EE9900600A - Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena - Google Patents

Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena

Info

Publication number
EE9900600A
EE9900600A EEP199900600A EEP9900600A EE9900600A EE 9900600 A EE9900600 A EE 9900600A EE P199900600 A EEP199900600 A EE P199900600A EE P9900600 A EEP9900600 A EE P9900600A EE 9900600 A EE9900600 A EE 9900600A
Authority
EE
Estonia
Prior art keywords
thrombin inhibitors
amidine derivatives
novel amidine
novel
derivatives
Prior art date
Application number
EEP199900600A
Other languages
English (en)
Estonian (et)
Inventor
Karlsson Olle
Linschoten Marcel
Nystr�m Jan-Erik
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9702378A external-priority patent/SE9702378D0/xx
Priority claimed from SE9801099A external-priority patent/SE9801099D0/xx
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9900600A publication Critical patent/EE9900600A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EEP199900600A 1997-06-19 1998-06-09 Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena EE9900600A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702378A SE9702378D0 (sv) 1997-06-19 1997-06-19 New compounds
SE9801099A SE9801099D0 (sv) 1998-03-30 1998-03-30 New compounds
PCT/SE1998/001103 WO1998057932A1 (en) 1997-06-19 1998-06-09 New amidino derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
EE9900600A true EE9900600A (et) 2000-08-15

Family

ID=26663014

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900600A EE9900600A (et) 1997-06-19 1998-06-09 Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena

Country Status (20)

Country Link
US (2) US6265397B1 (ja)
EP (1) EP1012140B1 (ja)
JP (2) JP3919236B2 (ja)
KR (1) KR100540413B1 (ja)
CN (1) CN1205187C (ja)
AR (1) AR013084A1 (ja)
AT (1) ATE277902T1 (ja)
AU (1) AU737645C (ja)
BR (1) BR9810177A (ja)
CA (1) CA2294059C (ja)
DE (1) DE69826693T2 (ja)
EE (1) EE9900600A (ja)
IL (1) IL133490A0 (ja)
IS (1) IS5302A (ja)
NO (1) NO315156B1 (ja)
NZ (1) NZ501635A (ja)
PL (1) PL337645A1 (ja)
SK (1) SK167099A3 (ja)
TR (1) TR199903134T2 (ja)
WO (1) WO1998057932A1 (ja)

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AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
TR200102037T2 (tr) 1999-01-13 2001-10-22 Astrazeneca Ab Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
EP1059302A1 (en) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
CA2445591A1 (en) 2001-04-27 2002-11-07 The Procter & Gamble Company Nitrogen heterocyclic compounds and compositions for controlling biofilms
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
PT1622569E (pt) 2003-04-24 2016-03-03 Incyte Corp Derivados de aza espiro alcanos como inibidores de metaloproteases
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
ES2291951T3 (es) * 2003-11-07 2008-03-01 F. Hoffmann-La Roche Ag Derivados de benzo (b) (1,4) dioxepina.
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
BRPI0914323A2 (pt) * 2008-06-23 2017-03-28 Astrazeneca Ab composto, formulação farmacêutica, uso de um composto, e, métodos de tratamento de uma condição e de tratamento e prevenção de distúrbios
CN104327029A (zh) * 2014-09-21 2015-02-04 湖南华腾制药有限公司 一种含氧杂环化合物的制备方法

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HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
ZA86746B (en) 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
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CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
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CA2131367A1 (en) 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
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JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
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US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
EA002767B1 (ru) 1995-02-10 2002-08-29 Басф Акциенгезельшафт Ингибиторы тромбина
SK104697A3 (en) 1995-02-17 1998-11-04 Basf Ag Novel dipeptide amidines as thrombin inhibitors
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
EP0820453A4 (en) 1995-04-04 2001-08-29 Merck & Co Inc THROMBIN INHIBITORS
US5629324A (en) * 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
WO1997033576A1 (en) 1996-03-12 1997-09-18 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
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DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
BR9810177A (pt) 2000-08-08
EP1012140B1 (en) 2004-09-29
WO1998057932A1 (en) 1998-12-23
JP2006321807A (ja) 2006-11-30
IL133490A0 (en) 2001-04-30
CA2294059C (en) 2008-12-09
AU737645B2 (en) 2001-08-23
AU737645C (en) 2002-03-21
US6265397B1 (en) 2001-07-24
KR20010013982A (ko) 2001-02-26
DE69826693T2 (de) 2006-02-16
NO996313L (no) 2000-02-21
CN1205187C (zh) 2005-06-08
AR013084A1 (es) 2000-12-13
JP2002503256A (ja) 2002-01-29
ATE277902T1 (de) 2004-10-15
US6576657B2 (en) 2003-06-10
US20020022612A1 (en) 2002-02-21
NO315156B1 (no) 2003-07-21
JP3919236B2 (ja) 2007-05-23
DE69826693D1 (de) 2004-11-04
NZ501635A (en) 2001-09-28
TR199903134T2 (xx) 2000-07-21
EP1012140A1 (en) 2000-06-28
CN1266427A (zh) 2000-09-13
PL337645A1 (en) 2000-08-28
CA2294059A1 (en) 1998-12-23
KR100540413B1 (ko) 2006-01-12
NO996313D0 (no) 1999-12-17
IS5302A (is) 1999-12-15
AU7946198A (en) 1999-01-04
SK167099A3 (en) 2000-06-12

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