EE04812B1 - 2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon - Google Patents
2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioonInfo
- Publication number
- EE04812B1 EE04812B1 EEP200100173A EEP200100173A EE04812B1 EE 04812 B1 EE04812 B1 EE 04812B1 EE P200100173 A EEP200100173 A EE P200100173A EE P200100173 A EEP200100173 A EE P200100173A EE 04812 B1 EE04812 B1 EE 04812B1
- Authority
- EE
- Estonia
- Prior art keywords
- phenylpyran
- intermediates
- derivatives
- preparation
- pharmaceutical composition
- Prior art date
Links
- UFECLJRYNAOWOI-UHFFFAOYSA-N 2-phenylpyran-4-one Chemical class O=C1C=COC(C=2C=CC=CC=2)=C1 UFECLJRYNAOWOI-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9802011A ES2154561B1 (es) | 1998-09-25 | 1998-09-25 | Derivados de 2-fenilpiran-4-ona. |
| ES009900619A ES2168895A1 (es) | 1999-03-26 | 1999-03-26 | Derivados de 2-fenilpiran-4-ona. |
| PCT/EP1999/006873 WO2000018753A1 (en) | 1998-09-25 | 1999-09-16 | 2-phenylpyran-4-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200100173A EE200100173A (et) | 2002-08-15 |
| EE04812B1 true EE04812B1 (et) | 2007-04-16 |
Family
ID=26155180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200100173A EE04812B1 (et) | 1998-09-25 | 1999-09-16 | 2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6518303B2 (cs) |
| EP (1) | EP1115716B1 (cs) |
| JP (1) | JP4717211B2 (cs) |
| KR (1) | KR100806684B1 (cs) |
| CN (1) | CN1202104C (cs) |
| AR (1) | AR021826A1 (cs) |
| AT (1) | ATE230405T1 (cs) |
| AU (1) | AU765653B2 (cs) |
| BG (1) | BG65308B1 (cs) |
| BR (1) | BR9913939A (cs) |
| CA (1) | CA2345069C (cs) |
| CO (1) | CO5140127A1 (cs) |
| CZ (1) | CZ300357B6 (cs) |
| DE (1) | DE69904738T2 (cs) |
| DK (1) | DK1115716T3 (cs) |
| EE (1) | EE04812B1 (cs) |
| EG (1) | EG23802A (cs) |
| ES (1) | ES2190252T3 (cs) |
| HU (1) | HUP0104620A3 (cs) |
| ID (1) | ID28624A (cs) |
| IL (1) | IL142087A0 (cs) |
| MX (1) | MXPA01003069A (cs) |
| MY (1) | MY121793A (cs) |
| NO (1) | NO327987B1 (cs) |
| NZ (1) | NZ510625A (cs) |
| PE (1) | PE20001067A1 (cs) |
| PL (1) | PL346895A1 (cs) |
| RU (1) | RU2232158C2 (cs) |
| SI (1) | SI1115716T1 (cs) |
| SK (1) | SK286471B6 (cs) |
| TR (1) | TR200100852T2 (cs) |
| TW (1) | TW587079B (cs) |
| WO (1) | WO2000018753A1 (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523954A (ja) | 1999-12-08 | 2003-08-12 | ファルマシア コーポレイション | 治療効果が迅速に開始されるシクロオキシゲナーゼ−２阻害剤組成物 |
| PE20011333A1 (es) * | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2 |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| WO2005009342A2 (en) * | 2003-07-16 | 2005-02-03 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
| US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| KR102557900B1 (ko) | 2016-09-07 | 2023-07-19 | 트러스티즈 오브 터프츠 칼리지 | 면역-dash 억제제와 pge2 길항제를 이용한 병행 요법 |
| US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US304728A (en) * | 1884-09-09 | Maubice hellwig | ||
| CH524612A (de) * | 1969-12-31 | 1972-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Imidazolderivaten |
| US3901908A (en) * | 1970-12-28 | 1975-08-26 | Ciba Geigy Corp | 2-alkyl- and 2-cycloalkyl-4,5-bis-phenyl-imidazoles |
| ES8104268A1 (es) | 1979-04-05 | 1981-04-01 | Lilly Industries Ltd | Procedimiento para preparar piranonas 5-sustituidas |
| US4304728A (en) * | 1979-04-05 | 1981-12-08 | Lilly Industries Limited | 6-Substituted pyranone compounds and their use as pharmaceuticals |
| JPS5834446B2 (ja) * | 1979-05-22 | 1983-07-27 | 三省製薬株式会社 | 消炎剤 |
| JPH0768234B2 (ja) * | 1989-12-14 | 1995-07-26 | 久光製薬株式会社 | コウジ酸エステル誘導体 |
| AU630822B2 (en) * | 1990-06-29 | 1992-11-05 | Upjohn Company, The | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones |
