EA200100096A1 - Кристаллические формы (r)-(+)-(n)[[3-[1-бензоил-3-(3,4-дихлорфенил)пиперидин-3-ил]проп-1-ил]-4-фенилпиперидин-4-ил]-n-метилацетамида (осанетана) и способ их получения - Google Patents

Кристаллические формы (r)-(+)-(n)[[3-[1-бензоил-3-(3,4-дихлорфенил)пиперидин-3-ил]проп-1-ил]-4-фенилпиперидин-4-ил]-n-метилацетамида (осанетана) и способ их получения

Info

Publication number
EA200100096A1
EA200100096A1 EA200100096A EA200100096A EA200100096A1 EA 200100096 A1 EA200100096 A1 EA 200100096A1 EA 200100096 A EA200100096 A EA 200100096A EA 200100096 A EA200100096 A EA 200100096A EA 200100096 A1 EA200100096 A1 EA 200100096A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenylpiperidin
methylacetamide
dichlorophenyl
piperidin
prop
Prior art date
Application number
EA200100096A
Other languages
English (en)
Other versions
EA003205B1 (ru
Inventor
Ален Алькад
Гий Анн-Аршар
Патрик Гросклод
Оливье Моннье
Жером Рош
Original Assignee
Санофи-Синтелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Синтелябо filed Critical Санофи-Синтелябо
Publication of EA200100096A1 publication Critical patent/EA200100096A1/ru
Publication of EA003205B1 publication Critical patent/EA003205B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение касается способа получения кристаллических форм 1 и 2 (R)-(+)-(N)-[[3-[1-бензоил-3-(3,4-дихлорфенил)пиперидин-3-ил]проп-1-ил]-4-фенилпиперидин-4-ил]-N-метилацетамида (осанетана), а также осанетана в указанных кристаллических формах 1 и 2. Подлежащий кристаллизации осанетан предпочтительно получают из его бензолсульфоната.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100096A 1998-08-05 1999-08-03 Кристаллические формы (r)-(+)-(n)-[[3-[1-бензоил-3-(3,4-дихлорфенил)пиперидин-3-ил]проп-1-ил]-4-фенилпиперидин-4-ил]-n-метилацетамида (осанетана) и способ их получения EA003205B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9810107A FR2782082B3 (fr) 1998-08-05 1998-08-05 Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
PCT/FR1999/001914 WO2000007987A1 (fr) 1998-08-05 1999-08-03 Formes cristallines du osanetant

Publications (2)

Publication Number Publication Date
EA200100096A1 true EA200100096A1 (ru) 2001-08-27
EA003205B1 EA003205B1 (ru) 2003-02-27

Family

ID=9529458

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100096A EA003205B1 (ru) 1998-08-05 1999-08-03 Кристаллические формы (r)-(+)-(n)-[[3-[1-бензоил-3-(3,4-дихлорфенил)пиперидин-3-ил]проп-1-ил]-4-фенилпиперидин-4-ил]-n-метилацетамида (осанетана) и способ их получения

Country Status (32)

Country Link
US (1) US7041679B2 (ru)
EP (1) EP1102747B1 (ru)
JP (1) JP3807938B2 (ru)
KR (1) KR100571944B1 (ru)
CN (1) CN1114592C (ru)
AR (1) AR019953A1 (ru)
AT (1) ATE243197T1 (ru)
AU (1) AU748177B2 (ru)
BR (1) BR9913357A (ru)
CA (1) CA2339007A1 (ru)
CO (1) CO5070576A1 (ru)
DE (1) DE69908951T2 (ru)
DK (1) DK1102747T3 (ru)
DZ (1) DZ3074A1 (ru)
EA (1) EA003205B1 (ru)
EE (1) EE04274B1 (ru)
ES (1) ES2200535T3 (ru)
FR (1) FR2782082B3 (ru)
HK (1) HK1035535A1 (ru)
HU (1) HUP0103134A3 (ru)
IS (1) IS5821A (ru)
MY (1) MY121447A (ru)
NO (1) NO320645B1 (ru)
NZ (1) NZ509561A (ru)
PL (1) PL345999A1 (ru)
PT (1) PT1102747E (ru)
SK (1) SK1742001A3 (ru)
TR (1) TR200100261T2 (ru)
TW (1) TW527354B (ru)
UA (1) UA72890C2 (ru)
WO (1) WO2000007987A1 (ru)
YU (1) YU8601A (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) * 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403085D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) * 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
TW200800954A (en) * 2006-03-16 2008-01-01 Astrazeneca Ab Novel crystal modifications
TW200831488A (en) * 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
WO2023278843A2 (en) * 2021-07-02 2023-01-05 Acer Therapeutics, Inc. Solid forms of osanetant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
JPH1053576A (ja) * 1996-06-07 1998-02-24 Eisai Co Ltd 塩酸ドネペジルの多形結晶およびその製造法
JP2000515534A (ja) * 1996-08-05 2000-11-21 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ ３，３―二置換ピペリジンの製造方法
US6040316A (en) * 1996-09-16 2000-03-21 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
FR2757543B1 (fr) * 1996-12-23 1999-04-02 Sanofi Sa Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues

Also Published As

Publication number Publication date
NZ509561A (en) 2002-10-25
EP1102747B1 (fr) 2003-06-18
ES2200535T3 (es) 2004-03-01
HUP0103134A2 (en) 2002-06-29
FR2782082B3 (fr) 2000-09-22
MY121447A (en) 2006-01-28
EE04274B1 (et) 2004-04-15
US20040044215A1 (en) 2004-03-04
PL345999A1 (en) 2002-01-14
BR9913357A (pt) 2001-05-15
US7041679B2 (en) 2006-05-09
EP1102747A1 (fr) 2001-05-30
CN1314888A (zh) 2001-09-26
EE200100070A (et) 2002-06-17
KR20010072220A (ko) 2001-07-31
DZ3074A1 (fr) 2004-07-20
AU748177B2 (en) 2002-05-30
IS5821A (is) 2001-01-23
SK1742001A3 (en) 2001-11-06
EA003205B1 (ru) 2003-02-27
WO2000007987A1 (fr) 2000-02-17
ATE243197T1 (de) 2003-07-15
JP2002522419A (ja) 2002-07-23
YU8601A (sh) 2003-07-07
NO20010553D0 (no) 2001-02-01
NO320645B1 (no) 2006-01-09
DK1102747T3 (da) 2003-09-29
CN1114592C (zh) 2003-07-16
NO20010553L (no) 2001-04-05
CA2339007A1 (en) 2000-02-17
TR200100261T2 (tr) 2001-06-21
JP3807938B2 (ja) 2006-08-09
AR019953A1 (es) 2002-03-27
AU5168599A (en) 2000-02-28
DE69908951T2 (de) 2004-05-19
KR100571944B1 (ko) 2006-04-18
DE69908951D1 (de) 2003-07-24
CO5070576A1 (es) 2001-08-28
TW527354B (en) 2003-04-11
FR2782082A1 (fr) 2000-02-11
PT1102747E (pt) 2003-09-30
HUP0103134A3 (en) 2003-03-28
HK1035535A1 (en) 2001-11-30
UA72890C2 (en) 2005-05-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): AM AZ KZ KG MD TJ TM