtention. |
Also Published As
Publication number | Publication date |
---|---|
DE8137962U1 (de) | 1982-06-16 |
ATE16320T1 (de) | 1985-11-15 |
US4770856A (en) | 1988-09-13 |
EP0084102B1 (fr) | 1985-10-30 |
DE3267183D1 (en) | 1985-12-05 |
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