EP0072284A2 - Multiple receptacle reaction support for testing liquid doses - Google Patents

Multiple receptacle reaction support for testing liquid doses Download PDF

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Publication number
EP0072284A2
EP0072284A2 EP82401379A EP82401379A EP0072284A2 EP 0072284 A2 EP0072284 A2 EP 0072284A2 EP 82401379 A EP82401379 A EP 82401379A EP 82401379 A EP82401379 A EP 82401379A EP 0072284 A2 EP0072284 A2 EP 0072284A2
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EP
European Patent Office
Prior art keywords
disc
support according
cells
eccentric
orifices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82401379A
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German (de)
French (fr)
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EP0072284A3 (en
EP0072284B1 (en
Inventor
Alain Charles Albert Benajam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
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Le Materiel Biomedical A Responsabilite Dite Ltee Ste
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Priority to AT82401379T priority Critical patent/ATE30215T1/en
Publication of EP0072284A2 publication Critical patent/EP0072284A2/en
Publication of EP0072284A3 publication Critical patent/EP0072284A3/en
Application granted granted Critical
Publication of EP0072284B1 publication Critical patent/EP0072284B1/en
Expired legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the present invention relates to a multi-container reaction medium for liquid dose testing.
  • reaction supports consisting of a transparent rectangular plate in which a plurality of cells are provided, distributed in rows and columns. Each of these cells forms an open container into which a dose of liquid and the corresponding reagent (s) can be introduced.
  • the results of the action of the reagents appear on the transparent background of the cells, where they are detected optically and / or electronically.
  • reaction supports are widely used and give full satisfaction. However, they are unusable in the case where the reactions require agitation or centrifugation, because then the liquid of the cells risks being projected out of the cells. In addition, they do not lend themselves well to the automation of tests performed on liquid doses.
  • the object of the present invention is to remedy these drawbacks. It relates to a reaction vessel with multiple vessels allowing both agitation and / or centrifugation and automation of the test processes.
  • the reaction container with multiple containers for testing doses of liquids comprising a transparent plate provided with a plurality of cells, each of which forms one of said containers, is remarkable in that said plate has the shape of a disc and in that the cells are closed upwards and are each in communication with the outside via an eccentric orifice opening onto the upper face of the disc .
  • the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means.
  • the disc it is possible to subject the disc to rotary agitation or centrifugation movements.
  • the eccentric orifice is closer to the center of the disc than the corresponding cavity, so that during centrifugation, the liquid cannot escape through said orifice.
  • the various cells and orifices are preferably arranged according to radii and concentric circles.
  • the disc is formed by the superposition and the joining of at least two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said orifices.
  • the embodiment of the reaction vessel with multiple containers according to the invention comprises an upper disc 1 (Figure 1) and a lower disc 2 ( Figure 3) superimposed and assembled by example by collage.
  • the discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the. discs 1 and 2 are superimposed.
  • the upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.
  • the lower transparent disc 2 has a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.
  • each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.
  • the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16.
  • each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and the holes 5 and 10.
  • the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).
  • the disc is composed of two superimposed plates 1, 2.
  • the disc according to the invention could be composed, for example, of three superimposed plates.
  • the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5.
  • the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Packages (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to a reaction support incorporating multiple recipients for testing liquid doses, comprising a transparent plate provided with a plurality of recesses of which each forms one of the recipient. According to the invention, this support is characterized in that the plate is in the form of a disc and in that the recesses are obturated at the top and are each in communication with the outside via an eccentric orifice opening on the upper face of the disc. The invention is particularly applicable in the domain of biology.

Description

La présente invention concerne un support de réaction à récipients multiples pour tests de doses liquides.The present invention relates to a multi-container reaction medium for liquid dose testing.

On sait que, par exemple en biologie, immunologie, etc.... il est nécessaire de soumettre simultanément une pluralité de doses de liquides, tels que sang, sérum, etc... à l'action de réactifs, pour permettre de classifier ces liquides.We know that, for example in biology, immunology, etc ... it is necessary to simultaneously submit a plurality of doses of liquids, such as blood, serum, etc ... to the action of reagents, to allow classification these liquids.

