EP0053253A2 - Dispositif d'inhalation pour animaux de laboratoire - Google Patents

Dispositif d'inhalation pour animaux de laboratoire Download PDF

Info

Publication number
EP0053253A2
EP0053253A2 EP81108263A EP81108263A EP0053253A2 EP 0053253 A2 EP0053253 A2 EP 0053253A2 EP 81108263 A EP81108263 A EP 81108263A EP 81108263 A EP81108263 A EP 81108263A EP 0053253 A2 EP0053253 A2 EP 0053253A2
Authority
EP
European Patent Office
Prior art keywords
openings
animal
tubes
wall
animal tubes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP81108263A
Other languages
German (de)
English (en)
Other versions
EP0053253B1 (fr
EP0053253A3 (en
Inventor
Richard Dr. Bung
Hartmut Dr. Giesbrecht
Wolfgang Dr. Leuckel
Hans-Joachim Dr. Klimisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to AT81108263T priority Critical patent/ATE13384T1/de
Publication of EP0053253A2 publication Critical patent/EP0053253A2/fr
Publication of EP0053253A3 publication Critical patent/EP0053253A3/de
Application granted granted Critical
Publication of EP0053253B1 publication Critical patent/EP0053253B1/fr
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices

Definitions

  • the invention relates to an inhalation apparatus for experimental animals for examining the biological effect of substances that are admixed with the breathing air, according to the preamble of patent claim 1.
  • inhalation devices have mainly been used up to now, in which the breathing air to be examined is directed into a distribution chamber and from there is distributed through openings in the chamber wall into connected animal tubes filled with the test animals. All breathing air flows past the test animals and escapes into the environment at the end of the animal tube, or a partial flow of the breathing air is led through the animal tubes, provided that the distribution chamber is connected to an exhaust system (open overpressure mode of operation).
  • the experimental animals mainly rodents and rats, are sufficiently exposed to the air they breathe, which is mostly unknown in their toxicity, but not only in the head and nose area, but also with their body surface, which leads to undesirable fur contamination. Furthermore, at least part of the air we breathe gets into the environment. This in turn requires protective measures such as a shelter, room ventilation and extraction. Furthermore, for safety reasons, devices of this type can only be started up when they are occupied; during this time there are undefined inflow conditions.
  • the inhalation apparatus is shown schematically in FIGS. 1 and 2. It essentially consists of a distribution chamber 1, a vacuum chamber 2 which extends directly parallel to it, and animal tubes 3 which can be connected to these chambers.
  • the distribution chamber 1 is connected to a breathing air supply via a feed hood 5 equipped with guide plates 4 (not in the drawing) shown) connected in which the toxicologically investigated pollutants are added to the breathing air.
  • the vacuum chamber 2 is connected to a waste disposal system (not shown in the drawing) via a collecting hood 6 opposite in the direction of flow to extract the exhaust air.
  • the entire inhalation apparatus is rotatably held about a horizontal axis in a mobile frame 7 by means of a pivot bearing 8 for easy handling and flexible use.
  • a wall 9 separating the distribution chamber 1 and the vacuum chamber 2 has openings 10 arranged in several rows, to which the animal tubes 3 are attached directly or at a distance with their head part end.
  • the animal tubes 3 made of transparent plastic or glass are each composed of a head part 11 and a fuselage part 12, which are connected by a transition 13.
  • the transition is through Refractions 14 provided, which are distributed in the form of holes over the circumference.
  • a recess 15 is provided in the body part of the animal tube for the excretions of the animal.
  • the cross section of the head part of the animal tube is in the form of a circle or polygon, preferably a hexagon. As a result, the tube cannot be sealed by the head of the test animal, so that a safe flow through the head part is ensured. It is therefore also expedient to make the openings 14 in the corners of the polygon.
  • supports 16 connected to the outer wall 21 of the vacuum chamber 2 are provided.
  • the negative pressure at the openings 14 at the transition 13 of the animal tubes 3 can be generated, for example, in that the animal tubes attached to the openings 10 of the distribution chamber 1 are wholly or partly, but at least up to the transition 13 in the negative pressure chamber 2.
  • the vacuum chamber is opened towards the end of the trunk of the animal tubes to such an extent that the animal tubes reach the openings 10 can be removed or introduced by these and environmental g ebungs Kunststoff between these can be sucked into the vacuum chamber.
