EE200000360A - Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod - Google Patents

Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod

Info

Publication number
EE200000360A
EE200000360A EEP200000360A EEP200000360A EE200000360A EE 200000360 A EE200000360 A EE 200000360A EE P200000360 A EEP200000360 A EE P200000360A EE P200000360 A EEP200000360 A EE P200000360A EE 200000360 A EE200000360 A EE 200000360A
Authority
EE
Estonia
Prior art keywords
receptor antagonists
beta
integrin receptor
alpha
preparation
Prior art date
Application number
EEP200000360A
Other languages
English (en)
Inventor
E. Duggan Mark
S. Meissner Robert
H. Hutchinson John
Halczenko Wasyl
C. Askew Ben
J. Coleman Paul
A. Patane Michael
Wang Jiabing
J. Perkins James
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810182.7A external-priority patent/GB9810182D0/en
Priority claimed from GBGB9810882.2A external-priority patent/GB9810882D0/en
Priority claimed from GBGB9810892.1A external-priority patent/GB9810892D0/en
Priority claimed from GBGB9811283.2A external-priority patent/GB9811283D0/en
Priority claimed from GBGB9812686.5A external-priority patent/GB9812686D0/en
Priority claimed from GBGB9822331.6A external-priority patent/GB9822331D0/en
Priority claimed from GBGB9822701.0A external-priority patent/GB9822701D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE200000360A publication Critical patent/EE200000360A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
EEP200000360A 1997-12-17 1998-12-14 Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod EE200000360A (et)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US6991097P 1997-12-17 1997-12-17
US7919798P 1998-03-24 1998-03-24
US7994498P 1998-03-30 1998-03-30
US8039798P 1998-04-02 1998-04-02
US8325198P 1998-04-27 1998-04-27
GBGB9810182.7A GB9810182D0 (en) 1998-05-13 1998-05-13 Vitronectin receptor antagonists
GBGB9810882.2A GB9810882D0 (en) 1998-05-20 1998-05-20 Vitronectin receptor antagonists
GBGB9810892.1A GB9810892D0 (en) 1998-05-20 1998-05-20 Vitronectin receptor antagonists
GBGB9811283.2A GB9811283D0 (en) 1998-05-26 1998-05-26 Vironectin receptor antagonists
GBGB9812686.5A GB9812686D0 (en) 1998-06-12 1998-06-12 Vitronectin receptor antagonists
US9262498P 1998-07-13 1998-07-13
US9258898P 1998-07-13 1998-07-13
US9994898P 1998-09-11 1998-09-11
GBGB9822331.6A GB9822331D0 (en) 1998-10-13 1998-10-13 Vitronectin receptor antagonists
GBGB9822701.0A GB9822701D0 (en) 1998-10-16 1998-10-16 Intergrin receptor antagonists
PCT/US1998/026568 WO1999031099A1 (en) 1997-12-17 1998-12-14 Integrin receptor antagonists

Publications (1)

Publication Number Publication Date
EE200000360A true EE200000360A (et) 2001-12-17

Family

ID=27585232

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000360A EE200000360A (et) 1997-12-17 1998-12-14 Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod

Country Status (23)