Pour ce faire, on connaît déjà des supports de réaction, dits plaques de TERASAKI, constituées d'une plaque rectangulaire transparente dans laquelle sont prévus une pluralité d'alvéoles, répartis en lignes et en colonnes. Chacun de ces alvéoles forme un récipient ouvert dans lequel on peut introduire une dose de liquide et le ou les réactifs correspondants. Les résultats de l'action des réactifs (par exemple la formation d'agglomérats) apparaissent sur le fond transparent des alvéoles, où ils sont détectés optiquement et/ou électroniquement.To do this, reaction supports are already known, called TERASAKI plates, consisting of a transparent rectangular plate in which a plurality of cells are provided, distributed in rows and columns. Each of these cells forms an open container into which a dose of liquid and the corresponding reagent (s) can be introduced. The results of the action of the reagents (for example the formation of agglomerates) appear on the transparent background of the cells, where they are detected optically and / or electronically.

De tels supports de réaction sont largement utilisés et donnent toute satisfaction. Cependant, ils sont inutilisables dans le cas où les réactions nécessitent une agitation ou une centrifugation, car alors le liquide des alvéoles risque d'être projeté hors des alvéoles. De plus, ils se prêtent mal à l'automatisation des tests'effectués sur les doses liquides.Such reaction supports are widely used and give full satisfaction. However, they are unusable in the case where the reactions require agitation or centrifugation, because then the liquid of the cells risks being projected out of the cells. In addition, they do not lend themselves well to the automation of tests performed on liquid doses.

La présente invention a pour.objet de remédier à ces inconvénients. Elle concerne un support de réaction à récipients multiples permettant à la fois l'agitation et/ou la centrifugation et l'automatisation des processus de tests.The object of the present invention is to remedy these drawbacks. It relates to a reaction vessel with multiple vessels allowing both agitation and / or centrifugation and automation of the test processes.

A cette fin, selon l'invention, le support de réaction à récipients multiples pour tests de doses de liquides, comportant une plaque transparente pourvue d'une pluralité d'alvéoles dont chacun d'eux forme l'un desdits récipients, est remarquable en ce que ladite plaque présente la forme d'un disque et en ce que les alvéoles sont obturés vers le haut et sont chacun en communication avec l'extérieur par l'intermédiaire d'un orifice excentré débouchant sur la face supérieure du disque.To this end, according to the invention, the reaction container with multiple containers for testing doses of liquids, comprising a transparent plate provided with a plurality of cells, each of which forms one of said containers, is remarkable in that said plate has the shape of a disc and in that the cells are closed upwards and are each in communication with the outside via an eccentric orifice opening onto the upper face of the disc .

Avantageusement, le disque est percé en son centre d'un trou permettant son montage sur un axe vertical rotatif, ou bien il est solidaire d'un axe orthogonal à son plan susceptible d'être relié à des moyens d'entraînement en rotation. Ainsi, il est possible de soumettre le disque à des mouvements d'agitation en rotation ou de centrifugation.Advantageously, the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means. Thus, it is possible to subject the disc to rotary agitation or centrifugation movements.

De préférence, l'orifice excentré est plus proche du centre du disque que l'alvéole correspondant, afin qu'au cours d'une centrifugation, le liquide ne puisse s'échapper par ledit orifice.Preferably, the eccentric orifice is closer to the center of the disc than the corresponding cavity, so that during centrifugation, the liquid cannot escape through said orifice.

Les différents alvéoles et orifices sont de préférence rangés selon des rayons et des cercles concentriques.The various cells and orifices are preferably arranged according to radii and concentric circles.

Dans un mode de réalisation avantageux, le disque est formé par la superposition et la solidarisation d'au moins deux plaques circulaires coaxiales dont l'une comporte lesdits alvéoles et l'autre des trous traversants formant chacun un desdits orifices.In an advantageous embodiment, the disc is formed by the superposition and the joining of at least two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said orifices.

