EE05534B1 - IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks - Google Patents

IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Info

Publication number
EE05534B1
EE05534B1 EEP200300328A EEP200300328A EE05534B1 EE 05534 B1 EE05534 B1 EE 05534B1 EE P200300328 A EEP200300328 A EE P200300328A EE P200300328 A EEP200300328 A EE P200300328A EE 05534 B1 EE05534 B1 EE 05534B1
Authority
EE
Estonia
Prior art keywords
cardiomyopathy
medicament
inhibitors
prevention
manufacture
Prior art date
Application number
EEP200300328A
Other languages
English (en)
Estonian (et)
Inventor
Dinarello Charles
Pomerantz Benjamin
Reznikov Leonid
Harken Alden
Chvatchko Yolande
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE200300328A publication Critical patent/EE200300328A/xx
Publication of EE05534B1 publication Critical patent/EE05534B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EEP200300328A 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks EE05534B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101959 2001-01-29
PCT/EP2002/000844 WO2002060479A1 (en) 2001-01-29 2002-01-28 Use of il-18 inhibitors for the treatment and/or prevention of heart disease

Publications (2)

Publication Number Publication Date
EE200300328A EE200300328A (et) 2003-10-15
EE05534B1 true EE05534B1 (et) 2012-04-16

Family

ID=8176323

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300328A EE05534B1 (et) 2001-01-29 2002-01-28 IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks

Country Status (32)

Country Link
US (1) US20040234523A1 (pl)
EP (1) EP1355668B1 (pl)
JP (2) JP4860897B2 (pl)
KR (1) KR100857376B1 (pl)
CN (1) CN1326562C (pl)
AR (1) AR032422A1 (pl)
AT (1) ATE380558T1 (pl)
BG (1) BG66483B1 (pl)
BR (1) BR0206819A (pl)
CA (1) CA2435466C (pl)
CY (1) CY1107203T1 (pl)
CZ (1) CZ305653B6 (pl)
DE (1) DE60224004T2 (pl)
DK (1) DK1355668T3 (pl)
EA (2) EA010180B1 (pl)
EE (1) EE05534B1 (pl)
ES (1) ES2295332T3 (pl)
HK (1) HK1062810A1 (pl)
HR (1) HRP20030609A2 (pl)
HU (1) HU229164B1 (pl)
IL (2) IL157024A0 (pl)
ME (1) ME00549B (pl)
MX (1) MXPA03006776A (pl)
NO (1) NO331083B1 (pl)
PL (1) PL213568B1 (pl)
PT (1) PT1355668E (pl)
RS (1) RS51125B (pl)
SI (1) SI1355668T1 (pl)
SK (1) SK287620B6 (pl)
UA (1) UA80676C2 (pl)
WO (1) WO2002060479A1 (pl)
ZA (1) ZA200305439B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1257585A2 (en) 2000-02-10 2002-11-20 Basf Aktiengesellschaft Antibodies that bind human interleukin-18 and methods of making and using
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
ES2384241T3 (es) 2003-05-13 2012-07-02 Merck Serono Sa Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
JP4961559B2 (ja) * 2004-03-11 2012-06-27 友昭 星野 インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
PL1885753T3 (pl) 2005-06-03 2011-12-30 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
AU2008324814B2 (en) * 2007-11-05 2013-05-16 Solventum Intellectual Properties Company Identification of tissue for debridement
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
AU2014317035B2 (en) * 2013-09-05 2020-02-27 Ab2 Bio Sa IL-18 binding protein (IL-18BP) in inflammatory diseases
CN107660150B (zh) * 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
WO1998010778A1 (en) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Inc. INHIBITION OF APOPTOSIS USING INTERLEUKIN-1β-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS
WO1998024804A2 (en) * 1996-12-06 1998-06-11 Vertex Pharmaceuticals Incorporated INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
ES2146192T1 (es) * 1997-03-18 2000-08-01 Basf Ag Metodo y composiciones para modular la sensibilidad a los corticosteroides.
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) * 1997-10-06 1998-11-26 Henkel Kgaa Detergensgemische und deren Verwendung
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
WO2000012555A1 (fr) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Proteine de liaison de l'interleukine 18
EP1022027A1 (en) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Tumor necrosis factor antagonists and their use in endometriosis
ATE336480T1 (de) * 1999-03-16 2006-09-15 Cytovia Inc Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
BR0009610A (pt) * 1999-04-09 2002-02-13 Cytovia Inc Inibidores de caspase e uso dos mesmos
AU6078500A (en) * 1999-07-09 2001-01-30 Amgen, Inc. Combination therapy for conditions leading to bone loss
EP1257585A2 (en) * 2000-02-10 2002-11-20 Basf Aktiengesellschaft Antibodies that bind human interleukin-18 and methods of making and using
EA007014B1 (ru) * 2000-05-05 2006-06-30 Апплайд Резеч Системз Арс Холдинг Н.В. Применение il-18 в качестве диагностического маркера
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders

