EE04815B1 - 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine - Google Patents

6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine

Info

Publication number
EE04815B1
EE04815B1 EEP200000489A EEP200000489A EE04815B1 EE 04815 B1 EE04815 B1 EE 04815B1 EE P200000489 A EEP200000489 A EE P200000489A EE P200000489 A EEP200000489 A EE P200000489A EE 04815 B1 EE04815 B1 EE 04815B1
Authority
EE
Estonia
Prior art keywords
aminocyclohexyl
purines
disubstituted
trans
amino
Prior art date
Application number
EEP200000489A
Other languages
English (en)
Estonian (et)
Inventor
Ann Dumont Jennifer
Joseph Bitonti Alan
Roger Borcherding David
Paul Peet Norton
Randall Munson Harry
Wai-Kwok Shum Patrick
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of EE200000489A publication Critical patent/EE200000489A/xx
Publication of EE04815B1 publication Critical patent/EE04815B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200000489A 1998-02-26 1999-02-18 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine EE04815B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3097598A 1998-02-26 1998-02-26
US13510998P 1998-02-26 1998-02-26
US09/247,053 US6479487B1 (en) 1998-02-26 1999-02-09 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
PCT/US1999/003450 WO1999043675A1 (fr) 1998-02-26 1999-02-18 2-[trans-(4- aminocyclohexyl) amino]purines 6,9-disubstituees

Publications (2)

Publication Number Publication Date
EE200000489A EE200000489A (et) 2002-04-15
EE04815B1 true EE04815B1 (et) 2007-04-16

Family

ID=27363758

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000489A EE04815B1 (et) 1998-02-26 1999-02-18 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine

Country Status (17)

