EP0072284B1 - Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben - Google Patents

Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben Download PDF

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Publication number
EP0072284B1
EP0072284B1 EP82401379A EP82401379A EP0072284B1 EP 0072284 B1 EP0072284 B1 EP 0072284B1 EP 82401379 A EP82401379 A EP 82401379A EP 82401379 A EP82401379 A EP 82401379A EP 0072284 B1 EP0072284 B1 EP 0072284B1
Authority
EP
European Patent Office
Prior art keywords
disc
rotatable support
support according
eccentric
recesses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP82401379A
Other languages
English (en)
French (fr)
Other versions
EP0072284A2 (de
EP0072284A3 (en
Inventor
Alain Charles Albert Benajam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Original Assignee
Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Materiel Biomedical A Responsabilite Dite Ltee Ste filed Critical Le Materiel Biomedical A Responsabilite Dite Ltee Ste
Priority to AT82401379T priority Critical patent/ATE30215T1/de
Publication of EP0072284A2 publication Critical patent/EP0072284A2/de
Publication of EP0072284A3 publication Critical patent/EP0072284A3/fr
Application granted granted Critical
Publication of EP0072284B1 publication Critical patent/EP0072284B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the present invention relates to a reaction vessel with multiple containers for testing liquid doses, allowing both agitation and / or centrifugation and automation of the test processes.
  • the rotary reaction support between liquid doses of samples and reagents in the form of a transparent disc in which are provided a plurality of flat-bottomed cells closed upwards and communicating with the outside each via an eccentric orifice opening into the upper face of the disc, is characterized in that said cells have no communication with each other.
  • the eccentric hole and the socket can communicate by an inclined face from top to bottom and from the inside of the disc to the outside. They can also communicate by a flat-bottom extension of said cell towards the orifice.
  • the rotary support according to the invention is of the type consisting of superimposed plates, it is advantageous for the disc to be formed by the superposition and the joining of two coaxial circular plates, one of which comprises said cells and the other of the through holes each forming one of said eccentric orifices.
  • the disc is pierced in its center with a hole allowing it to be mounted on a rotary vertical axis, or else it is integral with an axis orthogonal to its plane capable of being connected to rotation drive means.
  • the disc it is possible to subject the disc to rotary agitation or centrifugation movements.
  • the eccentric orifice is closer to the center of the disc than the corresponding socket, so that during centrifugation, the liquid cannot escape through said orifice.
  • the embodiment of the reaction vessel with multiple receptacles according to the invention comprises an upper disc 1 (FIG. 1) and a lower disc 2 (FIG. 3) superimposed and assembled by example by collage.
  • the discs 1 and 2 are made of a transparent synthetic material and are provided in their center with holes 3 or 4, respectively, to allow the passage of a rotary drive shaft when the discs 1 and 2 are superimposed.
  • the upper disc 1 is provided with a plurality of through holes 5 whose axes 6, orthogonal to the plane of the disc 1 are distributed at a plurality of points 7 located at the intersection of spokes 8 and concentric circles 9. Furthermore , each hole 5 widens upwards thanks to a portion 10 in the form of a funnel, of axis 6.
  • the lower transparent disc 2 comprises a plurality of blind holes 11 whose axes 12 are distributed at a plurality of points 13 located at the intersection of spokes 14 and concentric circles 15.
  • each blind hole 11 is associated with an inclined notch 16, symmetrical with respect to the corresponding diameter 14 and arranged with respect to the hole 11, on the side of the center of the disc 2.
  • the disc 1 is superimposed on the disc 2, so that the axis 6 of the holes 5 and 10 comes into correspondence with the median axis 17 of the oblique notches 16.
  • each blind hole 11 is closed by the disc 1, but it is in communication with the outside, at its upper part, via the oblique notch 16 and holes 5 and 10.
  • the radial length of the notches 16 is equal to the diameter of the holes 5 (see FIG. 6).
  • the disc was composed of two plates 1, superimposed.
  • the disc according to the invention could be composed, for example, of three superposed plates.
  • provision could be made for the holes 11 to pass completely through the plate 2 and for them to be closed off by a third plate disposed on the side opposite the disk 1 relative to the disk 2, as symbolized in FIG. 6 by the line in mixed line 18.
  • the upper disc 1 only has the portions 10, in the form of a funnel, with holes 5.
  • the blind holes 11 are, in the lower disc 2, extended in the direction portions 10, by a communication hole 11 ′ with a flat bottom, sufficiently elongated so that the upper edge of the funnels 10 is outside the container 11, or at least gives off on the bottom thereof vision 19 covering practically the greater part of said bottom.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Packages (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (10)