Also Published As

Publication number Publication date
BG108128A (bg) 2004-11-30
CZ305653B6 (cs) 2016-01-27
KR20030070143A (ko) 2003-08-27
SK287620B6 (sk) 2011-04-05
HUP0303306A3 (en) 2005-12-28
HRP20030609A2 (en) 2005-06-30
PL213568B1 (pl) 2013-03-29
MXPA03006776A (es) 2003-10-24
CN1326562C (zh) 2007-07-18
DK1355668T3 (da) 2008-05-05
HU229164B1 (en) 2013-09-30
RS51125B (sr) 2010-10-31
CZ20032335A3 (en) 2004-07-14
IL157024A0 (en) 2004-02-08
JP2009102354A (ja) 2009-05-14
EE200300328A (et) 2003-10-15
EA200300844A1 (ru) 2003-12-25
JP2004522748A (ja) 2004-07-29
PL366802A1 (pl) 2005-02-07
EP1355668A1 (en) 2003-10-29
NO331083B1 (no) 2011-10-03
EP1355668B1 (en) 2007-12-12
BG66483B1 (bg) 2015-03-31
ME00549B (me) 2011-10-10
AR032422A1 (es) 2003-11-05
SK10892003A3 (sk) 2004-02-03
CA2435466A1 (en) 2002-08-08
SI1355668T1 (sl) 2008-06-30
JP4860897B2 (ja) 2012-01-25
PT1355668E (pt) 2008-01-04
CY1107203T1 (el) 2012-11-21
IL157024A (en) 2014-02-27
ATE380558T1 (de) 2007-12-15
US20040234523A1 (en) 2004-11-25
EA200501549A1 (ru) 2006-04-28
HUP0303306A2 (hu) 2004-01-28
ES2295332T3 (es) 2008-04-16
YU57803A (sh) 2006-05-25
EA006767B1 (ru) 2006-04-28
WO2002060479A1 (en) 2002-08-08
HK1062810A1 (en) 2004-11-26
KR100857376B1 (ko) 2008-09-05
DE60224004D1 (de) 2008-01-24
EA010180B1 (ru) 2008-06-30
CA2435466C (en) 2012-04-03
BR0206819A (pt) 2004-02-03
NO20033228L (no) 2003-09-26
CN1499982A (zh) 2004-05-26
ZA200305439B (en) 2004-07-15
NO20033228D0 (no) 2003-07-16
UA80676C2 (en) 2007-10-25
DE60224004T2 (de) 2009-07-23

Similar Documents

Publication Publication Date Title
TWI346558B (en) Pharmaceutical composition for chronic treatment of inflammation and use thereof
EE200300485A (et) Tiohüdantoinid ja nende kasutamine diabeedi raviks
EE200300145A (et) Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon
CY2014001I1 (el) Συνδυασμος αζελαστινης και φλουτικαζονης
EE05056B1 (et) IL-18 inhibiitorite kasutamine ravimi valmistamiseks, mis on ette n„htud ateroskleroosi ravimiseks ja/v?i ennetamiseks
SI1487541T1 (sl) Uporaba inhibitorjev il-18 za zdravljenje in /alipreventivo bolezni perifernega oĺ˝ilja
NO20052009D0 (no) Kombinasjonsterapi for behandling av akutt leukumi og myelodysplastikksyndrom
EE200300311A (et) Ftalasinoon-piperidinoderivaadid, nende kasutamine ja ravim
DE60203929D1 (de) Behandlungsverfahren und pharmazeutische zusammensetzung zur notfall-empfängnisverhütung
EE05534B1 (et) IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks
EE200300473A (et) Tsüano-asendatud dihüdropürimidiinühendid ja nende kasutamine haiguste raviks
EE200300474A (et) Tsüano-asendatud dihüdropürimidiinühendid ja nende kasutamine haiguste raviks
DE60220060D1 (de) Wirbelbildung inhibitor mit opferkörper
AU2002346594A1 (en) Use of hiv-1 protease inhibitors and their derivatives in the treatment of inflammation
EE200300213A (et) SARP-1 kasutamine sklerodermia raviks ja/või ennetamiseks
EE200300057A (et) Koostis vähi profülaktikaks ja raviks
HUP0402061A3 (en) Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, cox-2 inhibitor and a taxol
EE05263B1 (et) IL-18 inhibiitorite kasutamine keskn„rvissteemi kahjustuste raviks v?i ennetamiseks
EE200300505A (et) Aromataasi inhibiitori kasutamine ravimi valmistamiseks viljatuse raviks
EE200200698A (et) Ravimid neurodegeneratiivsete haiguste ennetamiseks ja raviks
EE200300563A (et) Bensüülaminopürimidiiniühendid, nende kasutamine ja ravim
ATA6762000A (de) Zahnärztliches oder chirurgisches winkelstück
ITMI20021078A0 (it) Uso di sistemi topici transdermali per la prevenzione e cura della dismenorrea primaria
FI20021948A0 (fi) Menetelmiä ja koostumuksia sileän lihassolun uudiskasvun hoitoon ja ennaltaehkäisyyn
FI20020132A0 (fi) Diagnostisia ja terapeuttisia menetelmiõ

Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
HC1A Change of owner name