  • Les figures du dessin annexé feront bien comprendre comment l'invention peut être réalisée.The figures of the appended drawing will make it clear how the invention can be implemented.
  • La figure 1 est une vue de dessus de la plaque supérieure d'un exemple de réalisation de supports de réaction selon l'invention.Figure 1 is a top view of the upper plate of an exemplary embodiment of reaction supports according to the invention.
  • La figure 2 est une vue en coupe agrandie selon la ligne II-II de la figure 1.Figure 2 is an enlarged sectional view along line II-II of Figure 1.
  • La figure 3 est une vue de dessus du disque inférieur associé au disque supérieur des figures 1 et 2.FIG. 3 is a top view of the lower disk associated with the upper disk of FIGS. 1 and 2.
  • La figure 4 est une vue de dessus agrandie d'un orifice du disque inférieur de la figure 3.FIG. 4 is an enlarged top view of an orifice of the lower disc of FIG. 3.
  • La figure 5 est une vue en coupe agrandie selon la ligne V-V de la figure 3.FIG. 5 is an enlarged sectional view along the line V-V of FIG. 3.
  • La figure 6 est une vue en coupe diamétrale agrandie partielle du support selon l'invention, au niveau d'un récipient de réaction.Figure 6 is a partial enlarged diametral sectional view of the support according to the invention, at a reaction vessel.
  • La figure 7 illustre en vue de dessus agrandie une variante de réalisation de supports de réaction selon l'invention.FIG. 7 illustrates in enlarged top view an alternative embodiment of reaction supports according to the invention.
  • La figure 8 est une coupe longitudinale de la figure 7 et peut être comparée à la figure 6.Figure 8 is a longitudinal section of Figure 7 and can be compared to Figure 6.

Le mode de réalisation du support de réaction à récipients multiples selon l'invention, décrit ci-après en regard des figures 1 à 6, comporte un disque supérieur 1 (figure 1) et un disque inférieur 2 (figure 3) superposés et assemblés par exemple par collage. Les disques 1 et 2 sont dans une matière synthétique transparente et sont pourvus en leur centre de trous 3 ou 4, respectivement, pour permettre le passage d'un arbre rotatif d'entraînement lorsque les . disques 1 et 2 sont superposés.The embodiment of the reaction vessel with multiple containers according to the invention, described below with reference to Figures 1 to 6, comprises an upper disc 1 (Figure 1) and a lower disc 2 (Figure 3) superimposed and assembled by example by collage. The discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the. discs 1 and 2 are superimposed.

Le disque supérieur 1 est pourvu d'une pluralité de trous traversants 5 dont les axes 6, orthogonaux au plan du disque 1 sont répartis en une pluralité de points 7 se trouvant à l'intersection de rayons 8 et de cercles concentriques 9. Par ailleurs, chaque trou 5 s'évase vers le haut grâce à une portion 10 en forme d'entonnoir, d'axe 6.The upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.

A des fins de clarté du dessin, sur la figure 1, seuls quelques trous 5 ont été représentés.For the sake of clarity of the drawing, in FIG. 1, only a few holes 5 have been shown.

Le disque transparent inférieur 2 comporte une pluralité de trous borgnes 11 dont les axes 12 sont répartis en une pluralité de points 13 se trouvant à l'intersection de rayons 14 et de cercles concentriques 15.The lower transparent disc 2 has a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.

Par ailleurs, à chaque trou borgne 11 est associé une échancrure 16 inclinée, symétrique par rapport au diamètre 14 correspondant et disposée par rapport au trou 11, du côté du centre du disque 2.Furthermore, each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.

Pour obtenir un support de réaction selon l'invention, on superpose le disque 1 au disque 2,.de façon que l'axe 6 des trous 5 et 10 vienne en correspondance avec l'axe médian 17 des échancrures obliques 16. Dans cette position, représentée sur la figure 6, chaque trou borgne 11 est obturé par le disque 1, mais il est en communication avec l'extérieur, à sa partie supérieure, par l'intermédiaire de l'échancrure oblique 16 et des trous 5 et 10. De préférence, la longueur radiale des échancrures 16 est égale au diamètre des trous 5 (voir la figure 6).To obtain a reaction support according to the invention, the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16. In this position , shown in FIG. 6, each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and the holes 5 and 10. Preferably, the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).