Country Link
EP (1) EP1040111B1 (et)
JP (2) JP3589633B2 (et)
KR (2) KR20010024748A (et)
AT (1) ATE298338T1 (et)
AU (1) AU741769B2 (et)
BG (1) BG104601A (et)
CA (1) CA2315189C (et)
DK (1) DK1040111T3 (et)
EA (1) EA003095B1 (et)
EE (1) EE200000360A (et)
ES (1) ES2243016T3 (et)
HU (1) HUP0100178A3 (et)
IL (1) IL136314A0 (et)
IS (1) IS5513A (et)
NO (1) NO317975B1 (et)
NZ (1) NZ504896A (et)
PE (1) PE20000010A1 (et)
PL (1) PL341095A1 (et)
PT (1) PT1040111E (et)
SI (1) SI1040111T1 (et)
SK (1) SK9162000A3 (et)
TR (1) TR200001752T2 (et)
WO (1) WO1999031099A1 (et)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999030709A1 (en) * 1997-12-17 1999-06-24 Merck & Co., Inc. Integrin receptor antagonists
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
WO2000009503A1 (en) * 1998-08-13 2000-02-24 Merck & Co., Inc. Integrin receptor antagonists
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
EP1140179A2 (en) * 1998-12-23 2001-10-10 G.D. SEARLE & CO. Use of a cyclooxygenase 2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia
US7125883B1 (en) 1999-04-13 2006-10-24 Abbott Gmbh & Co. Kg Integrin receptor ligands
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
HUP0302468A2 (hu) 1999-06-02 2003-11-28 Merck & Co., Inc. Alfa V integrin receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
DE19936780A1 (de) * 1999-08-09 2001-02-15 Basf Ag Neue Antagonisten von Integrinrezeptoren
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
CA2386030A1 (en) 1999-10-04 2001-04-12 Merck & Co., Inc. Integrin receptor antagonists
US6407241B1 (en) 1999-11-08 2002-06-18 Merck & Co., Inc. Process and intermediates for the preparation of imidazolidinone αv integrin antagonists
MXPA02004547A (es) * 1999-11-08 2002-09-02 Merck & Co Inc Procedimiento e intermediarios para preparar antagonistas de alfa v integrina de tipo imidazolidinona.
GB2356630A (en) 1999-11-10 2001-05-30 Merck & Co Inc Intermediates used in the preparation of tetrahydronaphthyridine
DE60007894T2 (de) 1999-11-23 2004-10-28 Merck & Co., Inc. Verfahren für die herstellung und zwischenprodukte von tetrahydro-[1,8]-naphthyridin
US6849639B2 (en) * 1999-12-14 2005-02-01 Amgen Inc. Integrin inhibitors and their methods of use
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
JP4787447B2 (ja) * 2000-01-20 2011-10-05 メルク・シャープ・エンド・ドーム・コーポレイション αｖインテグリン受容体拮抗薬
DE60130910T2 (de) 2000-04-17 2008-07-10 Ucb Pharma, S.A. Enamin-derivate als zell-adhäsionsmoleküle
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
EP1301488A1 (en) 2000-07-07 2003-04-16 Celltech R&D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
AU2001275724A1 (en) 2000-08-02 2002-02-13 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
AU9088401A (en) * 2000-09-13 2002-03-26 Merck & Co Inc Alpha v integrin receptor antagonists
WO2002022615A1 (en) 2000-09-14 2002-03-21 Merck & Co., Inc. Alpha v integrin receptor antagonists
EP1349548A4 (en) * 2001-01-03 2004-06-02 Merck & Co Inc METHOD AND COMPOSITIONS FOR TREATING PERIODONTOSIS
ES2200617B1 (es) 2001-01-19 2005-05-01 Almirall Prodesfarma, S.A. Derivados de urea como antagonistas de integrinas alfa 4.
WO2002085405A2 (en) 2001-04-24 2002-10-31 Merck Patent Gmbh COMBINATION THERAPY USING ANTI-ANGIOGENIC AGENTS AND TNF$g(a)
US6855724B2 (en) 2002-04-08 2005-02-15 Agouron Pharmaceuticals, Inc. Tropane derivatives useful in therapy
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
WO2006038606A1 (ja) * 2004-10-05 2006-04-13 Shionogi & Co., Ltd. ビアリール誘導体
CA2637387A1 (en) 2006-01-18 2007-07-26 Simon Goodman Specific therapy using integrin ligands for treating cancer
DE102006024024A1 (de) 2006-05-23 2007-11-29 Bayer Healthcare Aktiengesellschaft Substituierte Arylimidazolone und -triazolone sowie ihre Verwendung
EP2441464B1 (en) 2007-01-18 2014-04-09 Merck Patent GmbH Integrin ligands for use in treating colon cancer
CA2715034C (en) 2008-03-14 2016-12-06 Visen Medical, Inc. Integrin targeting agents and in-vivo and in-vitro imaging methods using the same
DE102008060967A1 (de) 2008-12-06 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylsulfonyltriazolone und ihre Verwendung
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
EP2445534A2 (en) 2009-05-25 2012-05-02 Merck Patent GmbH Continuous administration of cilengitide in cancer treatments
DK2539326T3 (en) 2010-02-27 2017-08-28 Bayer Ip Gmbh BIS-ARYL-CONNECTED ARYLTRIZOLONES AND USE THEREOF
DE102010040187A1 (de) 2010-09-02 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung
DE102010040924A1 (de) 2010-09-16 2012-03-22 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung
BR122019026750B1 (pt) * 2013-02-07 2022-03-03 Scifluor Life Sciences, Inc Compostos antagonistas de integrina fluorados
US8901144B2 (en) * 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
ES2899860T3 (es) 2013-09-24 2022-03-15 Fujifilm Corp Nuevo compuesto que contiene nitrógeno o sal del mismo, o complejo de metal de los mismos
CA2950390C (en) 2014-05-30 2020-09-22 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
MY186908A (en) 2014-11-03 2021-08-26 Bayer Pharma AG Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
CA2976634C (en) * 2015-02-19 2023-10-17 Scifluor Life Sciences, Inc Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
WO2017189828A1 (en) * 2016-04-27 2017-11-02 Scifluor Life Sciences, Inc. Nonanoic and decanoic acid derivatives and uses thereof
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
EP4147698A1 (en) 2017-02-28 2023-03-15 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
RU2022108080A (ru) 2017-02-28 2022-04-07 Морфик Терапьютик, Инк. Ингибиторы интегрина avb6
TW202035400A (zh) 2018-08-29 2020-10-01 美商莫菲克醫療股份有限公司 抑制αvβ6整合素
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1598073A (en) * 1976-12-18 1981-09-16 Beecham Group Ltd 8,10,12-triazaprostaglandins
AU4806879A (en) * 1978-06-15 1979-12-20 Beecham Group Limited 1,2,4 triazole derivatives
DE3042466A1 (de) * 1980-11-11 1982-06-16 A. Nattermann & Cie GmbH, 5000 Köln N-substituierte (omega) -(2-oxo-4-imidazolin-l-yl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CA2083735A1 (en) * 1990-05-25 1991-11-26 Robert E. Manning N-substituted-1,2,4-triazolone compounds for treatment of cardiovascular disorders
US5416099A (en) * 1991-10-29 1995-05-16 Merck & Co., Inc. Fibrinogen receptor antagonists
PT626969E (pt) * 1992-02-11 2000-11-30 Smithkline Beecham Corp Inibidores de co.a-it e de p.a.f.
ES2186720T3 (es) * 1994-05-27 2003-05-16 Merck & Co Inc Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.