1. Drehbarer Träger für Reaktionen zwischen flüssigen Dosen von Proben und Reagenzien in Form einer transparenten Scheibe, in der eine Vielzahl von nach oben verschlossenen Zellen mit flachem Boden vorgesehen sind, die jeweils mit der Außenwelt über eine exzentrische, in die Oberfläche der Scheibe mündende Öffnung verbunden sind, dadurch gekennzeichnet, daß die Zellen (11) keine Verbindung untereinander aufweisen.
2. Drehbarer Träger nach Anspruch 1, dadurch gekennzeichnet, daß die exzentrische Öffnung (5, 10) und die Zelle (11) über eine von oben nach unten und von innen nach außen in der Scheibe geneigte Fläche (16) verbunden sind.
3. Drehbarer Träger nach Anspruch 1, dadurch gekennzeichnet, daß die exzentrische Öffnung (10) und die Zelle (11) über eine mit einem flachen Boden versehene Verlängerung (11') der Zelle (11) zur Öffnung (10) hin verbunden sind.
4. Drehbarer Träger nach einem der Ansprüche 1 bis 3, von der Gattung mit übereinander angeordneten Platten, dadurch gekennzeichnet, daß die Scheibe durch die Überlagerung und feste Verbindung zweier runder, koaxialer Platten (1 und 2) gebildet wird, von denen die eine die Zellen (11) aufweist und die andere Durchgangslöcher (5, 10) aufweist, die jeweils eine der exzentrischen Öffnungen bilden.
5. Drehbarer Träger nach den Ansprüchen 3 und 4, dadurch gekennzeichnet, daß die Verlängerungen (11') in der unteren Platte (2) ausgeführt sind.
6. Drehbarer Träger nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die exzentrischen Öffnungen derart angeordnet sind, daß sie in der Projektion höchstens den Boden der Zellen frei lassen.
7. Drehbarer Träger nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß die exzentrischen Öffnungen (5, 10) nach oben aufgeweitet sind.
8. Drehbarer Träger nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß jede exzentrische Öffnung (5, 10) sich näher zum Mittelpunkt der Scheibe befindet als die zugehörige Zelle (11).
9. Drehbarer Träger nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, daß die verschiedenen Zellen (11) und Öffnungen (5, 10) auf Radien (8, 14) und konzentrischen Kreisen (9, 13) angeordnet sind.
10. Drehbarer Träger nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, daß die Scheibe in ihrem Mittelpunkt von einem Loch (3, 4) durchbohrt ist, das ihre Montage auf einer senkrechten Drehachse erlaubt.
EP82401379A 1981-08-05 1982-07-26 Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben Expired EP0072284B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82401379T ATE30215T1 (de) 1981-08-05 1982-07-26 Mehrfachreagiergefaessehalter zum pruefen von fluessigkeitsproben.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115163 1981-08-05
FR8115163A FR2511153B1 (fr) 1981-08-05 1981-08-05 Support de reaction a recipients multiples pour tests de doses liquides

Publications (3)

Publication Number Publication Date
EP0072284A2 EP0072284A2 (de) 1983-02-16
EP0072284A3 EP0072284A3 (en) 1985-01-16
EP0072284B1 true EP0072284B1 (de) 1987-10-14

Family

ID=9261178

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82401379A Expired EP0072284B1 (de) 1981-08-05 1982-07-26 Mehrfachreagiergefässehalter zum Prüfen von Flüssigkeitsproben

Country Status (6)