Ainsi, il est possible de remplir le trou borgne 11 (ou récipient 11) en doses de liquide en introduisant, par exemple, l'aiguille d'une seringue dans l'entonnoir 10, le liquide traversant alors le trou 10 et l'échancrure 16 pour parvenir jusqu'au récipient 11. De la même façon, il est possible d'introduire un ou plusieurs réactifs dans les récipients 11. Lorsqu'une agitation ou une centrifugation est nécessaire, il suffit de soumettre le disque 1,2 à ce mouvement et, puisque les récipients 11 sont obturés par le disque 1 et que les échancrures 6 et les trous 10 se trouvent plus près du diamètre du disque 1,2 que les récipients 11, il n'y a aucun risque que le liquide contenu dans ces récipients 11 s'échappe vers l'extérieur.Thus, it is possible to fill the blind hole 11 (or container 11) with doses of liquid by introducing, for example, the needle of a syringe into the funnel 10, the liquid then passing through the hole 10 and the notch 16 to reach the container 11. In the same way, it is possible to introduce one or more reagents into the containers 11. When stirring or centrifugation is necessary, it suffices to subject the disc 1.2 to this movement and, since the containers 11 are closed by the disc 1 and the notches 6 and the holes 10 are closer to the diameter of the disc 1.2 than the containers 11, there is no risk that the liquid contained in these containers 11 escape towards the outside.

Dans l'exemple de réalisation représenté, on a supposé que le disque était composé de deux plaques 1,2 superposées. Bien entendu, le disque selon l'invention pourrait être composé, par exemple, de trois plaques superposées. Pour cela, on pourrait prévoir que les trous 11 traversent complètement la plaque 2 et qu'ils sont obturés par une troisième plaque disposée du côté opposé au disque 1 par rapport au disque 2, comme cela est symbolisé sur la figure 6 par la ligne en trait mixte 18.In the embodiment shown, it has been assumed that the disc is composed of two superimposed plates 1, 2. Of course, the disc according to the invention could be composed, for example, of three superimposed plates. For this, provision could be made for the holes 11 to pass completely through the plate 2 and for them to be closed off by a third plate disposed on the side opposite the disk 1 relative to the disk 2, as symbolized in FIG. 6 by the line in mixed line 18.

Dans la variante de réalisation des figures 7 et 8, le disque supérieur 1 ne comporte que les portions 10, en forme d'entonnoir, des trous 5. En revanche, les trous borgnes 11 sont, dans le disque inférieur 2, prolongés en direction des portions 10, par un trou de communication 11' à fond plat, suffisamment allongé pour que le bord supérieur des entonnoirs 10 se trouve à l'extérieur du récipient 11, ou tout au moins dégage sur le fond de celui-ci un champ de vision 19 recouvrant pratiquement la plus grande partie dudit fond.In the variant embodiment of FIGS. 7 and 8, the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5. On the other hand, the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

Claims (10)