Also Published As

Publication number Publication date
CA2315189C (en) 2005-04-19
AU741769B2 (en) 2001-12-06
EP1040111B1 (en) 2005-06-22
EP1040111A1 (en) 2000-10-04
NO20003113L (no) 2000-08-16
JP2004300158A (ja) 2004-10-28
CA2315189A1 (en) 1999-06-24
IS5513A (is) 2000-05-26
EA200000653A1 (ru) 2000-12-25
NZ504896A (en) 2002-10-25
AU1914499A (en) 1999-07-05
SK9162000A3 (en) 2001-03-12
PL341095A1 (en) 2001-03-26
JP3589633B2 (ja) 2004-11-17
KR20030048081A (ko) 2003-06-18
EA003095B1 (ru) 2002-12-26
HUP0100178A2 (hu) 2001-11-28
HUP0100178A3 (en) 2002-12-28
BG104601A (bg) 2001-01-31
JP2002508374A (ja) 2002-03-19
IL136314A0 (en) 2001-05-20
KR20010024748A (ko) 2001-03-26
PE20000010A1 (es) 2000-01-29
DK1040111T3 (da) 2005-10-10
ES2243016T3 (es) 2005-11-16
SI1040111T1 (en) 2005-10-31
NO317975B1 (no) 2005-01-17
TR200001752T2 (tr) 2000-12-21
WO1999031099A1 (en) 1999-06-24
ATE298338T1 (de) 2005-07-15
PT1040111E (pt) 2005-10-31
NO20003113D0 (no) 2000-06-16

Similar Documents

Publication Publication Date Title
EE200000360A (et) Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod
EE200000362A (et) Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod
ATE299023T1 (de) Integrinrezeptor antagonisten
ATE236626T1 (de) Integrin antagonist
CA2277273A1 (en) Integrin antagonists
DE69716900T2 (de) Alpha v Beta 3 ANTAGONISTEN
EE200100642A (et) Alfa-v integriinretseptori antagonistid ja farmatseutiline kompositsioon
YU38200A (sh) Antagonisti integrinskog receptora
YU38300A (sh) Antagonisti integrinskog receptora
ECSP992897A (es) Antagonistas del receptor de integrina
GEP20032898B (en) Integrin Receptor Antagonists, Pharmaceutical Composition Containing the Same and Methods for Treatment

Legal Events

Date Code Title Description
HD1A Correction of address