Country Link
US (1) US6479487B1 (fr)
EP (1) EP1056744B1 (fr)
JP (1) JP2002504552A (fr)
CN (1) CN1143858C (fr)
AP (1) AP1054A (fr)
AU (1) AU747151B2 (fr)
BR (1) BR9909256A (fr)
CA (1) CA2320474C (fr)
EE (1) EE04815B1 (fr)
HU (1) HUP0100889A3 (fr)
IL (1) IL138043A0 (fr)
NO (1) NO328509B1 (fr)
PL (1) PL194174B1 (fr)
SK (1) SK12902000A3 (fr)
TR (1) TR200002463T2 (fr)
WO (1) WO1999043675A1 (fr)
ZA (1) ZA991551B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642231B2 (en) * 1998-02-26 2003-11-04 Aventis Pharmaceuticals Inc. 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
CA2396276A1 (fr) * 2000-01-07 2001-07-12 Universitaire Instelling Antwerpen Derives de purine, procede de preparation et utilisation de ces derniers
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) * 2000-03-22 2003-11-28 Centre Nat Rech Scient Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
WO2001079198A1 (fr) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles permettant d'inhiber des proteines kinases
CA2411928A1 (fr) 2000-08-09 2002-02-14 Agouron Pharmaceuticals, Inc. Composes pyrazole-thiazole, compositions pharmaceutiques les contenant, et leurs procedes d'utilisation pour inhiber les kinases cyclino-dependantes
ES2238463T3 (es) 2000-08-18 2005-09-01 Agouron Pharmaceuticals, Inc. Hidroxiimino-fluorenos heterociclicos y uso para inhibir proteina-quinasas.
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
GB0117075D0 (en) * 2000-10-31 2001-09-05 Aventis Pharm Prod Inc Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
MXPA03003774A (es) * 2000-10-31 2003-07-28 Aventis Pharm Prod Inc Derivados de acilo y sulfonilo de 2-(trans-1, 4-diaminociclohexil)-purinas 6,9-disubstituidas y sus uso como agentes antiproliferativos.
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
ATE405269T1 (de) * 2002-12-13 2008-09-15 Smithkline Beecham Corp Cyclohexylverbindungen als ccr5-antagonisten
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
KR100677396B1 (ko) * 2004-11-20 2007-02-02 엘지전자 주식회사 음성인식장치의 음성구간 검출방법
PE20120493A1 (es) 2009-06-29 2012-05-20 Incyte Corp Pirimidinonas como inhibidores de pi3k
US8759359B2 (en) * 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
CA2796311A1 (fr) 2010-04-14 2011-10-20 Incyte Corporation Derives condenses en tant qu'inhibiteurs de pi3k.sigma.
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CN102898356B (zh) * 2011-07-29 2015-08-26 上海医药工业研究院 1-(3-甲氧基丙基)-4-哌啶胺及其盐的制备方法
KR101982475B1 (ko) 2011-09-02 2019-05-27 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2014109858A1 (fr) 2013-01-14 2014-07-17 Amgen Inc. Méthodes d'utilisation d'inhibiteurs de cycle cellulaire pour moduler une ou plusieurs propriétés d'une culture cellulaire
CN103193699B (zh) * 2013-04-18 2015-04-15 安徽赛诺医药化工有限公司 一种制备普卡必利中间体的新方法
CN103508939A (zh) * 2013-06-30 2014-01-15 北京万全德众医药生物技术有限公司 一种制备普卡必利中间体1-（3-甲氧基丙基）-4-哌啶胺的方法
CN103848777B (zh) * 2014-03-18 2016-04-13 悦康药业集团有限公司 一种n-(3-甲氧基丙基)-4-氨基哌啶的合成方法
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
MY187502A (en) 2015-02-27 2021-09-24 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
TWI703150B (zh) * 2015-06-04 2020-09-01 美商庫拉腫瘤技術股份有限公司 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
EP3302057A4 (fr) 2015-06-04 2018-11-21 Kura Oncology, Inc. Méthodes et compositions d'inhibition de l'interaction de la ménine avec les protéines mll
ES2947636T3 (es) 2016-03-16 2023-08-14 Kura Oncology Inc Derivados de tieno[2,3-d]pirimidina sustituida como inhibidores de menina-MLL y métodos de uso
AU2017235462B2 (en) 2016-03-16 2021-07-01 Kura Oncology, Inc. Bridged bicyclic inhibitors of menin-MLL and methods of use
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
US11944627B2 (en) 2017-03-24 2024-04-02 Kura Oncology, Inc. Methods for treating hematological malignancies and Ewing's sarcoma
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
EP3684361A4 (fr) 2017-09-20 2021-09-08 Kura Oncology, Inc. Inhibiteurs substitués de ménine-mll et méthodes d'utilisation
CN115677567A (zh) * 2022-11-15 2023-02-03 大唐环境产业集团股份有限公司 一种4-氨基-1-哌啶丙醇的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232155A (en) 1979-09-13 1980-11-04 Bristol-Myers Company Purine compounds
ATE219519T1 (de) * 1989-01-23 2002-07-15 Chiron Corp Rekombinanttherapien für infektionen und hyperproliferative störungen
CA2084222C (fr) 1991-12-06 2004-04-06 David R. Borcherding Nouveaux analogues de trans-cyclopentanypurine utiles comme immunosuppresseurs
US5516631A (en) * 1992-10-13 1996-05-14 La Jolla Cancer Research Foundation Method of inhibiting replication of hyperproliferative cells
GB9301000D0 (en) 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
US5688665A (en) * 1994-01-07 1997-11-18 Fred Hutchinson Cancer Research Center Isolated nucleic acid molecules encoding the p27 KIP-1 protein
GB9414208D0 (en) 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
CN1066147C (zh) 1995-11-01 2001-05-23 诺瓦提斯公司 嘌呤衍生物及其制备方法
FR2741881B1 (fr) 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
AU735127B2 (en) 1997-08-07 2001-06-28 Regents Of The University Of California, The Purine inhibitor of protein kinases, G proteins and polymerases
TR200102714T2 (tr) 1999-02-01 2002-01-21 Cv Therapeutics, Inc. Sikline bağımlı kinaz 2 ve IkB-&'nın pürün inhibitörleri
FR2793794B1 (fr) * 1999-05-21 2001-07-27 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Also Published As

