EE04274B1 - (R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod - Google Patents

(R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod

Info

Publication number
EE04274B1
EE04274B1 EEP200100070A EEP200100070A EE04274B1 EE 04274 B1 EE04274 B1 EE 04274B1 EE P200100070 A EEP200100070 A EE P200100070A EE P200100070 A EEP200100070 A EE P200100070A EE 04274 B1 EE04274 B1 EE 04274B1
Authority
EE
Estonia
Prior art keywords
osetane
phenylpiperidin
methylacetamide
dichlorophenyl
piperidin
Prior art date
Application number
EEP200100070A
Other languages
English (en)
Inventor
Alcade Alain
Anne-Archard Gilles
Grosclaude Patrick
Monnier Olivier
Roche J�rome
Original Assignee
Sanofi-Synthlabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo
Publication of EE200100070A publication Critical patent/EE200100070A/et
Publication of EE04274B1 publication Critical patent/EE04274B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP200100070A 1998-08-05 1999-08-03 (R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod EE04274B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9810107A FR2782082B3 (fr) 1998-08-05 1998-08-05 Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
PCT/FR1999/001914 WO2000007987A1 (fr) 1998-08-05 1999-08-03 Formes cristallines du osanetant

Publications (2)

Publication Number Publication Date
EE200100070A EE200100070A (et) 2002-06-17
EE04274B1 true EE04274B1 (et) 2004-04-15

Family

ID=9529458

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100070A EE04274B1 (et) 1998-08-05 1999-08-03 (R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod

Country Status (32)

Country Link
US (1) US7041679B2 (et)
EP (1) EP1102747B1 (et)
JP (1) JP3807938B2 (et)
KR (1) KR100571944B1 (et)
CN (1) CN1114592C (et)
AR (1) AR019953A1 (et)
AT (1) ATE243197T1 (et)
AU (1) AU748177B2 (et)
BR (1) BR9913357A (et)
CA (1) CA2339007A1 (et)
CO (1) CO5070576A1 (et)
DE (1) DE69908951T2 (et)
DK (1) DK1102747T3 (et)
DZ (1) DZ3074A1 (et)
EA (1) EA003205B1 (et)
EE (1) EE04274B1 (et)
ES (1) ES2200535T3 (et)
FR (1) FR2782082B3 (et)
HK (1) HK1035535A1 (et)
HU (1) HUP0103134A3 (et)
IS (1) IS5821A (et)
MY (1) MY121447A (et)
NO (1) NO320645B1 (et)
NZ (1) NZ509561A (et)
PL (1) PL345999A1 (et)
PT (1) PT1102747E (et)
SK (1) SK1742001A3 (et)
TR (1) TR200100261T2 (et)
TW (1) TW527354B (et)
UA (1) UA72890C2 (et)
WO (1) WO2000007987A1 (et)
YU (1) YU8601A (et)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US7648992B2 (en) * 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
TW200800954A (en) * 2006-03-16 2008-01-01 Astrazeneca Ab Novel crystal modifications
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
WO2023278843A2 (en) * 2021-07-02 2023-01-05 Acer Therapeutics, Inc. Solid forms of osanetant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
JPH1053576A (ja) * 1996-06-07 1998-02-24 Eisai Co Ltd 塩酸ドネペジルの多形結晶およびその製造法
WO1998005640A2 (en) * 1996-08-05 1998-02-12 Smithkline Beecham S.P.A. Process for the preparation of 3,3-disubstituted piperidines
US6040316A (en) * 1996-09-16 2000-03-21 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
FR2757543B1 (fr) * 1996-12-23 1999-04-02 Sanofi Sa Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues

Also Published As

Publication number Publication date
EE200100070A (et) 2002-06-17
AU748177B2 (en) 2002-05-30
AU5168599A (en) 2000-02-28
US7041679B2 (en) 2006-05-09
DZ3074A1 (fr) 2004-07-20
WO2000007987A1 (fr) 2000-02-17
EP1102747A1 (fr) 2001-05-30
CN1314888A (zh) 2001-09-26
NO20010553D0 (no) 2001-02-01
NO20010553L (no) 2001-04-05
EA200100096A1 (ru) 2001-08-27
JP3807938B2 (ja) 2006-08-09
EP1102747B1 (fr) 2003-06-18
SK1742001A3 (en) 2001-11-06
TR200100261T2 (tr) 2001-06-21
JP2002522419A (ja) 2002-07-23
EA003205B1 (ru) 2003-02-27
DK1102747T3 (da) 2003-09-29
CA2339007A1 (en) 2000-02-17
BR9913357A (pt) 2001-05-15
DE69908951D1 (de) 2003-07-24
AR019953A1 (es) 2002-03-27
PT1102747E (pt) 2003-09-30
KR100571944B1 (ko) 2006-04-18
FR2782082B3 (fr) 2000-09-22
ES2200535T3 (es) 2004-03-01
ATE243197T1 (de) 2003-07-15
KR20010072220A (ko) 2001-07-31
US20040044215A1 (en) 2004-03-04
FR2782082A1 (fr) 2000-02-11
HUP0103134A3 (en) 2003-03-28
NO320645B1 (no) 2006-01-09
MY121447A (en) 2006-01-28
IS5821A (is) 2001-01-23
TW527354B (en) 2003-04-11
HK1035535A1 (en) 2001-11-30
DE69908951T2 (de) 2004-05-19
CN1114592C (zh) 2003-07-16
CO5070576A1 (es) 2001-08-28
PL345999A1 (en) 2002-01-14
UA72890C2 (en) 2005-05-16
NZ509561A (en) 2002-10-25
YU8601A (sh) 2003-07-07
HUP0103134A2 (en) 2002-06-29

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Legal Events

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HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

MM4A Lapsed by not paying the annual fees

Effective date: 20070803