EE05384B1 - LaiaspektrilisedÁ2-(asendatudÁamino)bensoksasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁkasutamine,ÁfarmatseutilineÁkompositsioonÁjaÁmeetodÁretroviiruseÁreplikatsiooniÁinhibeerimiseks - Google Patents
LaiaspektrilisedÁ2-(asendatudÁamino)bensoksasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁkasutamine,ÁfarmatseutilineÁkompositsioonÁjaÁmeetodÁretroviiruseÁreplikatsiooniÁinhibeerimiseksInfo
- Publication number
- EE05384B1 EE05384B1 EEP200300494A EEP200300494A EE05384B1 EE 05384 B1 EE05384 B1 EE 05384B1 EE P200300494 A EEP200300494 A EE P200300494A EE P200300494 A EEP200300494 A EE P200300494A EE 05384 B1 EE05384 B1 EE 05384B1
- Authority
- EE
- Estonia
- Prior art keywords
- ákuiáhiváprotease
- áamino
- sulphonamides
- antiretroviral
- benzoxazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201308 | 2001-04-09 | ||
| US28770401P | 2001-05-02 | 2001-05-02 | |
| PCT/EP2002/004012 WO2002081478A2 (en) | 2001-04-09 | 2002-04-09 | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200300494A EE200300494A (et) | 2003-12-15 |
| EE05384B1 true EE05384B1 (et) | 2011-02-15 |
Family
ID=26076876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200300494A EE05384B1 (et) | 2001-04-09 | 2002-04-09 | LaiaspektrilisedÁ2-(asendatudÁamino)bensoksasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁkasutamine,ÁfarmatseutilineÁkompositsioonÁjaÁmeetodÁretroviiruseÁreplikatsiooniÁinhibeerimiseks |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7244752B2 (bg) |
| EP (1) | EP1397367A2 (bg) |
| JP (1) | JP4417010B2 (bg) |
| KR (1) | KR100872029B1 (bg) |
| CN (1) | CN100491360C (bg) |
| AP (1) | AP1544A (bg) |
| AR (1) | AR035819A1 (bg) |
| AU (1) | AU2002257774B2 (bg) |
| BG (1) | BG66371B1 (bg) |
| BR (1) | BR0208796A (bg) |
| CA (1) | CA2442870C (bg) |
| CZ (1) | CZ303139B6 (bg) |
| EA (1) | EA007383B1 (bg) |
| EE (1) | EE05384B1 (bg) |
| HR (1) | HRP20030905B1 (bg) |
| HU (1) | HUP0303744A3 (bg) |
| IL (1) | IL158092A0 (bg) |
| MX (1) | MXPA03009179A (bg) |
| NO (1) | NO328896B1 (bg) |
| NZ (1) | NZ528954A (bg) |
| OA (1) | OA12464A (bg) |
| PL (1) | PL367084A1 (bg) |
| SK (1) | SK288232B6 (bg) |
| WO (1) | WO2002081478A2 (bg) |
| ZA (1) | ZA200307683B (bg) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL367084A1 (en) * | 2001-04-09 | 2005-02-21 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
| WO2002092595A1 (en) * | 2001-05-11 | 2002-11-21 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors |
| US7285566B2 (en) * | 2002-01-07 | 2007-10-23 | Erickson John W | Resistance-repellent retroviral protease inhibitors |
| EP1472536A4 (en) | 2002-01-07 | 2007-02-14 | Sequoia Pharmaceuticals | VERSATILE INHIBITORS |
| US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
| DE60315984T2 (de) * | 2002-05-17 | 2008-05-29 | Tibotec Pharmaceuticals Ltd. | Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung |
| CN1953964A (zh) * | 2004-03-11 | 2007-04-25 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
| JP5073480B2 (ja) * | 2004-05-07 | 2012-11-14 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
| DK1856125T3 (da) | 2005-02-25 | 2009-12-07 | Tibotec Pharm Ltd | Syntese af proteasehæmmerforstadie |
| DE102010044584A1 (de) * | 2010-09-07 | 2012-03-08 | Kautex Textron Gmbh & Co. Kg | Kraftstoffbehälter aus thermoplastischem Kunststoff |
| WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3021326A1 (de) | 1980-06-06 | 1981-12-17 | Drägerwerk AG, 2400 Lübeck | Einrichtung zur messung von mindestens zwei pneumatischen lungenparametern und messverfahren hierzu |
| US4448192A (en) | 1982-03-05 | 1984-05-15 | Hewlett Packard Company | Medical ventilator device parametrically controlled for patient ventilation |
| IT1185906B (it) | 1985-09-13 | 1987-11-18 | Luciano Gattinoni | Sistema ed apparecchio biomedicale per la misurazione con precisione dei valori di variazione di pressione e volume nei polmoni di un paziente |
| DE3919840A1 (de) | 1989-06-17 | 1991-01-17 | Hoechst Ag | Verfahren zur herstellung von aromatischen sulfonsaeurechloriden |
| US5136043A (en) | 1989-06-17 | 1992-08-04 | Hoechst Aktiengesellschaft | Process for the preparation of aromatic sulfonyl chlorides |
| DE69121436T2 (de) | 1990-03-09 | 1997-01-09 | Milliken Res Corp | Organische Materialien, die sulfonamidogebundene Poly(oxyalkylen)gruppen tragen und ihre Herstellung |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| WO1995006030A1 (en) * | 1993-08-24 | 1995-03-02 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| PL175564B1 (pl) | 1993-10-01 | 1999-01-29 | Astra Ab | Sposób i urządzenie do formowania leku w proszku oraz lek w proszku |