Country Link
US (1) US4656009A (de)
EP (1) EP0072284B1 (de)
JP (1) JPS5830669A (de)
AT (1) ATE30215T1 (de)
DE (1) DE3277454D1 (de)
FR (1) FR2511153B1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1174039B (it) * 1984-06-19 1987-06-24 Finbiomedica Srl Metodo ed apparecchiatura per analisi chimico-cliniche automatiche ad alta velocita'
FR2618553B1 (fr) * 1987-07-24 1989-10-20 Materiel Biomedical Support de reaction a recipients multiples, et systeme de tests comportant ledit support
DE8715505U1 (de) * 1987-11-23 1988-02-18 LMB Medizin Technik GmbH, 8059 Oberding Reaktionsgefäß zur Untersuchung flüssiger Proben im Mikroliterbereich
US5195825A (en) * 1988-05-09 1993-03-23 Gene-Trak Systems Device for mixing at least one aqueous fluid substance
FR2638844A1 (fr) * 1988-11-09 1990-05-11 Rene Hamelin Dispositif a recipients multiples pour effectuer des tests, et element pour realiser un tel dispositif
US5266268A (en) * 1991-08-15 1993-11-30 Iniziative Maritime 1991, S.R.L. Centrifugal analyzer rotors
JPH05118671A (ja) * 1991-10-30 1993-05-14 Mitsubishi Electric Corp 空気調和装置の電気品箱
DE19649811B4 (de) * 1996-12-02 2007-02-22 Abb Research Ltd. Vorrichtung zur Analyse von Flüssigkeiten
FR2770515B1 (fr) * 1997-11-06 2000-01-21 Corning Inc Plaques a godets et son procede de fabrication
US5963318A (en) * 1998-08-07 1999-10-05 Bio-Tek Holdings, Inc. Method of and apparatus for performing fixed pathlength vertical photometry
US20040124231A1 (en) * 1999-06-29 2004-07-01 Hasz Wayne Charles Method for coating a substrate
JP5287609B2 (ja) * 2009-08-26 2013-09-11 株式会社島津製作所 反応容器
JP5932077B1 (ja) * 2015-02-24 2016-06-08 シャープ株式会社 成分分析用容器
JP6733861B2 (ja) * 2016-01-06 2020-08-05 エア・ウォーター・バイオデザイン株式会社 成分分析システム
US20190086324A1 (en) * 2016-03-23 2019-03-21 Truvian Sciences, Inc. Systems and Methods for Multianalyte Detection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883308A (en) * 1967-05-12 1975-05-13 Centre Nat Rech Scient Apparatus for analysing liquid substances likely to form agglutinates
US3813031A (en) * 1972-08-02 1974-05-28 Atomic Energy Commission Rotor having sample holding means
US3763374A (en) * 1972-08-22 1973-10-02 Atomic Energy Commission Dynamic multistation photometer-fluorometer
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
US3864089A (en) * 1973-12-10 1975-02-04 Atomic Energy Commission Multiple-sample rotor assembly for blood fraction preparation
US3890101A (en) * 1974-02-15 1975-06-17 Us Energy Collection ring for use in multiple-sample blood fractionation centrifugal rotors
US3901658A (en) * 1974-07-30 1975-08-26 Us Energy Whole blood analysis rotor assembly having removable cellular sedimentation bowl
NL7613690A (nl) * 1976-12-09 1978-06-13 Cenco Instr Bv Cytocentrifuge.
US4035156A (en) * 1977-01-21 1977-07-12 The United States Of America As Represented By The United States Energy Research And Development Administration Filter type rotor for multistation photometer
FR2418673A1 (fr) * 1978-03-01 1979-09-28 Nal Transfusion Sanguine Centr Dispositif de centrifugation de liquides contenant des particules ou cellules en suspension
JPS55121150A (en) * 1979-03-14 1980-09-18 Hitachi Ltd Plural items analyzing unit
JPS5644852A (en) * 1979-09-21 1981-04-24 Hitachi Ltd Centrifugal sampler for automatic chemical analysis device

Also Published As

Publication number Publication date
ATE30215T1 (de) 1987-10-15
DE3277454D1 (en) 1987-11-19
EP0072284A2 (de) 1983-02-16
JPS5830669A (ja) 1983-02-23
EP0072284A3 (en) 1985-01-16
FR2511153B1 (fr) 1986-01-10
FR2511153A1 (fr) 1983-02-11
US4656009A (en) 1987-04-07

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