Publication number Publication date
WO1999043675A1 (fr) 1999-09-02
CN1143858C (zh) 2004-03-31
AU747151B2 (en) 2002-05-09
CA2320474C (fr) 2005-05-10
ZA991551B (en) 1999-08-26
SK12902000A3 (sk) 2001-04-09
HUP0100889A2 (hu) 2002-01-28
BR9909256A (pt) 2000-11-28
NO20004280D0 (no) 2000-08-25
EP1056744B1 (fr) 2003-10-22
EP1056744A1 (fr) 2000-12-06
CN1292789A (zh) 2001-04-25
IL138043A0 (en) 2001-10-31
NO328509B1 (no) 2010-03-08
EE200000489A (et) 2002-04-15
PL342604A1 (en) 2001-06-18
AU2770999A (en) 1999-09-15
TR200002463T2 (tr) 2000-12-21
PL194174B1 (pl) 2007-05-31
NO20004280L (no) 2000-10-25
AP2000001922A0 (en) 2000-09-30
AP1054A (en) 2002-04-01
HUP0100889A3 (en) 2003-07-28
JP2002504552A (ja) 2002-02-12
CA2320474A1 (fr) 1999-09-02
US6479487B1 (en) 2002-11-12

Similar Documents

Publication Publication Date Title
EE04815B1 (et) 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid, neid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
EE9900546A (et) LH-RH peptiidi analoogid, nende kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
EE9800028A (et) Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
EE04853B1 (et) Adenosiini derivaadid ja neid sisaldavad farmatseutilised kompositsioonid kasutamiseks meditsiinis
HUP0401567A3 (en) Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them
NO20002359L (no) Adenosinderivater og farmasoytisk sammensetning inneholdende derivatene
HUP0100101A3 (en) Prostaglandin agonists, pharmaceutical compositions comprising thereof and their use
DE69822209D1 (de) ESTRON-SULFatase HEMMENDE ESTRON-SULFAMATVERBINDUNGEN, PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND VERWENDUNGEN DAVON
IS5409A (is) Útskipt karboxamídóþíasól, framleiðsla þeirra og lyfjablöndur sem innihalda þau
EE05181B1 (et) Prasolo[4,3-d]primidiini derivaadid, neid sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja meetodid nende valmistamiseks
HUP0200588A2 (hu) Diarilszármazékok és azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
EP1420777A4 (fr) Compositions pharmaceutiques contenant beta-lapachone ou des derives ou des analogues correspondants, et leurs methodes d'utilisation
DK1112266T3 (da) Substituerede 4-amino-2-arylpyrimidiner, fremstilling og anvendelse deraf og farmaceutiske præparater indeholdende dem
EE04315B1 (et) 6,9-diasendatud-2-[trans-(4-aminotsükloheksüül)amino]puriinid
HUP0102766A2 (hu) Aminometilkarbonsavszármazékok, gyógyászati alkalmazásuk és ilyen vegyületeket tartalmazó gyógyászati készítmények
IL148876A0 (en) Sulfonamide derivatives, their preparation and pharmaceutical compositions containing them
IL138725A0 (en) Sulfonamide derivatives and pharmaceutical compositions containing the same
NO20001914D0 (no) <alfa>-Aryl-N-alkylnitroner og farmasøytiske blandinger som inneholder slike
HUP0002272A3 (en) Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
HUP0000762A3 (en) 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines, and pharmaceutical compositions containing them
HUP0401403A3 (en) 2,4-diaminothiazole derivatives, their use and pharmaceutical compositions containing them
EE9800426A (et) Asendatud 2,4-tiasolidiindiooni derivaadid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
IL122740A0 (en) 16-hydroxy-11-(substituted phenyl)-estra-9, 4-diene derivatives their preparation and pharmaceutical compositions containing them
HUP9800147A3 (en) Isoxasol-and crotonoil-amide derivatives and pharmaceutical and diagnostical compositions containing them
HUP0105075A3 (en) 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives, their use and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
HD1A Correction of address
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090218