1.Support de réaction à récipients multiples pour tests de doses de liquide, comportant une plaque transparente pourvue d'une pluralité d'alvéoles dont chacun d'eux forme l'un des dits récipients, caractérisé en ce que ladite plaque présente la forme d'un disque et en ce que les alvéoles (11) sont obturés vers le haut et sont chacun en communication avec l'extérieur par l'intermédiaire d'un orifice excentré (5) débouchant sur la face supérieure du disque.1. Reaction support with multiple receptacles for liquid dose tests, comprising a transparent plate provided with a plurality of cells, each of which forms one of the said receptacles, characterized in that said plate has the form d 'a disc and in that the cells (11) are closed up and are each in communication with the outside via an eccentric orifice (5) opening on the upper face of the disc. 2. Support selon la revendication 1, caractérisé en ce que le disque est percé en son centre d'un trou (3,4) permettant son montage sur un axe vertical rotatif.2. Support according to claim 1, characterized in that the disc is pierced in its center with a hole (3,4) allowing it to be mounted on a rotary vertical axis. 3. Support selon l'une quelconque des revendications 1 ou 2, caractérisé en ce que l'orifice excentré (5) est plus proche du centre du disque que l'alvéole (11) correspondant.3. Support according to any one of claims 1 or 2, characterized in that the eccentric orifice (5) is closer to the center of the disc than the corresponding socket (11). 4. Support de réaction selon l'une quelconque des revendications 1 à 3,
caractérisé en ce que les différents alvéoles (11) et orifices (5) sont rangés selon des rayons (8,14) et des cercles concentriques (9,13).4. Reaction support according to any one of claims 1 to 3,
characterized in that the various cells (11) and orifices (5) are arranged according to radii (8,14) and concentric circles (9,13). 5. Support selon l'une 'quelconque des revendications 1 à 4,
caractérisé en ce que le disque est formé par la superposition et la solidarisation d'au moins deux plaques circulaires coaxiales (1 et 2) dont l'une comporte les dits alvéoles (11) et l'autre des trous traversants (5,10) formant chacun un desdits orifices.5. Support according to any one of claims 1 to 4,
characterized in that the disc is formed by the superposition and the joining of at least two coaxial circular plates (1 and 2), one of which comprises the said cells (11) and the other of the through holes (5,10) each forming one of said orifices. 6. Support selon l'une quelconque des revendications 1 a 5,
caractérisé en ce que les orifices excentrés sont évasés vers le haut.6. Support according to any one of claims 1 to 5,
characterized in that the eccentric orifices are flared upwards. 7.Support selon l'une quelconque des revendications précédentes,
caractérisé en ce que l'orifice excentré (5,10) et le récipient (11) communiquent par un passage (16) incliné du haut vers le bas et de l'intérieur du disque vers l'extérieur.7. Support according to any one of the preceding claims,
characterized in that the eccentric orifice (5,10) and the container (11) communicate by a passage (16) inclined from the top to the bottom and from the inside of the disc towards the outside. 8. Support selon l'une quelconque des revendications 1 à 6,
caractérisé en ce que l'orifice excentré (10) et le récipient (1) communiquent par un prolongement (11') à fond plat du récipient (11) vers l'orifice (10).8. Support according to any one of claims 1 to 6,
characterized in that the eccentric orifice (10) and the container (1) communicate by an extension (11 ') with a flat bottom of the container (11) towards the orifice (10). 9. Support de réaction selon les revendications précédentes, caractérisé en ce que le passage incliné (6) ou le prolongement (11') sont pratiqués dans la plaque inférieure (2).9. Reaction support according to the preceding claims, characterized in that the inclined passage (6) or the extension (11 ') are formed in the lower plate (2). 10. Support selon l'une quelconque des revendications précédentes,
caractérisé en ce que les orifices excentrés sont disposés de façon à dégager au maximum, en projection, le fond desdits récipients.10. Support according to any one of the preceding claims,
characterized in that the eccentric orifices are arranged so as to free as much as possible, in projection, the bottom of said containers.
EP82401379A 1981-08-05 1982-07-26 Multiple receptacle reaction support for testing liquid doses Expired EP0072284B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82401379T ATE30215T1 (en) 1981-08-05 1982-07-26 MULTIPLE REACTION VESSEL HOLDER FOR TESTING LIQUID SAMPLES.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115163 1981-08-05
FR8115163A FR2511153B1 (en) 1981-08-05 1981-08-05 MULTIPLE CONTAINER REACTION HOLDER FOR TESTING LIQUID DOSES

Publications (3)

Publication Number Publication Date
EP0072284A2 true EP0072284A2 (en) 1983-02-16
EP0072284A3 EP0072284A3 (en) 1985-01-16
EP0072284B1 EP0072284B1 (en) 1987-10-14

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EP82401379A Expired EP0072284B1 (en) 1981-08-05 1982-07-26 Multiple receptacle reaction support for testing liquid doses

Country Status (6)

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US (1) US4656009A (en)
EP (1) EP0072284B1 (en)
JP (1) JPS5830669A (en)
AT (1) ATE30215T1 (en)
DE (1) DE3277454D1 (en)
FR (1) FR2511153B1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168657A1 (en) * 1984-06-19 1986-01-22 FINBIOMEDICA S.r.l. Method and equipment for rapid, automatic chemical-clinical analysis
FR2618553A1 (en) * 1987-07-24 1989-01-27 Materiel Biomedical Reaction support with multiple receptacles, and test system comprising the said support
EP0317987A2 (en) * 1987-11-23 1989-05-31 Lmb Medizin Technik Gmbh Reagent container for the analysis of fluid samples in the microliter domain
FR2638844A1 (en) * 1988-11-09 1990-05-11 Rene Hamelin MULTIPLE CONTAINER DEVICE FOR TESTING, AND ELEMENT FOR CARRYING OUT SUCH A DEVICE
WO1998025140A1 (en) * 1996-12-02 1998-06-11 Abb Kent-Taylor Limited Apparatus for the analysis of liquid