| JPH04173391A (ja) * | 1990-11-07 | 1992-06-22 | Sanyo Chem Ind Ltd | 感熱記録用増感剤および感熱記録用材料 |
| DE4103904C2 (de) * | 1991-02-08 | 1995-06-14 | Analyticon Ges Fuer Chemische | Neue Arzneimittel aus Gamma-Pyronen, Gamma-Pyridonen sowie Gamma-Thiopyronen |
| US6048850A (en) | 1992-09-22 | 2000-04-11 | Young; Donald A. | Method of inhibiting prostaglandin synthesis in a human host |
| CA2174124A1 (en) * | 1993-11-19 | 1995-05-26 | John Michael Domagala | Pyrone derivatives as protease inhibitors and antiviral agents |
| US5521213A (en) * | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| AU5276696A (en) | 1995-04-04 | 1996-10-23 | Glaxo Group Limited | Imidazo{1,2-a}pyridine derivatives |
| US6136839A (en) * | 1995-06-12 | 2000-10-24 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
| CA2307111C (en) * | 1997-11-19 | 2009-06-30 | Kowa Co., Ltd. | Novel pyridazine derivatives and drugs containing the same as the active ingredient |
-
1999
- 1999-09-15 TW TW088115924A patent/TW587079B/zh not_active IP Right Cessation
- 1999-09-16 CA CA002345069A patent/CA2345069C/en not_active Expired - Fee Related
- 1999-09-16 ES ES99947372T patent/ES2190252T3/es not_active Expired - Lifetime
- 1999-09-16 DE DE69904738T patent/DE69904738T2/de not_active Expired - Lifetime
- 1999-09-16 RU RU2001111323/04A patent/RU2232158C2/ru not_active IP Right Cessation
- 1999-09-16 WO PCT/EP1999/006873 patent/WO2000018753A1/en active IP Right Grant
- 1999-09-16 HU HU0104620A patent/HUP0104620A3/hu unknown
- 1999-09-16 TR TR2001/00852T patent/TR200100852T2/xx unknown
- 1999-09-16 MX MXPA01003069A patent/MXPA01003069A/es not_active IP Right Cessation
- 1999-09-16 IL IL14208799A patent/IL142087A0/xx unknown
- 1999-09-16 AT AT99947372T patent/ATE230405T1/de active
- 1999-09-16 PL PL99346895A patent/PL346895A1/xx not_active Application Discontinuation
- 1999-09-16 ID IDW20010685D patent/ID28624A/id unknown
- 1999-09-16 SI SI9930232T patent/SI1115716T1/xx unknown
- 1999-09-16 NZ NZ510625A patent/NZ510625A/xx not_active IP Right Cessation
- 1999-09-16 KR KR1020017003835A patent/KR100806684B1/ko not_active Expired - Fee Related
- 1999-09-16 SK SK370-2001A patent/SK286471B6/sk not_active IP Right Cessation
- 1999-09-16 JP JP2000572213A patent/JP4717211B2/ja not_active Expired - Fee Related
- 1999-09-16 DK DK99947372T patent/DK1115716T3/da active
- 1999-09-16 AU AU60847/99A patent/AU765653B2/en not_active Ceased
- 1999-09-16 CN CNB998125709A patent/CN1202104C/zh not_active Expired - Fee Related
- 1999-09-16 CZ CZ20011058A patent/CZ300357B6/cs not_active IP Right Cessation
- 1999-09-16 EP EP99947372A patent/EP1115716B1/en not_active Expired - Lifetime
- 1999-09-16 BR BR9913939-1A patent/BR9913939A/pt not_active Application Discontinuation
- 1999-09-16 EE EEP200100173A patent/EE04812B1/xx not_active IP Right Cessation
- 1999-09-21 MY MYPI99004101A patent/MY121793A/en unknown
- 1999-09-23 CO CO99060536A patent/CO5140127A1/es unknown
- 1999-09-23 PE PE1999000966A patent/PE20001067A1/es not_active Application Discontinuation
- 1999-09-24 AR ARP990104836A patent/AR021826A1/es active IP Right Grant
- 1999-09-25 EG EG118999A patent/EG23802A/xx active
-
2001
- 2001-03-16 US US09/809,645 patent/US6518303B2/en not_active Expired - Fee Related
- 2001-03-22 BG BG105373A patent/BG65308B1/bg unknown
- 2001-03-23 NO NO20011512A patent/NO327987B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB1A | Change in the ownership or in the address of the owner | ||
| HD1A | Correction of address | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| GB1A | Change in the ownership or in the address of the owner | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20110916 |