  • FIGs 2 and 3 show an embodiment of the inhalation chamber according to the invention, in which the outer wall 21 of the vacuum chamber 2 is set back up to the level of the head part 11 of the animal tube 3, so that when the animal tube is attached, the transition 13 with the openings 14 lies outside the chamber.
  • the animal tubes are easy to handle and the test animals inside can be easily observed.
  • channels 23, which are closed off from the vacuum chamber 2 and taper towards the openings 10 extend in the region of the head part 11 of the animal tube 3 to be received in the form of bores in the channel wall 24 have passages 25 distributed over the channel circumference.
  • the channels 23 are expanded at the outer wall openings 22 by cylindrical extensions 26 to the transition 13 of the attached animal tubes 3, the extensions with an annular shoulder 27 of the animal tubes each forming an annular gap 28 between the opposing end faces.
  • the extension 26 and the shoulder 27 can also be dimensioned such that the circumferential surfaces face each other to produce a concentric annular gap. Spacer knobs 29 on one of the surfaces ensure a defined annular gap.
  • the openings 14 of the animal tubes 3 are in the effective area of the vacuum chamber, so that both the breathing air guided through the head part 11 of the animal tubes and the ambient air flowing in through the fuselage part 12 are sucked into the extension 26 ′ of the channels 23 via these openings will.
  • the air mixture which is composed of the exhaust air is discharged via the passages 25 of the channel wall 24 into the vacuum chamber. This air flow ensures that the breathing air intended for animal inhalation cannot get into the vicinity of the inhalation apparatus. This is ensured even when animal tubes are not attached, since in this case the breathing air is sucked directly from the openings 10 of the distribution chamber 1 to the passages 25.
  • the animal tubes used in the apparatus are more or less enclosed by the channel wall 24 at their free head end 30 due to the conical shape of the head part 11, depending on the immersion depth in the channels 23, so that with the help of the resulting annular gap 31 a side stream of the breathing air and thus the amount of breathing air flowing over the head of the test animal can be adjusted.
  • the distributor chamber 1 tapers upwards due to a slight inclination of the outer wall 33 of the chamber, so that the chamber cross section is reduced in view of the decreasing breathing air volume flow in the flow direction.
  • a corresponding cross-sectional expansion of the vacuum chamber 2 is not necessary because of the small pressure loss along the exhaust air flow.
  • the distributor chamber 1 is perforated at its upper end towards the vacuum chamber 2, through bores 34 or other opening shapes, in order to support the vertical distribution of the breathing air in the distributor chamber with the partial flow which is thereby fed directly into the vacuum chamber. It is also achieved that the influence of the animal tubes on the pressure and flow conditions in the channels 23 is reduced.
  • the following flow diagram illustrates the volume flow distribution in the inhalation device (for 21 animal tubes).
  • the numerical values entered relate to an operating example. Depending on the size of the apparatus and the examination task, other operating parameters can of course also be selected.
  • the arrows entered in FIG. 3 provide a further illustration of the air flows in the apparatus.
  • the inhalation apparatus For the construction of the inhalation apparatus, it is expedient because of a stable and yet light construction to produce individual wall elements 35 (FIG. 1) with a deep-drawn channel part 23 and to join them together at their angled circumference 36 by welded connections, for example spot welding, to the outer wall 21 of the vacuum chamber 2.
  • the partition 9 is connected in the same way at the openings 10 to the tapered channel part end 38 of the wall elements which is formed into a collar 37.
  • the attachment of the remaining wall parts and the structure of the distribution chamber 1 and the hoods 5 and 6 can then be carried out in the manner known to those skilled in the art.
  • the displacers 32 are fastened to the inner wall of the channel parts 23 by means of webs 39. Near the expanse tion 40 are the passages 25. The extensions 26 are inserted into the channels 23 in the form of a frictional connection.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Housing For Livestock And Birds (AREA)
  • Catching Or Destruction (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP81108263A 1980-11-27 1981-10-13 Dispositif d'inhalation pour animaux de laboratoire Expired EP0053253B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT81108263T ATE13384T1 (de) 1980-11-27 1981-10-13 Inhalationsapparatur fuer versuchstiere.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3044640 1980-11-27
DE19803044640 DE3044640A1 (de) 1980-11-27 1980-11-27 Inhalationsapparatur fuer versuchstiere