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* Cited by examiner, † Cited by third party
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US5195825A (en) * 1988-05-09 1993-03-23 Gene-Trak Systems Device for mixing at least one aqueous fluid substance
US5266268A (en) * 1991-08-15 1993-11-30 Iniziative Maritime 1991, S.R.L. Centrifugal analyzer rotors
JPH05118671A (en) * 1991-10-30 1993-05-14 Mitsubishi Electric Corp Electric component box of air conditioner
FR2770515B1 (en) * 1997-11-06 2000-01-21 Corning Inc BUCKET PLATES AND ITS MANUFACTURING METHOD
US5963318A (en) * 1998-08-07 1999-10-05 Bio-Tek Holdings, Inc. Method of and apparatus for performing fixed pathlength vertical photometry
US20040124231A1 (en) * 1999-06-29 2004-07-01 Hasz Wayne Charles Method for coating a substrate
JP5287609B2 (en) * 2009-08-26 2013-09-11 株式会社島津製作所 Reaction vessel
JP5932077B1 (en) * 2015-02-24 2016-06-08 シャープ株式会社 Component analysis container
JP6733861B2 (en) * 2016-01-06 2020-08-05 エア・ウォーター・バイオデザイン株式会社 Component analysis system
US20190086324A1 (en) * 2016-03-23 2019-03-21 Truvian Sciences, Inc. Systems and Methods for Multianalyte Detection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
GB2015729A (en) * 1978-03-01 1979-09-12 Centre Nat Transfusion Automatic analysis centrifuging device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883308A (en) * 1967-05-12 1975-05-13 Centre Nat Rech Scient Apparatus for analysing liquid substances likely to form agglutinates
US3813031A (en) * 1972-08-02 1974-05-28 Atomic Energy Commission Rotor having sample holding means
US3763374A (en) * 1972-08-22 1973-10-02 Atomic Energy Commission Dynamic multistation photometer-fluorometer
US3864089A (en) * 1973-12-10 1975-02-04 Atomic Energy Commission Multiple-sample rotor assembly for blood fraction preparation
US3890101A (en) * 1974-02-15 1975-06-17 Us Energy Collection ring for use in multiple-sample blood fractionation centrifugal rotors
US3901658A (en) * 1974-07-30 1975-08-26 Us Energy Whole blood analysis rotor assembly having removable cellular sedimentation bowl
NL7613690A (en) * 1976-12-09 1978-06-13 Cenco Instr Bv CYTOCENTRIFUGE.
US4035156A (en) * 1977-01-21 1977-07-12 The United States Of America As Represented By The United States Energy Research And Development Administration Filter type rotor for multistation photometer
JPS55121150A (en) * 1979-03-14 1980-09-18 Hitachi Ltd Plural items analyzing unit
JPS5644852A (en) * 1979-09-21 1981-04-24 Hitachi Ltd Centrifugal sampler for automatic chemical analysis device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
GB2015729A (en) * 1978-03-01 1979-09-12 Centre Nat Transfusion Automatic analysis centrifuging device

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168657A1 (en) * 1984-06-19 1986-01-22 FINBIOMEDICA S.r.l. Method and equipment for rapid, automatic chemical-clinical analysis
US4767600A (en) * 1984-06-19 1988-08-30 Finbiomedica S.R.L. Equipment for rapid, automatic chemical-clinical analysis
FR2618553A1 (en) * 1987-07-24 1989-01-27 Materiel Biomedical Reaction support with multiple receptacles, and test system comprising the said support
EP0317987A2 (en) * 1987-11-23 1989-05-31 Lmb Medizin Technik Gmbh Reagent container for the analysis of fluid samples in the microliter domain
EP0317987A3 (en) * 1987-11-23 1990-06-27 Lmb Medizin Technik Gmbh Reagent container for the analysis of fluid samples in the microliter domain
FR2638844A1 (en) * 1988-11-09 1990-05-11 Rene Hamelin MULTIPLE CONTAINER DEVICE FOR TESTING, AND ELEMENT FOR CARRYING OUT SUCH A DEVICE
WO1990005294A1 (en) * 1988-11-09 1990-05-17 Hamelin Rene Multiple-container device for conducting tests, and element for achieving such a device
WO1998025140A1 (en) * 1996-12-02 1998-06-11 Abb Kent-Taylor Limited Apparatus for the analysis of liquid

Also Published As

Publication number Publication date
ATE30215T1 (en) 1987-10-15
DE3277454D1 (en) 1987-11-19
JPS5830669A (en) 1983-02-23
EP0072284A3 (en) 1985-01-16
FR2511153B1 (en) 1986-01-10
FR2511153A1 (en) 1983-02-11
US4656009A (en) 1987-04-07
EP0072284B1 (en) 1987-10-14

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