| DK0730570T3 (da) | 1993-11-23 | 2000-07-17 | Searle & Co | Fremgangsmåde til fremstilling af mellemprodukter, der er anvendelige til syntese af retroviral protease-inhibitorer |
| EP1586558A3 (en) * | 1995-01-20 | 2005-10-26 | G.D. Searle LLC. | Bis-sulfonamide hydroxyethylamino retroviral protease inhinitors |
| US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6150556A (en) | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| AU717598B2 (en) | 1995-03-10 | 2000-03-30 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| JP2000515488A (ja) * | 1995-11-15 | 2000-11-21 | ジー．ディー．サール アンド カンパニー | 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤 |
| GB9525994D0 (en) | 1995-12-20 | 1996-02-21 | Univ Manitoba | Improvements in delivery of assist modes of mechanical ventilation |
| CN1165291C (zh) | 1996-05-20 | 2004-09-08 | 詹森药业有限公司 | 具有改进的生物利用度的抗真菌组合物 |
| ES2201485T3 (es) | 1997-03-26 | 2004-03-16 | Janssen Pharmaceutica N.V. | Palets que tienen un nucleo recubierto con un agente antifungico y un polimero. |
| SE513969C2 (sv) | 1997-05-17 | 2000-12-04 | Draegerwerk Ag | Anordning och förfarande för bestämning av respirationssystemetsmekaniska egenskaper |
| WO1999006254A1 (de) * | 1997-07-31 | 1999-02-11 | Continental Teves Ag & Co. Ohg | Verfahren und vorrichtung zur aktivierung einer bremsanlage |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| CN1110492C (zh) | 1997-12-24 | 2003-06-04 | 沃泰克斯药物股份有限公司 | 天冬氨酰蛋白酶抑制剂的前药 |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| WO1999067254A2 (en) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| JP4776775B2 (ja) | 1998-06-23 | 2011-09-21 | アメリカ合衆国 | Ｈｉｖ感染哺乳動物を治療するための医薬組成物 |
| RU2247123C2 (ru) * | 1999-10-06 | 2005-02-27 | Тиботек Фармасьютикалз Лтд. | Гексагидрофуро [2,3-b] фуран-3-ил-n-{3-[(1,3-бензодиоксол-5- илсульфонил)(изобутил)амино]-1-бензил -2-гидроксипропил}карбамат, фармацевтическая композиция на их основе, способы ингибирования и способ лечения |
| PL367084A1 (en) * | 2001-04-09 | 2005-02-21 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors |
-
2002
- 2002-04-09 PL PL02367084A patent/PL367084A1/xx unknown
- 2002-04-09 US US10/474,162 patent/US7244752B2/en not_active Expired - Fee Related
- 2002-04-09 OA OA1200300253A patent/OA12464A/en unknown
- 2002-04-09 JP JP2002579466A patent/JP4417010B2/ja not_active Expired - Fee Related
- 2002-04-09 AU AU2002257774A patent/AU2002257774B2/en not_active Ceased
- 2002-04-09 CA CA2442870A patent/CA2442870C/en not_active Expired - Fee Related
- 2002-04-09 IL IL15809202A patent/IL158092A0/xx not_active IP Right Cessation
- 2002-04-09 CZ CZ20032936A patent/CZ303139B6/cs not_active IP Right Cessation
- 2002-04-09 SK SK1339-2003A patent/SK288232B6/sk not_active IP Right Cessation
- 2002-04-09 KR KR1020037013144A patent/KR100872029B1/ko not_active IP Right Cessation
- 2002-04-09 AR ARP020101301A patent/AR035819A1/es not_active Application Discontinuation
- 2002-04-09 HU HU0303744A patent/HUP0303744A3/hu unknown
- 2002-04-09 WO PCT/EP2002/004012 patent/WO2002081478A2/en active IP Right Grant
- 2002-04-09 MX MXPA03009179A patent/MXPA03009179A/es active IP Right Grant
- 2002-04-09 EP EP02727554A patent/EP1397367A2/en not_active Withdrawn
- 2002-04-09 NZ NZ528954A patent/NZ528954A/en not_active IP Right Cessation
- 2002-04-09 AP APAP/P/2003/002882A patent/AP1544A/en active
- 2002-04-09 EA EA200301110A patent/EA007383B1/ru not_active IP Right Cessation
- 2002-04-09 CN CNB028114809A patent/CN100491360C/zh not_active Expired - Fee Related
- 2002-04-09 EE EEP200300494A patent/EE05384B1/xx not_active IP Right Cessation
- 2002-04-09 BR BR0208796-0A patent/BR0208796A/pt not_active IP Right Cessation
-
2003
- 2003-10-01 ZA ZA2003/07683A patent/ZA200307683B/en unknown
- 2003-10-01 BG BG108218A patent/BG66371B1/bg unknown
- 2003-10-08 NO NO20034505A patent/NO328896B1/no not_active IP Right Cessation
- 2003-11-07 HR HR20030905A patent/HRP20030905B1/xx not_active IP Right Cessation
-
2007
- 2007-01-23 US US11/626,183 patent/US7595334B2/en not_active Expired - Fee Related
Also Published As
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| HE1A | Change of address | ||
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Effective date: 20160409 |