Publications (3)

Publication Number Publication Date
EP0053253A2 true EP0053253A2 (fr) 1982-06-09
EP0053253A3 EP0053253A3 (en) 1982-08-25
EP0053253B1 EP0053253B1 (fr) 1985-05-22

Family

ID=6117687

Family Applications (1)

Application Number Title Priority Date Filing Date
EP81108263A Expired EP0053253B1 (fr) 1980-11-27 1981-10-13 Dispositif d'inhalation pour animaux de laboratoire

Country Status (4)

Country Link
US (1) US4479493A (fr)
EP (1) EP0053253B1 (fr)
AT (1) ATE13384T1 (fr)
DE (2) DE3044640A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121795A2 (fr) * 1983-03-10 1984-10-17 Stauffer Chemical Company Dispositif d'inhalation d'une atmosphère d'essai
EP0282444A1 (fr) * 1987-02-09 1988-09-14 Research And Consulting Company Ag Tour d'inhalation modulaire pour animaux de laboratoire
DE4240685C1 (de) * 1992-12-03 1994-05-11 Gsf Forschungszentrum Umwelt Apparatur zur Exposition von Versuchstieren
WO1996000046A1 (fr) * 1994-06-23 1996-01-04 Astra Aktiebolag Procedes et systemes de mesure
RU208954U1 (ru) * 2021-10-28 2022-01-24 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Устройство для моделирования у животных отравления газами

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4917046A (en) * 1986-04-21 1990-04-17 Spengler Charles W Aerosol testing method and chamber for experimental animals
US4781146A (en) * 1986-04-21 1988-11-01 Spengler Charles W Aerosol testing chamber for experimental animals
US4721060A (en) * 1986-07-17 1988-01-26 Battelle Memorial Institute Nose-only exposure system
US5109797A (en) * 1990-08-29 1992-05-05 Briant James K Avian inhalation exposure chamber
US5099792A (en) * 1991-04-08 1992-03-31 Battelle Memorial Institute Interchangeable whole-body and nose-only exposure system
US5297502A (en) * 1993-05-05 1994-03-29 Jaeger Rudolf J Modular reversible-flow-past nasopulmonary respiratory dosing system for laboratory animals
US5379777A (en) * 1994-01-07 1995-01-10 Buxco Electronics, Inc. Whole body plethysmograph for non-invasive pulmonary measurements of unrestrained small animals
US6725859B1 (en) * 1997-01-22 2004-04-27 Charles River Laboratories Apparatus for delivering air-borne substances
US6651587B1 (en) * 2002-03-29 2003-11-25 Battelle Memorial Institute Container for containing an experimental test animal
US6902532B2 (en) * 2003-06-12 2005-06-07 Buxco Electronics, Inc. Reduced-noise plethysmograph
CA2624487A1 (fr) * 2005-09-30 2007-04-12 Battelle Memorial Institute Systeme d'exposition a un inhalant
US8066646B2 (en) * 2005-12-01 2011-11-29 Buxco Electronics, Inc. Large diameter plethysmograph
WO2007135248A1 (fr) * 2006-05-24 2007-11-29 Equipement Veterinaire Minerve Cellule universelle pour l'imagerie medicale d'un petit animal sous anesthesie
EP2095791A1 (fr) * 2008-02-29 2009-09-02 Philip Morris Products S.A. Appareil d'exposition
US20090223460A1 (en) * 2008-03-10 2009-09-10 Starr Life Sciences Corp. Bioactive gas supply chamber for animal research such as hypoxia studies on non-anesthetized small animals with direct physiologic monitoring
US8788236B2 (en) 2011-01-31 2014-07-22 Covidien Lp Systems and methods for medical device testing
US8676529B2 (en) 2011-01-31 2014-03-18 Covidien Lp Systems and methods for simulation and software testing
US10357348B2 (en) * 2013-08-19 2019-07-23 Warren Matthew Leevy Fluid manifold

