EP0072284A2 - Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben - Google Patents

Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben Download PDF

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Publication number
EP0072284A2
EP0072284A2 EP82401379A EP82401379A EP0072284A2 EP 0072284 A2 EP0072284 A2 EP 0072284A2 EP 82401379 A EP82401379 A EP 82401379A EP 82401379 A EP82401379 A EP 82401379A EP 0072284 A2 EP0072284 A2 EP 0072284A2
Authority
EP
European Patent Office
Prior art keywords
disc
support according
cells
eccentric
orifices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82401379A
Other languages
English (en)
French (fr)
Other versions
EP0072284B1 (de
EP0072284A3 (en
Inventor
Alain Charles Albert Benajam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Original Assignee
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Materiel Biomedical A Responsabilite Dite Ltee Ste filed Critical Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority to AT82401379T priority Critical patent/ATE30215T1/de
Publication of EP0072284A2 publication Critical patent/EP0072284A2/de
Publication of EP0072284A3 publication Critical patent/EP0072284A3/fr
Application granted granted Critical
Publication of EP0072284B1 publication Critical patent/EP0072284B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the present invention relates to a multi-container reaction medium for liquid dose testing.
  • reaction supports consisting of a transparent rectangular plate in which a plurality of cells are provided, distributed in rows and columns. Each of these cells forms an open container into which a dose of liquid and the corresponding reagent (s) can be introduced.
  • the results of the action of the reagents appear on the transparent background of the cells, where they are detected optically and / or electronically.
  • reaction supports are widely used and give full satisfaction. However, they are unusable in the case where the reactions require agitation or centrifugation, because then the liquid of the cells risks being projected out of the cells. In addition, they do not lend themselves well to the automation of tests performed on liquid doses.
  • the object of the present invention is to remedy these drawbacks. It relates to a reaction vessel with multiple vessels allowing both agitation and / or centrifugation and automation of the test processes.
  • the reaction container with multiple containers for testing doses of liquids comprising a transparent plate provided with a plurality of cells, each of which forms one of said containers, is remarkable in that said plate has the shape of a disc and in that the cells are closed upwards and are each in communication with the outside via an eccentric orifice opening onto the upper face of the disc .
  • the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means.
  • the disc it is possible to subject the disc to rotary agitation or centrifugation movements.
  • the eccentric orifice is closer to the center of the disc than the corresponding cavity, so that during centrifugation, the liquid cannot escape through said orifice.
  • the various cells and orifices are preferably arranged according to radii and concentric circles.
  • the disc is formed by the superposition and the joining of at least two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said orifices.
  • the embodiment of the reaction vessel with multiple containers according to the invention comprises an upper disc 1 (Figure 1) and a lower disc 2 ( Figure 3) superimposed and assembled by example by collage.
  • the discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the. discs 1 and 2 are superimposed.
  • the upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.
  • the lower transparent disc 2 has a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.
  • each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.
  • the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16.
  • each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and the holes 5 and 10.
  • the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).
  • the disc is composed of two superimposed plates 1, 2.
  • the disc according to the invention could be composed, for example, of three superimposed plates.
  • the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5.
  • the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Packages (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
EP82401379A 1981-08-05 1982-07-26 Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben Expired EP0072284B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82401379T ATE30215T1 (de) 1981-08-05 1982-07-26 Mehrfachreagiergefaessehalter zum pruefen von fluessigkeitsproben.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115163 1981-08-05
FR8115163A FR2511153B1 (fr) 1981-08-05 1981-08-05 Support de reaction a recipients multiples pour tests de doses liquides

Publications (3)

Publication Number Publication Date
EP0072284A2 true EP0072284A2 (de) 1983-02-16
EP0072284A3 EP0072284A3 (en) 1985-01-16
EP0072284B1 EP0072284B1 (de) 1987-10-14

Family

ID=9261178

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82401379A Expired EP0072284B1 (de) 1981-08-05 1982-07-26 Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben

Country Status (6)

Country Link
US (1) US4656009A (de)
EP (1) EP0072284B1 (de)
JP (1) JPS5830669A (de)
AT (1) ATE30215T1 (de)
DE (1) DE3277454D1 (de)
FR (1) FR2511153B1 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168657A1 (de) * 1984-06-19 1986-01-22 FINBIOMEDICA S.r.l. Verfahren und Vorrichtung zur schnellen automatischen Durchführung kliniko-chemischer Analysen
FR2618553A1 (fr) * 1987-07-24 1989-01-27 Materiel Biomedical Support de reaction a recipients multiples, et systeme de tests comportant ledit support
FR2638844A1 (fr) * 1988-11-09 1990-05-11 Rene Hamelin Dispositif a recipients multiples pour effectuer des tests, et element pour realiser un tel dispositif
EP0317987A3 (de) * 1987-11-23 1990-06-27 Lmb Medizin Technik Gmbh Reaktionsgefäss zur Untersuchung flüssiger Proben im Mikroliterbereich
WO1998025140A1 (en) * 1996-12-02 1998-06-11 Abb Kent-Taylor Limited Apparatus for the analysis of liquid