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418773A1 (de) * 1973-04-18 1974-10-31 Connel Allan A Vorrichtung zum inhalieren eines anaesthetischen mittels
DE2341924A1 (de) * 1973-08-18 1975-03-06 Gerhard Goetze Vorrichtung zur pruefung von aerosolen im tierversuch
US4053604A (en) * 1975-11-26 1977-10-11 Ayerst, Mckenna & Harrison Limited Method for improving anesthesia and compositions therefor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3402530A (en) * 1962-08-21 1968-09-24 Israel State Air filter installations
US3464388A (en) * 1967-03-06 1969-09-02 Rodney W Stout Gnotobiotic systems
US3557785A (en) * 1968-02-28 1971-01-26 Dow Chemical Co Gas administration apparatus
US4278048A (en) * 1979-10-11 1981-07-14 Klein Edward J Veterinary medicine facility
US4348985A (en) * 1980-10-22 1982-09-14 The Upjohn Company Animal inhalation exposure system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418773A1 (de) * 1973-04-18 1974-10-31 Connel Allan A Vorrichtung zum inhalieren eines anaesthetischen mittels
DE2341924A1 (de) * 1973-08-18 1975-03-06 Gerhard Goetze Vorrichtung zur pruefung von aerosolen im tierversuch
US4053604A (en) * 1975-11-26 1977-10-11 Ayerst, Mckenna & Harrison Limited Method for improving anesthesia and compositions therefor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGS OF THE EUROPEAN SOCIETY FOR THE STUDY OF DRUG TOXICITY, Band XV, 1974, Seiten 239-251, K. SACHSSE et al.: "Measurement of inhalation toxicity of aerosols in small laboratory animals" *
PROCEEDINGS OF THE EUROPEAN SOCIETY FOR THE STUDY OF DRUG TOXICITY, Band XV, 1974, Seiten 259-268, J.E. BEACH et al.: "Inhalation toxicity study of a dry powder aerosol of disodium chromoglycate in rats. Part I. 5 week toxicity study" *
PROCEEDINGS OF THE EUROPEAN SOCIETY FOR THE STUDY OF DRUG TOXICITY, Band XV, 1974, Seiten 269-274, K.M. JONES et al.: "Inhalation toxicity study of a dry powder aerosol of disodium chromoglycate in rats. Part II. Estimation of the amount absorbed" *
TOXICOLOGY AND APPLIED PHARMACOLOGY, Band 26, 1973, Seiten 264-273, O.G. RAABE et al.: "An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols" *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121795A2 (fr) * 1983-03-10 1984-10-17 Stauffer Chemical Company Dispositif d'inhalation d'une atmosphère d'essai
EP0121795A3 (fr) * 1983-03-10 1987-08-12 Stauffer Chemical Company Dispositif d'inhalation d'une atmosphère d'essai
EP0282444A1 (fr) * 1987-02-09 1988-09-14 Research And Consulting Company Ag Tour d'inhalation modulaire pour animaux de laboratoire
CH670378A5 (fr) * 1987-02-09 1989-06-15 Res And Consulting Company A G
DE4240685C1 (de) * 1992-12-03 1994-05-11 Gsf Forschungszentrum Umwelt Apparatur zur Exposition von Versuchstieren
WO1996000046A1 (fr) * 1994-06-23 1996-01-04 Astra Aktiebolag Procedes et systemes de mesure
RU208954U1 (ru) * 2021-10-28 2022-01-24 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Устройство для моделирования у животных отравления газами

Also Published As

Publication number Publication date
US4479493A (en) 1984-10-30
EP0053253B1 (fr) 1985-05-22
EP0053253A3 (en) 1982-08-25
DE3044640A1 (de) 1982-07-08
ATE13384T1 (de) 1985-06-15
DE3170625D1 (en) 1985-06-27

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