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421985B1 (de) * 1988-05-09 1992-04-15 Amoco Corporation Vorrichtung zum mischen mindestens eines wässrigen stoffes
US5266268A (en) * 1991-08-15 1993-11-30 Iniziative Maritime 1991, S.R.L. Centrifugal analyzer rotors
JPH05118671A (ja) * 1991-10-30 1993-05-14 Mitsubishi Electric Corp 空気調和装置の電気品箱
FR2770515B1 (fr) * 1997-11-06 2000-01-21 Corning Inc Plaques a godets et son procede de fabrication
US5963318A (en) * 1998-08-07 1999-10-05 Bio-Tek Holdings, Inc. Method of and apparatus for performing fixed pathlength vertical photometry
US20040124231A1 (en) * 1999-06-29 2004-07-01 Hasz Wayne Charles Method for coating a substrate
JP5287609B2 (ja) * 2009-08-26 2013-09-11 株式会社島津製作所 反応容器
JP5932077B1 (ja) * 2015-02-24 2016-06-08 シャープ株式会社 成分分析用容器
JP6733861B2 (ja) * 2016-01-06 2020-08-05 エア・ウォーター・バイオデザイン株式会社 成分分析システム
US20190086324A1 (en) * 2016-03-23 2019-03-21 Truvian Sciences, Inc. Systems and Methods for Multianalyte Detection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883308A (en) * 1967-05-12 1975-05-13 Centre Nat Rech Scient Apparatus for analysing liquid substances likely to form agglutinates
US3813031A (en) * 1972-08-02 1974-05-28 Atomic Energy Commission Rotor having sample holding means
US3763374A (en) * 1972-08-22 1973-10-02 Atomic Energy Commission Dynamic multistation photometer-fluorometer
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
US3864089A (en) * 1973-12-10 1975-02-04 Atomic Energy Commission Multiple-sample rotor assembly for blood fraction preparation
US3890101A (en) * 1974-02-15 1975-06-17 Us Energy Collection ring for use in multiple-sample blood fractionation centrifugal rotors
US3901658A (en) * 1974-07-30 1975-08-26 Us Energy Whole blood analysis rotor assembly having removable cellular sedimentation bowl
NL7613690A (nl) * 1976-12-09 1978-06-13 Cenco Instr Bv Cytocentrifuge.
US4035156A (en) * 1977-01-21 1977-07-12 The United States Of America As Represented By The United States Energy Research And Development Administration Filter type rotor for multistation photometer
FR2418673A1 (fr) * 1978-03-01 1979-09-28 Nal Transfusion Sanguine Centr Dispositif de centrifugation de liquides contenant des particules ou cellules en suspension
JPS55121150A (en) * 1979-03-14 1980-09-18 Hitachi Ltd Plural items analyzing unit
JPS5644852A (en) * 1979-09-21 1981-04-24 Hitachi Ltd Centrifugal sampler for automatic chemical analysis device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168657A1 (de) * 1984-06-19 1986-01-22 FINBIOMEDICA S.r.l. Verfahren und Vorrichtung zur schnellen automatischen Durchführung kliniko-chemischer Analysen
US4767600A (en) * 1984-06-19 1988-08-30 Finbiomedica S.R.L. Equipment for rapid, automatic chemical-clinical analysis
FR2618553A1 (fr) * 1987-07-24 1989-01-27 Materiel Biomedical Support de reaction a recipients multiples, et systeme de tests comportant ledit support
EP0317987A3 (de) * 1987-11-23 1990-06-27 Lmb Medizin Technik Gmbh Reaktionsgefäss zur Untersuchung flüssiger Proben im Mikroliterbereich
FR2638844A1 (fr) * 1988-11-09 1990-05-11 Rene Hamelin Dispositif a recipients multiples pour effectuer des tests, et element pour realiser un tel dispositif
WO1990005294A1 (fr) * 1988-11-09 1990-05-17 Hamelin Rene Dispositif a recipients multiples pour effectuer des tests, et element pour realiser un tel dispositif
WO1998025140A1 (en) * 1996-12-02 1998-06-11 Abb Kent-Taylor Limited Apparatus for the analysis of liquid

Also Published As

Publication number Publication date
FR2511153A1 (fr) 1983-02-11
ATE30215T1 (de) 1987-10-15
JPS5830669A (ja) 1983-02-23
FR2511153B1 (fr) 1986-01-10
DE3277454D1 (en) 1987-11-19
US4656009A (en) 1987-04-07
EP0072284B1 (de) 1987-10-14
EP0072284A3 (en) 1985-01-16

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